BRPI0215312B8 - composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto - Google Patents

composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto

Info

Publication number
BRPI0215312B8
BRPI0215312B8 BRPI0215312A BR0215312A BRPI0215312B8 BR PI0215312 B8 BRPI0215312 B8 BR PI0215312B8 BR PI0215312 A BRPI0215312 A BR PI0215312A BR 0215312 A BR0215312 A BR 0215312A BR PI0215312 B8 BRPI0215312 B8 BR PI0215312B8
Authority
BR
Brazil
Prior art keywords
compound
preparing
pharmaceutical composition
preparation
aurora kinase
Prior art date
Application number
BRPI0215312A
Other languages
English (en)
Other versions
BRPI0215312B1 (pt
BR0215312A (pt
Inventor
Henri Jung Frederic
Rene Pasquet Georges
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0215312A publication Critical patent/BR0215312A/pt
Publication of BRPI0215312B1 publication Critical patent/BRPI0215312B1/pt
Publication of BRPI0215312B8 publication Critical patent/BRPI0215312B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"uso de um composto, método para inibir a aurora quinase em um animal de sangue quente, composto, composição farmacêutica, e, processo para a preparação de um composto". a invenção fornece derivados de quinazolina de fórmula (i): na preparação de um medicamento para uso na inibição da aurora quinase e, também, novos derivados de quinazolina, processos para sua preparação, composições farmacêuticas contendo-os, e seu uso em terapia.
BRPI0215312A 2001-12-24 2002-12-20 composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto BRPI0215312B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01403357.5 2001-12-24
EP01403357 2001-12-24
PCT/GB2002/005845 WO2003055491A1 (en) 2001-12-24 2002-12-20 Substituted quinazoline derivatives as inhibitors of aurora kinases

Publications (3)

Publication Number Publication Date
BR0215312A BR0215312A (pt) 2004-12-07
BRPI0215312B1 BRPI0215312B1 (pt) 2018-03-27
BRPI0215312B8 true BRPI0215312B8 (pt) 2021-05-25

Family

ID=8183051

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0215312A BRPI0215312B8 (pt) 2001-12-24 2002-12-20 composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto

Country Status (32)

Country Link
US (2) US7402585B2 (pt)
EP (1) EP1463506B1 (pt)
JP (1) JP4498741B2 (pt)
KR (1) KR101029281B1 (pt)
CN (1) CN100491372C (pt)
AR (1) AR038052A1 (pt)
AT (1) ATE446093T1 (pt)
AU (1) AU2002353196B2 (pt)
BR (1) BRPI0215312B8 (pt)
CA (1) CA2471577C (pt)
CY (1) CY1109681T1 (pt)
DE (1) DE60234125D1 (pt)
DK (1) DK1463506T3 (pt)
ES (1) ES2333702T3 (pt)
HK (1) HK1076598A1 (pt)
HU (1) HU229477B1 (pt)
IL (1) IL162541A0 (pt)
IS (1) IS2758B (pt)
MX (1) MXPA04006260A (pt)
MY (1) MY141739A (pt)
NO (1) NO328159B1 (pt)
NZ (1) NZ533440A (pt)
PL (1) PL211694B1 (pt)
PT (1) PT1463506E (pt)
RU (1) RU2323215C2 (pt)
SA (1) SA03230531B1 (pt)
SI (1) SI1463506T1 (pt)
TW (1) TWI335818B (pt)
UA (1) UA82058C2 (pt)
UY (1) UY27604A1 (pt)
WO (1) WO2003055491A1 (pt)
ZA (1) ZA200404923B (pt)

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Also Published As

Publication number Publication date
UY27604A1 (es) 2003-07-31
KR101029281B1 (ko) 2011-04-18
CY1109681T1 (el) 2014-08-13
PL371253A1 (en) 2005-06-13
CA2471577A1 (en) 2003-07-10
AR038052A1 (es) 2004-12-22
JP4498741B2 (ja) 2010-07-07
HUP0402454A2 (hu) 2005-03-29
BRPI0215312B1 (pt) 2018-03-27
ES2333702T3 (es) 2010-02-26
PT1463506E (pt) 2009-12-10
SI1463506T1 (sl) 2010-01-29
SA03230531A (ar) 2005-12-03
RU2004122926A (ru) 2005-07-10
US20050070561A1 (en) 2005-03-31
AU2002353196A1 (en) 2003-07-15
DE60234125D1 (de) 2009-12-03
KR20040066929A (ko) 2004-07-27
CN1620296A (zh) 2005-05-25
IS7328A (is) 2004-06-21
EP1463506A1 (en) 2004-10-06
ZA200404923B (en) 2005-11-30
EP1463506B1 (en) 2009-10-21
ATE446093T1 (de) 2009-11-15
NO328159B1 (no) 2009-12-21
UA82058C2 (uk) 2008-03-11
IS2758B (is) 2011-10-15
MY141739A (en) 2010-06-15
IL162541A0 (en) 2005-11-20
MXPA04006260A (es) 2005-03-31
WO2003055491A1 (en) 2003-07-10
HUP0402454A3 (en) 2009-08-28
HU229477B1 (en) 2014-01-28
PL211694B1 (pl) 2012-06-29
BR0215312A (pt) 2004-12-07
CA2471577C (en) 2011-08-02
TWI335818B (en) 2011-01-11
US20090215770A1 (en) 2009-08-27
DK1463506T3 (da) 2010-01-11
NO20043158L (no) 2004-09-16
HK1076598A1 (en) 2006-01-20
TW200410697A (en) 2004-07-01
US7402585B2 (en) 2008-07-22
CN100491372C (zh) 2009-05-27
JP2005525307A (ja) 2005-08-25
SA03230531B1 (ar) 2008-09-08
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NZ533440A (en) 2006-08-31

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