CY1116230T1 - Παραγοντες και ανταγωνιστες δεσμευσης-notch και μεθοδοι χρησης εξ' αυτων - Google Patents
Παραγοντες και ανταγωνιστες δεσμευσης-notch και μεθοδοι χρησης εξ' αυτωνInfo
- Publication number
- CY1116230T1 CY1116230T1 CY20151100376T CY151100376T CY1116230T1 CY 1116230 T1 CY1116230 T1 CY 1116230T1 CY 20151100376 T CY20151100376 T CY 20151100376T CY 151100376 T CY151100376 T CY 151100376T CY 1116230 T1 CY1116230 T1 CY 1116230T1
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- Cyprus
- Prior art keywords
- methods
- notch
- present
- antagonists
- competitors
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
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- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
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- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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Abstract
Η παρούσα εφεύρεση σχετίζεται με παράγοντες δέσμευσης-Notch και ανταγωνιστές του Notch και με μεθόδους χρήσεις των παραγόντων και/ή ανταγωνιστών για την αγωγή παθήσεων όπως είναι ο καρκίνος. Η παρούσα εφεύρεση παρέχει αντισώματα που δεσμεύονται συγκεκριμένα σε μια περιοχή δέσμευσης μη-προσδέτη της εξωκυτταρικής επικράτειας ενός ή περισσότερων υποδοχέα του Notch ανθρώπου, όπως είναι τα Notch2 και/ή Notch3, και αναστέλλουν την αύξηση των όγκων. Η παρούσα εφεύρεση παρέχει περαιτέρω μεθόδους αγωγής του καρκίνου, οι δε μέθοδοι περιλαμβάνοντας την χορήγηση μιας θεραπευτικώς αποτελεσματικής ποσότητας ενός αντισώματος που δεσμεύεται συγκεκριμένα σε μια περιοχή δέσμευσης μη-προσδέτη της εξωκυτταρικής επικράτειας της πρωτεΐνης ενός υποδοχέα του Notch ανθρώπου και αναστέλλει την αύξηση των όγκων.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7909508P | 2008-07-08 | 2008-07-08 | |
US11269908P | 2008-11-07 | 2008-11-07 | |
US11270108P | 2008-11-07 | 2008-11-07 | |
EP09794821.0A EP2307051B1 (en) | 2008-07-08 | 2009-07-08 | Notch-binding agents and antagonists and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116230T1 true CY1116230T1 (el) | 2017-02-08 |
Family
ID=41507637
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100227T CY1116195T1 (el) | 2008-07-08 | 2015-03-03 | Παραγοντες δεσμευσης του notch 1 υποδοχεα και μεθοδοι χρησης αυτων |
CY20151100376T CY1116230T1 (el) | 2008-07-08 | 2015-04-24 | Παραγοντες και ανταγωνιστες δεσμευσης-notch και μεθοδοι χρησης εξ' αυτων |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100227T CY1116195T1 (el) | 2008-07-08 | 2015-03-03 | Παραγοντες δεσμευσης του notch 1 υποδοχεα και μεθοδοι χρησης αυτων |
Country Status (32)
Country | Link |
---|---|
US (11) | US8435513B2 (el) |
EP (4) | EP2924051A1 (el) |
JP (2) | JP5560270B2 (el) |
KR (2) | KR101682490B1 (el) |
CN (3) | CN102112490B (el) |
AU (2) | AU2009269095B2 (el) |
BR (2) | BRPI0914007A2 (el) |
CA (2) | CA2729306C (el) |
CO (2) | CO6612253A2 (el) |
CR (1) | CR20110069A (el) |
CY (2) | CY1116195T1 (el) |
DK (2) | DK2307051T3 (el) |
DO (2) | DOP2011000002A (el) |
EA (2) | EA201170157A1 (el) |
ES (2) | ES2531541T3 (el) |
HK (2) | HK1151218A1 (el) |
HR (2) | HRP20150256T1 (el) |
IL (2) | IL210222A (el) |
MA (2) | MA32449B1 (el) |
ME (2) | ME02069B (el) |
MX (2) | MX2011000236A (el) |
MY (2) | MY159815A (el) |
NZ (2) | NZ590131A (el) |
PL (2) | PL2307051T3 (el) |
PT (2) | PT2307051E (el) |
RS (2) | RS53750B1 (el) |
SG (2) | SG192468A1 (el) |
SI (2) | SI2307051T1 (el) |
SM (2) | SMT201500047B (el) |
UA (1) | UA101672C2 (el) |
WO (2) | WO2010005567A2 (el) |
ZA (2) | ZA201009280B (el) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US9540694B2 (en) * | 2006-05-19 | 2017-01-10 | The Johns Hopkins University | HEYL as a therapeutic target and a diagnostic marker for neoplasia and uses therefor |
PL2032166T3 (pl) | 2006-06-13 | 2013-09-30 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworów |
US7935791B2 (en) | 2006-12-18 | 2011-05-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
EP2125887A4 (en) | 2007-01-24 | 2010-11-10 | Oncomed Pharm Inc | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF CANCER |
KR101682490B1 (ko) | 2008-07-08 | 2016-12-05 | 온코메드 파마슈티칼스, 인크. | Notch-결합제 및 길항제 및 이들의 사용 방법 |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
ES2541726T3 (es) * | 2008-10-01 | 2015-07-23 | F. Hoffmann-La Roche Ag | Anticuerpos anti-Notch2 y métodos de uso |
CN102686610A (zh) | 2009-06-18 | 2012-09-19 | 辉瑞公司 | 抗刻缺蛋白-1抗体 |
ES2580229T3 (es) * | 2009-09-30 | 2016-08-22 | F. Hoffmann-La Roche Ag | Anticuerpos antagonistas anti-Notch3 para el tratamiento de una leucemia de linfocitos T positiva a un inhibidor de la gamma-secretasa que no responde a un anticuerpo antagonista anti-Notch1 |
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