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rdmorin edited this page Jun 20, 2024 · 15 revisions

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

MYD88

History

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timeline
    title Publication timing
      2011-02-03 : Ngo : DLBCL
      2012-04-01 : Yan : MZL
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Relevance tier by entity

Entity Tier Description
MZL 1 high-confidence MZL gene[@yanBCRTLRSignaling2012a]
DLBCL 1 high-confidence DLBCL gene [@ngoOncogenicallyActiveMYD882011a]
FL 2 relevance in FL not firmly established

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
BL GAMBL genomes+capture 0.46
BL Thomas cohort 0.40
BL Panea cohort 1.00
DLBCL GAMBL genomes 13.38
DLBCL Schmitz cohort 26.38
DLBCL Reddy cohort 15.12
DLBCL Chapuy cohort 21.37
FL GAMBL genomes 1.85

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 1.809 0
DLBCL No Yes 56.390 0
FL No No 17.159 0

MYD88 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr3 38182641 T>C L265P

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

MYD88 Expression

References

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