ATE482275T1 - Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden - Google Patents

Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden

Info

Publication number
ATE482275T1
ATE482275T1 AT00947904T AT00947904T ATE482275T1 AT E482275 T1 ATE482275 T1 AT E482275T1 AT 00947904 T AT00947904 T AT 00947904T AT 00947904 T AT00947904 T AT 00947904T AT E482275 T1 ATE482275 T1 AT E482275T1
Authority
AT
Austria
Prior art keywords
poly
binding partners
ests
genomic dna
dna fragments
Prior art date
Application number
AT00947904T
Other languages
English (en)
Inventor
Christian Frisch
Titus Kretzschmar
Adolf Hoess
Rueden Thomas Von
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Application granted granted Critical
Publication of ATE482275T1 publication Critical patent/ATE482275T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018Orthomyxoviridae, e.g. influenza virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00947904T 1999-07-02 2000-06-30 Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden ATE482275T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99112815 1999-07-02
PCT/EP2000/006137 WO2001002588A2 (en) 1999-07-02 2000-06-30 Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests

Publications (1)

Publication Number Publication Date
ATE482275T1 true ATE482275T1 (de) 2010-10-15

Family

ID=8238496

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00947904T ATE482275T1 (de) 1999-07-02 2000-06-30 Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden

Country Status (9)

Country Link
US (2) US6653068B2 (de)
EP (1) EP1133565B1 (de)
JP (1) JP4794789B2 (de)
AT (1) ATE482275T1 (de)
CA (1) CA2339889C (de)
DE (1) DE60044997D1 (de)
DK (1) DK1133565T3 (de)
ES (1) ES2353268T3 (de)
WO (1) WO2001002588A2 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696251B1 (en) * 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
WO2001077365A2 (en) 2000-04-06 2001-10-18 Pharmacia & Upjohn Company Antimicrobial methods and materials
WO2003029484A2 (en) * 2001-09-28 2003-04-10 Pharmacia & Upjohn Company Antimicrobial methods and materials
US20030235814A1 (en) * 2002-06-19 2003-12-25 Los Alamos National Laboratory Compositions and methods for selecting open reading frames
DOP2006000277A (es) 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp Anticuerpos anti mn y métodos para su utilización
JP5524610B2 (ja) * 2006-04-07 2014-06-18 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法
US9044461B2 (en) 2006-04-07 2015-06-02 The Research Foundation Of State University Of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
AU2008218925A1 (en) 2007-02-20 2008-08-28 Anaptysbio, Inc. Somatic hypermutation systems
US10485879B2 (en) 2008-04-15 2019-11-26 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues
EP2276511A2 (de) 2008-04-15 2011-01-26 Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Zusammensetzungen und verfahren zur abgabe von hemmenden oligonucleotiden
NZ590131A (en) 2008-07-08 2012-10-26 Oncomed Pharm Inc Notch-binding agents and antagonists and methods of use thereof
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
US8832581B2 (en) * 2009-03-05 2014-09-09 Ming Zhang Gene expression browser for web-based search and visualization of characteristics of gene expression
AR076284A1 (es) 2009-04-29 2011-06-01 Bayer Schering Pharma Ag Inmunoconjugados de antimesotelina y usos de los mismos
WO2011088215A2 (en) 2010-01-13 2011-07-21 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
SG10201503736XA (en) 2010-02-12 2015-06-29 Oncomed Pharm Inc Methods for identifying and isolating cells expressing a polypeptide
WO2011103330A2 (en) 2010-02-17 2011-08-25 The Johns Hopkins University Novel phosphorylation of cardiac troponin i as a monitor for cardiac injury
AU2011220728B2 (en) 2010-02-24 2014-07-31 Immunogen, Inc. Folate receptor 1 antibodies and immunoconjugates and uses thereof
NZ703481A (en) 2010-03-12 2016-02-26 Immunogen Inc Cd37-binding molecules and immunoconjugates thereof
US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
WO2012019024A2 (en) 2010-08-04 2012-02-09 Immunogen, Inc. Her3-binding molecules and immunoconjugates thereof
WO2012162561A2 (en) 2011-05-24 2012-11-29 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
BR112014000765A2 (pt) 2011-07-15 2017-06-13 Oncomed Pharm Inc agentes de ligação a rspo e seus usos
US9120858B2 (en) 2011-07-22 2015-09-01 The Research Foundation Of State University Of New York Antibodies to the B12-transcobalamin receptor
ES2707580T3 (es) 2011-09-23 2019-04-04 Oncomed Pharm Inc Agentes de unión a VEGF/DLL4 y usos de los mismos
WO2013071233A1 (en) 2011-11-10 2013-05-16 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for detecting infectious agents and a novel virus detected thereby
EP2797957B1 (de) 2011-11-23 2019-06-19 MedImmune, LLC Her3-spezifische bindungsmoleküle und verwendungen davon
EP3202419A1 (de) 2012-06-06 2017-08-09 OncoMed Pharmaceuticals, Inc. Pvrig bindungsmittel zur modulation des hippo-pfads und verwendungen davon
BR112015004229B1 (pt) 2012-08-31 2023-02-07 Immunogen, Inc Anticorpos ou fragmentos de ligação ao antígeno do mesmo que se liga especificamente à proteína folr1, kit de imunoensaio, método de detecção in vitro de proteína folr1, uso de um agente ativo, e método para monitoramento da eficácia terapêutica
WO2014071282A1 (en) 2012-11-05 2014-05-08 Genzyme Corporation Compositions and methods for treating proteinopathies
EP2968541A4 (de) 2013-03-15 2017-02-08 Zyngenia, Inc. Multivalente und monovalente multispezifische komplexe und deren verwendungen
MX2015013703A (es) 2013-03-27 2016-08-11 Cedars Sinai Medical Center Mitigacion e inversion de la fibrosis e inflamacion mediante la inhibicion de la funcion de tl1a y vias de señalizacion relacionadas.
DE102013106462B3 (de) * 2013-06-20 2014-10-09 Airbus Defence and Space GmbH Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
KR102428492B1 (ko) 2013-08-30 2022-08-03 이뮤노젠 아이엔씨 엽산 수용체 1의 검출을 위한 항체 및 분석
ES2983055T3 (es) 2013-10-08 2024-10-21 Immunogen Inc Regímenes de dosificación de inmunoconjugado anti-FOLR1
CN111560071B (zh) 2014-04-08 2023-09-05 波士顿制药有限公司 对il-21具有特异性的结合分子及其用途
KR20160143808A (ko) 2014-04-11 2016-12-14 메디뮨 엘엘씨 이중특이적 her2 항체
JP6755866B2 (ja) 2014-11-10 2020-09-16 メディミューン リミテッド Cd73特異的結合分子及びその使用
GB2538120A (en) 2014-11-11 2016-11-09 Medimmune Ltd Therapeutic combinations comprising anti-CD73 antibodies and uses thereof
SI3277717T1 (sl) 2015-03-31 2021-03-31 Medimmune Limited, Milstein Nova oblika IL33, mutirane oblike IL33, protitelesa, testi in postopki njihove uporabe
US10077313B2 (en) 2015-06-29 2018-09-18 Immunogen, Inc. Anti-CD123 antibodies and conjugates and derivatives thereof
JP6880006B2 (ja) 2015-09-17 2021-06-02 イミュノジェン, インコーポレイテッド 抗folr1免疫複合体を含む治療組み合わせ
MX2018005541A (es) 2015-11-10 2018-08-01 Medimmune Llc Moleculas de union especificas para transportador 2 con preferencia a alanina, serina y cistenia (asct2) y usos de las mismas.
BR112018067951A2 (pt) 2016-03-10 2019-02-05 Viela Bio Inc moléculas que se ligam a ilt7 e métodos de uso destas
AU2017230091B2 (en) 2016-03-10 2022-04-07 Acceleron Pharma Inc. Activin type 2 receptor binding proteins and uses thereof
KR20240095481A (ko) 2016-03-17 2024-06-25 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법
LT3464318T (lt) 2016-06-02 2021-06-25 Abbvie Inc. Gliukokortikoidų receptorių agonistas ir jo imunokonjugatai
CN109689090B (zh) 2016-08-05 2023-12-26 免疫医疗有限责任公司 抗o2抗体及其用途
BR112019007147A2 (pt) 2016-10-19 2019-06-25 Humabs Biomed Sa anticorpos anti-o1 e usos dos mesmos
KR20240128132A (ko) 2016-10-26 2024-08-23 세다르스-신나이 메디칼 센터 중화 항-tl1a 단일 클론 항체
WO2018098363A2 (en) 2016-11-23 2018-05-31 Bioverativ Therapeutics Inc. Bispecific antibodies binding to coagulation factor ix and coagulation factor x
WO2019160976A1 (en) 2018-02-14 2019-08-22 Viela Bio, Inc. Antibodies to feline mcdonough sarcoma (fms)-like tyrosine kinase 3 receptor ligand (flt3l) and uses thereof for treating autoimmune and inflammatory diseases
CN112585165A (zh) 2018-04-25 2021-03-30 普罗米修斯生物科学公司 优化的抗tl1a抗体
EP3883961A1 (de) 2018-11-20 2021-09-29 Takeda Vaccines, Inc. Neuartige zika-virus-antikörper und ihre verwendungen
JP7520848B2 (ja) 2018-12-28 2024-07-23 スパークス・セラピューティクス・インコーポレイテッド 癌および他の疾患の治療のための、クローディン18.2に特異的な結合分子、その組成物および方法
JP7504992B2 (ja) 2019-10-24 2024-06-24 プロメテウス バイオサイエンシーズ,インク. Tnf様リガンド1a(tl1a)に対するヒト化抗体およびその使用
KR20230084497A (ko) 2020-09-11 2023-06-13 메디뮨 리미티드 치료용 b7-h4 결합 분자
WO2022053685A2 (en) 2020-09-12 2022-03-17 Medimmune Limited A scoring method for an anti-b7h4 antibody-drug conjugate therapy
US11452757B2 (en) * 2021-02-25 2022-09-27 Intron Biotechnology, Inc. Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same
CR20230488A (es) 2021-03-18 2023-12-12 Medimmune Ltd Moléculas de unión terapéuticas
US11807685B2 (en) 2021-08-05 2023-11-07 The Uab Research Foundation Anti-CD47 antibody and uses thereof
TW202348252A (zh) 2022-02-16 2023-12-16 英商梅迪繆思有限公司 用治療性結合分子治療癌症的組合療法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5601823A (en) * 1989-10-31 1997-02-11 Ophidian Pharmaceuticals, Inc. Avian antitoxins to clostridium difficle toxin A
US6069230A (en) * 1994-11-10 2000-05-30 Promega Corporation High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
US5895651A (en) * 1996-06-27 1999-04-20 The United States Of America As Represented By The Secretary Of The Navy Recombinant dengue virus envelope protein/maltose-binding protein antigens and subunit vaccine compositions containing said antigens
US6703484B2 (en) * 1997-01-08 2004-03-09 Invitrogen Corporation Methods for production of proteins

Also Published As

Publication number Publication date
CA2339889C (en) 2012-01-31
EP1133565B1 (de) 2010-09-22
JP4794789B2 (ja) 2011-10-19
WO2001002588A2 (en) 2001-01-11
WO2001002588A3 (en) 2001-07-12
US20040157291A1 (en) 2004-08-12
US20030170622A1 (en) 2003-09-11
DK1133565T3 (da) 2011-01-24
ES2353268T3 (es) 2011-02-28
CA2339889A1 (en) 2001-01-11
JP2003504031A (ja) 2003-02-04
EP1133565A2 (de) 2001-09-19
US6653068B2 (en) 2003-11-25
DE60044997D1 (de) 2010-11-04

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