BR9806870A - Composto, processo para a profilaxia ou tratamento de uma condição clìnica em um mamìfero, formulação farmacêutica, e, uso de um composto e processo para preparar o mesmo. - Google Patents

Composto, processo para a profilaxia ou tratamento de uma condição clìnica em um mamìfero, formulação farmacêutica, e, uso de um composto e processo para preparar o mesmo.

Info

Publication number
BR9806870A
BR9806870A BR9806870-9A BR9806870A BR9806870A BR 9806870 A BR9806870 A BR 9806870A BR 9806870 A BR9806870 A BR 9806870A BR 9806870 A BR9806870 A BR 9806870A
Authority
BR
Brazil
Prior art keywords
compound
prophylaxis
prepare
treatment
pharmaceutical formulation
Prior art date
Application number
BR9806870-9A
Other languages
English (en)
Other versions
BR9806870B1 (pt
Inventor
Richard Mansfield Beams
Martin James Drysdale
Karl Witold Franzmann
Anthony Joseph Frend
Harold Francis Hodson
Richard Graham Knowles
Daryl David Rees
David Alan Sawyer
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR9806870A publication Critical patent/BR9806870A/pt
Publication of BR9806870B1 publication Critical patent/BR9806870B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"COMPOSTO, PROCESSO PARA A PROFILAXIA OU TRATAMENTO DE UMA CONDIçãO CLìNICA EM UM MAMìFERO, FORMULAçãO FARMACêUTICA, E, USO DE UM COMPOSTO E PROCESSO PARA PREPARAR O MESMO". A presente invenção refere-se a novos compostos amidino de fórmula (I): a um processo para sua manufatura, a composições farmacêuticas contendo-os e a seu uso em terapia, em particular seu uso como inibidores seletivos da sintase do óxido nítrico indutiva.
BRPI9806870-9A 1997-01-13 1998-01-09 composto amidino, formulação farmacêutica, uso de um composto, e, processo papa preparar o mesmo. BR9806870B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78340297A 1997-01-13 1997-01-13
PCT/EP1998/000096 WO1998030537A1 (en) 1997-01-13 1998-01-09 Nitric oxide synthase inhibitors

Publications (2)

Publication Number Publication Date
BR9806870A true BR9806870A (pt) 2000-04-18
BR9806870B1 BR9806870B1 (pt) 2009-05-05

Family

ID=25129141

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9806870-9A BR9806870B1 (pt) 1997-01-13 1998-01-09 composto amidino, formulação farmacêutica, uso de um composto, e, processo papa preparar o mesmo.

Country Status (35)

Country Link
EP (1) EP0958277B1 (pt)
JP (1) JP3251301B2 (pt)
KR (1) KR20000070070A (pt)
CN (1) CN1149190C (pt)
AP (1) AP1204A (pt)
AR (1) AR011069A1 (pt)
AT (1) ATE209183T1 (pt)
AU (1) AU723095B2 (pt)
BR (1) BR9806870B1 (pt)
CA (1) CA2277877C (pt)
CO (1) CO4950524A1 (pt)
CY (1) CY2263B1 (pt)
CZ (1) CZ293099B6 (pt)
DE (1) DE69803272T2 (pt)
DK (1) DK0958277T3 (pt)
EA (1) EA002033B1 (pt)
EE (1) EE04013B1 (pt)
ES (1) ES2168737T3 (pt)
HK (1) HK1021531A1 (pt)
HU (1) HU226241B1 (pt)
ID (1) ID21981A (pt)
IL (1) IL130551A (pt)
IS (1) IS1847B (pt)
MY (1) MY117948A (pt)
NO (1) NO312192B1 (pt)
NZ (1) NZ336379A (pt)
PE (1) PE44599A1 (pt)
PL (1) PL189973B1 (pt)
PT (1) PT958277E (pt)
RS (1) RS49673B (pt)
SK (1) SK283201B6 (pt)
TR (1) TR199901680T2 (pt)
TW (2) TW502010B (pt)
WO (1) WO1998030537A1 (pt)
ZA (1) ZA98179B (pt)

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Also Published As

Publication number Publication date
AU723095B2 (en) 2000-08-17
CN1149190C (zh) 2004-05-12
HU226241B1 (en) 2008-07-28
JP3251301B2 (ja) 2002-01-28
CZ293099B6 (cs) 2004-02-18
CZ248399A3 (cs) 1999-12-15
TW538021B (en) 2003-06-21
PT958277E (pt) 2002-05-31
HUP0001539A2 (hu) 2000-11-28
HK1021531A1 (en) 2000-06-16
RS49673B (sr) 2007-11-15
TW502010B (en) 2002-09-11
CN1249744A (zh) 2000-04-05
DK0958277T3 (da) 2002-02-18
EA002033B1 (ru) 2001-12-24
AR011069A1 (es) 2000-08-02
DE69803272D1 (en) 2002-02-21
NO312192B1 (no) 2002-04-08
DE69803272T2 (de) 2002-07-18
CO4950524A1 (es) 2000-09-01
HUP0001539A3 (en) 2003-01-28
NO993429L (no) 1999-07-12
IL130551A (en) 2004-01-04
PL189973B1 (pl) 2005-10-31
MY117948A (en) 2004-08-30
AP1204A (en) 2003-09-15
TR199901680T2 (xx) 1999-09-21
CA2277877A1 (en) 1998-07-16
CA2277877C (en) 2008-01-08
PL334368A1 (en) 2000-02-28
IS5094A (is) 1999-06-25
IL130551A0 (en) 2000-06-01
NO993429D0 (no) 1999-07-12
NZ336379A (en) 2001-01-26
EE9900281A (et) 2000-02-15
SK93399A3 (en) 2000-03-13
ES2168737T3 (es) 2002-06-16
YU31399A (sh) 2002-06-19
EP0958277A1 (en) 1999-11-24
JP2000504041A (ja) 2000-04-04
AP9901603A0 (en) 1999-09-30
ZA98179B (en) 1999-07-09
EA199900532A1 (ru) 2000-08-28
KR20000070070A (ko) 2000-11-25
IS1847B (is) 2003-02-07
AU6208398A (en) 1998-08-03
CY2263B1 (en) 2003-07-04
ID21981A (id) 1999-08-19
ATE209183T1 (de) 2001-12-15
SK283201B6 (sk) 2003-03-04
PE44599A1 (es) 1999-05-05
EP0958277B1 (en) 2001-11-21
EE04013B1 (et) 2003-04-15
WO1998030537A1 (en) 1998-07-16
BR9806870B1 (pt) 2009-05-05

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