CCL11
CCL11
C-C 모티브 케모카인 11은 호산구 케모타틱 단백질이라고도 하며, eotaxin-1은 CCL11 유전자에 의해 인체 내에서 코드되는 단백질이다.이 유전자는 3개의 엑손에 암호화되어 있으며 [5][6]17번 염색체에 위치해 있다.
기능.
CCL11은 CC케모카인족에 속하는 작은 사이토카인이다.CCL11은 호산구의 화학작용을 유도하여 선택적으로 호산구를 모집하므로 알레르기 반응에 [7][8][9]관여한다.CCL11의 효과는 케모카인 수용체로 알려진 G단백질 연결 수용체와의 결합에 의해 매개된다.CCL11이 배위자인 케모카인 수용체는 CCR2,[10] CCR3[5], CCR5를 [10]포함한다.단, eotaxin-1(CCL11)은 CCR3을 [11]발현하지 않는 호중구 및 단구에서는 불활성이기 때문에 수용체에 대한 높은 선택성을 갖는 것으로 밝혀졌다.
임상적 의의
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혈장의 CCL11 수치 증가는 생쥐와 사람의 [12]노화와 관련이 있다.또한 어린 생쥐를 CCL11 또는 나이든 생쥐의 혈장에 노출시키는 것은 [12]해마의 신경 발생에 의존하는 것으로 생각되는 행동 태스크에 대한 신경 발생과 인지 성능을 감소시키는 것으로 입증되었다.
CCL11의 혈장 농도는 과거 사용자 및 사용하지 않은 사용자에 비해 현재 대마초 사용자에게서 더 높게 나타났다.CCL11은 또한 정신분열증 환자들에게서 더 높은 농도로 발견되었다; 대마초는 정신분열증의 [13]알려진 촉발제이다.
CTE나 펀치-드렁크 [14]증후군의 바이오마커이기도 합니다.
뼈에 염증이 생기는 동안 CCL11과 CCR3은 상향 조절된다.이것은 골세포 활동의 증가와 [15]관련이 있다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000172156 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020676 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
- ^ Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
- ^ Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (Mar 1994). "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation". The Journal of Experimental Medicine. 179 (3): 881–7. doi:10.1084/jem.179.3.881. PMC 2191401. PMID 7509365.
- ^ Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.
- ^ Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956. S2CID 25571283.
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- ^ a b Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. (Sep 2011). "The ageing systemic milieu negatively regulates neurogenesis and cognitive function". Nature. 477 (7362): 90–4. Bibcode:2011Natur.477...90V. doi:10.1038/nature10357. PMC 3170097. PMID 21886162.
- ^ Fernandez-Egea E, Scoriels L, Theegala S, Giro M, Ozanne SE, Burling K, Jones PB (Oct 2013). "Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 46: 25–8. doi:10.1016/j.pnpbp.2013.06.011. PMID 23820464. S2CID 207410464.
- ^ Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC (2017). "CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease". PLOS ONE. 12 (9): e0185541. Bibcode:2017PLoSO..1285541C. doi:10.1371/journal.pone.0185541. PMC 5614644. PMID 28950005.
- Michelle Taylor (2017-09-28). "Biomarker May Distinguish Between CTE, Alzheimer's During Life". LabEquipment. Archived from the original on 2017-10-16.
- ^ Kindstedt E, Holm CK, Sulniute R, Martinez-Carrasco I, Lundmark R, Lundberg P (July 2017). "CCL11, a novel mediator of inflammatory bone resorption". Scientific Reports. 7 (1): 5334. Bibcode:2017NatSR...7.5334K. doi:10.1038/s41598-017-05654-w. PMC 5509729. PMID 28706221.
외부 링크
- UCSC 게놈 브라우저의 인간 CCL11 게놈 위치 및 CCL11 유전자 상세 페이지.
추가 정보
- Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956. S2CID 25571283.
- Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.
- Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
- Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". The Journal of Experimental Medicine. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
- Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J (Jun 1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates". Cell. 85 (7): 1135–48. doi:10.1016/S0092-8674(00)81313-6. PMID 8674119. S2CID 16198200.
- Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR (Jun 1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". The Journal of Experimental Medicine. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.
- Bartels J, Schlüter C, Richter E, Noso N, Kulke R, Christophers E, Schröder JM (Aug 1996). "Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants". Biochemical and Biophysical Research Communications. 225 (3): 1045–51. doi:10.1006/bbrc.1996.1292. PMID 8780731.
- Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, Sarafi MN, Morton CC, Luster AD (May 1997). "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine". Genomics. 41 (3): 471–6. doi:10.1006/geno.1997.4656. PMID 9169149.
- Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
- Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Dec 1997). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". The Journal of Biological Chemistry. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
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