호모 사피엔스 종의 단백질 코드 유전자
전사인자 E2F5 는 인간 에서 E2F5 유전자에 [5] [6] 단백질 이다.
기능. 이 유전자에 의해 암호화된 단백질은 전사 인자의 E2F 계열의 구성원이다. E2F 패밀리는 세포주기와 종양억제단백질의 작용 제어에 중요한 역할을 하며 작은 DNA 종양 바이러스의 변형단백질의 표적이 되기도 한다. E2F 단백질은 대부분의 가족 구성원에게 존재하는 여러 진화적으로 보존된 도메인을 포함합니다. 이들 도메인은 DNA결합 도메인, 분화조절전사인자단백질(DP)과의 상호작용을 결정하는 이합체 도메인, 산성아미노산으로 농축된 트랜스액티베이션 도메인 및 트랜스액티베이션 도메인 내에 내장된 종양억제단백질 어소시에이션 도메인을 포함한다. 이 단백질은 차등적으로 인산화되며 다양한 인체 조직에서 발현된다. 다른 가족들보다 E2F4에 더 높은 정체성을 가지고 있습니다. 이 단백질과 E2F4는 모두 종양억제단백질 p130 및 p107과 상호작용하지만 pRB와는 상호작용하지 않는다. 대체 스플라이싱을 사용하면 여러 변형에서 서로 다른 Isoform을 [6]
상호 작용 E2F5는 TFDP1 과 [5] [7] 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000133740 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027552 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle" . Proceedings of the National Academy of Sciences of the United States of America . 92 (6): 2403–7. Bibcode :1995PNAS...92.2403S . doi :10.1073/pnas.92.6.2403 PMC 42492 PMID 7892279 . ^ a b "Entrez Gene: E2F5 E2F transcription factor 5, p130-binding" .^ Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo" . Molecular and Cellular Biology . 15 (6): 3082–9. doi :10.1128/mcb.15.6.3082 . PMC 230539 PMID 7760804 .
추가 정보 Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo" . Molecular and Cellular Biology . 15 (6): 3082–9. doi :10.1128/mcb.15.6.3082 . PMC 230539 PMID 7760804 . Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (Nov 1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107" . Genes & Development . 8 (22): 2665–79. doi :10.1101/gad.8.22.2665 PMID 7958924 . Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R (Nov 1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo" . Genes & Development . 8 (22): 2680–90. doi :10.1101/gad.8.22.2680 PMID 7958925 . Itoh A, Levinson SF, Morita T, Kourembanas S, Brody JS, Mitsialis SA (1996). "Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors". Cellular & Molecular Biology Research . 41 (3): 147–54. PMID 8589754 . Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (May 1997). "The subcellular localization of E2F-4 is cell-cycle dependent" . Proceedings of the National Academy of Sciences of the United States of America . 94 (10): 5095–100. Bibcode :1997PNAS...94.5095L . doi :10.1073/pnas.94.10.5095 PMC 24637 PMID 9144196 . Vaishnav YN, Vaishnav MY, Pant V (Jan 1998). "The molecular and functional characterization of E2F-5 transcription factor". Biochemical and Biophysical Research Communications . 242 (3): 586–92. doi :10.1006/bbrc.1997.8010 . PMID 9464260 . Morris L, Allen KE, La Thangue NB (Apr 2000). "Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators". Nature Cell Biology . 2 (4): 232–9. doi :10.1038/35008660 . PMID 10783242 . S2CID 36134762 . Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM, Rempel RE (Sep 2000). "E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control" . Molecular Cell . 6 (3): 729–35. doi :10.1016/S1097-2765(00)00071-X PMID 11030352 . D'Souza SJ, Pajak A, Balazsi K, Dagnino L (Jun 2001). "Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation" . The Journal of Biological Chemistry . 276 (26): 23531–8. doi :10.1074/jbc.M100780200 PMID 11319226 . Chestukhin A, Litovchick L, Rudich K, DeCaprio JA (Jan 2002). "Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism" . Molecular and Cellular Biology . 22 (2): 453–68. doi :10.1128/MCB.22.2.453-468.2002 . PMC 139733 PMID 11756542 . Apostolova MD, Ivanova IA, Dagnino C, D'Souza SJ, Dagnino L (Sep 2002). "Active nuclear import and export pathways regulate E2F-5 subcellular localization" . The Journal of Biological Chemistry . 277 (37): 34471–9. doi :10.1074/jbc.M205827200 PMID 12089160 . Chen CR, Kang Y, Siegel PM, Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression" . Cell . 110 (1): 19–32. doi :10.1016/S0092-8674(02)00801-2 PMID 12150994 . S2CID 8945574 . Macaluso M, Cinti C, Russo G, Russo A, Giordano A (Jun 2003). "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer" . Oncogene . 22 (23): 3511–7. doi :10.1038/sj.onc.1206578 PMID 12789259 . Ohtani N, Brennan P, Gaubatz S, Sanij E, Hertzog P, Wolvetang E, Ghysdael J, Rowe M, Hara E (Jul 2003). "Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5" . The Journal of Cell Biology . 162 (2): 173–83. doi :10.1083/jcb.200302085 . PMC 2172795 PMID 12860972 . Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA (Sep 2004). "Aberrant regulation of survivin by the RB/E2F family of proteins" . The Journal of Biological Chemistry . 279 (39): 40511–20. doi :10.1074/jbc.M404496200 PMID 15271987 . Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Research . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (Mar 2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors" . Oncogene . 24 (13): 2204–17. doi :10.1038/sj.onc.1208206 PMID 15735762 . Swetloff A, Ferretti P (2006). "Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development" . The International Journal of Developmental Biology . 49 (7): 859–65. doi :10.1387/ijdb.051996as PMID 16172982 . 외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
PDB 갤러리
1cf7 : 헤테로다이머 세포주기전사인자 E2F-DP에 의한 DNA 인식의 구조적 기초
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY
