TMSB4X
TMSB4X is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
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timeline
title Publication timing
2013-01-01 : Zhang : DLBCL
2017-05-01 : Albuquerque : DLBCL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-05-01 : Chapuy : DLBCL
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1-a | aSHM target and high-confidence DLBCL gene [@zhangGeneticHeterogeneityDiffuse2013; @albuquerqueEnhancingKnowledgeDiscovery2017a] |
 |
1-a | aSHM target and high-confidence FL gene |
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 12.43 |
| DLBCL | Schmitz cohort | 20.85 |
| DLBCL | Reddy cohort | 13.11 |
| DLBCL | Chapuy cohort | 18.38 |
| FL | GAMBL genomes | 4.39 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 0.000 | 0.000 |
| DLBCL | Yes | Yes | 23.522 | 254.537 |
| FL | Yes | Yes | 60.545 | 310.498 |
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chrX | 12993308 | 12994511 | intron | active_promoter |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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