아다탄세린

Adatanserin
아다탄세린
Adatanserin.svg
임상자료
ATC 코드
  • 없는
식별자
  • N-[2-(4-피리미딘-2-ylpiperazin-1-yl)ethyl]adamantane-1-carboxamide
CAS 번호
펍켐 CID
켐스파이더
유니
켐벨
화학 및 물리적 데이터
공식C21H31N5O
어금질량369.513 g·1998−1
3D 모델(JSmol)
  • O=C(NCCN2CCN(c1ncccn1)CC2)C35CC4CC(CC(C3)C4)C5
  • InChI=1S/C21H31N5O/c27-19(21-13-16-10-17(14-21)12-18(11-16)15-21)22-4-5-25-6-8-26(9-7-25)20-23-2-1-3-24-20/h1-3,16-18H,4-15H2,(H,22,27) checkY
  • 키:HPFLVTSWRFCPCV-UHFFFAOYSA-N
☒NcheckY (이게 뭐야?) (iii)

아다탄세린(Adatanserin, WY-50,324, SEP-324)은 5-HT1A 수용체 부분작용제 및 5-HT2A2C 수용체 길항제 혼합물이다.[1][2][3] 그것은 와이엣에 의해 항우울제로 개발되고 있었지만 결국 추구되지 않았다.[3][4]

아단타제린은 5-HT2A 수용체 봉쇄에 의해 매개되는 것으로 보이는 허혈 유도 글루타마테라민성 흥분성에 대해 신경보호성이 있는 것으로 나타났다.[5]

참고 항목

참조

  1. ^ Singh A, Lucki I (April 1993). "Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors". Neuropharmacology. 32 (4): 331–40. doi:10.1016/0028-3908(93)90153-T. PMID 8497336. S2CID 38611829.
  2. ^ Kleven MS, Koek W (February 1996). "Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon". The Journal of Pharmacology and Experimental Therapeutics. 276 (2): 388–97. PMID 8632301.
  3. ^ a b Abou-Gharbia MA, Childers WE, Fletcher H, et al. (December 1999). "Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents". Journal of Medicinal Chemistry. 42 (25): 5077–94. doi:10.1021/jm9806704. PMID 10602693.
  4. ^ Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. p. 262. ISBN 0-521-64615-4. adatanserin.
  5. ^ Dawson LA, Galandak J, Djali S (March 2002). "Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin". Neurochemistry International. 40 (3): 203–9. doi:10.1016/S0197-0186(01)00082-1. PMID 11741003. S2CID 24104458.