CY1116230T1 - Παραγοντες και ανταγωνιστες δεσμευσης-notch και μεθοδοι χρησης εξ' αυτων - Google Patents

Παραγοντες και ανταγωνιστες δεσμευσης-notch και μεθοδοι χρησης εξ' αυτων

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Publication number
CY1116230T1
CY1116230T1 CY20151100376T CY151100376T CY1116230T1 CY 1116230 T1 CY1116230 T1 CY 1116230T1 CY 20151100376 T CY20151100376 T CY 20151100376T CY 151100376 T CY151100376 T CY 151100376T CY 1116230 T1 CY1116230 T1 CY 1116230T1
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Cyprus
Prior art keywords
methods
notch
present
antagonists
competitors
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CY20151100376T
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English (en)
Inventor
Austin L Gurney
Timothy Charles Hoey
Van Der Horst Edward Thein Htun
Aaron Ken Sato
Yuan Ching Liu
Maureen Fitch Bruhns
John A Lewicki
Original Assignee
Oncomed Pharmaceuticals, Inc.
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Application filed by Oncomed Pharmaceuticals, Inc. filed Critical Oncomed Pharmaceuticals, Inc.
Publication of CY1116230T1 publication Critical patent/CY1116230T1/el

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Abstract

Η παρούσα εφεύρεση σχετίζεται με παράγοντες δέσμευσης-Notch και ανταγωνιστές του Notch και με μεθόδους χρήσεις των παραγόντων και/ή ανταγωνιστών για την αγωγή παθήσεων όπως είναι ο καρκίνος. Η παρούσα εφεύρεση παρέχει αντισώματα που δεσμεύονται συγκεκριμένα σε μια περιοχή δέσμευσης μη-προσδέτη της εξωκυτταρικής επικράτειας ενός ή περισσότερων υποδοχέα του Notch ανθρώπου, όπως είναι τα Notch2 και/ή Notch3, και αναστέλλουν την αύξηση των όγκων. Η παρούσα εφεύρεση παρέχει περαιτέρω μεθόδους αγωγής του καρκίνου, οι δε μέθοδοι περιλαμβάνοντας την χορήγηση μιας θεραπευτικώς αποτελεσματικής ποσότητας ενός αντισώματος που δεσμεύεται συγκεκριμένα σε μια περιοχή δέσμευσης μη-προσδέτη της εξωκυτταρικής επικράτειας της πρωτεΐνης ενός υποδοχέα του Notch ανθρώπου και αναστέλλει την αύξηση των όγκων.
CY20151100376T 2008-07-08 2015-04-24 Παραγοντες και ανταγωνιστες δεσμευσης-notch και μεθοδοι χρησης εξ' αυτων CY1116230T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11269908P 2008-11-07 2008-11-07
US11270108P 2008-11-07 2008-11-07
EP09794821.0A EP2307051B1 (en) 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of use thereof

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CY1116230T1 true CY1116230T1 (el) 2017-02-08

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CY20151100227T CY1116195T1 (el) 2008-07-08 2015-03-03 Παραγοντες δεσμευσης του notch 1 υποδοχεα και μεθοδοι χρησης αυτων
CY20151100376T CY1116230T1 (el) 2008-07-08 2015-04-24 Παραγοντες και ανταγωνιστες δεσμευσης-notch και μεθοδοι χρησης εξ' αυτων

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CY20151100227T CY1116195T1 (el) 2008-07-08 2015-03-03 Παραγοντες δεσμευσης του notch 1 υποδοχεα και μεθοδοι χρησης αυτων

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EP (4) EP2924051A1 (el)
JP (2) JP5560270B2 (el)
KR (2) KR101682490B1 (el)
CN (3) CN102112490B (el)
AU (2) AU2009269095B2 (el)
BR (2) BRPI0914007A2 (el)
CA (2) CA2729306C (el)
CO (2) CO6612253A2 (el)
CR (1) CR20110069A (el)
CY (2) CY1116195T1 (el)
DK (2) DK2307051T3 (el)
DO (2) DOP2011000002A (el)
EA (2) EA201170157A1 (el)
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HK (2) HK1151218A1 (el)
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MA (2) MA32449B1 (el)
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SG (2) SG192468A1 (el)
SI (2) SI2307051T1 (el)
SM (2) SMT201500047B (el)
UA (1) UA101672C2 (el)
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US7935791B2 (en) 2006-12-18 2011-05-03 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
EP2125887A4 (en) 2007-01-24 2010-11-10 Oncomed Pharm Inc COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF CANCER
KR101682490B1 (ko) 2008-07-08 2016-12-05 온코메드 파마슈티칼스, 인크. Notch-결합제 및 길항제 및 이들의 사용 방법
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
ES2541726T3 (es) * 2008-10-01 2015-07-23 F. Hoffmann-La Roche Ag Anticuerpos anti-Notch2 y métodos de uso
CN102686610A (zh) 2009-06-18 2012-09-19 辉瑞公司 抗刻缺蛋白-1抗体
ES2580229T3 (es) * 2009-09-30 2016-08-22 F. Hoffmann-La Roche Ag Anticuerpos antagonistas anti-Notch3 para el tratamiento de una leucemia de linfocitos T positiva a un inhibidor de la gamma-secretasa que no responde a un anticuerpo antagonista anti-Notch1
DK2488204T3 (en) 2009-10-16 2016-06-06 Oncomed Pharm Inc Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents
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