갑상선호르몬수용체β

스러비
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2NLL, 357, D4X
식별자
에일리어스	TRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, TRB1, TRB2, 갑상선 호르몬 수용체 베타, TRbeta
외부 ID	OMIM : 190160MGI : 98743 HomoloGene : 36025 GenCard : TRB
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	24,495,756 bp
유전자 위치(마우스)
크르.	14번 염색체(쥐)
끝.	4,809,435 bp
RNA발현패턴
	상단 표시 위치:
	브로드만 23구역; ; 중측두회; ; 경골; ; 후중심회; ; 내피 세포; ; 상전두회; ; 장피질; ; 아킬레스건; ; 유즙관; ; 이하선;
	상단 표시 위치:
	나선 신경절; ; 코르티 기관; ; 상전두회; ; 근위 요세관; ; 입술; ; 우심실; ; 식도; ; 대동맥 판막; ; 상행 대동맥; ; 상완 삼두근;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	배열특이적 DNA결합; 전사 코어프레서 활성; 아연 이온 결합; 금속 이온 결합; 스테로이드 호르몬 수용체 활성; 단백질 결합; 효소결합; 크로마틴DNA결합; 갑상선 호르몬 결합; DNA결합전사인자활성; DNA결합; DNA결합전사인자활성, RNA중합효소II 특이적; 전사 시스 조절 영역 결합; RNA중합효소II전사조절영역배열특이적DNA결합; 전사 인자 결합; 핵수용체공활성화제활성; 시그널링수용체활성; 핵수용체활성;
셀룰러 컴포넌트	핵소체; 핵; 핵체; RNA중합효소II전사조절복합체;
생물학적 과정	전사조절, DNA템플릿화; 심장 수축 조절; 여성 구애 행동; RNA중합효소II에 의한 전사조절; RNA중합효소II에 의한 전사 음성 조절; 소리에 대한 감각 지각; 제1형 기흉구 분화; 여성 수용성의 부정적인 조절; 동물 기관 형태 형성; RNA중합효소II 프로모터로부터의 전사 개시; 전사 음성 조절, DNA 템플릿; RNA중합효소II에 의한 전사의 양성 조절; 스테로이드 호르몬 매개 신호 경로; 세포내수용체신호경로; 전사, DNA 템플릿; 눈 광수용체 세포 발달의 음성 조절; 망막원추세포발달; 망막원추세포아포토시스 과정; 다세포 생물 발달; 호르몬 유도 신호 경로; 세포 분화; 갑상선 발달; 지질에 대한 반응; 갑상선 호르몬 매개 신호 경로;
	출처:아미고 / QuickGO
맞춤법
	7068
	21834
	ENSG00000151090
	ENSMUSG000021779
	P10828
	P37242
NM_000461; NM_001128176; NM_001128177; NM_001252634; NM_001354708;
	NM_001354709; NM_001354710; NM_001354711; NM_001354712; NM_001354713; NM_001354714; NM_001354715; NM_001374822; NM_001374823; NM_001374824; NM_001374825; NM_001374826; NM_001374827
	NM_001113417; NM_009380
NP_000452; NP_001121648; NP_001121649; NP_001239563; NP_001341637;
	NP_001341638; NP_001341639; NP_001341640; NP_001341641; NP_001341642; NP_001341643; NP_001341644; NP_001361751; NP_001361752; NP_001361753; NP_001361754; NP_001361755; NP_001361756
	NP_001106888; NP_033406
	위키데이터
인간 보기/편집	마우스 표시/편집

핵수용체 서브패밀리 1, 그룹 A, 멤버 2(NR1A2)라고도 알려진 갑상선 호르몬 수용체 베타(TR-베타)는 인간에서 TRB ^[5]^[6]유전자에 의해 암호화되는 핵수용체 단백질이다.

기능.

이 유전자에 의해 코드된 단백질은 트리요오드티로닌의 핵호르몬 수용체이다.그것은 갑상선 호르몬에 대한 여러 수용체 중 하나이며, 갑상선 호르몬의 생물학적 활동을 중재하는 것으로 나타났다.생쥐의 녹아웃 연구는 다양한 수용체가 일정 정도의 중복성을 가지면서도 갑상선 호르몬의 다른 기능을 매개할 수 있다는 것을 시사한다.이 유전자의 결함은 갑상선 호르몬(TSH)이 정상적이거나 약간 상승한 상태에서 갑상선 호르몬(T-T₃₄)의 높은 수치와 갑상선 호르몬(T-T)으로 특징지어지는 증후군인 일반 갑상선 호르몬 저항(GTHR)의 원인으로 알려져 있다.이 유전자에 대해 여러 개의 전사 변형이 관찰되었지만,^[7] 지금까지 오직 하나의 전장 성질이 관찰되었다.

상호 작용

갑상선 호르몬 수용체 베타는 다음과 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000151090 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000021779 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^ Sakurai A, Nakai A, DeGroot LJ (June 1990). "Structural analysis of human thyroid hormone receptor beta gene". Mol. Cell. Endocrinol. 71 (2): 83–91. doi:10.1016/0303-7207(90)90245-4. PMID 1973914. S2CID 54389426.
^ "Entrez Gene: THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)".
^ ^a ^b Monden T, Wondisford FE, Hollenberg AN (November 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J. Biol. Chem. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056.
^ Lin HM, Zhao L, Cheng SY (August 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol. Chem. 277 (32): 28733–41. doi:10.1074/jbc.M203380200. PMID 12048199.
^ ^a ^b Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (October 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–204. doi:10.1210/endo.139.10.6218. PMID 9751500.
^ ^a ^b Jeyakumar M, Tanen MR, Bagchi MK (June 1997). "Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor". Mol. Endocrinol. 11 (6): 755–67. doi:10.1210/mend.11.6.0003. PMID 9171239.
^ Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/mend.15.2.0595. PMID 11158331.
^ Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (November 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
^ Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. Bibcode:2000PNAS...97.6212K. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.
^ Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (January 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi:10.1210/mend.16.1.0755. PMID 11773444.
^ Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. doi:10.1006/bbrc.1998.9799. PMID 9878542.
^ Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM (September 2001). "Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance". Mol. Endocrinol. 15 (9): 1529–38. doi:10.1210/mend.15.9.0687. PMID 11518802.
^ Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Mol. Cell. Biol. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182.
^ Wu Y, Delerive P, Chin WW, Burris TP (March 2002). "Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1". J. Biol. Chem. 277 (11): 8898–905. doi:10.1074/jbc.M110761200. PMID 11751919.

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