YU75082A - Process for obtaining (1-arylcyclobutyl)alkylamines - Google Patents

Process for obtaining (1-arylcyclobutyl)alkylamines

Info

Publication number
YU75082A
YU75082A YU00750/82A YU75082A YU75082A YU 75082 A YU75082 A YU 75082A YU 00750/82 A YU00750/82 A YU 00750/82A YU 75082 A YU75082 A YU 75082A YU 75082 A YU75082 A YU 75082A
Authority
YU
Yugoslavia
Prior art keywords
arylcyclobutyl
alkylamines
obtaining
Prior art date
Application number
YU00750/82A
Other versions
YU44336B (en
Inventor
J E Jeffery
A Kozlik
E C Wilmshurst
Original Assignee
Boots Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26279045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU75082(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boots Co Ltd filed Critical Boots Co Ltd
Priority to SI8210750A priority Critical patent/SI8210750A8/en
Publication of YU75082A publication Critical patent/YU75082A/en
Priority to SI8510063A priority patent/SI8510063A8/en
Publication of YU44336B publication Critical patent/YU44336B/en
Priority to HRP-750/8202.04.1982A priority patent/HRP930743B1/en
Priority to HR930744A priority patent/HRP930744B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/50Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/227Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C07C49/237Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/567Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/40Unsaturated compounds containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
YU750/82A 1981-04-06 1982-04-02 Process for obtaining (1-arylcyclobutyl)alkylamines YU44336B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SI8210750A SI8210750A8 (en) 1981-04-06 1982-04-02 Therapeutical agents - process for obtaining (1- arylcyclobutyl) alkylamine
SI8510063A SI8510063A8 (en) 1981-04-06 1985-11-17 Process for obtaining (1-arylcyclobutyl)alkylamines
HRP-750/8202.04.1982A HRP930743B1 (en) 1981-04-06 1993-04-02 Process for the preparation of (1-arylcyclobutyl)alkylamines
HR930744A HRP930744B1 (en) 1981-04-06 1993-04-02 Process for the preparation of /1-arylcyclobutyl)alkylamine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8110710 1981-04-06
GB8110709 1981-04-06

Publications (2)

Publication Number Publication Date
YU75082A true YU75082A (en) 1985-08-31
YU44336B YU44336B (en) 1990-06-30

Family

ID=26279045

Family Applications (2)

Application Number Title Priority Date Filing Date
YU750/82A YU44336B (en) 1981-04-06 1982-04-02 Process for obtaining (1-arylcyclobutyl)alkylamines
YU63/85A YU44253B (en) 1981-04-06 1985-01-17 Process for obtaining (1-arylcyclobutyl)alkylamines

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU63/85A YU44253B (en) 1981-04-06 1985-01-17 Process for obtaining (1-arylcyclobutyl)alkylamines

Country Status (40)

Country Link
KR (1) KR900000274B1 (en)
AT (1) AT382612B (en)
AU (1) AU545595B2 (en)
BG (2) BG40651A3 (en)
CA (1) CA1248955A (en)
CH (1) CH652117A5 (en)
CS (1) CS244672B2 (en)
CY (1) CY1408A (en)
DD (1) DD208348A5 (en)
DE (1) DE3212682A1 (en)
DK (1) DK161770C (en)
ES (5) ES511152A0 (en)
FI (1) FI77223C (en)
FR (1) FR2504920B1 (en)
GB (1) GB2098602B (en)
GE (1) GEP19970661B (en)
GR (1) GR76697B (en)
HK (1) HK13888A (en)
HU (1) HU186582B (en)
IE (1) IE52768B1 (en)
IL (1) IL65257A0 (en)
IN (1) IN155773B (en)
IT (1) IT1235758B (en)
JO (1) JO1184B1 (en)
KE (1) KE3753A (en)
LU (1) LU84070A1 (en)
MY (1) MY8800048A (en)
NL (1) NL192201C (en)
NO (1) NO156785C (en)
NZ (1) NZ200178A (en)
PH (1) PH22762A (en)
PL (2) PL136242B1 (en)
PT (1) PT74580B (en)
RO (2) RO84802B (en)
SE (1) SE452611B (en)
SG (1) SG67287G (en)
SU (2) SU1482522A3 (en)
UA (2) UA7589A1 (en)
YU (2) YU44336B (en)
ZW (1) ZW4982A1 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56001B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylmethylamine compounds
IE56000B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylalkylamine compounds
GB8412480D0 (en) * 1984-05-16 1984-06-20 Elliott M Pesticides
DK58285D0 (en) * 1984-05-30 1985-02-08 Novo Industri As PEPTIDES AND MANUFACTURING AND USING THEREOF
GB8501192D0 (en) * 1985-01-17 1985-02-20 Boots Co Plc Therapeutic agents
DK119785D0 (en) * 1985-03-15 1985-03-15 Nordisk Gentofte INSULIN PREPARATION
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB2184122B (en) * 1985-12-17 1989-10-18 Boots Co Plc N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (en) * 1988-03-31 1997-11-12 科研製薬株式会社 Brain function improver
CA2138998A1 (en) * 1992-06-23 1994-01-06 James W. Young Methods and compositions for treating depression and other disorders using optically pure(-) sibutramine
GB9309749D0 (en) * 1993-05-12 1993-06-23 Boots Co Plc Therapeutic agents
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
DE19518988A1 (en) * 1995-05-29 1996-12-05 Basf Ag Use of aryl substituted cyclobutylalkylamines to treat obesity
GB9524681D0 (en) 1995-12-02 1996-01-31 Knoll Ag Chemical process
GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process
GB9619961D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9619962D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9727131D0 (en) 1997-12-24 1998-02-25 Knoll Ag Therapeutic agents
US6331571B1 (en) * 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
AU2007200334B8 (en) * 1998-08-24 2010-10-21 Sepracor, Inc. Methods of using and compositions comprising dopamine reuptake inhibitors
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
BG65170B1 (en) * 1999-03-17 2007-05-31 Knoll Gmbh Use of n-substituted derivatives of 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine for the production of a medicine for treating eating disorders
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
GB9915617D0 (en) 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
US6399826B1 (en) * 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
WO2002036540A2 (en) * 2000-11-02 2002-05-10 Torrent Pharmaceuticals Ltd PROCESS FOR PREPARATION OF β-PHENETHYLAMINE DERIVATIVE
WO2002083631A1 (en) 2001-04-13 2002-10-24 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
KR100536750B1 (en) * 2002-10-05 2005-12-16 한미약품 주식회사 Pharmaceutical composition comprising crystalline hemihydrate of sibutramine methanesulfonate
FR2870537A1 (en) * 2004-05-19 2005-11-25 Servier Lab NOVEL PROCESS FOR SYNTHESIZING (1S) -4,5-DIMETHOXY-1- (METHYL AMINOMETHYL) BENZOCYCLOBUTANE AND ITS ADDITION SALTS AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS ADDITION SALTS PHARMACEUTICALLY ACCEPTABLE ACID
KR100606533B1 (en) 2004-08-27 2006-08-01 한올제약주식회사 An improved synthetic method of sibutramine
KR100606534B1 (en) 2004-11-01 2006-08-01 한올제약주식회사 An improved synthetic method of sibutramine
KR100618176B1 (en) * 2004-12-02 2006-09-01 휴먼팜 주식회사 Sibutramine tartrate, its preparation process and phamaceutical composition comprising it
WO2006073292A1 (en) 2005-01-06 2006-07-13 Cj Corporation Inorganic acid salts of sibutramine
CN101626768B (en) 2006-09-15 2013-08-21 雷维瓦药品公司 Synthesis, methods of using, and compositions of cycloalkylmethylamines
US8604244B2 (en) 2010-07-02 2013-12-10 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
CN101555214B (en) * 2008-04-08 2012-07-11 北京嘉事联博医药科技有限公司 Phenylcyclobutylacylamide derivative as well as optical isomer, preparation method and application thereof
FR2935381B1 (en) * 2008-08-29 2010-12-17 Servier Lab NOVEL METHOD FOR THE RESOLUTION OF ENANTIOMERES OF (3,4-DIMETHOXY-BICYCLOO-4.2.0-OCTA-1,3,5-TRIEN-7-YL) NITRILE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE
WO2010082216A2 (en) * 2008-12-08 2010-07-22 Matrix Laboratories Ltd Novel salts of sibutramine and their crystal forms
JP5696156B2 (en) 2009-11-02 2015-04-08 ファイザー・インク Dioxa-bicyclo [3.2.1] octane-2,3,4-triol derivative
CA2858837C (en) * 2011-12-30 2022-08-30 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
FR2993561B1 (en) * 2012-07-17 2014-10-31 Servier Lab PROCESS FOR ENZYMATIC SYNTHESIS OF (7S) -1- (3,4-DIMETHOXY BICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-YL) N-METHYL METHANAMINE, AND APPLICATION TO THE SYNTHESIS OF THE IVABRADINE AND ITS SALTS

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Publication number Priority date Publication date Assignee Title
DE1124485B (en) * 1960-02-12 1962-03-01 Hoechst Ag Process for the preparation of analeptically active phenylcycloalkylmethylamines
US3526656A (en) * 1967-05-25 1970-09-01 Parke Davis & Co (1-arylcyclobutyl)carbonyl carbamic acid derivatives

Also Published As

Publication number Publication date
PL139120B1 (en) 1986-12-31
IE820481L (en) 1982-10-06
DK161770B (en) 1991-08-12
NZ200178A (en) 1985-07-31
RO89436A2 (en) 1986-06-30
LU84070A1 (en) 1983-06-07
NL192201B (en) 1996-11-01
ATA132582A (en) 1986-08-15
AT382612B (en) 1987-03-25
RO84802A (en) 1984-09-29
ZW4982A1 (en) 1982-11-03
PT74580B (en) 1983-12-23
CY1408A (en) 1988-04-22
RO84802B (en) 1984-10-30
CS245782A2 (en) 1985-08-15
SG67287G (en) 1988-02-19
IE52768B1 (en) 1988-02-17
FR2504920B1 (en) 1985-06-28
FI821197L (en) 1982-10-07
KR830010065A (en) 1983-12-26
ES519031A0 (en) 1984-08-16
HU186582B (en) 1985-08-28
ES8403097A1 (en) 1984-03-01
PT74580A (en) 1982-04-01
SE8202166L (en) 1982-11-25
DE3212682A1 (en) 1982-10-21
YU44336B (en) 1990-06-30
BG40651A3 (en) 1986-01-15
NO156785C (en) 1987-11-25
FI77223C (en) 1989-02-10
DK146482A (en) 1982-10-07
DD208348A5 (en) 1984-05-02
PL235832A1 (en) 1983-09-12
KR900000274B1 (en) 1990-01-24
PH22762A (en) 1988-12-12
FI77223B (en) 1988-10-31
IL65257A0 (en) 1983-12-30
JO1184B1 (en) 1983-11-30
ES519030A0 (en) 1984-08-01
PL136242B1 (en) 1986-02-28
SU1461372A3 (en) 1989-02-23
ES8407002A1 (en) 1984-08-16
CH652117A5 (en) 1985-10-31
ES519029A0 (en) 1984-08-01
CS244672B2 (en) 1986-08-14
ES8305678A1 (en) 1983-04-16
DE3212682C2 (en) 1992-03-26
GR76697B (en) 1984-08-28
NL8201347A (en) 1982-11-01
HK13888A (en) 1988-02-26
BG40652A3 (en) 1986-01-15
YU6385A (en) 1985-08-31
FR2504920A1 (en) 1982-11-05
GEP19970661B (en) 1997-01-04
UA7589A1 (en) 1995-09-29
SE452611B (en) 1987-12-07
FI821197A0 (en) 1982-04-05
IT8248157A0 (en) 1982-04-02
PL240079A1 (en) 1983-09-12
MY8800048A (en) 1988-12-31
NL192201C (en) 1997-03-04
UA7838A1 (en) 1995-12-26
AU8221382A (en) 1982-10-14
GB2098602B (en) 1984-08-22
IN155773B (en) 1985-03-09
DK161770C (en) 1992-02-10
CA1248955A (en) 1989-01-17
GB2098602A (en) 1982-11-24
NO156785B (en) 1987-08-17
YU44253B (en) 1990-04-30
ES8406413A1 (en) 1984-08-01
ES519032A0 (en) 1984-03-01
NO821087L (en) 1982-10-07
SU1482522A3 (en) 1989-05-23
KE3753A (en) 1987-10-02
ES511152A0 (en) 1983-04-16
AU545595B2 (en) 1985-07-18
IT1235758B (en) 1992-09-28
ES8406414A1 (en) 1984-08-01

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