CCL19
CCL19
케모킨(C-C 모티브) 리간드 19(CCL19)는 인간에서 CCL19 유전자에 의해 인코딩되는 단백질이다.[5][6]
이 유전자는 9번 염색체의 p-팔에 군집된 여러 CC 사이토카인 유전자 중 하나이다.사이토카인은 면역억제 작용과 염증 작용에 관여하는 분비 단백질이다.CC 사이토카인은 두 개의 인접한 사이스테인이 특징인 단백질이다.이 유전자에 의해 암호화된 사이토카인은 정상적인 림프구 재순환과 호밍에 역할을 할 수 있다.흉선 내 T세포의 밀매, T세포와 B세포가 2차 림프관으로 이동하는 데도 중요한 역할을 한다.그것은 특히 케모킨 수용체 CCR7에 결합된다.[6]
케모카인(C-C 모티브) 리간드 19(CCL19)는 CC 케모카인 계열에 속하는 작은 사이토카인으로 EBI1 리간드 케모킨(ELC)과 대식세포 염증성 단백질-3-베타(MIP-3-베타)로도 알려져 있다.CCL19는 흉선과 림프절에 풍부하게 표현되며 기관과 대장에 적당한 레벨이 있고 위, 소장, 폐, 신장, 비장이 낮은 레벨이다.[7]CCL19의 유전자는 9번 염색체에 위치한다.[8]이 케모카인은 케모카인 수용체 케모카인 수용체 CCR7에 결합하여 목표 세포에 미치는 영향을 도출한다.[7]덴드리트리틱 세포와 항원이 결합된 B세포, CCR7+[9][10]중앙기억 T세포 등 면역체계의 특정 세포를 끌어들인다.[11]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000172724 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000118633 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
- ^ a b "Entrez Gene: CCL19 chemokine (C-C motif) ligand 19".
- ^ a b Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
- ^ Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. PMID 9013939.
- ^ Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes". Cell. 103 (5): 757–68. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332. S2CID 15592251.
- ^ Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature. 416 (6876): 94–9. Bibcode:2002Natur.416...94R. doi:10.1038/416094a. PMID 11882900. S2CID 4403093.
- ^ Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. doi:10.1038/ni1240. PMID 16116469. S2CID 443455.
추가 읽기
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- Rossi DL, Vicari AP, Franz-Bacon K, et al. (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. PMID 9013939.
- Nagira M, Imai T, Hieshima K, et al. (1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". J. Biol. Chem. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955.
- Kim CH, Pelus LM, White JR, et al. (1998). "CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells". J. Immunol. 160 (5): 2418–24. PMID 9498785.
- Yanagihara S, Komura E, Nagafune J, et al. (1998). "EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation". J. Immunol. 161 (6): 3096–102. PMID 9743376.
- Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
- Annunziato F, Romagnani P, Cosmi L, et al. (2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection". J. Immunol. 165 (1): 238–46. doi:10.4049/jimmunol.165.1.238. PMID 10861057.
- Ueno T, Hara K, Willis MS, et al. (2002). "Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus". Immunity. 16 (2): 205–18. doi:10.1016/S1074-7613(02)00267-4. PMID 11869682.
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- Till KJ, Lin K, Zuzel M, Cawley JC (2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes". Blood. 99 (8): 2977–84. doi:10.1182/blood.V99.8.2977. PMID 11929789.
- Townson JR, Nibbs RJ (2002). "Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR". Eur. J. Immunol. 32 (5): 1230–41. doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L. PMID 11981810.
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- Katou F, Ohtani H, Nakayama T, et al. (2003). "Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin". J. Pathol. 199 (1): 98–106. doi:10.1002/path.1255. PMID 12474232. S2CID 25424987.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scandella E, Men Y, Legler DF, et al. (2004). "CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2". Blood. 103 (5): 1595–601. doi:10.1182/blood-2003-05-1643. PMID 14592837.
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외부 링크
- UCSC 게놈 브라우저의 인간 CCL19 게놈 위치 및 CCL19 유전자 세부 정보 페이지.
