IL121860A0 - Interleukin-18 binding proteins their preparation and use - Google Patents

Interleukin-18 binding proteins their preparation and use

Info

Publication number
IL121860A0
IL121860A0 IL12186097A IL12186097A IL121860A0 IL 121860 A0 IL121860 A0 IL 121860A0 IL 12186097 A IL12186097 A IL 12186097A IL 12186097 A IL12186097 A IL 12186097A IL 121860 A0 IL121860 A0 IL 121860A0
Authority
IL
Israel
Prior art keywords
interleukin
preparation
binding proteins
proteins
binding
Prior art date
Application number
IL12186097A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12155497A external-priority patent/IL121554A0/xx
Priority claimed from IL12163997A external-priority patent/IL121639A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12186097A priority Critical patent/IL121860A0/xx
Priority to IL12213497A priority patent/IL122134A0/xx
Publication of IL121860A0 publication Critical patent/IL121860A0/xx
Priority to IL12546398A priority patent/IL125463A0/xx
Priority to PCT/IL1998/000379 priority patent/WO1999009063A1/en
Priority to KR1020007001504A priority patent/KR100687388B1/ko
Priority to EP98938877A priority patent/EP1003781B1/en
Priority to HU0003533A priority patent/HU226698B1/hu
Priority to CNB988081342A priority patent/CN1243021C/zh
Priority to JP2000509740A priority patent/JP4272348B2/ja
Priority to AT98938877T priority patent/ATE443719T1/de
Priority to NZ502392A priority patent/NZ502392A/xx
Priority to US09/485,632 priority patent/US6605280B1/en
Priority to ES98938877T priority patent/ES2149149T3/es
Priority to DE69841175T priority patent/DE69841175D1/de
Priority to PT98938877T priority patent/PT1003781E/pt
Priority to SI9830922T priority patent/SI1003781T1/sl
Priority to CZ20000490A priority patent/CZ300818B6/cs
Priority to AU87460/98A priority patent/AU755794B2/en
Priority to PL338647A priority patent/PL206070B1/pl
Priority to BRPI9811940 priority patent/BRPI9811940B8/pt
Priority to EA200000216A priority patent/EA003675B1/ru
Priority to UA2000031437A priority patent/UA75862C2/uk
Priority to IL13452398A priority patent/IL134523A0/xx
Priority to CA2298855A priority patent/CA2298855C/en
Priority to EEP200000073A priority patent/EE05538B1/xx
Priority to DK98938877.2T priority patent/DK1003781T3/da
Priority to DE1003781T priority patent/DE1003781T1/de
Priority to SK176-2000A priority patent/SK287194B6/sk
Priority to ARP980104054A priority patent/AR013422A1/es
Priority to BG104149A priority patent/BG65519B1/bg
Priority to NO20000700A priority patent/NO327240B1/no
Priority to IL134523A priority patent/IL134523A/en
Priority to HK00108180A priority patent/HK1028773A1/xx
Priority to US09/790,338 priority patent/US7220717B2/en
Priority to US10/434,583 priority patent/US7101689B2/en
Priority to US11/376,794 priority patent/US7799541B2/en
Priority to US11/505,554 priority patent/US7704944B2/en
Priority to US11/724,737 priority patent/US7696154B2/en
Priority to ARP070104104A priority patent/AR062867A2/es
Priority to US12/511,756 priority patent/US8436148B2/en
Priority to CY20091101232T priority patent/CY1109664T1/el
Priority to US12/715,089 priority patent/US20100254941A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
IL12186097A 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use IL121860A0 (en)

Priority Applications (42)

Application Number Priority Date Filing Date Title
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
DK98938877.2T DK1003781T3 (da) 1997-08-14 1998-08-13 Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse
DE1003781T DE1003781T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
SK176-2000A SK287194B6 (sk) 1997-08-14 1998-08-13 Interleukínový-18 väzbový proteín - IL-18BP, DNA, replikovateľný vektor, transformovaná hostiteľská bunka, protilátka k IL-18BP, spôsob výroby IL-18BP, prostriedok s jeho obsahom a jeho použitie
PL338647A PL206070B1 (pl) 1997-08-14 1998-08-13 Izolowane białko wiążące IL-18, sposób jego wytwarzania i izolowania, izolowana cząsteczka DNA, zdolny do replikacji wektor, transformowana komórka gospodarza, przeciwciało, kompozycja farmaceutyczna oraz zastosowanie
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
EP98938877A EP1003781B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
HU0003533A HU226698B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
CNB988081342A CN1243021C (zh) 1997-08-14 1998-08-13 白细胞介素－18结合蛋白质及其制备和用途
JP2000509740A JP4272348B2 (ja) 1997-08-14 1998-08-13 インターロイキン−１８結合タンパク質、それらの調製および用途
AT98938877T ATE443719T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
NZ502392A NZ502392A (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins (IL-18BP) their preparation and use in pharmaceuticals
US09/485,632 US6605280B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
ES98938877T ES2149149T3 (es) 1997-08-14 1998-08-13 Proteinas de union a interleuquina-18, su preparacion y uso.
DE69841175T DE69841175D1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
PT98938877T PT1003781E (pt) 1997-08-14 1998-08-13 Proteínas de ligação a interleucina-18, sua preparação e utilização
SI9830922T SI1003781T1 (sl) 1997-08-14 1998-08-13 Interlevkin-18 vezavni proteini, njihova priprava in uporaba
CZ20000490A CZ300818B6 (cs) 1997-08-14 1998-08-13 Interleukin-18-vazebné proteiny, príprava a použití
AU87460/98A AU755794B2 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
BRPI9811940 BRPI9811940B8 (pt) 1997-08-14 1998-08-13 vetor de expressão para um polipeptídeo de ligação da interleucina-18 (il-18-bp), célula hospedeira procariótica transformada com o referido vetor, processo para produção de il-18-bp, proteína de fusão compreendendo o referido polipeptídeo, bem como il-18bp modificada.
EA200000216A EA003675B1 (ru) 1997-08-14 1998-08-13 Белки, связывающие интерлейкин-18, их получение и применение
UA2000031437A UA75862C2 (uk) 1997-08-14 1998-08-13 Виділений поліпептид, що зв'язується з il-18 (il-18bp) (варіанти), виділена молекула нуклеїнової кислоти, що його кодує (варіанти), антитіло, що зв'язується з даним поліпептидом, спосіб очищення il-18bp та композиція, що його містить
KR1020007001504A KR100687388B1 (ko) 1997-08-14 1998-08-13 인터루킨-18 결합 단백질, 이들의 제조방법 및 용도
CA2298855A CA2298855C (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
EEP200000073A EE05538B1 (et) 1997-08-14 1998-08-13 Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine
ARP980104054A AR013422A1 (es) 1997-08-14 1998-08-14 UN VECTOR DE EXPRESIoN REPLICABLE QUE COMPRENDE UN ÁCIDO NUCLEICO QUE CODIFICA PARA UN POLIPÉPTIDO, UNA CÉLULA HUÉSPED ANIMAL AISLADA INCAPAZ DE CONDUCIR A UN ORGANISMO COMPLETO, UN MICROORGANISMO, UN MÉTODO PARA PRODUCIR UN POLIPEPTIDO DE SEC IN N° 2, UNA PROTEíNA DE FUSIoN, UN ANTICUERPO MONOCLONA
BG104149A BG65519B1 (bg) 1997-08-14 2000-02-10 Белтъци, свързващи интерлевкин-18, тяхното получаване и приложение
NO20000700A NO327240B1 (no) 1997-08-14 2000-02-11 Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter.
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use
HK00108180A HK1028773A1 (en) 1997-08-14 2000-12-19 Interleukin-18 binding proteins, their preparationand use
US09/790,338 US7220717B2 (en) 1997-08-14 2001-02-21 Interleukin-18 binding proteins, their preparation and use
US10/434,583 US7101689B2 (en) 1997-08-14 2003-05-08 Interleukin-18 binding proteins, their preparation and use
US11/376,794 US7799541B2 (en) 1997-08-14 2006-03-15 Interleukin-18 binding proteins, their preparation and use
US11/505,554 US7704944B2 (en) 1997-08-14 2006-08-16 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
US11/724,737 US7696154B2 (en) 1997-08-14 2007-03-15 Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
ARP070104104A AR062867A2 (es) 1997-08-14 2007-09-17 Proteinas de enlace a interleuquina -18, (il- 18bp), secuencias de adn que codifican para la il -18 bp, secuencias de adnc, un vehiculo de expresion replicable, celula huesped, un proceso para su produccion y aislacion, anticuerpos, composiciones farmaceuticas, el uso de dichas composiciones para la
US12/511,756 US8436148B2 (en) 1997-08-14 2009-07-29 Antibodies against interleukin-18 binding protein, their preparation and use
CY20091101232T CY1109664T1 (el) 1997-08-14 2009-11-25 Πρωτεϊνες δεσμευσεως ιντερλευκινης-18, η παρασκευη και η χρηση τους
US12/715,089 US20100254941A1 (en) 1997-08-14 2010-03-01 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL12155497A IL121554A0 (en) 1997-08-14 1997-08-14 Interleukin-18 binding proteins their preparation and use
IL12163997A IL121639A0 (en) 1997-08-14 1997-08-27 Interleukin-18 binding proteins their preparation and use
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use

Publications (1)

Publication Number Publication Date
IL121860A0 true IL121860A0 (en) 1998-02-22

Family

ID=27517687

Family Applications (5)

Application Number Title Priority Date Filing Date
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Country Status (29)

Country Link
US (4) US6605280B1 (es)
EP (1) EP1003781B1 (es)
JP (1) JP4272348B2 (es)
KR (1) KR100687388B1 (es)
CN (1) CN1243021C (es)
AR (2) AR013422A1 (es)
AT (1) ATE443719T1 (es)
AU (1) AU755794B2 (es)
BG (1) BG65519B1 (es)
BR (1) BRPI9811940B8 (es)
CA (1) CA2298855C (es)
CY (1) CY1109664T1 (es)
CZ (1) CZ300818B6 (es)
DE (2) DE69841175D1 (es)
DK (1) DK1003781T3 (es)
EA (1) EA003675B1 (es)
EE (1) EE05538B1 (es)
ES (1) ES2149149T3 (es)
HK (1) HK1028773A1 (es)
HU (1) HU226698B1 (es)
IL (5) IL121860A0 (es)
NO (1) NO327240B1 (es)
NZ (1) NZ502392A (es)
PL (1) PL206070B1 (es)
PT (1) PT1003781E (es)
SI (1) SI1003781T1 (es)
SK (1) SK287194B6 (es)
UA (1) UA75862C2 (es)
WO (1) WO1999009063A1 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393663B2 (en) * 1997-08-01 2008-07-01 Serono Genetics Institute S.A. Expressed sequence tags and encoded human proteins
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
WO2000012555A1 (fr) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Proteine de liaison de l'interleukine 18
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
IL131047A0 (en) * 1999-07-22 2001-01-28 Yeda Res & Dev Use of il-18 inhibitors
DE60041432D1 (de) * 1999-11-16 2009-03-12 Hayashibara Biochem Lab Antikörper spezifisch für den Interleukin-18 Vorläufer
CA2399148A1 (en) 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
WO2001062285A1 (en) * 2000-02-21 2001-08-30 Applied Research Systems Ars Holding N.V. Use of il-18 inhibitors
AU2005211606B2 (en) * 2000-05-05 2007-02-22 Inserm - Institut National De La Sante Et De La Recherche Medicale Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis
DE60134009D1 (de) * 2000-05-05 2008-06-26 Inst Nat Sante Rech Med Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose
US6894155B2 (en) 2000-10-11 2005-05-17 Viron Therapeutics Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) * 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
KR100857376B1 (ko) * 2001-01-29 2008-09-05 라보라토리스 세로노 에스.에이. 심장 질환의 치료 및/또는 예방에 사용되는 ｉｌ-18저해물질
JP4502580B2 (ja) * 2001-05-16 2010-07-14 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド 敗血症の治療または予防のためのｉｌ−１８阻害剤の使用
HU230294B1 (hu) * 2001-05-25 2015-12-28 Ares Trading S.A. IL-18-inhibitorok alkalmazása központi idegrendszeri sérülések kezelésére vagy megelőzésére
NZ530765A (en) 2001-06-26 2006-11-30 Amgen Fremont Inc Antibodies that bind OPGL and compositions and methods for the treatment of bone diseases
UA78516C2 (en) * 2001-08-10 2007-04-10 Applied Research Systems Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity
KR20050004809A (ko) * 2002-03-22 2005-01-12 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 말초 맥관 질환 치료 및/또는 예방에 사용되는 ｉｌ-18저해제
EP1545578A4 (en) 2002-08-28 2010-07-07 Immunex Corp COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASES
ES2416510T3 (es) * 2002-10-08 2013-08-01 Ares Trading S.A. Uso de una citocina capaz de unirse a IL 18BP y de inhibir la actividad de una segunda citocina
IL152232A0 (en) * 2002-10-10 2003-05-29 Yeda Res & Dev Promoter to il-18bp, its preparation and use
US7491803B2 (en) 2003-04-30 2009-02-17 Japan Science & Technology Agency Human anti-human interleukin-18 antibody, fragment thereof and method for using same
ATE549353T1 (de) * 2003-05-13 2012-03-15 Merck Serono Sa Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen
JP4741504B2 (ja) 2003-11-05 2011-08-03 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製方法
AU2004290049B2 (en) * 2003-11-12 2011-09-29 The Regents Of The University Of Colorado Compositions and methods for regulation of tumor necrosis factor-alpha
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
IL159670A0 (en) * 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
US7553665B2 (en) * 2004-03-01 2009-06-30 Ares Trading S.A. Process for the cultivation of mammalian cells producing IL-18BP in serum-free cell culture medium
US7557084B2 (en) * 2004-03-31 2009-07-07 Regeneron Pharmaceuticals, Inc. IL-18 specific polypeptides and therapeutic uses thereof
ES2313367T3 (es) 2004-06-29 2009-03-01 Ares Trading S.A. Procedimiento para la purificacion de proteina de union al il-18.
AU2006254103B2 (en) 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
US8128920B2 (en) * 2005-06-03 2012-03-06 Merck Serono Sa Use of IL-18BP isoforms for the treatment and/or prevention of neurological inflammatory diseases
PT1891088E (pt) * 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
CN101003812B (zh) * 2006-01-17 2011-01-05 温州医学院 一种用于制备重组人egf-il18融合蛋白的方法
PE20080262A1 (es) 2006-05-25 2008-04-30 Glaxo Group Ltd Anticuerpo humanizado contra interleuquina-18
WO2010040736A2 (en) * 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
CA2897067A1 (en) * 2013-01-02 2014-07-10 Wilsa, Inc. Method and apparatus for conditioning fluids
JP6820743B2 (ja) * 2013-09-05 2021-01-27 エイビー２ バイオ ソシエテアノニム 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ）
CN107660150B (zh) * 2015-03-05 2023-10-24 Ab2生物股份有限公司 Il-18结合蛋白(il-18bp)和抗体在炎性疾病中
EP3943097A1 (en) 2020-07-24 2022-01-26 AB2 Bio SA Car-t cell therapy
CN117279950A (zh) * 2022-01-28 2023-12-22 和径医药科技（上海）有限公司 一种靶向il-18bp的抗体及其应用
WO2023178192A1 (en) * 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
CN114605521A (zh) * 2022-04-06 2022-06-10 内蒙古农业大学 一种细胞免疫调节蛋白及其应用
CN114891125B (zh) * 2022-06-16 2023-04-11 广东医科大学 一种长效重组白细胞介素-18结合蛋白及其生产方法与应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985863A (en) 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
US5744451A (en) 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US5776731A (en) 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
DE69726878T2 (de) 1996-11-15 2004-10-21 Kennedy Inst Of Rheumatology L UNTERDRÜCKUNG VON TNFalpha UND IL-12 IN DER THERAPIE
AU7624798A (en) 1996-12-06 1998-06-29 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1 beta converting enzyme
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6087116A (en) 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
ES2146192T1 (es) 1997-03-18 2000-08-01 Basf Ag Metodo y composiciones para modular la sensibilidad a los corticosteroides.
PT1375514E (pt) 1997-08-01 2006-10-31 Serono Genetics Inst Sa Ests 5' para proteinas secretadas expressas em varios tecidos
AU8555098A (en) 1997-08-01 1999-02-22 Genset 5' ests for secreted proteins expressed in testis and other tissues
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
ATE275422T1 (de) 1998-04-28 2004-09-15 Applied Research Systems Konjugate aus polyole und beta-interferon
CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
WO2000012555A1 (fr) 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Proteine de liaison de l'interleukine 18
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
WO2001003719A2 (en) 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss
WO2001019373A2 (en) 1999-09-17 2001-03-22 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids

Also Published As

Publication number Publication date
AU755794B2 (en) 2002-12-19
PT1003781E (pt) 2009-10-26
HK1028773A1 (en) 2001-03-02
US8436148B2 (en) 2013-05-07
CN1267307A (zh) 2000-09-20
CN1243021C (zh) 2006-02-22
NO20000700L (no) 2000-04-14
SK1762000A3 (en) 2000-09-12
HUP0003533A3 (en) 2003-08-28
EE200000073A (es) 2000-10-16
EP1003781B1 (en) 2009-09-23
SK287194B6 (sk) 2010-03-08
US7799541B2 (en) 2010-09-21
AR013422A1 (es) 2000-12-27
DE69841175D1 (de) 2009-11-05
DE1003781T1 (de) 2001-01-11
ES2149149T1 (es) 2000-11-01
BRPI9811940B1 (pt) 2011-10-04
HUP0003533A2 (hu) 2001-01-29
IL125463A0 (en) 1999-03-12
PL206070B1 (pl) 2010-06-30
JP4272348B2 (ja) 2009-06-03
AU8746098A (en) 1999-03-08
NO327240B1 (no) 2009-05-18
AR062867A2 (es) 2008-12-10
ES2149149T3 (es) 2009-12-01
KR20010022900A (ko) 2001-03-26
CA2298855C (en) 2014-05-27
UA75862C2 (uk) 2006-06-15
BRPI9811940A (pt) 2000-09-05
SI1003781T1 (sl) 2009-12-31
DK1003781T3 (da) 2010-01-25
CY1109664T1 (el) 2014-08-13
CZ2000490A3 (cs) 2000-08-16
EA003675B1 (ru) 2003-08-28
ATE443719T1 (de) 2009-10-15
JP2001514876A (ja) 2001-09-18
WO1999009063A1 (en) 1999-02-25
EP1003781A1 (en) 2000-05-31
CZ300818B6 (cs) 2009-08-19
EA200000216A1 (ru) 2000-08-28
HU226698B1 (en) 2009-07-28
BRPI9811940B8 (pt) 2021-07-06
CA2298855A1 (en) 1999-02-25
NO20000700D0 (no) 2000-02-11
US20100010200A1 (en) 2010-01-14
EE05538B1 (et) 2012-04-16
US7101689B2 (en) 2006-09-05
PL338647A1 (en) 2000-11-06
IL122134A0 (en) 1998-04-05
KR100687388B1 (ko) 2007-02-26
IL134523A (en) 2011-09-27
BG65519B1 (bg) 2008-10-31
BG104149A (en) 2000-08-31
US20040037829A1 (en) 2004-02-26
US6605280B1 (en) 2003-08-12
IL134523A0 (en) 2001-04-30
NZ502392A (en) 2002-12-20
US20060154294A1 (en) 2006-07-13

Similar Documents

Publication Publication Date Title
IL121860A0 (en) Interleukin-18 binding proteins their preparation and use
HUP0001400A3 (en) Osteoprotegerin binding proteins and receptors
ZA983189B (en) Osteoprotegerin binding proteins and receptors
EP1007562A4 (en) TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR
GB9705903D0 (en) VP22 Proteins and uses thereof
EP0796321A4 (en) PROTEINS BINDING TO PROTEIN E2
IL131929A0 (en) Rap protein its preparation and use
AU8596498A (en) Annexin binding protein
EP1210110A4 (en) PROTEINS BINDING TO PRION PROTEIN AND THEIR USE
EP1012262A4 (en) HFLP PROTEIN HFLP
AU7410598A (en) Novel human RNA binding protein
IL131247A0 (en) Cash protein its preparation and use
GB9423372D0 (en) Proteins and their uses
AU6035298A (en) Human zinc binding proteins
IL128746A0 (en) Ptx-sensitive g proteins their preparation and use
IL121554A0 (en) Interleukin-18 binding proteins their preparation and use
IL121639A0 (en) Interleukin-18 binding proteins their preparation and use
AU1320600A (en) Human rna binding proteins
AU6894398A (en) Human gtp binding protein
AU2003200442A1 (en) Interleukin-18 binding proteins, their preparation and use
IL123477A0 (en) Nik binding proteins their preparation and use
AUPP004197A0 (en) Novel hbv binding protein and portions thereof
GB9424797D0 (en) Binding proteins
IL120413A0 (en) Novel PKA-binding proteins and uses thereof
IL120392A0 (en) Novel PKA-binding proteins and uses thereof