DOP2011000002A - Agentes de fijación al receptor notch1 y metodos de uso de los mismos - Google Patents

Agentes de fijación al receptor notch1 y metodos de uso de los mismos

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Publication number
DOP2011000002A
DOP2011000002A DO2011000002A DO2011000002A DOP2011000002A DO P2011000002 A DOP2011000002 A DO P2011000002A DO 2011000002 A DO2011000002 A DO 2011000002A DO 2011000002 A DO2011000002 A DO 2011000002A DO P2011000002 A DOP2011000002 A DO P2011000002A
Authority
DO
Dominican Republic
Prior art keywords
cancer
notch1
present
fixing agents
use methods
Prior art date
Application number
DO2011000002A
Other languages
English (en)
Inventor
Austin L Gurney
Timothy Charles Hoey
Maureen Fitch Bruhns
Fumiko Takada Axelrod
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Publication of DOP2011000002A publication Critical patent/DOP2011000002A/es

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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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Abstract

La presente invención se refiere a composiciones y métodos para la caracterización, diagnóstico y tratamiento del cáncer. En particular, la invención proporciona los medios y métodos para el diagnóstico, caracterización, pronóstico y tratamiento del cáncer y atacando específicamente a las células madre de cáncer. La presente invención proporciona un anticuerpo que se fija específicamente a la región proximal de membrana no fijadora de ligandos del dominio extracelular de un receptor Notch humano e inhibe el crecimiento tumoral. La presente invención proporciona además un método de tratamiento del cáncer, el método que comprende administrar una cantidad terapéuticamente efectiva de un anticuerpo que se fija específicamente a una región proximal de membrana no fijadora de ligandos del dominio extracelular de una proteína del receptor de Notch e inhibe el crecimiento tumoral.
DO2011000002A 2008-07-08 2011-01-05 Agentes de fijación al receptor notch1 y metodos de uso de los mismos DOP2011000002A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11269908P 2008-11-07 2008-11-07
US11270108P 2008-11-07 2008-11-07

Publications (1)

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DOP2011000002A true DOP2011000002A (es) 2011-04-15

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DO2011000002A DOP2011000002A (es) 2008-07-08 2011-01-05 Agentes de fijación al receptor notch1 y metodos de uso de los mismos
DO2011000004A DOP2011000004A (es) 2008-07-08 2011-01-05 Agentes y antagonistas fijadores de notch y metodos para el uso de los mismos

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DO2011000004A DOP2011000004A (es) 2008-07-08 2011-01-05 Agentes y antagonistas fijadores de notch y metodos para el uso de los mismos

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US (11) US8435513B2 (es)
EP (4) EP2924051A1 (es)
JP (2) JP5560270B2 (es)
KR (2) KR101682490B1 (es)
CN (3) CN102112490B (es)
AU (2) AU2009269095B2 (es)
BR (2) BRPI0914007A2 (es)
CA (2) CA2729306C (es)
CO (2) CO6612253A2 (es)
CR (1) CR20110069A (es)
CY (2) CY1116195T1 (es)
DK (2) DK2307051T3 (es)
DO (2) DOP2011000002A (es)
EA (2) EA201170157A1 (es)
ES (2) ES2531541T3 (es)
HK (2) HK1151218A1 (es)
HR (2) HRP20150256T1 (es)
IL (2) IL210222A (es)
MA (2) MA32449B1 (es)
ME (2) ME02069B (es)
MX (2) MX2011000236A (es)
MY (2) MY159815A (es)
NZ (2) NZ590131A (es)
PL (2) PL2307051T3 (es)
PT (2) PT2307051E (es)
RS (2) RS53750B1 (es)
SG (2) SG192468A1 (es)
SI (2) SI2307051T1 (es)
SM (2) SMT201500047B (es)
UA (1) UA101672C2 (es)
WO (2) WO2010005567A2 (es)
ZA (2) ZA201009280B (es)

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US7935791B2 (en) 2006-12-18 2011-05-03 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
EP2125887A4 (en) 2007-01-24 2010-11-10 Oncomed Pharm Inc COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF CANCER
KR101682490B1 (ko) 2008-07-08 2016-12-05 온코메드 파마슈티칼스, 인크. Ｎｏｔｃｈ-결합제 및 길항제 및 이들의 사용 방법
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
ES2541726T3 (es) * 2008-10-01 2015-07-23 F. Hoffmann-La Roche Ag Anticuerpos anti-Notch2 y métodos de uso
CN102686610A (zh) 2009-06-18 2012-09-19 辉瑞公司 抗刻缺蛋白-1抗体
ES2580229T3 (es) * 2009-09-30 2016-08-22 F. Hoffmann-La Roche Ag Anticuerpos antagonistas anti-Notch3 para el tratamiento de una leucemia de linfocitos T positiva a un inhibidor de la gamma-secretasa que no responde a un anticuerpo antagonista anti-Notch1
DK2488204T3 (en) 2009-10-16 2016-06-06 Oncomed Pharm Inc Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents
AU2011205316B2 (en) * 2010-01-13 2015-05-28 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
EP2542155B1 (en) 2010-03-01 2015-11-04 TAU Therapeutics LLC Method for imaging a disease
WO2011139985A1 (en) * 2010-05-03 2011-11-10 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
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