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DLBCL_genes

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rdmorin edited this page Sep 5, 2024 · 127 revisions

title: 'DLBCL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of DLBCL genes

Tier 1, high-confidence DLBCL genes

125 total

Gene Summary First DLBCL study Other entities QC result
ACTB Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], aSHM Lohr et al [@drevalGeneticSubdivisionsFollicular2023; @wienandGenomicAnalysesFlowsorted2019]
ACTG1 Tier 1 GE[@fanComprehensiveCharacterizationDriver2020], aSHM Fan et al [@deschGenotypingCirculatingTumor2020; @hubschmannMutationalMechanismsShaping2021; @spinaGeneticsNodalMarginal2016]
ARID1A Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@barisicARID1AOrchestratesSWI2024] Zhang et al [@krysiakRecurrentSomaticMutations2017; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012; @wienandGenomicAnalysesFlowsorted2019]
ATM Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@camachoATMGeneInactivation2002] Reddy et al [@beaLandscapeSomaticMutations2013; @braggioGenomicAnalysisMarginal2012]
B2M Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@challa-malladiCombinedGeneticInactivation2011] Morin et al [@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015]
BCL10 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@xiaBCL10MutationsDefine2022] Morin et al [@russler-germainMutationsAssociatedProgression2023; @spinaGeneticsNodalMarginal2016]
BCL2 Tier 1 GE[@tanakaFrequentIncidenceSomatic1992], aSHM Tanaka et al [@burkhardtClinicalRelevanceMolecular2022; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021]
BCL6 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@masclePointMutationsBCL62003], aSHM Morin et al [@drevalGeneticSubdivisionsFollicular2023; @loveGeneticLandscapeMutations2012]
BCL7A Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@balinas-gaviraFrequentMutationsAminoterminal2020], aSHM Morin et al [@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @reichelFlowSortingExome2015]
BIRC6 Tier 1 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@sarkozyMutationalLandscapeGray2021]
BRAF Tier 1 GE[@tiacciBRAFMutationsHairycell2011], FE[@wanMechanismActivationRAFERK2004] Tiacci et al [@loveGeneticLandscapeMutations2012]
BTG1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@almasmoumFrequentLossBTG12021], aSHM Morin et al [@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @sarkozyMutationalLandscapeGray2021]
BTG2 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM Morin et al [@drevalGeneticSubdivisionsFollicular2023; @loveGeneticLandscapeMutations2012]
BTK Tier 1 GE[@albuquerqueEnhancingKnowledgeDiscovery2017], FE[@huFollicularLymphomaassociatedBTK2021] Albuquerque et al [@krysiakRecurrentSomaticMutations2017]
CARD11 Tier 1 GE[@lenzOncogenicCARD11Mutations2008], FE[@lenzOncogenicCARD11Mutations2008] Lenz et al [@morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012]
CCND3 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@schmitzBurkittLymphomaPathogenesis2012] Morin et al [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012]
CD58 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@challa-malladiCombinedGeneticInactivation2011] Morin et al [@schneiderAlterationsCD58Gene2015]
CD70 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@nieDualRoleCD702022] Morin et al [@russler-germainMutationsAssociatedProgression2023]
CD79B Tier 1 GE[@davisChronicActiveBcellreceptor2010], FE[@davisChronicActiveBcellreceptor2010] Davis et al [@drevalGeneticSubdivisionsFollicular2023; @paneaWholeGenomeLandscape2019]
CD83 Tier 1 GE[@morinMutationalStructuralAnalysis2013], aSHM Morin et al [@dunsCharacterizationDLBCLPMBL2021; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023]
CDKN2A Tier 1 GE[@morinMutationalStructuralAnalysis2013], FE[@kannengiesserFunctionalStructuralGenetic2009] Morin et al [@grandeGenomewideDiscoverySomatic2019; @spinaGeneticsNodalMarginal2016]
CIITA Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@mottokGenomicAlterationsCIITA2015], aSHM Morin et al [@mottokGenomicAlterationsCIITA2015]
CREBBP Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] Pasqualucci et al [@dunsCharacterizationDLBCLPMBL2021; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]
CXCR4 Tier 1 GE[@khodabakhshiRecurrentTargetsAberrant2012], FE[@zmajkovicovaGenotypephenotypeCorrelationsWHIM2022], aSHM Khodabakhshi et al [@krysiakRecurrentSomaticMutations2017; @paneaWholeGenomeLandscape2019]
DDX3X Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@gongSequentialInverseDysregulation2021] Reddy et al [@mottokIntegrativeGenomicAnalysis2019; @schmitzBurkittLymphomaPathogenesis2012]
DTX1 Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], aSHM Zhang et al [@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012]
DUSP2 Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], aSHM Lohr et al [@drevalGeneticSubdivisionsFollicular2023; @dunsCharacterizationDLBCLPMBL2021]
EBF1 Tier 1 GE[@bohleRoleEarlyBcell2013], FE[@ramirez-komoSpontaneousLossLineage2017], aSHM Bohle et al [@drevalGeneticSubdivisionsFollicular2023; @reichelFlowSortingExome2015; @thomasGeneticSubgroupsInform2023]
EEF1A1 Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al [@hubschmannMutationalMechanismsShaping2021; @reichelFlowSortingExome2015]
EP300 Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] Pasqualucci et al [@rossiCodingGenomeSplenic2012]
ETS1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM Morin et al [@paneaWholeGenomeLandscape2019]
ETV6 Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], FE[@wangETV6MutationCohort2014], aSHM Lohr et al
EZH2 Tier 1 GE[@morinSomaticMutationsAltering2010], FE[@sneeringerCoordinatedActivitiesWildtype2010] Morin et al [@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019]
FAS Tier 1 GE[@schollMutationsRegionFAS2007], FE[@wangFasFADDDeathDomain2010] Scholl et al [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016]
FBXO11 Tier 1 GE[@arthurGenomewideDiscoverySomatic2018], FE[@duanFBXO11TargetsBCL62011] Arthur et al [@parryWholeExomeSequencing2013; @richterRecurrentMutationID32012]
FBXW7 Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@saffieFBXW7TriggersDegradation2020] Zhang et al
FOXO1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@trinhAnalysisFOXO1Mutations] Morin et al [@dunsCharacterizationDLBCLPMBL2021; @schmitzBurkittLymphomaPathogenesis2012]
GNA13 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@muppidiLossSignalingGa132014] Morin et al [@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015]
GNAI2 Tier 1 GE[@morinMutationalStructuralAnalysis2013], FE[@muppidiLossSignalingGa132014] Morin et al [@drevalGeneticSubdivisionsFollicular2023; @grandeGenomewideDiscoverySomatic2019]
GRB2 Tier 1 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
GRHPR Tier 1 GE[@schmitzGeneticsPathogenesisDiffuse2018], aSHM Schmitz et al
HIST1H1B Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018], aSHM Chapuy et al [@krysiakRecurrentSomaticMutations2017; @sarkozyMutationalLandscapeGray2021]
HIST1H1C Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM Morin et al [@paneaWholeGenomeLandscape2019]
HIST1H1D Tier 1 GE[@morinMutationalStructuralAnalysis2013], aSHM Morin et al [@jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017]
HIST1H1E Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], aSHM Lohr et al [@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @reichelFlowSortingExome2015]
HIST1H2AC Tier 1 GE[@morinMutationalStructuralAnalysis2013], aSHM Morin et al [@krysiakRecurrentSomaticMutations2017]
HIST1H2AM Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018], aSHM Chapuy et al [@krysiakRecurrentSomaticMutations2017; @paneaWholeGenomeLandscape2019]
HIST1H2BC Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], aSHM Lohr et al [@krysiakRecurrentSomaticMutations2017; @mottokIntegrativeGenomicAnalysis2019]
HIST1H2BK Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], aSHM Zhang et al [@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012]
HIST1H3B Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], aSHM Lohr et al [@reichelFlowSortingExome2015]
HIST2H2BE Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018], aSHM Chapuy et al
HLA-A Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], FE[@fangazioGeneticMechanismsHLAI2021] Lohr et al [@deschGenotypingCirculatingTumor2020]
HLA-B Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], FE[@fangazioGeneticMechanismsHLAI2021] Lohr et al [@wienandGenomicAnalysesFlowsorted2019]
HLA-C Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018], FE[@fangazioGeneticMechanismsHLAI2021] Chapuy et al [@gomezUltraDeepSequencingReveals2023]
HLA-DMB Tier 1 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al
HNRNPU Tier 1 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@paneaWholeGenomeLandscape2019]
HVCN1 Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al [@krysiakRecurrentSomaticMutations2017]
IKZF3 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@lazarianHotspotMutationTranscription2021] Morin et al [@paneaWholeGenomeLandscape2019]
IL4R Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@viganoSomaticIL4RMutations2018], aSHM Duns et al [@viganoSomaticIL4RMutations2018]
IRF4 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM Morin et al [@drevalGeneticSubdivisionsFollicular2023; @mottokIntegrativeGenomicAnalysis2019]
IRF8 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@qiuIRF8mutantCellLymphoma2024], aSHM Morin et al [@mottokIntegrativeGenomicAnalysis2019; @paneaWholeGenomeLandscape2019]
ITPKB Tier 1 GE[@schmitzGeneticsPathogenesisDiffuse2018], FE[@tiacciPervasiveMutationsJAKSTAT2018], aSHM Schmitz et al [@drevalGeneticSubdivisionsFollicular2023; @reichelFlowSortingExome2015]
JUNB Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al [@mottokIntegrativeGenomicAnalysis2019] PASS
KLF2 Tier 1 GE[@pasqualucciAnalysisCodingGenome2011], aSHM Pasqualucci et al [@deschGenotypingCirculatingTumor2020; @drevalGeneticSubdivisionsFollicular2023; @jalladesExomeSequencingIdentifies2017]
KLHL14 Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@choiRegulationCellReceptordependent2020] Zhang et al
KLHL6 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@choiLossKLHL6Promotes2018], aSHM Morin et al [@ganapathiGeneticLandscapeDural2016]
KMT2C Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@sarkozyMutationalLandscapeGray2021; @zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019]
KMT2D Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@zhangDisruptionKMT2DPerturbs2015] Morin et al [@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012]
KRAS Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], FE[@scheffzekRasRasGAPComplexStructural1997] Lohr et al
LRRN3 Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@sarkozyMutationalLandscapeGray2021]
LTB Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018], aSHM Chapuy et al [@deschGenotypingCirculatingTumor2020; @drevalGeneticSubdivisionsFollicular2023]
MEF2B Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@ponMEF2BMutationsNonHodgkin2015], aSHM Morin et al [@beaLandscapeSomaticMutations2013]
MEF2C Tier 1 GE[@hubschmannMutationalMechanismsShaping2021], aSHM Hubschmann et al
MGA Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@depaoliMGASuppressorMYC2013] Reddy et al [@jalladesExomeSequencingIdentifies2017]
MIR142 Tier 1 GE[@kwanhianMicroRNA142Mutated202012], FE[@trissalMIR142LossofFunctionMutations2018], aSHM Kwanhian et al [@grandeGenomewideDiscoverySomatic2019]
MPEG1 Tier 1 GE[@morinMutationalStructuralAnalysis2013] Morin et al
MS4A1 Tier 1 GE[@rushtonGeneticEvolutionaryPatterns2020], FE[@rushtonGeneticEvolutionaryPatterns2020], aSHM Rushton et al [@mottokIntegrativeGenomicAnalysis2019]
MTOR Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@grabinerDiverseArrayCancerassociated2014] Zhang et al [@paneaWholeGenomeLandscape2019]
MYC Tier 1 GE[@pasqualucciHypermutationMultipleProtooncogenes2001], FE[@freieGermlinePointMutation2024], aSHM Pasqualucci et al [@dunsCharacterizationDLBCLPMBL2021; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992]
MYD88 Tier 1 GE[@ngoOncogenicallyActiveMYD882011], FE[@ngoOncogenicallyActiveMYD882011] Ngo et al [@drevalGeneticSubdivisionsFollicular2023; @yanBCRTLRSignaling2012]
NFKBIA Tier 1 GE[@thomasMutationalAnalysisIkappaBalpha2004], FE[@jungnickelClonalDeleteriousMutations2000] Thomas et al [@russler-germainMutationsAssociatedProgression2023; @wienandGenomicAnalysesFlowsorted2019]
NFKBIE Tier 1 GE[@morinGeneticLandscapesRelapsed2016], FE[@mansouriFunctionalLossIkBe2015] Morin et al [@mansouriFrequentNFKBIEDeletions2016; @pararajalingamCodingNoncodingDrivers2020]
NFKBIZ Tier 1 GE[@morinGeneticLandscapesRelapsed2016], FE[@arthurGenomewideDiscoverySomatic2018], aSHM Morin et al
NOL9 Tier 1 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al [@spinaGeneticsNodalMarginal2016]
NOTCH1 Tier 1 GE[@pasqualucciAnalysisCodingGenome2011], FE[@ryanCellRegulomeLinks2017] Pasqualucci et al [@beaLandscapeSomaticMutations2013; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012]
NOTCH2 Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@leeGainoffunctionMutationsCopy2009] Zhang et al [@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012]
OSBPL10 Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], aSHM Zhang et al
P2RY8 Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], FE[@muppidiLossSignalingGa132014] Lohr et al [@drevalGeneticSubdivisionsFollicular2023; @muppidiLossSignalingGa132014]
PIM1 Tier 1 GE[@pasqualucciHypermutationMultipleProtooncogenes2001], FE[@kuoRolePIM1Ibrutinibresistant2016], aSHM Pasqualucci et al [@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @dunsCharacterizationDLBCLPMBL2021]
PIM2 Tier 1 GE[@reddyGeneticFunctionalDrivers2017], aSHM Reddy et al [@reichelFlowSortingExome2015]
POU2AF1 Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018], FE[@gonzalez-rinconUnravelingTransformationFollicular2019], aSHM Chapuy et al [@krysiakRecurrentSomaticMutations2017]
POU2F2 Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], FE[@hodsonRegulationNormalBcell2016] Lohr et al [@krysiakRecurrentSomaticMutations2017]
PRDM1 Tier 1 GE[@pasqualucciInactivationPRDM1BLIMP12006], FE[@pasqualucciInactivationPRDM1BLIMP12006] Pasqualucci et al
PTEN Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@pfeiferPTENLossDefines2013] Reddy et al [@loveGeneticLandscapeMutations2012]
PTPN6 Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@demosthenousLossFunctionMutations2015] Reddy et al PASS
RB1 Tier 1 GE[@morinMutationalStructuralAnalysis2013], FE[@pinyolInactivationRB1Mantlecell2007] Morin et al [@zhangGenomicLandscapeMantle2014]
RFX7 Tier 1 GE[@arthurGenomewideDiscoverySomatic2018], FE[@weberPiggyBacTransposonTools2019] Arthur et al [@grandeGenomewideDiscoverySomatic2019]
RHOA Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@ohayreInactivatingMutationsGNA132016] Zhang et al [@richterRecurrentMutationID32012]
RRAGC Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016], FE[@okosunRecurrentMTORC1activatingRRAGC2016] Okosun et al
S1PR2 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@muppidiLossSignalingGa132014], aSHM Morin et al [@drevalGeneticSubdivisionsFollicular2023; @muppidiLossSignalingGa132014]
SETD1B Tier 1 GE[@albuquerqueEnhancingKnowledgeDiscovery2017], FE[@] Albuquerque et al
SF3B1 Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@cazzolaBiologicClinicalSignificance2013] Reddy et al [@loveGeneticLandscapeMutations2012]
SGK1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@gaoSGK1MutationsDLBCL2021], aSHM Morin et al [@dunsCharacterizationDLBCLPMBL2021]
SIN3A Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al [@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012]
SMARCA4 Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@fernandoFunctionalCharacterizationSMARCA42020] Reddy et al [@krysiakRecurrentSomaticMutations2017; @nadeuGenomicEpigenomicInsights2020b; @richterRecurrentMutationID32012]
SOCS1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@melznerBiallelicMutationSOCS12005], aSHM Morin et al [@drevalGeneticSubdivisionsFollicular2023; @wenigerMutationsTumorSuppressor2006]
SPEN Tier 1 GE[@albuquerqueEnhancingKnowledgeDiscovery2017] Albuquerque et al [@rossiCodingGenomeSplenic2012; @sarkozyMutationalLandscapeGray2021]
STAT3 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@huNovelMissenseM206K2013] Morin et al
STAT6 Tier 1 GE[@yildizActivatingSTAT6Mutations2015], FE[@mentzPARP14NovelTarget2022] Yildiz et al [@ritzRecurrentMutationsSTAT62009]
TAF1 Tier 1 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@spinaGeneticsNodalMarginal2016]
TBL1XR1 Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012], FE[@venturuttiTBL1XR1MutationsDrive2020] Lohr et al [@drevalGeneticSubdivisionsFollicular2023; @rossiCodingGenomeSplenic2012]
TET2 Tier 1 GE[@albuquerqueEnhancingKnowledgeDiscovery2017], FE[@asmarGenomewideProfilingIdentifies2013] Albuquerque et al [@thomasGeneticSubgroupsInform2023]
TMEM30A Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@ennishiTMEM30ALossoffunctionMutations2020] Morin et al
TMSB4X Tier 1 GE[@reddyGeneticFunctionalDrivers2017], aSHM Reddy et al [@drevalGeneticSubdivisionsFollicular2023]
TNFAIP3 Tier 1 GE[@compagnoMutationsMultipleGenes2009], FE[@compagnoMutationsMultipleGenes2009] Compagno et al [@drevalGeneticSubdivisionsFollicular2023; @rossiAlterationBIRC3Multiple2011; @schmitzTNFAIP3A20Tumor2009]
TNFRSF14 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@] Morin et al [@cheungAcquiredTNFRSF14Mutations2010; @spinaGeneticsNodalMarginal2016]
TOX Tier 1 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
TP53 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@katoUnderstandingFunctionstructureFunctionmutation2003] Morin et al [@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012; @tiacciPervasiveMutationsJAKSTAT2018; @wildaInactivationARFMDM2p53Pathway2004]
UBE2A Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al [@reichelFlowSortingExome2015]
WEE1 Tier 1 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al [@reichelFlowSortingExome2015]
XPO1 Tier 1 GE[@mareschalWholeExomeSequencing2016], FE[@miloudiXPO1E571KMutationModifies2020] Mareschal et al [@jardinRecurrentMutationsExportin2016]
ZC3H12A Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018], FE[@skalniakRegulatoryFeedbackLoop2009] Chapuy et al
ZFP36L1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM Morin et al [@paneaWholeGenomeLandscape2019; @reichelFlowSortingExome2015]
ZNF292 Tier 1 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
ZNF608 Tier 1 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@krysiakRecurrentSomaticMutations2017]

Tier 2, low-confidence DLBCL genes

210 total

Gene Summary First DLBCL study Other entities QC result
ABI3BP Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
ADAMTS1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
ADAMTSL3 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
AICDA Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
AKAP8 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
ANKLE2 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
ANKRD12 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
ANKRD17 Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ARAP2 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al
ARID5B Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@gomezUltraDeepSequencingReveals2023] PASS
ASXL3 Tier 2 GE[@albuquerqueEnhancingKnowledgeDiscovery2017] Albuquerque et al
ATR Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
BCL11A Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018], aSHM Chapuy et al
BCL2L10 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
BCR Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
BIRC3 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al [@beaLandscapeSomaticMutations2013; @dunsCharacterizationDLBCLPMBL2021; @rossiAlterationBIRC3Multiple2011]
BLK Tier 2 GE, aSHM
BRINP3 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
BRSK1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
BTBD3 Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
C12orf35 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
CADPS2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
CAMTA1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
CASP8 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
CD22 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
CD274 Tier 2 GE[@morinFrequentMutationHistonemodifying2011] Morin et al
CD36 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
CD44 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
CD74 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
CDH9 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
CEP164 Tier 2 GE[@albuquerqueEnhancingKnowledgeDiscovery2017] Albuquerque et al
CNOT2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
CNTNAP5 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
COQ7 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al PASS
CPS1 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
CRIP1 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al PASS
CXCR5 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al [@mottokIntegrativeGenomicAnalysis2019]
CYTSB Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
DAZAP1 Tier 2 GE[@pararajalingamCodingNoncodingDrivers2020] Pararajalingam et al
DCHS1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
DDX10 Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DHX16 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
DNAH5 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@jalladesExomeSequencingIdentifies2017] PASS
DNM2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
DNMT3B Tier 2 GE[@albuquerqueEnhancingKnowledgeDiscovery2017] Albuquerque et al
DOCK1 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al PASS
DPYD Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
DSC3 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
DSEL Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al
DSG4 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
DUSP27 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
DUSP9 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
EIF2AK3 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018], aSHM Schmitz et al
ERAP2 Tier 2 GE[@albuquerqueEnhancingKnowledgeDiscovery2017] Albuquerque et al
EZR Tier 2 GE, aSHM [@deschGenotypingCirculatingTumor2020]
FAM102A Tier 2 GE, aSHM
FANK1 Tier 2 GE, aSHM
FAT2 Tier 2 GE[@morinFrequentMutationHistonemodifying2011] Morin et al
FAT4 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@parryWholeExomeSequencing2013; @zhangGenomicLandscapeMantle2014] PASS
FBXO31 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
FCRL3 Tier 2 GE, aSHM
FNBP1 Tier 2 GE, aSHM
FOXC1 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
FOXP1 Tier 2 GE[@reddyGeneticFunctionalDrivers2017], aSHM Reddy et al PASS
FUBP1 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
GABRA1 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
GABRA2 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al
GOLGA5 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
GPC5 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
GSG2 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
H1FOO Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
HDAC7 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
HIST1H2AG Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@krysiakRecurrentSomaticMutations2017; @paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012] PASS
HIST1H2AL Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
HIST1H2BO Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
HIST1H3A Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
HLA-DMA Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al
HMGB1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
HNF1B Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
HNRNPD Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
HNRNPH1 Tier 2 GE[@pararajalingamCodingNoncodingDrivers2020] Pararajalingam et al
ID3 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al [@richterRecurrentMutationID32012; @spinaGeneticsNodalMarginal2016]
IFNGR1 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
IGLL5 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018], aSHM Chapuy et al [@deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023]
IKBKB Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@rossiAlterationBIRC3Multiple2011; @wienandGenomicAnalysesFlowsorted2019] PASS
IKBKE Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
IL16 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
IL6 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al PASS
INO80 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
IRF1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021], aSHM Hubschmann et al PASS
JAK1 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@mottokIntegrativeGenomicAnalysis2019]
JAK3 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
KCMF1 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
KDM2B Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
KLHL21 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
KRTAP5-5 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
LAMA5 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
LAPTM5 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021], aSHM Hubschmann et al PASS
LCOR Tier 2 GE[@]
LPP Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
LRP12 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
LYN Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al PASS
MAGEC3 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
MAGT1 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
MALAT1 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
MAP2K1 Tier 2 GE[@shinBRAFV600EMAP2K12015] Shin et al [@louissaintPediatrictypeNodalFollicular2016]
MCL1 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@dunsCharacterizationDLBCLPMBL2021; @paneaWholeGenomeLandscape2019] PASS
MECOM Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
MED12L Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
MET Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
MIR155HG Tier 2 GE, aSHM
MPDZ Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@reichelFlowSortingExome2015] PASS
MSH6 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
MTMR8 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
MYBPC2 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
MYO1G Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
MYOM2 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
NAV1 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al
NCOA3 Tier 2 GE, aSHM
NEAT1 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
NF1 Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NLRP5 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
ODZ2 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
OFD1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
OR6K3 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
P2RX5 Tier 2 GE[@morinMutationalStructuralAnalysis2013], aSHM Morin et al PASS
PAPOLG Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
PASD1 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
PASK Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
PAX5 Tier 2 GE[@pasqualucciHypermutationMultipleProtooncogenes2001], aSHM Pasqualucci et al
PCDHB11 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
PCDHB6 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
PCLO Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
PDGFC Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
PDS5B Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@hubschmannMutationalMechanismsShaping2021] PASS
PIK3CD Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PIK3R1 Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@paneaWholeGenomeLandscape2019]
PMS1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
PNPO Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
PPP2R5A Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
PRKCB Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
PRKDC Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al [@hubschmannMutationalMechanismsShaping2021]
PRPS1 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al PASS
PTPN21 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
PTPRD Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@spinaGeneticsNodalMarginal2016]
RAC2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
RAPGEF1 Tier 2 GE[@morinFrequentMutationHistonemodifying2011] Morin et al
RASGEF1A Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
RBP3 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al [@loveGeneticLandscapeMutations2012]
RCC Tier 2 GE, aSHM
RFTN1 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al [@dunsCharacterizationDLBCLPMBL2021]
RFXAP Tier 2 GE
RGAG1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
RHEX Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
RHOH Tier 2 GE[@pasqualucciHypermutationMultipleProtooncogenes2001], aSHM Pasqualucci et al
RUBCNL Tier 2 GE, aSHM
S1PR1 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al [@pararajalingamCodingNoncodingDrivers2020]
SAMD9L Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
SEL1L3 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018], aSHM Schmitz et al
SEPTIN9 Tier 2 GE, aSHM
SERPINA1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
SERPINA9 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
SETD2 Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SETD5 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@tiacciPervasiveMutationsJAKSTAT2018] PASS
SIAH2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al [@reichelFlowSortingExome2015] PASS
SLC34A2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
SLC38A8 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
SLITRK6 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
SMARCA1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
SMEK1 Tier 2 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SRPX Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
SRRM2 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al [@russler-germainMutationsAssociatedProgression2023] PASS
ST6GAL1 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
STAT5B Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@tiacciPervasiveMutationsJAKSTAT2018]
SYN2 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
SYPL1 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
TAP1 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018] Schmitz et al
TBC1D4 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
TBP Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
TCL1A Tier 2 GE[@reddyGeneticFunctionalDrivers2017], aSHM Reddy et al [@grandeGenomewideDiscoverySomatic2019]
TGFBR2 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
TIPARP Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
TLL2 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
TLR2 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al [@beaLandscapeSomaticMutations2013] PASS
TMSL3 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
TNF Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
TRAF3 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al [@ottoGeneticLesionsTRAF32012; @rossiAlterationBIRC3Multiple2011]
TRAF6 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
TRIP12 Tier 2 GE
TSC22D1 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
UBE2J1 Tier 2 GE[@schmitzGeneticsPathogenesisDiffuse2018], aSHM Schmitz et al
UBR5 Tier 2 GE[@albuquerqueEnhancingKnowledgeDiscovery2017] Albuquerque et al [@pararajalingamCodingNoncodingDrivers2020]
UHRF1BP1 Tier 2 GE[@albuquerqueEnhancingKnowledgeDiscovery2017] Albuquerque et al
UNC5B Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al PASS
UNC5C Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
UNC5D Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
USP7 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018] Arthur et al [@grandeGenomewideDiscoverySomatic2019]
VAX1 Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
WDFY3 Tier 2 GE[@morinMutationalStructuralAnalysis2013] Morin et al PASS
WNK1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al [@jalladesExomeSequencingIdentifies2017; @thomasGeneticSubgroupsInform2023] PASS
XBP1 Tier 2 GE, aSHM
YY1 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
ZCCHC7 Tier 2 GE[@arthurGenomewideDiscoverySomatic2018], aSHM Arthur et al
ZEB2 Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al
ZFX Tier 2 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al PASS
ZNF217 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al [@reichelFlowSortingExome2015] PASS
ZNF385B Tier 2 GE[@lohrDiscoveryPrioritizationSomatic2012] Lohr et al
ZNF423 Tier 2 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al PASS
ZNF521 Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al
ZWILCH Tier 2 GE[@pasqualucciAnalysisCodingGenome2011] Pasqualucci et al

Tier 3, retired DLBCL genes

387 total

Gene Summary First DLBCL study Other entities QC result
ABCA3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@beaLandscapeSomaticMutations2013]
ABCA4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ABCB1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
ACE Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@loveGeneticLandscapeMutations2012]
ACSM3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ACSS2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ACSS3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ACTN1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ADAM2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ADAMTS15 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ADH7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
AFAP1L2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
AGA Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
AHR Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
AKAP9 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ALAS1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ALDH1L2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
AMAC1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
AMIGO3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
AMPH Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ANK2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@zhangGenomicLandscapeMantle2014]
ANKRD44 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ANTXR1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
AP1G2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
APBB1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
APC Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
APMAP Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
APOA5 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
APP Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ARID1B Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
ATIC Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ATP10A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ATP1A2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ATP2A3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ATP6V0A1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
B4GALNT2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
BAZ1A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
BCAT2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
BLM Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
BMPR1A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
BRCA1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
BRCA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
BRD4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@loveGeneticLandscapeMutations2012]
BSCL2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
BTAF1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
C9 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CAD Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@loveGeneticLandscapeMutations2012]
CAPN5 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CAPN7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CBLB Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
CBX3 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
CCDC132 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CCDC46 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CCDC97 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CCL4 Tier 3 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al FAIL
CCNF Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@abateDistinctViralMutational2015]
CDC123 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CDC73 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@loveGeneticLandscapeMutations2012] FAIL
CDH1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
CDH10 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CDH7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CDH8 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@zhangGenomicLandscapeMantle2014] FAIL
CDK3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CDKN1A Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
CECR1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CELSR2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CGN Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
CHD1 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
CHD3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CHEK2 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
CHRM5 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CHST2 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
CIC Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CNGA4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CNOT6 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CNP Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CNTN6 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
COL5A2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CORO2A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CORO7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CRELD2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CRTC3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CSNK1A1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
CSNK2A1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
CST7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CTNNA3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CYP24A1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CYP2C18 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
CYYR1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
DCAF6 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
DDB1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DGCR8 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
DHX33 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
DIAPH3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DICER1 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
DIP2B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DLGAP1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@loveGeneticLandscapeMutations2012]
DMXL1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DNMT3A Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
DOCK2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DOCK5 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
DOLK Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DSC2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DSCAML1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DSG2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DSP Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DUOXA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DUPD1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DYNC1H1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
DYNC1I1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ECGF1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ECT2L Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
EGFR Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
EPHA3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
EPHA5 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
EPHA7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@mottokIntegrativeGenomicAnalysis2019]
ERBB3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ERN2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ETNPPL Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
EXTL3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FAIM Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
FAM161A Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
FAM38B Tier 3 GE[@morinMutationalStructuralAnalysis2013] Morin et al FAIL
FAM62C Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FANCD2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FGD3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FGFR1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FIGN Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FLNA Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
FLNC Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FLT1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
FMO2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FN1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
FNDC1 Tier 3 GE[@morinMutationalStructuralAnalysis2013] Morin et al FAIL
FRMPD1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
FUT5 Tier 3 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al FAIL
FZD1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
GABRG1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GAK Tier 3 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al FAIL
GATA2 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
GATA3 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
GCN1L1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GJA8 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GJB4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GNAS Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
GOPC Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GPD2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GPR133 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GPR15 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GREM2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GRIA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
GRM5 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
H6PD Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
HACE1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
HCK Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
HFE Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
HIPK3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
HIST1H4I Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
HK3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
HLA-DQA1 Tier 3 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al FAIL
HLA-DRB1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
HNRNPR Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
HRAS Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@jalladesExomeSequencingIdentifies2017] FAIL
HSF2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
IDH1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
IER2 Tier 3 GE[@morinMutationalStructuralAnalysis2013] Morin et al FAIL
IL6ST Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
INSC Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
INTS6 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
IQGAP1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
IQUB Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ITGA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ITGA8 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ITGB3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ITGB4 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
ITPR1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
JAG1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
JAKMIP2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KCNA3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KCNAB3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KCNJ6 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KCNT2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KDR Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KIF21B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KIT Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KITLG Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
KLB Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KLC3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KLF4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
KLRC4 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
KRT6A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LEPR Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
LEPREL1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LIFR Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LILRA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LIN54 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
LIN7C Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LPHN2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LRAP Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LRIG3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LRP1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LRP10 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LRP1B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@spinaGeneticsNodalMarginal2016]
LRP3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
LYST Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MAP2K3 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
MAP4K4 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
MARCHF7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MARK1 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
MBL2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MCM8 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
MED13L Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MIB1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MLH1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
MMEL1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
MN1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MORC2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MPL Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MSH2 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
MSN Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
MTMR3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MYB Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@deschGenotypingCirculatingTumor2020] FAIL
MYL7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MYO5C Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
MYRIP Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NANOG Tier 3 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al FAIL
NCOR1 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
NDUFS1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NELL2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NFIB Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NFKB2 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@mottokIntegrativeGenomicAnalysis2019] FAIL
NFX1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NGFR Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NIPBL Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NLGN2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NLRP7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NLRP8 Tier 3 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al FAIL
NOTCH3 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
NPHP1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NPY2R Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NR2F2 Tier 3 GE[@hubschmannMutationalMechanismsShaping2021] Hubschmann et al FAIL
NRXN2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@loveGeneticLandscapeMutations2012]
NSD1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
NSD2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@beaLandscapeSomaticMutations2013]
NUP153 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
ONECUT1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PABPC1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PADI1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PAPPA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PBX1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCCB Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCDE1C Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCDH7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCDHB1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCDHB15 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCDHB3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCDHB5 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PCDHGA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PDE1C Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PDE4DIP Tier 3 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al FAIL
PDGFRA Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PDGFRB Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PDIA2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PDZRN3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@paneaWholeGenomeLandscape2019]
PDZRN4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PFN1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PGR Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PHF6 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@thomasGeneticSubgroupsInform2023] FAIL
PKD1 Tier 3 GE[@morinMutationalStructuralAnalysis2013] Morin et al FAIL
PLA2G4B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PLCB4 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PLCG2 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al [@paneaWholeGenomeLandscape2019]
PLEKHA7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PNLIPRP1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PNPT1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
POGZ Tier 3 GE[@morinMutationalStructuralAnalysis2013] Morin et al FAIL
POLD3 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
POLE Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
POLQ Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PPARGC1A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PPP2R2B Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PPWD1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PRDM16 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PRKCB1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PRKCQ Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PROS1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PRSS7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PTCH1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
PTPN14 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PTPN23 Tier 3 GE[@morinMutationalStructuralAnalysis2013] Morin et al FAIL
PTPRF Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PTPRK Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
PTPRT Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
PXK Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RAB3GAP1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RAD9A Tier 3 GE[@chapuyMolecularSubtypesDiffuse2018] Chapuy et al FAIL
RAF1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al [@jalladesExomeSequencingIdentifies2017]
RAPGEF2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RAPGEF3 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
RARA Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
RBM15B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RECQL4 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
RELN Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@sarkozyMutationalLandscapeGray2021]
RET Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al [@loveGeneticLandscapeMutations2012]
RFC1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RGS1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@mottokIntegrativeGenomicAnalysis2019]
RHPN2 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
RIF1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
RIMS4 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
ROR2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RPTOR Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
RSL1D1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RUNDC1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
RUNX1 Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
RYR1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SAPS3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SARM1 Tier 3 GE[@morinMutationalStructuralAnalysis2013] Morin et al FAIL
SCYL1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SEMA3A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SEMA3D Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SEMA5A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SERINC2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SH3PXD2B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SHMT2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SIGLEC10 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SLC16A7 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SLC16A8 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
SLC4A8 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SLC5A1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SLC9A5 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SMO Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
SOS2 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
SOX6 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SPEG Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SPTBN1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ST8SIA3 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SULF2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
SYK Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
TAF1L Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TAF4B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TECRL Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
THBS4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TIMM50 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TLN1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
TLN2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TLR4 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
TMC1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TMEM161A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TMEM16E Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TMEM63A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TNPO1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
TPR Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
TPRKB Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TRIM37 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TRIP11 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@reichelFlowSortingExome2015]
TRRAP Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al [@rossiCodingGenomeSplenic2012]
TSC2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TSHZ2 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
TYRO3 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
UBXN11 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
UBXN2B Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
UHRF1BP1L Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
UNC13B Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
UQCRC1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
VANGL1 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
VPS13A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
WAC Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@rossiCodingGenomeSplenic2012] FAIL
WDR65 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
WDR66 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
WDR67 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
WIF1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
WNK4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
WT1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
XDH Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZBTB7A Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al [@burkhardtClinicalRelevanceMolecular2022] FAIL
ZFAT Tier 3 GE[@reddyGeneticFunctionalDrivers2017] Reddy et al FAIL
ZIC4 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZMYM4 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
ZNF354A Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZNF366 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZNF439 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZNF474 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZNF700 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZNF790 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZNF814 Tier 3 GE[@fanComprehensiveCharacterizationDriver2020] Fan et al
ZNF91 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al
ZP1 Tier 3 GE[@zhangGeneticHeterogeneityDiffuse2013] Zhang et al

References

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