TR200100410T2 - 2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri. - Google Patents
2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri.Info
- Publication number
- TR200100410T2 TR200100410T2 TR2001/00410T TR200100410T TR200100410T2 TR 200100410 T2 TR200100410 T2 TR 200100410T2 TR 2001/00410 T TR2001/00410 T TR 2001/00410T TR 200100410 T TR200100410 T TR 200100410T TR 200100410 T2 TR200100410 T2 TR 200100410T2
- Authority
- TR
- Turkey
- Prior art keywords
- purin
- tetrahydrofuran
- diol derivatives
- diol
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bulusa göre, yeni formül (I) bilesikleri saglanmaktadir ki burada R1, R2 ve R3 tarifnamede tanimlandigi gibi olup, ayrica bunlarin hazirlanmasi için islemler, bunlari içeren formülasyonlar ve bunlarin enflamatuar hastaliklarin tedavisi için kullanimi saglanmaktadir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9813538.7A GB9813538D0 (en) | 1998-06-23 | 1998-06-23 | Chemical compounds |
GBGB9909482.3A GB9909482D0 (en) | 1999-04-23 | 1999-04-23 | 2-(Purin-9-yl)-tetahydrofuran-3,4-diol derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200100410T2 true TR200100410T2 (tr) | 2001-06-21 |
Family
ID=26313917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/00410T TR200100410T2 (tr) | 1998-06-23 | 1999-06-23 | 2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6495528B1 (tr) |
EP (1) | EP1090022B1 (tr) |
JP (1) | JP3933870B2 (tr) |
KR (1) | KR20010071591A (tr) |
CN (1) | CN1313861A (tr) |
AP (1) | AP2000002016A0 (tr) |
AT (1) | ATE246701T1 (tr) |
AU (1) | AU750462B2 (tr) |
BR (1) | BR9911482A (tr) |
CA (1) | CA2335809A1 (tr) |
CZ (1) | CZ20004868A3 (tr) |
DE (1) | DE69910213T2 (tr) |
EA (1) | EA200001224A1 (tr) |
EE (1) | EE200000768A (tr) |
ES (1) | ES2204139T3 (tr) |
HR (1) | HRP20000894A2 (tr) |
HU (1) | HUP0103025A3 (tr) |
ID (1) | ID29609A (tr) |
IL (1) | IL140396A0 (tr) |
IS (1) | IS5779A (tr) |
NO (1) | NO20006548L (tr) |
NZ (1) | NZ509030A (tr) |
PL (1) | PL345062A1 (tr) |
SK (1) | SK19542000A3 (tr) |
TR (1) | TR200100410T2 (tr) |
WO (1) | WO1999067265A1 (tr) |
YU (1) | YU81100A (tr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
CO4990969A1 (es) * | 1998-02-14 | 2000-12-26 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7427606B2 (en) | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
ATE284712T1 (de) * | 2000-04-26 | 2005-01-15 | Eisai Co Ltd | Medizinische zusammensetzungen zur förderung der aktivierung der eingeweide |
GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
GB0104555D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New Therapeutic method |
NZ532062A (en) | 2001-10-01 | 2006-09-29 | Univ Virginia | 2-propynyl adenosine analogues having A2 adenosine recepter agonist activity and compositions thereof to treat inflammatory responses |
GB0206655D0 (en) * | 2002-03-21 | 2002-05-01 | Glaxo Group Ltd | Novel process |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
TWI346109B (en) * | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
WO2006028618A1 (en) | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
US7442687B2 (en) | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
WO2006015357A2 (en) | 2004-08-02 | 2006-02-09 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0505219D0 (en) * | 2005-03-14 | 2005-04-20 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
AR058104A1 (es) | 2005-10-21 | 2008-01-23 | Novartis Ag | Compuestos organicos |
GB0523845D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel salts |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
PT2322525E (pt) | 2006-04-21 | 2013-12-26 | Novartis Ag | Derivados de purina para utilização como agonistas do recetor de adenosina a2a |
GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
EP1889846A1 (en) * | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
EP1903044A1 (en) | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
JP2010504933A (ja) | 2006-09-29 | 2010-02-18 | ノバルティス アーゲー | Pi3k脂質キナーゼ阻害剤としてのピラゾロピリミジン |
EP2089393A1 (en) | 2006-10-30 | 2009-08-19 | Novartis AG | Heterocyclic compounds as antiinflammatory agents |
PL2231642T3 (pl) | 2008-01-11 | 2014-04-30 | Novartis Ag | Pirymidyny jako inhibitory kinazy |
US20110281917A1 (en) | 2009-01-29 | 2011-11-17 | Darrin Stuart | Substituted Benzimidazoles for the Treatment of Astrocytomas |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
AU2010283806A1 (en) | 2009-08-12 | 2012-03-01 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
SG178454A1 (en) | 2009-08-17 | 2012-03-29 | Intellikine Inc | Heterocyclic compounds and uses thereof |
JP5775871B2 (ja) | 2009-08-20 | 2015-09-09 | ノバルティス アーゲー | ヘテロ環式オキシム化合物 |
UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
JP5957526B2 (ja) | 2011-09-15 | 2016-07-27 | ノバルティス アーゲー | チロシンキナーゼとしての6−置換3−(キノリン−6−イルチオ)−[1,2,4]トリアゾロ[4,3−a]ピラジン |
WO2013078440A2 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
CN110507654A (zh) | 2012-04-03 | 2019-11-29 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Mdm2抑制劑與BRAF抑制劑之組合及其用途 |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
US10195208B2 (en) | 2014-07-31 | 2019-02-05 | Novartis Ag | Combination therapy |
CN106632572B (zh) * | 2016-12-16 | 2018-08-14 | 中国科学院成都生物研究所 | 一种黄芪甲苷衍生物及其制备方法和应用 |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE768925A (fr) | 1970-06-30 | 1971-11-03 | Takeda Chemical Industries Ltd | Derives d'adenosine et procede de preparation |
US4224438A (en) | 1970-07-14 | 1980-09-23 | Boehringer Mannheim Gmbh | Adenosine-5'-carboxylic acid amides |
CA1019727A (en) | 1971-03-18 | 1977-10-25 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
BE789773A (fr) | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
US3864483A (en) | 1972-03-22 | 1975-02-04 | Abbott Lab | Adenosine-5{40 -carboxylic acid amides |
CA1082695A (en) | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Process for preparing adenosine-5'-carboxamides |
US3966917A (en) | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
DE2621470A1 (de) | 1976-05-14 | 1977-12-01 | Pharma Waldhof Gmbh & Co | Nucleosidcarbonsaeurenitrile und ihre derivate, und verfahren zu ihrer herstellung |
US4167565A (en) | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
AU8379182A (en) | 1981-06-04 | 1982-12-09 | Procter & Gamble Company, The | Composition of salicylates and purine derivatives |
JPS58167599A (ja) | 1982-03-29 | 1983-10-03 | Tanabe Seiyaku Co Ltd | アデノシン誘導体及びその製法 |
JPS58174322A (ja) | 1982-04-07 | 1983-10-13 | Tanabe Seiyaku Co Ltd | 線溶促進剤 |
CA1239397A (en) | 1983-08-01 | 1988-07-19 | James A. Bristol | N.sup.6-substituted adenosines |
DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
US4496643A (en) | 1984-03-23 | 1985-01-29 | Eastman Kodak Company | Two-component dry electrostatic developer composition containing onium charge control agent |
JPH0655756B2 (ja) | 1984-04-18 | 1994-07-27 | ネルソン・リサ−チ・アンド・デベロツプメント・カンパニ− | 心臓血管拡張薬としてのn−6置換アデノシン誘導体 |
US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
US4663313A (en) | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
AU575438B2 (en) | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
US4738954A (en) | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
US4755594A (en) | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
US5106837A (en) | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
JPH0696534B2 (ja) | 1986-04-25 | 1994-11-30 | ヘキストジヤパン株式会社 | 抗痴呆剤 |
US4767747A (en) | 1986-08-28 | 1988-08-30 | Warner-Lambert Company | Method for treating congestive heart failure with N6 -acenaphthyl adenosine |
AU8274187A (en) | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
WO1988003147A1 (en) | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
HU198950B (en) | 1986-12-15 | 1989-12-28 | Sandoz Ag | Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds |
US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
FI880405A (fi) | 1987-02-04 | 1988-08-05 | Ciba Geigy Ag | Adenosin-5'-karboxamidderivat. |
US4962194A (en) | 1987-04-02 | 1990-10-09 | Warner-Lambert Company | Method of preparing 51,N6-disubstituted adenosines from inosines |
US5219840A (en) | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
LU87181A1 (fr) | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
JPH0725785B2 (ja) | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
KR910007655A (ko) | 1989-10-03 | 1991-05-30 | 엠. 피. 잭슨 | 치료용 뉴클레오시드 |
CA2028002A1 (en) | 1989-10-19 | 1991-04-20 | Daniel P. Becker | Method of treating gastrointestinal motility disorders |
US5055569A (en) | 1989-10-19 | 1991-10-08 | G. D. Searle & Co. | N-(6)-substituted adenosine compounds |
US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
WO1992005177A1 (en) | 1990-09-25 | 1992-04-02 | Rhone-Poulenc Rorer International (Holdings) Inc. | Compounds having antihypertensive and anti-ischemic properties |
FR2685918B1 (fr) | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
FR2687678B1 (fr) | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
US5424297A (en) | 1992-04-27 | 1995-06-13 | University Of Virginia Alumni Patents Foundation | Adenosine dextran conjugates |
WO1994002497A1 (en) | 1992-07-15 | 1994-02-03 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sulfo-derivatives of adenosine |
GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
WO1994018215A1 (en) | 1993-02-03 | 1994-08-18 | Gensia, Inc. | Adenosine kinase inhibitors comprising lyxofuranosyl derivatives |
US5773423A (en) | 1993-07-13 | 1998-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | A3 adenosine receptor agonists |
US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
WO1995018817A1 (fr) | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
GB9414193D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
GB9414208D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
AU3255097A (en) | 1996-07-05 | 1998-02-02 | Novo Nordisk A/S | Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors |
UA51716C2 (uk) | 1996-07-08 | 2002-12-16 | Авентіс Фармасьютікалз Продактс Інк. | Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування |
AU4377397A (en) | 1996-10-14 | 1998-05-11 | Novo Nordisk A/S | Novel therapeutically active adenosine derivatives |
TW528755B (en) * | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
ZA9810766B (en) | 1997-11-28 | 1999-05-25 | Mochida Pharm Co Ltd | Novel compounds having cgmp-pde inhibitory activity |
YU44900A (sh) * | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
CO4990969A1 (es) * | 1998-02-14 | 2000-12-26 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
-
1999
- 1999-06-23 US US09/720,390 patent/US6495528B1/en not_active Expired - Fee Related
- 1999-06-23 YU YU81100A patent/YU81100A/sh unknown
- 1999-06-23 AP APAP/P/2000/002016A patent/AP2000002016A0/en unknown
- 1999-06-23 CN CN99809892A patent/CN1313861A/zh active Pending
- 1999-06-23 KR KR1020007014720A patent/KR20010071591A/ko not_active Application Discontinuation
- 1999-06-23 CA CA002335809A patent/CA2335809A1/en not_active Abandoned
- 1999-06-23 ES ES99931113T patent/ES2204139T3/es not_active Expired - Lifetime
- 1999-06-23 DE DE69910213T patent/DE69910213T2/de not_active Expired - Lifetime
- 1999-06-23 NZ NZ509030A patent/NZ509030A/en not_active Application Discontinuation
- 1999-06-23 IL IL14039699A patent/IL140396A0/xx unknown
- 1999-06-23 JP JP2000555916A patent/JP3933870B2/ja not_active Expired - Fee Related
- 1999-06-23 EA EA200001224A patent/EA200001224A1/ru unknown
- 1999-06-23 TR TR2001/00410T patent/TR200100410T2/tr unknown
- 1999-06-23 AU AU47744/99A patent/AU750462B2/en not_active Ceased
- 1999-06-23 ID IDW20010189D patent/ID29609A/id unknown
- 1999-06-23 EE EEP200000768A patent/EE200000768A/xx unknown
- 1999-06-23 PL PL99345062A patent/PL345062A1/xx unknown
- 1999-06-23 WO PCT/EP1999/004269 patent/WO1999067265A1/en not_active Application Discontinuation
- 1999-06-23 AT AT99931113T patent/ATE246701T1/de not_active IP Right Cessation
- 1999-06-23 BR BR9911482-8A patent/BR9911482A/pt not_active IP Right Cessation
- 1999-06-23 CZ CZ20004868A patent/CZ20004868A3/cs unknown
- 1999-06-23 EP EP99931113A patent/EP1090022B1/en not_active Expired - Lifetime
- 1999-06-23 HU HU0103025A patent/HUP0103025A3/hu unknown
- 1999-06-23 SK SK1954-2000A patent/SK19542000A3/sk unknown
-
2000
- 2000-12-19 IS IS5779A patent/IS5779A/is unknown
- 2000-12-21 HR HR20000894A patent/HRP20000894A2/hr not_active Application Discontinuation
- 2000-12-21 NO NO20006548A patent/NO20006548L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EE200000768A (et) | 2002-04-15 |
HUP0103025A3 (en) | 2002-04-29 |
IS5779A (is) | 2000-12-19 |
BR9911482A (pt) | 2002-01-22 |
DE69910213D1 (de) | 2003-09-11 |
AU4774499A (en) | 2000-01-10 |
CN1313861A (zh) | 2001-09-19 |
SK19542000A3 (sk) | 2001-09-11 |
AU750462B2 (en) | 2002-07-18 |
WO1999067265A1 (en) | 1999-12-29 |
US6495528B1 (en) | 2002-12-17 |
JP2002518512A (ja) | 2002-06-25 |
HUP0103025A2 (hu) | 2001-12-28 |
DE69910213T2 (de) | 2004-07-01 |
NO20006548D0 (no) | 2000-12-21 |
JP3933870B2 (ja) | 2007-06-20 |
NO20006548L (no) | 2001-02-22 |
EA200001224A1 (ru) | 2001-08-27 |
CA2335809A1 (en) | 1999-12-29 |
IL140396A0 (en) | 2002-02-10 |
HRP20000894A2 (en) | 2001-12-31 |
ID29609A (id) | 2001-09-06 |
EP1090022B1 (en) | 2003-08-06 |
EP1090022A1 (en) | 2001-04-11 |
AP2000002016A0 (en) | 2000-12-31 |
NZ509030A (en) | 2003-07-25 |
YU81100A (sh) | 2003-10-31 |
CZ20004868A3 (cs) | 2001-08-15 |
KR20010071591A (ko) | 2001-07-28 |
ES2204139T3 (es) | 2004-04-16 |
PL345062A1 (en) | 2001-11-19 |
ATE246701T1 (de) | 2003-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200100410T2 (tr) | 2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri. | |
DE69912606D1 (de) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate | |
AP2000001875A0 (en) | 2-(Purin-9-yl)-tetrahydrofuran -3,4-diol derivatives. | |
TR199901905T2 (tr) | 2-(Pürin-9-il)-tetrahidrofuran-3,4-diol türevleri. | |
AP2000001881A0 (en) | 2-(Purine-9-YL)-tetrahydrofuran-3,4 4-diol derivatives. | |
TR200101709T2 (tr) | İltihabik hastalıkların tedavisinde yararlı olan bileşikler | |
TR200100411T2 (tr) | 2-(Pürin-9-il)-tetrahidrofuran-3,4-diol türevleri. | |
FI93831B (fi) | Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita | |
TR200003011T2 (tr) | Yeni dihidropirimidinler. | |
DK1200418T3 (da) | Nematodicide trifluorbutener | |
TR200100448T2 (tr) | Fenil ksantin türevleri | |
BR0109780A (pt) | Soluções de ácido ascórbico estabilizadas; uso das mesmas; processo para sua obtenção e formulações compreendendo as mesmas | |
SE9804212D0 (sv) | Compounds | |
TR200002380T2 (tr) | Yeni triazolo (4,5-d) pirimidin bileşikleri | |
AR020563A1 (es) | Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion | |
SE9802574D0 (sv) | Novel compounds | |
SE9904128D0 (sv) | Novel compounds | |
TR200100475T2 (tr) | N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları. | |
SE9803107D0 (sv) | Novel Compunds | |
MXPA03003466A (es) | Derivados de piranosido. | |
SE9803277D0 (sv) | Novel compounds | |
ECSP972255A (es) | Nuevos derivados de piranosido |