PL144948B1 - Method of obtaining novel thienotriazolo-1,4-diazepin-2-carboxylamides - Google Patents

Method of obtaining novel thienotriazolo-1,4-diazepin-2-carboxylamides Download PDF

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Publication number
PL144948B1
PL144948B1 PL1986257602A PL25760286A PL144948B1 PL 144948 B1 PL144948 B1 PL 144948B1 PL 1986257602 A PL1986257602 A PL 1986257602A PL 25760286 A PL25760286 A PL 25760286A PL 144948 B1 PL144948 B1 PL 144948B1
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formula
group
carbon atoms
general formula
atom
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PL1986257602A
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PL257602A1 (en
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Boehringer Ingelheim Kg
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Publication of PL257602A1 publication Critical patent/PL257602A1/xx
Publication of PL144948B1 publication Critical patent/PL144948B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (2)

1. Zastrzezenia patentowe 1. Sposób wytwarzania nowych amidów kwasów tienotriazolo-1,4-diazepino-2-karboksy- lowych o wzorze ogólnym 1, w którym Rj oznacza atom wodoru, prosta lub rozgaleziona gru¬ pe alkilowa o 1- 4 atomach wegla, grupe cyklopropylowa, metoksylowa lub atom chloru lub bromu, IU i R*9 które sa jednakowe albo rózne, oznaczaja atom wodoru, prosta lub rozgale¬ ziona grupe alkilowa albo hydroksyalkilowa o 1 - 4 atomach wegla, albo obie grupy Rp i R, razem z atomem azotu oznaczaja 5-, 6- lub 7-czlonowy pierscien, który ewentualnie jako dalszy heteroatom zawiera atom azotu, tlenu lub siarki i przy czym drugi atom azotu jest ewentualnie podstawiony grupa metylowa, R, oznacza grupe fenylowa, przy czym pierscien fenyIowy jest podstawiony atomem chloru lub bromu, zas n oznacza jedna z liczb 0-8, znamienny tym, ze kwas 2-karboksylowy o wzorze ogólnym 2, w którym grupy R- i R« oraz n maja wyzej podane znaczenie poddaje sie reakcji z amina o wzorze ogólnym 3, w którym grupy R2 i R3 maja wyzej podane znaczenie, albo kwas o wzorze 2 przeprowadza w zwykly sposób w halogenek kwasowy albo bezwodnik kwasowy, który nastepnie poddaje reakcji z amina o wzorze ogólnym 3, przy czym Rg i R* maja wyzej podane znaczenie.
2. Sposób wytwarzania nowych amidów kwasów tienotriazolo-1,4-diazepino-2-karbo- ksylowych o wzorze ogólnym 1, w którym R^ oznacza prosta lub rozgaleziona grupe alkilowa o 1- 4 atomach wegla, podstawiona przez atom chlorowca albo przez grupe hydroksylowa, da¬ lej R1 oznacza grupe alkoksylowa o 2 lub 3 atomach wegla lub atom fluoru lub jodu, R~ i R,t które sa Jednakowe albo rózne, oznaczaja razem z atomem azotu 5-, 6- lub 7-czlonowy pierscien, który ewentualnie jako dalszy heteroatom zawiera atom azotu, tlenu lub siarki i przy czym drugi atom azotu Jest ewentualnie podstawiony grupa alkilowa o 2 - 4 atomach wegla, R^ oznacza grupe fenylowa, przy czym pierscien fenylowy jest ewentualnie podstawio¬ ny w pozycji 2 albo w pozycji 2 i 6 grupa metylowa, atomem chlorowca, grupa nitrowa albo grupa trifluorometylowa, albo oznacza grupe oC -pirydylcwa, zas n oznacza jedna z liczb 0-8, znamienny tym, ze kwas 2-karboksylowy o wzorze ogólnym 2, w którym grupy R* i R/ oraz n maja wyzej podane znaczenie, poddaje sie reakcji z amina o wzorze ogólnym 3, w którym grupy Rp i R3 maja wyzej podane znaczenie, albo kwas o wzorze 2 prze¬ prowadza w zwykly sposób w halogenek kwasowy lub bezwodnik kwasowy i te nastepnie poddaje reakcji z amina o wzorze ogólnym 3, w którym Rp i R, maja wyzej podane znaczenie.144 948 R<,-^ N, 2v s V " N-C-(CH2)n -b^IN I I R3' :N R4 WZÓR 1 R1 N. II*, s ^N HO-C-(CH2)n—£Y N WZÓR 2 Ra /R2 HN R3 WZÓR 3 — N WZÓR 3a CH3 \ WZÓR U N — Cl 0 WZtfR 5CH3 HC CH3 \j- / WZÓR 6 144 948 CH3 \ CH- / N- WZdR 7 D- WZÓR 8 CH3-N N- WZOR 10 o- WZdR 9 H WZÓR 11 HrC 5^2 \ N— H5C2^ WZdR 12 0 N — \ / WZÓR 13 N. CH2CH20H CH2CH2OH o WZÓR U WZdR 15144 948 PL PL PL
PL1986257602A 1985-01-25 1986-01-23 Method of obtaining novel thienotriazolo-1,4-diazepin-2-carboxylamides PL144948B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853502392 DE3502392A1 (de) 1985-01-25 1985-01-25 Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen

Publications (2)

Publication Number Publication Date
PL257602A1 PL257602A1 (en) 1987-05-04
PL144948B1 true PL144948B1 (en) 1988-07-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL1986257602A PL144948B1 (en) 1985-01-25 1986-01-23 Method of obtaining novel thienotriazolo-1,4-diazepin-2-carboxylamides

Country Status (28)

Country Link
US (3) US4968794A (pl)
EP (1) EP0194416B1 (pl)
JP (2) JPH0633278B2 (pl)
KR (1) KR920010711B1 (pl)
AT (1) ATE42556T1 (pl)
AU (1) AU584663B2 (pl)
CA (1) CA1269373A (pl)
CS (1) CS254992B2 (pl)
CZ (1) CZ410791A3 (pl)
DD (3) DD265799A5 (pl)
DE (2) DE3502392A1 (pl)
DK (2) DK165323C (pl)
ES (3) ES8704949A1 (pl)
FI (1) FI86851C (pl)
GR (1) GR860189B (pl)
HK (1) HK75792A (pl)
HU (2) HU195821B (pl)
IE (1) IE58728B1 (pl)
IL (1) IL77702A (pl)
MX (1) MX9203258A (pl)
NO (2) NO164029C (pl)
NZ (1) NZ214926A (pl)
PL (1) PL144948B1 (pl)
PT (1) PT81898B (pl)
SG (1) SG44292G (pl)
SU (1) SU1402265A3 (pl)
YU (2) YU44280B (pl)
ZA (1) ZA86542B (pl)

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CA2083611A1 (en) * 1990-05-31 1991-12-01 David Frederick Woodward Use of platelet activating factor antagonists as anti-pruritic agents
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TW219935B (pl) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
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US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
CA2202985A1 (en) * 1994-11-08 1996-05-17 Haruhiko Makino Thienopyridine or thienopyrimidine derivatives and their use
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AP2501A (en) 2003-05-30 2012-10-22 Ranbaxy Lab Ltd Substituted pyrrole derivatives
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IE58728B1 (en) 1993-11-03
IL77702A (en) 1989-02-28
YU44280B (en) 1990-04-30
DD265899A5 (de) 1989-03-15
NO894640L (no) 1986-07-28
DE3502392A1 (de) 1986-07-31
ES551198A0 (es) 1987-04-16
HK75792A (en) 1992-10-09
DD263063A5 (de) 1988-12-21
KR860005822A (ko) 1986-08-13
HU193624B (en) 1987-11-30
DK46292A (da) 1992-04-06
IE860209L (en) 1986-07-25
NO166646C (no) 1991-08-21
HUT40441A (en) 1986-12-28
KR920010711B1 (ko) 1992-12-14
NO166646B (no) 1991-05-13
SU1402265A3 (ru) 1988-06-07
NZ214926A (en) 1989-04-26
ES557344A0 (es) 1988-07-16
ZA86542B (en) 1987-09-30
YU46049B (sh) 1992-12-21
ES8704949A1 (es) 1987-04-16
EP0194416A1 (de) 1986-09-17
DD265799A5 (de) 1989-03-15
CA1269373A (en) 1990-05-22
YU79987A (en) 1988-06-30
FI860296A (fi) 1986-07-26
EP0194416B1 (de) 1989-04-26
NO164029C (no) 1990-08-22
AU5272886A (en) 1986-07-31
NO894640D0 (no) 1989-11-22
ES557343A0 (es) 1988-06-01
FI86851B (fi) 1992-07-15
PL257602A1 (en) 1987-05-04
US5155103A (en) 1992-10-13
DE3663028D1 (en) 1989-06-01
AU584663B2 (en) 1989-06-01
SG44292G (en) 1992-09-04
ES8802426A1 (es) 1988-06-01
PT81898A (de) 1986-02-01
DK165323B (da) 1992-11-09
US4968794A (en) 1990-11-06
JPH0651704B2 (ja) 1994-07-06
JPH02191281A (ja) 1990-07-27
ES8802523A1 (es) 1988-07-16
YU7886A (en) 1987-10-31
ATE42556T1 (de) 1989-05-15
DK46292D0 (da) 1992-04-06
JPH0633278B2 (ja) 1994-05-02
CZ410791A3 (en) 1993-04-14
DK165323C (da) 1993-03-29
MX9203258A (es) 1992-07-01
JPS61176591A (ja) 1986-08-08
DK36786A (da) 1986-07-26
DK36786D0 (da) 1986-01-24
US5082839A (en) 1992-01-21
NO855260L (no) 1986-07-28
FI86851C (fi) 1992-10-26
HU195821B (en) 1988-07-28
GR860189B (en) 1986-05-26
NO164029B (no) 1990-05-14
CS254992B2 (en) 1988-02-15
FI860296A0 (fi) 1986-01-22
PT81898B (pt) 1988-05-27

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