HIST1H1C
This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.1,2 Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.
<<Warn("The variants reported in BL in this gene failed QC")>>
See below or the study page for more information
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timeline
title Publication timing
2011-07-27 : Morin : DLBCL
2019-09-26 : Panea : BL
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011] |
 |
1 | high-confidence FL gene [@morinFrequentMutationHistonemodifying2011] |
 |
3 | Retired, Failed QC[@paneaWholeGenomeLandscape2019]] |
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 4.85 |
| BL | Thomas cohort | 3.80 |
| BL | Panea cohort | 9.90 |
| DLBCL | GAMBL genomes | 9.94 |
| DLBCL | Schmitz cohort | 9.79 |
| DLBCL | Reddy cohort | 9.41 |
| DLBCL | Chapuy cohort | 12.39 |
| FL | GAMBL genomes | 5.08 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 10.205 | 0 |
| DLBCL | No | Yes | 9.354 | 0 |
| FL | No | No | 4.446 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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