DD263063A5 - Verfahren zur herstellung von neuen thieno-triazolo-1,4-diazepino-2-carbonsaeureamide - Google Patents

Verfahren zur herstellung von neuen thieno-triazolo-1,4-diazepino-2-carbonsaeureamide Download PDF

Info

Publication number: DD263063A5
Authority: DD; German Democratic Republic
Prior art keywords: triazolo; carboxylic acid; thieno; carbon atoms; methyl
Prior art date: 1985-01-25

Application number

DD86286429A

Other languages

German (de)

English (en)

Inventor

Karl-Heinz Weber

Gerhard Walther

Albrecht Harreus

Jorge Casals-Stenzel

Gojki Muacevic

Wolfgang Troeger

Original Assignee

��@��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-25

Filing date

1986-01-23

Publication date

1988-12-21

1986-01-23 Application filed by ��@��@��k�� filed Critical ��@��@��k��

1988-12-21 Publication of DD263063A5 publication Critical patent/DD263063A5/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DD86286429A 1985-01-25 1986-01-23 Verfahren zur herstellung von neuen thieno-triazolo-1,4-diazepino-2-carbonsaeureamide DD263063A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19853502392 DE3502392A1 (de)	1985-01-25	1985-01-25	Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen

Publications (1)

Publication Number	Publication Date
DD263063A5 true DD263063A5 (de)	1988-12-21

Family

ID=6260695

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DD86311014A DD265799A5 (de)	1985-01-25	1986-01-23	Verwendung von neuen thieno-triazolo-1,4-diazepino-2-carbonsaeureamiden
DD86311011A DD265899A5 (de)	1985-01-25	1986-01-23	Verfahren zur herstellung neuer thieno-triazolo-1,4-diazepino-2-carbonsaeuren
DD86286429A DD263063A5 (de)	1985-01-25	1986-01-23	Verfahren zur herstellung von neuen thieno-triazolo-1,4-diazepino-2-carbonsaeureamide

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DD86311014A DD265799A5 (de)	1985-01-25	1986-01-23	Verwendung von neuen thieno-triazolo-1,4-diazepino-2-carbonsaeureamiden
DD86311011A DD265899A5 (de)	1985-01-25	1986-01-23	Verfahren zur herstellung neuer thieno-triazolo-1,4-diazepino-2-carbonsaeuren

Country Status (28)

Country	Link
US (3)	US4968794A (fr)
EP (1)	EP0194416B1 (fr)
JP (2)	JPH0633278B2 (fr)
KR (1)	KR920010711B1 (fr)
AT (1)	ATE42556T1 (fr)
AU (1)	AU584663B2 (fr)
CA (1)	CA1269373A (fr)
CS (1)	CS254992B2 (fr)
CZ (1)	CZ410791A3 (fr)
DD (3)	DD265799A5 (fr)
DE (2)	DE3502392A1 (fr)
DK (2)	DK165323C (fr)
ES (3)	ES8704949A1 (fr)
FI (1)	FI86851C (fr)
GR (1)	GR860189B (fr)
HK (1)	HK75792A (fr)
HU (2)	HU195821B (fr)
IE (1)	IE58728B1 (fr)
IL (1)	IL77702A (fr)
MX (1)	MX9203258A (fr)
NO (2)	NO164029C (fr)
NZ (1)	NZ214926A (fr)
PL (1)	PL144948B1 (fr)
PT (1)	PT81898B (fr)
SG (1)	SG44292G (fr)
SU (1)	SU1402265A3 (fr)
YU (2)	YU44280B (fr)
ZA (1)	ZA86542B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3502392A1 (de) *	1985-01-25	1986-07-31	Boehringer Ingelheim KG, 6507 Ingelheim	Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) *	1986-01-21	1993-06-16	Boehringer Ingelheim Kg	Procedimiento para preparar tieno-1,4-diazepinas.
DE3610848A1 (de) *	1986-04-01	1987-10-15	Boehringer Ingelheim Kg	Neue 1,4-diazepine
PH30676A (en) *	1986-07-22	1997-09-16	Boehringer Ingelhein Kg	Hetrazepine compounds which have useful pharmaceutical utility
DE3745135C2 (de) *	1986-10-21	1999-05-12	Korth Ruth	Verwendung von hydrophilen Triazolothieno-diazepinen zur Behandlung von Arteriosklerose
EP0268242B1 (fr) *	1986-11-17	1992-03-18	Yoshitomi Pharmaceutical Industries, Ltd.	Composés du type thiénotriazolodiazépine antagonistes du PAF et leurs applications pharmaceutiques
DE3725130C2 (de) *	1987-07-29	1996-12-12	Boehringer Ingelheim Kg	Tritium-oder ·1··4·C-markiertes 4-(2-Chlorphenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanon-1-yl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin, Verfahren zu deren Herstellung und deren Verwendung als Radiorezeptorassay sowie zu diagnostischen Zwecken
US5895785A (en) *	1987-10-20	1999-04-20	Ruth Korth	Treatment and prevention of disorders mediated by LA-paf or endothelial cells
US4959361A (en) *	1987-12-18	1990-09-25	Hoffmann-La Roche Inc.	Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
CA1324863C (fr) *	1988-01-30	1993-11-30	Minoru Moriwaki	Composes thienotriazolodiazepine et leurs utilisations pharmaceutiques
EP0338993A1 (fr) *	1988-04-21	1989-10-25	Sandoz Ag	4H-thiéno[2,3-e][1,2,4]triazolo[3,4-c][1,4]diazépines substituées par aryle sur la position 6
JPH0655673B2 (ja) *	1988-04-27	1994-07-27	シェリング・コーポレーション	Ｐａｆ拮抗薬‐抗ヒスタミン剤の組合せ及び使用方法
US5334592A (en) *	1988-04-27	1994-08-02	Schering Corporation	Certain PAF antagonist antihistamine combinations and methods
CA1322367C (fr) *	1988-05-17	1993-09-21	Yoshitomi Pharmaceutical Industries Ltd.	Composes thienotrizolodiazepine et leurs utilisations pharmaceutiques
US5221671A (en) *	1988-10-31	1993-06-22	Eisai Co., Ltd.	Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5468740A (en) *	1988-10-31	1995-11-21	Eisai Co., Ltd.	1,4-diazepine derivative and its pharmaceutical use
RU2117670C1 (ru) *	1988-10-31	1998-08-20	Эйсай Ко., Лтд.	Производные триазоло[1,4]диазепина и способы их получения
FI95708C (fi)	1988-10-31	1996-03-11	Eisai Co Ltd	Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
US5304553A (en) *	1988-10-31	1994-04-19	Eisai Co., Ltd.	1,4-diazepine derivative and its pharmaceutical use
US5382579A (en) *	1988-10-31	1995-01-17	Eisai Co., Ltd.	Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
EP0387613A1 (fr) *	1989-03-03	1990-09-19	Boehringer Ingelheim Kg	Thiénodiazépines
DE4010528A1 (de) *	1990-04-02	1991-10-17	Boehringer Ingelheim Kg	Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
CA2083611A1 (fr) *	1990-05-31	1991-12-01	David Frederick Woodward	Utilisation d'antagonistes du facteur d'activation des plaquettes comme agents antiprurigineux
DE4027470A1 (de) *	1990-08-30	1992-03-05	Boehringer Ingelheim Kg	Neue hetrazepinoide amide
DE4128579A1 (de) *	1991-08-28	1993-03-04	Boehringer Ingelheim Kg	Verwendung von 4-(2-chlorphenyl)-9-methyl-2-(3(4-morpholinyl)-3-propanon-1-y1)-6h-thieno-(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin zur behandlung der allergischen rhinitis
DE69133083C5 (de) *	1991-11-04	2007-05-31	Korth, Ruth-Maria, Dr.med.	Behandlung und Vorbeugung von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten
TW219935B (fr) *	1991-12-25	1994-02-01	Mitsubishi Chemicals Co Ltd
DE4200619A1 (de) *	1992-01-13	1993-07-15	Boehringer Ingelheim Kg	Verwendung von 4-(2-chlorphenyl)-9-methyl-2-/3(4-morpholinyl)-3-propanon-1-yl/-6h-thieno-/3,2-f//1,2,4/ triazolo/4,3-a//1,4/diazepin zur behandlung der dysmenorrhes
GB9207645D0 (en) *	1992-04-08	1992-05-27	Smithkline Beecham Corp	Methods
EP0656004A1 (fr) *	1992-08-20	1995-06-07	Cytomed, Inc.	Agents a double fonctionnalite anti-inflammatoire et d'immunosuppression
US5288514A (en) *	1992-09-14	1994-02-22	The Regents Of The University Of California	Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5302590A (en) *	1992-12-18	1994-04-12	Hoffmann-La Roche Inc.	Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
CA2202985A1 (fr) *	1994-11-08	1996-05-17	Haruhiko Makino	Derives de thienopyridine ou de thienopyrimidine et leur utilisation
WO1998058930A1 (fr)	1997-06-25	1998-12-30	Nikken Chemicals Co., Ltd.	Composes de triazolo-1,4-diazepine et composition medicinale les contenant
AP2501A (en)	2003-05-30	2012-10-22	Ranbaxy Lab Ltd	Substituted pyrrole derivatives
US7223167B2 (en) *	2005-04-01	2007-05-29	Cnh America Llc	Anti-wind wiper with adjustable extension
EP1948599A1 (fr)	2005-11-08	2008-07-30	Ranbaxy Laboratories Limited	Procede de preparation de sel hemicalcique d acide (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoique
US9638493B2 (en)	2011-11-26	2017-05-02	Orval E. Bowman	Pointing devices, apparatus, systems and methods for high shock environments
WO2022101377A1 (fr)	2020-11-16	2022-05-19	Boehringer Ingelheim International Gmbh	Dérivés de cyclopentathiophène carboxamide utiles en tant qu'antagonistes du récepteur du facteur d'activation des plaquettes
CN118414340A (zh)	2021-12-22	2024-07-30	勃林格殷格翰国际有限公司	作为血小板活化因子受体拮抗剂的环戊烷并噻吩甲酰胺衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH12303A (en) *	1973-02-08	1979-01-16	Hoffmann La Roche	Thienotriazolodiazepine derivatives
DE2503235A1 (de) *	1975-01-27	1976-07-29	Boehringer Sohn Ingelheim	Neues verfahren zur herstellung von 8-brom-thieno-triazolo-1,4-diazepinen
US4201712A (en) *	1975-07-16	1980-05-06	Boehringer Ingelheim Gmbh	Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
AU518438B2 (en) *	1978-04-26	1981-10-01	Boehringer Ingelheim International Gmbh	Substituted 6-aryl-4h-s-triazolo-3,4-c-thieno-2,3-e-1,4-diazepines
AU520063B2 (en) *	1978-07-13	1982-01-14	Boehringer Ingelheim International Gmbh	Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines
DE3435973A1 (de) *	1984-10-01	1986-04-10	Boehringer Ingelheim KG, 6507 Ingelheim	Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) *	1985-01-25	1986-07-31	Boehringer Ingelheim KG, 6507 Ingelheim	Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) *	1986-01-21	1993-06-16	Boehringer Ingelheim Kg	Procedimiento para preparar tieno-1,4-diazepinas.
WO1988009333A1 (fr) *	1987-05-28	1988-12-01	Yoshitomi Pharmaceutical Industries, Ltd.	Compose a base de thieno(triazolo)diazepine et applications medicales de ce compose
US4959361A (en) *	1987-12-18	1990-09-25	Hoffmann-La Roche Inc.	Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US4914096A (en) *	1988-04-21	1990-04-03	Sandoz Pharmaceuticals Corp.	6-aryl-substituted-4H-thieno(2,3-e)(1,2,4)triazolo(3,4-c)(1,4)diazepines

1985
- 1985-01-25 DE DE19853502392 patent/DE3502392A1/de not_active Withdrawn
- 1985-12-23 NO NO855260A patent/NO164029C/no unknown
1986
- 1986-01-16 SU SU864008368A patent/SU1402265A3/ru active
- 1986-01-20 DE DE8686100656T patent/DE3663028D1/de not_active Expired
- 1986-01-20 EP EP86100656A patent/EP0194416B1/fr not_active Expired
- 1986-01-20 YU YU78/86A patent/YU44280B/xx unknown
- 1986-01-20 AT AT86100656T patent/ATE42556T1/de not_active IP Right Cessation
- 1986-01-21 CS CS86452A patent/CS254992B2/cs not_active IP Right Cessation
- 1986-01-22 FI FI860296A patent/FI86851C/fi not_active IP Right Cessation
- 1986-01-23 GR GR860189A patent/GR860189B/el not_active IP Right Cessation
- 1986-01-23 DD DD86311014A patent/DD265799A5/de not_active IP Right Cessation
- 1986-01-23 PL PL1986257602A patent/PL144948B1/pl unknown
- 1986-01-23 DD DD86311011A patent/DD265899A5/de not_active IP Right Cessation
- 1986-01-23 DD DD86286429A patent/DD263063A5/de unknown
- 1986-01-24 PT PT81898A patent/PT81898B/pt not_active IP Right Cessation
- 1986-01-24 HU HU852044A patent/HU195821B/hu not_active IP Right Cessation
- 1986-01-24 IL IL77702A patent/IL77702A/xx not_active IP Right Cessation
- 1986-01-24 JP JP61013605A patent/JPH0633278B2/ja not_active Expired - Fee Related
- 1986-01-24 DK DK036786A patent/DK165323C/da not_active IP Right Cessation
- 1986-01-24 ES ES551198A patent/ES8704949A1/es not_active Expired
- 1986-01-24 NZ NZ214926A patent/NZ214926A/xx unknown
- 1986-01-24 AU AU52728/86A patent/AU584663B2/en not_active Ceased
- 1986-01-24 ZA ZA85542A patent/ZA86542B/xx unknown
- 1986-01-24 IE IE20986A patent/IE58728B1/en not_active IP Right Cessation
- 1986-01-24 CA CA000500345A patent/CA1269373A/fr not_active Expired - Fee Related
- 1986-01-24 KR KR1019860000445A patent/KR920010711B1/ko not_active IP Right Cessation
- 1986-01-24 HU HU86356A patent/HU193624B/hu not_active IP Right Cessation
1987
- 1987-01-21 ES ES557344A patent/ES8802523A1/es not_active Expired
- 1987-01-21 ES ES557343A patent/ES8802426A1/es not_active Expired
- 1987-05-05 YU YU79987A patent/YU46049B/sh unknown
1988
- 1988-10-03 US US07/252,725 patent/US4968794A/en not_active Expired - Lifetime
1989
- 1989-09-13 JP JP1238305A patent/JPH0651704B2/ja not_active Expired - Fee Related
- 1989-11-22 NO NO894640A patent/NO166646C/no unknown
1990
- 1990-06-15 US US07/539,416 patent/US5082839A/en not_active Expired - Lifetime
1991
- 1991-10-11 US US07/774,683 patent/US5155103A/en not_active Expired - Fee Related
- 1991-12-27 CZ CS914107A patent/CZ410791A3/cs unknown
1992
- 1992-04-06 DK DK92462A patent/DK46292D0/da not_active Application Discontinuation
- 1992-04-22 SG SG442/92A patent/SG44292G/en unknown
- 1992-06-24 MX MX9203258A patent/MX9203258A/es unknown
- 1992-10-01 HK HK757/92A patent/HK75792A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE58728B1 (en)	1993-11-03
IL77702A (en)	1989-02-28
YU44280B (en)	1990-04-30
DD265899A5 (de)	1989-03-15
NO894640L (no)	1986-07-28
DE3502392A1 (de)	1986-07-31
ES551198A0 (es)	1987-04-16
HK75792A (en)	1992-10-09
KR860005822A (ko)	1986-08-13
HU193624B (en)	1987-11-30
DK46292A (da)	1992-04-06
IE860209L (en)	1986-07-25
NO166646C (no)	1991-08-21
HUT40441A (en)	1986-12-28
KR920010711B1 (ko)	1992-12-14
NO166646B (no)	1991-05-13
SU1402265A3 (ru)	1988-06-07
NZ214926A (en)	1989-04-26
ES557344A0 (es)	1988-07-16
ZA86542B (en)	1987-09-30
YU46049B (sh)	1992-12-21
ES8704949A1 (es)	1987-04-16
EP0194416A1 (fr)	1986-09-17
DD265799A5 (de)	1989-03-15
CA1269373A (fr)	1990-05-22
YU79987A (en)	1988-06-30
FI860296A (fi)	1986-07-26
EP0194416B1 (fr)	1989-04-26
PL144948B1 (en)	1988-07-30
NO164029C (no)	1990-08-22
AU5272886A (en)	1986-07-31
NO894640D0 (no)	1989-11-22
ES557343A0 (es)	1988-06-01
FI86851B (fi)	1992-07-15
PL257602A1 (en)	1987-05-04
US5155103A (en)	1992-10-13
DE3663028D1 (en)	1989-06-01
AU584663B2 (en)	1989-06-01
SG44292G (en)	1992-09-04
ES8802426A1 (es)	1988-06-01
PT81898A (de)	1986-02-01
DK165323B (da)	1992-11-09
US4968794A (en)	1990-11-06
JPH0651704B2 (ja)	1994-07-06
JPH02191281A (ja)	1990-07-27
ES8802523A1 (es)	1988-07-16
YU7886A (en)	1987-10-31
ATE42556T1 (de)	1989-05-15
DK46292D0 (da)	1992-04-06
JPH0633278B2 (ja)	1994-05-02
CZ410791A3 (en)	1993-04-14
DK165323C (da)	1993-03-29
MX9203258A (es)	1992-07-01
JPS61176591A (ja)	1986-08-08
DK36786A (da)	1986-07-26
DK36786D0 (da)	1986-01-24
US5082839A (en)	1992-01-21
NO855260L (no)	1986-07-28
FI86851C (fi)	1992-10-26
HU195821B (en)	1988-07-28
GR860189B (en)	1986-05-26
NO164029B (no)	1990-05-14
CS254992B2 (en)	1988-02-15
FI860296A0 (fi)	1986-01-22
PT81898B (pt)	1988-05-27

Publication	Publication Date	Title
DD263063A5 (de)	1988-12-21	Verfahren zur herstellung von neuen thieno-triazolo-1,4-diazepino-2-carbonsaeureamide
EP0254245B1 (fr)	1994-09-28	Hétrazépines et leurs procédés de préparation
EP0230942B1 (fr)	1992-04-29	Thiéno-1,4-diazépines
EP0059391B1 (fr)	1985-05-08	Imidazodiazépines, procédé pour leur préparation et compositions pharmaceutiques les contenant
DE3724164A1 (de)	1988-01-28	Neue 1,4-benzodiazepine, ihre herstellung und verwendung
DE3724031A1 (de)	1988-01-28	Neue hetrazepine und verfahren zu ihrer herstellung
EP0240899B1 (fr)	1992-08-19	1,4-Diazépines
DE3701344A1 (de)	1987-07-23	Neue thieno-1,4-diazepine
DE2552403C2 (de)	1986-06-19	Thieno[1,5]-benzodiazepine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
EP0255028A2 (fr)	1988-02-03	1,4-Benzodiazépines, leur préparation et utilisation comme antagonistes PAF
WO1996023790A1 (fr)	1996-08-08	Acetylimidazobenzodiazepines
DE3624779C2 (de)	1996-03-07	Verfahren zur Herstellung von Thieno-triazolo-1,4-diazepino-2- carbonsäureamiden
EP0057428B1 (fr)	1985-04-10	Pyrroles tricycliques, procédé pour leur préparation, leur application et compositions pharmaceutiques les contenant
DE69230110T2 (de)	2000-06-15	An drei ringen substituierte tetrahydropyridin-derivate
EP0084155B1 (fr)	1987-03-25	1,4-Benzodiazépines (1,2) anellés ainsi qu'un procédé pour leur préparation et médicaments contenant ces composés
EP0045519B1 (fr)	1985-06-19	Pyrrolo-(3,4-d)-benzazépines, procédé et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant
DD265405A5 (de)	1989-03-01	Neue thieno-1,4-diazepine
DE2638828A1 (de)	1978-03-09	Neue thieno-pyridine
EP0072029A2 (fr)	1983-02-16	Triazolobenzazépines, procédé et intermédiaires pour leur fabrication et médicaments les contenant
DE2410030C3 (de)	1982-11-11	8-Brom-6-phenyl-4H-s-triazolo[3,4-c]thieno[2,3-e]1,4-diazepine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE2460776C2 (de)	1982-12-09	1-substituierte 6-Aryl-4H-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate sowie Zwischenprodukte und Verfahren zur Herstellung dieser Zwischenprodukte
DE2435041B2 (de)	1977-08-04	8-substituierte 6-aryl-4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln und diese enthaltende pharmazeutische praeparate
CH622517A5 (en)	1981-04-15	Process for the preparation of 6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine and 4,5-dihydro-7-phenyl-s-triazolo- [4,3-a][1,5]benzodiazocines
CH642374A5 (de)	1984-04-13	Substituierte 1-piperazinyl-triazolo-thieno-1,4-diazepine.
DE2445430A1 (de)	1976-04-01	Neue 1-substituierte 6-aryl-4h-striazolo- eckige klammer auf 3,4c eckige klammer zu -thieno- eckige klammer auf 2,3e eckige klammer zu -1,4-diazepine, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln sowie zwischenprodukte und verfahren zur herstellung dieser zwischenprodukte