YM-348

YM-348
식별자
	IUPAC 이름 (2S)-1-(7-에틸-1H-푸로[2,3-g]indazol-1-yl)프로판-2-아민;
CAS 번호	372163-84-3;
펍켐 CID	3045225;
IUPHAR/BPS	230;
켐스파이더	2308001;
CompTox 대시보드 (EPA)	DTXSID50190708 ;
화학 및 물리적 데이터
공식	C14H17N3O
어금질량	243.1987 g·properties−1
3D 모델(JSmol)	인터랙티브 이미지;
	스마일즈 n3cc2ccc1oc(cc1c2n3C[C@@H](N)C)CC;
	인치 InChi=1S/C14H17N3O/c1-3-11-6-12-13(18-11)5-4-10-7-16-17(14-12)8-9-9(2)15/7,9H,3,8,15H2,1-2H3/t9/m0/m01; 키:QLOWOVVZLBYHU-VIFPVBQESA-N;
	(iii)

YM-348은 인다졸 파생 의약품으로_2B, 밀접하게 연관된 5-HT 수용체보다 3배 정도 선택성이 있지만 EC는₅₀ 1nM, 선택성은 15배인 5-HT에_2A 걸쳐 강력한 선택적 5-HT_2C 수용체 작용제로 작용한다.^[1]^[2] 동물 연구에서 열성 및 식이성 효과가 있어 비만 치료에 잠재적으로 유용하다.^[3]^[4]^[5]^[6]

참고 항목

참조

^ Kimura Y, Hatanaka K, Naitou Y, Maeno K, Shimada I, Koakutsu A, et al. (January 2004). "Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist". European Journal of Pharmacology. 483 (1): 37–43. doi:10.1016/j.ejphar.2003.10.004. PMID 14709324.
^ Shimada I, Maeno K, Kazuta K, Kubota H, Kimizuka T, Kimura Y, et al. (February 2008). "Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists". Bioorganic & Medicinal Chemistry. 16 (4): 1966–82. doi:10.1016/j.bmc.2007.10.100. PMID 18035544.
^ Hayashi A, Sonoda R, Kimura Y, Takasu T, Suzuki M, Sasamata M, Miyata K (June 2004). "Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats". Brain Research. 1011 (2): 221–7. doi:10.1016/j.brainres.2004.03.032. PMID 15157808. S2CID 23199460.
^ Smith BM, Thomsen WJ, Grottick AJ (March 2006). "The potential use of selective 5-HT2C agonists in treating obesity". Expert Opinion on Investigational Drugs. 15 (3): 257–66. doi:10.1517/13543784.15.3.257. PMID 16503763. S2CID 22100586.
^ Nilsson BM (July 2006). "5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents". Journal of Medicinal Chemistry. 49 (14): 4023–34. doi:10.1021/jm058240i. PMID 16821762.
^ Wacker DA, Miller KJ (July 2008). "Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases". Current Opinion in Drug Discovery & Development. 11 (4): 438–45. PMID 18600561.

신경계통에 관한 이 약물 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[1] Kimura Y, Hatanaka K, Naitou Y, Maeno K, Shimada I, Koakutsu A, et al. (January 2004). "Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist". European Journal of Pharmacology. 483 (1): 37–43. doi:10.1016/j.ejphar.2003.10.004. PMID 14709324.

[2] Shimada I, Maeno K, Kazuta K, Kubota H, Kimizuka T, Kimura Y, et al. (February 2008). "Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists". Bioorganic & Medicinal Chemistry. 16 (4): 1966–82. doi:10.1016/j.bmc.2007.10.100. PMID 18035544.

[3] Hayashi A, Sonoda R, Kimura Y, Takasu T, Suzuki M, Sasamata M, Miyata K (June 2004). "Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats". Brain Research. 1011 (2): 221–7. doi:10.1016/j.brainres.2004.03.032. PMID 15157808. S2CID 23199460.

[4] Smith BM, Thomsen WJ, Grottick AJ (March 2006). "The potential use of selective 5-HT2C agonists in treating obesity". Expert Opinion on Investigational Drugs. 15 (3): 257–66. doi:10.1517/13543784.15.3.257. PMID 16503763. S2CID 22100586.

[5] Nilsson BM (July 2006). "5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents". Journal of Medicinal Chemistry. 49 (14): 4023–34. doi:10.1021/jm058240i. PMID 16821762.

[6] Wacker DA, Miller KJ (July 2008). "Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases". Current Opinion in Drug Discovery & Development. 11 (4): 438–45. PMID 18600561.

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YM-348

네임스페이스

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참고 항목

참조

식별자

IUPAC 이름 (2S)-1-(7-에틸-1H-푸로[2,3-g]indazol-1-yl)프로판-2-아민
CAS 번호	372163-84-3
펍켐 CID	3045225
IUPHAR/BPS	230
켐스파이더	2308001
CompTox 대시보드 (EPA)	DTXSID50190708
화학 및 물리적 데이터
공식	C₁₄H₁₇N₃O
어금질량	243.1987 g·properties⁻¹
3D 모델(JSmol)	인터랙티브 이미지
스마일즈 n3cc2ccc1oc(cc1c2n3C[C@@H](N)C)CC
인치 InChi=1S/C14H17N3O/c1-3-11-6-12-13(18-11)5-4-10-7-16-17(14-12)8-9-9(2)15/7,9H,3,8,15H2,1-2H3/t9/m0/m01 키:QLOWOVVZLBYHU-VIFPVBQESA-N
(iii)