WO2000041681A3 - ARZNEIFORMULIERUNGEN ENTHALTEND EIN OPIOID UND EINEN α-AGONISTEN - Google Patents

ARZNEIFORMULIERUNGEN ENTHALTEND EIN OPIOID UND EINEN α-AGONISTEN Download PDF

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Publication number
WO2000041681A3
WO2000041681A3 PCT/EP2000/000318 EP0000318W WO0041681A3 WO 2000041681 A3 WO2000041681 A3 WO 2000041681A3 EP 0000318 W EP0000318 W EP 0000318W WO 0041681 A3 WO0041681 A3 WO 0041681A3
Authority
WO
WIPO (PCT)
Prior art keywords
opioid
antagonist
formulations containing
medicinal formulations
medicinal
Prior art date
Application number
PCT/EP2000/000318
Other languages
English (en)
French (fr)
Other versions
WO2000041681A2 (de
Inventor
Johannes Bartholomaeus
Juergen Betzing
Original Assignee
Gruenenthal Gmbh
Johannes Bartholomaeus
Juergen Betzing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh, Johannes Bartholomaeus, Juergen Betzing filed Critical Gruenenthal Gmbh
Priority to SK1001-2001A priority Critical patent/SK10012001A3/sk
Priority to JP2000593293A priority patent/JP2002534458A/ja
Priority to AU21090/00A priority patent/AU772886B2/en
Priority to NZ513501A priority patent/NZ513501A/en
Priority to EP00901108A priority patent/EP1143936A2/de
Priority to CA002359273A priority patent/CA2359273A1/en
Publication of WO2000041681A2 publication Critical patent/WO2000041681A2/de
Publication of WO2000041681A3 publication Critical patent/WO2000041681A3/de
Priority to NO20013302A priority patent/NO20013302L/no
Priority to US09/907,447 priority patent/US20020044966A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die Erfindung betrifft Arzneiformulierungen enthaltend ein Opioid, einen α-Agonisten und/oder jeweils dessen physiologisch verträgliches Salz, aus denen wenigstens ein Arzneimittelwirkstoff verzögert freigesetzt wird.
PCT/EP2000/000318 1999-01-18 2000-01-17 ARZNEIFORMULIERUNGEN ENTHALTEND EIN OPIOID UND EINEN α-AGONISTEN WO2000041681A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SK1001-2001A SK10012001A3 (sk) 1999-01-18 2000-01-17 Farmaceutická formulácia obsahujúca opiát a alfa-agonistu
JP2000593293A JP2002534458A (ja) 1999-01-18 2000-01-17 オピオイド及びα−アゴニストを含有する薬剤
AU21090/00A AU772886B2 (en) 1999-01-18 2000-01-17 Medicinal formulations containing an opioid and an alpha-antagonist
NZ513501A NZ513501A (en) 1999-01-18 2000-01-17 Pharmaceutical formulations containing an opioid and an alpha-agonist
EP00901108A EP1143936A2 (de) 1999-01-18 2000-01-17 ARZNEIFORMULIERUNGEN ENTHALTEND EIN OPIOID UND EINEN $g(a)-AGONISTEN
CA002359273A CA2359273A1 (en) 1999-01-18 2000-01-17 Pharmaceutical formulations containing an opioid and an .alpha.-agonist
NO20013302A NO20013302L (no) 1999-01-18 2001-07-03 Medisinsk preparat inneholdende et opioid og en <alfa>- agonist
US09/907,447 US20020044966A1 (en) 1999-01-18 2001-07-18 Pharmaceutical formulations containing an opioid and an alpha-agonist

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19901684 1999-01-18
DE19901684.4 1999-01-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/907,447 Continuation US20020044966A1 (en) 1999-01-18 2001-07-18 Pharmaceutical formulations containing an opioid and an alpha-agonist

Publications (2)

Publication Number Publication Date
WO2000041681A2 WO2000041681A2 (de) 2000-07-20
WO2000041681A3 true WO2000041681A3 (de) 2000-12-07

Family

ID=7894563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/000318 WO2000041681A2 (de) 1999-01-18 2000-01-17 ARZNEIFORMULIERUNGEN ENTHALTEND EIN OPIOID UND EINEN α-AGONISTEN

Country Status (15)

Country Link
US (1) US20020044966A1 (de)
EP (1) EP1143936A2 (de)
JP (1) JP2002534458A (de)
AR (1) AR022252A1 (de)
AU (1) AU772886B2 (de)
BR (1) BR0000578A (de)
CA (1) CA2359273A1 (de)
CO (1) CO5160243A1 (de)
HU (2) HUP0105043A3 (de)
NO (2) NO20000225D0 (de)
NZ (1) NZ513501A (de)
PE (1) PE20001396A1 (de)
SK (1) SK10012001A3 (de)
UY (1) UY25936A1 (de)
WO (1) WO2000041681A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962019B2 (en) 2005-09-09 2015-02-24 Angelini Pharma, Inc. Sustained drug release composition

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2374717T3 (es) 1999-10-29 2012-02-21 Euro-Celtique S.A. Formulaciones de hidrocodona de liberación controlada.
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
CA2424021A1 (en) * 2000-09-29 2002-04-04 Board Of Trustees Operating Michigan State University Catecholamine compositions and uses thereof
KR100960200B1 (ko) 2000-10-30 2010-05-27 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
US6287599B1 (en) * 2000-12-20 2001-09-11 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
EP1395243A2 (de) * 2001-05-31 2004-03-10 SkyePharma Inc. Verkapselung von nanosuspensionen in liposomen und mikrosphärulen
US8329216B2 (en) * 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
KR20030034171A (ko) * 2001-07-06 2003-05-01 엔도 파마슈티걸즈, 인크. 옥시모르폰 제어 방출 제형
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
AU2002337686B2 (en) * 2001-09-26 2008-05-15 Penwest Pharmaceuticals Company Opioid formulations having reduced potential for abuse
US7854230B2 (en) * 2001-10-22 2010-12-21 O.R. Solutions, Inc. Heated medical instrument stand with surgical drape and method of detecting fluid and leaks in the stand tray
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US7648981B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
US7648982B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
US20050100594A1 (en) * 2003-11-12 2005-05-12 Nilendu Sen Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
DE102005013726A1 (de) * 2005-03-22 2006-09-28 Grünenthal GmbH Transdermale therapeutische Systeme mit verbesserter Verträglichkeit
US7485323B2 (en) * 2005-05-31 2009-02-03 Gelita Ag Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions
NZ565649A (en) * 2005-07-28 2011-03-31 Shire Llc Pharmaceutical formulations/composition of guanfacine suitable for single dose form administration daily
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
US20080069891A1 (en) * 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US20100172991A1 (en) * 2007-06-08 2010-07-08 Henry Joseph Horacek Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
US20090087490A1 (en) 2007-06-08 2009-04-02 Addrenex Pharmaceuticals, Inc. Extended release formulation and method of treating adrenergic dysregulation
US20090124650A1 (en) * 2007-06-21 2009-05-14 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol
WO2009130715A1 (en) * 2008-04-25 2009-10-29 Cadila Healtcare Limited Rapidly disintegrating oral compositions of tramadol
EP2309993A1 (de) * 2008-06-25 2011-04-20 US Worldmeds LLC Hautpflaster und lofexidin enthaltende formulierungen mit verzögerter freisetzung zur transdermalen und oralen verabreichung
US8603497B2 (en) * 2008-10-30 2013-12-10 National University Corporation Okayama University Composition for local anesthesia
NZ600640A (en) * 2009-12-17 2014-11-28 Cima Labs Inc Abuse-resistant formulations
EP2568977A1 (de) 2010-05-11 2013-03-20 Cima Labs Inc. Alkoholresistente metoprololhaltige orale retard-dosierformen
SG10201510564PA (en) 2010-12-22 2016-01-28 Purdue Pharma Lp Encased tamper resistant controlled release dosage forms
CA2850964C (en) 2011-10-05 2021-02-02 Jennifer L. Sanders Methods and compositions for treating foot or hand pain
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
EP3054935B1 (de) 2013-10-07 2020-12-09 Teikoku Pharma USA, Inc. Verfahren und zusammensetzungen zur behandlung von hyperaktivität mit aufmerksamkeitsstörungen, angstzuständen und schlaflosigkeit mit transdermalen descmedetomidin-zusammensetzungen
RU2646512C2 (ru) 2013-10-07 2018-03-05 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Устройства для трансдермальной доставки дексмедетомидина и способы их применения
RU2648449C2 (ru) 2013-10-07 2018-03-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина
US20150118300A1 (en) 2013-10-31 2015-04-30 Cima Labs Inc. Immediate Release Abuse-Deterrent Granulated Dosage Forms
EP3965733A4 (de) 2019-05-07 2023-01-11 Clexio Biosciences Ltd. Esketamin enthaltende missbrauchssichere darreichungsformen
US20220062200A1 (en) 2019-05-07 2022-03-03 Clexio Biosciences Ltd. Abuse-deterrent dosage forms containing esketamine
CN112494486B (zh) * 2020-12-07 2022-01-21 深圳善康医疗健康产业有限公司 一种用于减轻或消除阿片戒断综合症的药物组合物及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946848A (en) * 1985-10-29 1990-08-07 Baker Cumins Dermatologicals, Inc. Method of treating pruritus with nalmefene and clonidine
PT99629A (pt) * 1991-11-28 1993-05-31 Antonio Feria Reis Valle Metodo de desintoxicacao de opiaceos
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
WO1999024023A2 (de) * 1997-11-11 1999-05-20 Grünenthal GmbH FORMULIERUNG EINER KOMBINATION AUS OPIOID UND α-ADRENERGEM AGONISTEN UND DEREN VERWENDUNG

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946848A (en) * 1985-10-29 1990-08-07 Baker Cumins Dermatologicals, Inc. Method of treating pruritus with nalmefene and clonidine
PT99629A (pt) * 1991-11-28 1993-05-31 Antonio Feria Reis Valle Metodo de desintoxicacao de opiaceos
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
WO1999024023A2 (de) * 1997-11-11 1999-05-20 Grünenthal GmbH FORMULIERUNG EINER KOMBINATION AUS OPIOID UND α-ADRENERGEM AGONISTEN UND DEREN VERWENDUNG

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199325, Derwent World Patents Index; AN 1993-203390 [25], XP002143493 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962019B2 (en) 2005-09-09 2015-02-24 Angelini Pharma, Inc. Sustained drug release composition
US9439866B2 (en) 2005-09-09 2016-09-13 Angelini Pharma, Inc. Trazodone composition for once a day administration

Also Published As

Publication number Publication date
US20020044966A1 (en) 2002-04-18
BR0000578A (pt) 2001-08-14
AU2109000A (en) 2000-08-01
EP1143936A2 (de) 2001-10-17
JP2002534458A (ja) 2002-10-15
UY25936A1 (es) 2001-07-31
NO20013302D0 (no) 2001-07-03
PE20001396A1 (es) 2000-12-23
WO2000041681A2 (de) 2000-07-20
NO20000225D0 (no) 2000-01-17
AR022252A1 (es) 2002-09-04
CO5160243A1 (es) 2002-05-30
HUP0105043A2 (en) 2002-06-29
HUP0105043A3 (en) 2005-06-28
HU0000139D0 (en) 2000-03-28
NO20013302L (no) 2001-07-03
SK10012001A3 (sk) 2002-01-07
AU772886B2 (en) 2004-05-13
CA2359273A1 (en) 2000-07-20
NZ513501A (en) 2003-11-28

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