ATE482275T1 - Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden - Google Patents
Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden bindenInfo
- Publication number
- ATE482275T1 ATE482275T1 AT00947904T AT00947904T ATE482275T1 AT E482275 T1 ATE482275 T1 AT E482275T1 AT 00947904 T AT00947904 T AT 00947904T AT 00947904 T AT00947904 T AT 00947904T AT E482275 T1 ATE482275 T1 AT E482275T1
- Authority
- AT
- Austria
- Prior art keywords
- poly
- binding partners
- ests
- genomic dna
- dna fragments
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 239000012634 fragment Substances 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 230000009870 specific binding Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 230000027455 binding Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 210000003000 inclusion body Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 241000724791 Filamentous phage Species 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99112815 | 1999-07-02 | ||
PCT/EP2000/006137 WO2001002588A2 (en) | 1999-07-02 | 2000-06-30 | Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE482275T1 true ATE482275T1 (de) | 2010-10-15 |
Family
ID=8238496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00947904T ATE482275T1 (de) | 1999-07-02 | 2000-06-30 | Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden |
Country Status (9)
Country | Link |
---|---|
US (2) | US6653068B2 (de) |
EP (1) | EP1133565B1 (de) |
JP (1) | JP4794789B2 (de) |
AT (1) | ATE482275T1 (de) |
CA (1) | CA2339889C (de) |
DE (1) | DE60044997D1 (de) |
DK (1) | DK1133565T3 (de) |
ES (1) | ES2353268T3 (de) |
WO (1) | WO2001002588A2 (de) |
Families Citing this family (64)
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US6696251B1 (en) * | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
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US20030235814A1 (en) * | 2002-06-19 | 2003-12-25 | Los Alamos National Laboratory | Compositions and methods for selecting open reading frames |
DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
JP5524610B2 (ja) * | 2006-04-07 | 2014-06-18 | ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク | トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法 |
US9044461B2 (en) | 2006-04-07 | 2015-06-02 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
AU2008218925A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Somatic hypermutation systems |
US10485879B2 (en) | 2008-04-15 | 2019-11-26 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues |
EP2276511A2 (de) | 2008-04-15 | 2011-01-26 | Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Zusammensetzungen und verfahren zur abgabe von hemmenden oligonucleotiden |
NZ590131A (en) | 2008-07-08 | 2012-10-26 | Oncomed Pharm Inc | Notch-binding agents and antagonists and methods of use thereof |
US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
US8832581B2 (en) * | 2009-03-05 | 2014-09-09 | Ming Zhang | Gene expression browser for web-based search and visualization of characteristics of gene expression |
AR076284A1 (es) | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
WO2011088215A2 (en) | 2010-01-13 | 2011-07-21 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
SG10201503736XA (en) | 2010-02-12 | 2015-06-29 | Oncomed Pharm Inc | Methods for identifying and isolating cells expressing a polypeptide |
WO2011103330A2 (en) | 2010-02-17 | 2011-08-25 | The Johns Hopkins University | Novel phosphorylation of cardiac troponin i as a monitor for cardiac injury |
AU2011220728B2 (en) | 2010-02-24 | 2014-07-31 | Immunogen, Inc. | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
NZ703481A (en) | 2010-03-12 | 2016-02-26 | Immunogen Inc | Cd37-binding molecules and immunoconjugates thereof |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
WO2012019024A2 (en) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
BR112014000765A2 (pt) | 2011-07-15 | 2017-06-13 | Oncomed Pharm Inc | agentes de ligação a rspo e seus usos |
US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
ES2707580T3 (es) | 2011-09-23 | 2019-04-04 | Oncomed Pharm Inc | Agentes de unión a VEGF/DLL4 y usos de los mismos |
WO2013071233A1 (en) | 2011-11-10 | 2013-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for detecting infectious agents and a novel virus detected thereby |
EP2797957B1 (de) | 2011-11-23 | 2019-06-19 | MedImmune, LLC | Her3-spezifische bindungsmoleküle und verwendungen davon |
EP3202419A1 (de) | 2012-06-06 | 2017-08-09 | OncoMed Pharmaceuticals, Inc. | Pvrig bindungsmittel zur modulation des hippo-pfads und verwendungen davon |
BR112015004229B1 (pt) | 2012-08-31 | 2023-02-07 | Immunogen, Inc | Anticorpos ou fragmentos de ligação ao antígeno do mesmo que se liga especificamente à proteína folr1, kit de imunoensaio, método de detecção in vitro de proteína folr1, uso de um agente ativo, e método para monitoramento da eficácia terapêutica |
WO2014071282A1 (en) | 2012-11-05 | 2014-05-08 | Genzyme Corporation | Compositions and methods for treating proteinopathies |
EP2968541A4 (de) | 2013-03-15 | 2017-02-08 | Zyngenia, Inc. | Multivalente und monovalente multispezifische komplexe und deren verwendungen |
MX2015013703A (es) | 2013-03-27 | 2016-08-11 | Cedars Sinai Medical Center | Mitigacion e inversion de la fibrosis e inflamacion mediante la inhibicion de la funcion de tl1a y vias de señalizacion relacionadas. |
DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
KR102428492B1 (ko) | 2013-08-30 | 2022-08-03 | 이뮤노젠 아이엔씨 | 엽산 수용체 1의 검출을 위한 항체 및 분석 |
ES2983055T3 (es) | 2013-10-08 | 2024-10-21 | Immunogen Inc | Regímenes de dosificación de inmunoconjugado anti-FOLR1 |
CN111560071B (zh) | 2014-04-08 | 2023-09-05 | 波士顿制药有限公司 | 对il-21具有特异性的结合分子及其用途 |
KR20160143808A (ko) | 2014-04-11 | 2016-12-14 | 메디뮨 엘엘씨 | 이중특이적 her2 항체 |
JP6755866B2 (ja) | 2014-11-10 | 2020-09-16 | メディミューン リミテッド | Cd73特異的結合分子及びその使用 |
GB2538120A (en) | 2014-11-11 | 2016-11-09 | Medimmune Ltd | Therapeutic combinations comprising anti-CD73 antibodies and uses thereof |
SI3277717T1 (sl) | 2015-03-31 | 2021-03-31 | Medimmune Limited, Milstein | Nova oblika IL33, mutirane oblike IL33, protitelesa, testi in postopki njihove uporabe |
US10077313B2 (en) | 2015-06-29 | 2018-09-18 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
JP6880006B2 (ja) | 2015-09-17 | 2021-06-02 | イミュノジェン, インコーポレイテッド | 抗folr1免疫複合体を含む治療組み合わせ |
MX2018005541A (es) | 2015-11-10 | 2018-08-01 | Medimmune Llc | Moleculas de union especificas para transportador 2 con preferencia a alanina, serina y cistenia (asct2) y usos de las mismas. |
BR112018067951A2 (pt) | 2016-03-10 | 2019-02-05 | Viela Bio Inc | moléculas que se ligam a ilt7 e métodos de uso destas |
AU2017230091B2 (en) | 2016-03-10 | 2022-04-07 | Acceleron Pharma Inc. | Activin type 2 receptor binding proteins and uses thereof |
KR20240095481A (ko) | 2016-03-17 | 2024-06-25 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
LT3464318T (lt) | 2016-06-02 | 2021-06-25 | Abbvie Inc. | Gliukokortikoidų receptorių agonistas ir jo imunokonjugatai |
CN109689090B (zh) | 2016-08-05 | 2023-12-26 | 免疫医疗有限责任公司 | 抗o2抗体及其用途 |
BR112019007147A2 (pt) | 2016-10-19 | 2019-06-25 | Humabs Biomed Sa | anticorpos anti-o1 e usos dos mesmos |
KR20240128132A (ko) | 2016-10-26 | 2024-08-23 | 세다르스-신나이 메디칼 센터 | 중화 항-tl1a 단일 클론 항체 |
WO2018098363A2 (en) | 2016-11-23 | 2018-05-31 | Bioverativ Therapeutics Inc. | Bispecific antibodies binding to coagulation factor ix and coagulation factor x |
WO2019160976A1 (en) | 2018-02-14 | 2019-08-22 | Viela Bio, Inc. | Antibodies to feline mcdonough sarcoma (fms)-like tyrosine kinase 3 receptor ligand (flt3l) and uses thereof for treating autoimmune and inflammatory diseases |
CN112585165A (zh) | 2018-04-25 | 2021-03-30 | 普罗米修斯生物科学公司 | 优化的抗tl1a抗体 |
EP3883961A1 (de) | 2018-11-20 | 2021-09-29 | Takeda Vaccines, Inc. | Neuartige zika-virus-antikörper und ihre verwendungen |
JP7520848B2 (ja) | 2018-12-28 | 2024-07-23 | スパークス・セラピューティクス・インコーポレイテッド | 癌および他の疾患の治療のための、クローディン18.2に特異的な結合分子、その組成物および方法 |
JP7504992B2 (ja) | 2019-10-24 | 2024-06-24 | プロメテウス バイオサイエンシーズ,インク. | Tnf様リガンド1a(tl1a)に対するヒト化抗体およびその使用 |
KR20230084497A (ko) | 2020-09-11 | 2023-06-13 | 메디뮨 리미티드 | 치료용 b7-h4 결합 분자 |
WO2022053685A2 (en) | 2020-09-12 | 2022-03-17 | Medimmune Limited | A scoring method for an anti-b7h4 antibody-drug conjugate therapy |
US11452757B2 (en) * | 2021-02-25 | 2022-09-27 | Intron Biotechnology, Inc. | Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same |
CR20230488A (es) | 2021-03-18 | 2023-12-12 | Medimmune Ltd | Moléculas de unión terapéuticas |
US11807685B2 (en) | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
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US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
US6069230A (en) * | 1994-11-10 | 2000-05-30 | Promega Corporation | High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications |
US5895651A (en) * | 1996-06-27 | 1999-04-20 | The United States Of America As Represented By The Secretary Of The Navy | Recombinant dengue virus envelope protein/maltose-binding protein antigens and subunit vaccine compositions containing said antigens |
US6703484B2 (en) * | 1997-01-08 | 2004-03-09 | Invitrogen Corporation | Methods for production of proteins |
-
2000
- 2000-06-30 WO PCT/EP2000/006137 patent/WO2001002588A2/en active Application Filing
- 2000-06-30 DK DK00947904.9T patent/DK1133565T3/da active
- 2000-06-30 JP JP2001508360A patent/JP4794789B2/ja not_active Expired - Lifetime
- 2000-06-30 AT AT00947904T patent/ATE482275T1/de active
- 2000-06-30 ES ES00947904T patent/ES2353268T3/es not_active Expired - Lifetime
- 2000-06-30 CA CA2339889A patent/CA2339889C/en not_active Expired - Lifetime
- 2000-06-30 EP EP00947904A patent/EP1133565B1/de not_active Expired - Lifetime
- 2000-06-30 DE DE60044997T patent/DE60044997D1/de not_active Expired - Lifetime
-
2001
- 2001-02-28 US US09/795,872 patent/US6653068B2/en not_active Expired - Lifetime
-
2003
- 2003-09-16 US US10/662,824 patent/US20040157291A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2339889C (en) | 2012-01-31 |
EP1133565B1 (de) | 2010-09-22 |
JP4794789B2 (ja) | 2011-10-19 |
WO2001002588A2 (en) | 2001-01-11 |
WO2001002588A3 (en) | 2001-07-12 |
US20040157291A1 (en) | 2004-08-12 |
US20030170622A1 (en) | 2003-09-11 |
DK1133565T3 (da) | 2011-01-24 |
ES2353268T3 (es) | 2011-02-28 |
CA2339889A1 (en) | 2001-01-11 |
JP2003504031A (ja) | 2003-02-04 |
EP1133565A2 (de) | 2001-09-19 |
US6653068B2 (en) | 2003-11-25 |
DE60044997D1 (de) | 2010-11-04 |
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