CO6390041A2 - Agentes y antagonistas fijaodres de notch y metodos para el uso de los mismos. - Google Patents

Agentes y antagonistas fijaodres de notch y metodos para el uso de los mismos.

Info

Publication number
CO6390041A2
CO6390041A2 CO11014588A CO11014588A CO6390041A2 CO 6390041 A2 CO6390041 A2 CO 6390041A2 CO 11014588 A CO11014588 A CO 11014588A CO 11014588 A CO11014588 A CO 11014588A CO 6390041 A2 CO6390041 A2 CO 6390041A2
Authority
CO
Colombia
Prior art keywords
methods
cancer
present
antagonists
same
Prior art date
Application number
CO11014588A
Other languages
English (en)
Inventor
Austin Gurney
Timothy Charles Hoey
Maureen Fitch Bruhns
Fumiko Axelrod
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Publication of CO6390041A2 publication Critical patent/CO6390041A2/es

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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
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    • C07K16/46—Hybrid immunoglobulins
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    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Oncology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente invención se refiere a composiciones y métodos para la caracterización, diagnóstico y tratamiento del cáncer. En particular, la invención proporciona los medios y métodos para el diagnóstico, caracterización, pronóstico y tratamiento del cáncer y atacando específicamente a las células madre de cáncer. La presente invención proporciona un anticuerpo que se une específicamente a la región proximal de membrana no fijadora de ligandos del dominio extracelular de un receptor Notch humano e inhibe el crecimiento tumoral. La presente invención proporciona además un método de tratamiento del cáncer, el método que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo que se une específicamente a una región proximal de membrana no fijadora de ligandos del dominio extracelular de una proteína del receptor de Notch e inhibe el crecimiento tumoral.
CO11014588A 2008-07-08 2011-02-08 Agentes y antagonistas fijaodres de notch y metodos para el uso de los mismos. CO6390041A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11269908P 2008-11-07 2008-11-07
US11270108P 2008-11-07 2008-11-07

Publications (1)

Publication Number Publication Date
CO6390041A2 true CO6390041A2 (es) 2012-02-29

Family

ID=41507637

Family Applications (2)

Application Number Title Priority Date Filing Date
CO11014588A CO6390041A2 (es) 2008-07-08 2011-02-08 Agentes y antagonistas fijaodres de notch y metodos para el uso de los mismos.
CO11014579A CO6612253A2 (es) 2008-07-08 2011-02-08 Agentas y antagonistas fijadores de notch y metodos para el uso de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CO11014579A CO6612253A2 (es) 2008-07-08 2011-02-08 Agentas y antagonistas fijadores de notch y metodos para el uso de los mismos

Country Status (32)

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US (11) US8226943B2 (es)
EP (4) EP2924051A1 (es)
JP (2) JP5560271B2 (es)
KR (2) KR101640099B1 (es)
CN (3) CN104402998A (es)
AU (2) AU2009269095B2 (es)
BR (2) BRPI0914004A2 (es)
CA (2) CA2729602A1 (es)
CO (2) CO6390041A2 (es)
CR (1) CR20110069A (es)
CY (2) CY1116195T1 (es)
DK (2) DK2307459T3 (es)
DO (2) DOP2011000002A (es)
EA (2) EA026109B1 (es)
ES (2) ES2535614T3 (es)
HK (2) HK1151296A1 (es)
HR (2) HRP20150256T1 (es)
IL (2) IL210221A (es)
MA (2) MA32449B1 (es)
ME (2) ME02148B (es)
MX (2) MX2011000233A (es)
MY (2) MY159815A (es)
NZ (2) NZ590127A (es)
PL (2) PL2307051T3 (es)
PT (2) PT2307459E (es)
RS (2) RS53924B1 (es)
SG (2) SG192467A1 (es)
SI (2) SI2307051T1 (es)
SM (2) SMT201500047B (es)
UA (1) UA101672C2 (es)
WO (2) WO2010005566A2 (es)
ZA (2) ZA201009280B (es)

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MX2009006500A (es) 2006-12-18 2009-06-26 Genentech Inc Anticuerpos antagonistas anti-notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3.
WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
BRPI0914004A2 (pt) 2008-07-08 2015-11-17 Oncomed Pharm Inc agentes de aglutinação de receptor notch1 e métodos de uso mesmo
CA2736429A1 (en) * 2008-10-01 2010-04-08 Genentech, Inc. Anti-notch2 antibodies and methods of use
PE20121494A1 (es) 2009-06-18 2012-11-01 Pfizer Anticuerpos anti notch-1
PE20120998A1 (es) * 2009-09-30 2012-08-14 Genentech Inc Metodos para el tratamiento del cancer usando antagonistas de notch
US8883145B2 (en) 2009-10-16 2014-11-11 Oncomed Pharmaceuticals, Inc. Methods of treatment with DLL4 antagonists and an anti-hypertensive agent
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NZ611785A (en) 2010-12-15 2015-04-24 Wyeth Llc Anti-notch1 antibodies
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