PT2986610T - Heterociclos bicíclicos como inibidores de fgfr - Google Patents

Heterociclos bicíclicos como inibidores de fgfr

Info

Publication number
PT2986610T
PT2986610T PT147326623T PT14732662T PT2986610T PT 2986610 T PT2986610 T PT 2986610T PT 147326623 T PT147326623 T PT 147326623T PT 14732662 T PT14732662 T PT 14732662T PT 2986610 T PT2986610 T PT 2986610T
Authority
PT
Portugal
Prior art keywords
bicyclic heterocycles
fgfr inhibitors
fgfr
inhibitors
heterocycles
Prior art date
Application number
PT147326623T
Other languages
English (en)
Inventor
Xu Meizhong
Sun Yaping
Lu Liang
Qian Ding-Quan
Zhuo Jincong
Yao Wenqing
Wu Liangxing
Zhang Fenglei
He Chunhong
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of PT2986610T publication Critical patent/PT2986610T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT147326623T 2013-04-19 2014-04-18 Heterociclos bicíclicos como inibidores de fgfr PT2986610T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361813782P 2013-04-19 2013-04-19

Publications (1)

Publication Number Publication Date
PT2986610T true PT2986610T (pt) 2018-03-09

Family

ID=50983108

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147326623T PT2986610T (pt) 2013-04-19 2014-04-18 Heterociclos bicíclicos como inibidores de fgfr

Country Status (35)

Country Link
US (5) US9533984B2 (pt)
EP (2) EP2986610B9 (pt)
JP (3) JP6449244B2 (pt)
KR (2) KR102469849B1 (pt)
CN (3) CN109912594A (pt)
AR (1) AR096097A1 (pt)
AU (3) AU2014253798C1 (pt)
BR (1) BR112015026307B1 (pt)
CA (2) CA3130452C (pt)
CL (1) CL2015003089A1 (pt)
CR (1) CR20150578A (pt)
CY (1) CY1120556T1 (pt)
DK (1) DK2986610T5 (pt)
EA (2) EA202090516A3 (pt)
EC (1) ECSP15048555A (pt)
ES (2) ES2893725T3 (pt)
HK (2) HK1255159A1 (pt)
HR (1) HRP20180365T2 (pt)
HU (1) HUE036571T2 (pt)
IL (2) IL241982B (pt)
LT (1) LT2986610T (pt)
ME (1) ME03015B (pt)
MX (2) MX367878B (pt)
MY (1) MY181497A (pt)
NO (1) NO3087075T3 (pt)
PE (1) PE20152033A1 (pt)
PH (2) PH12015502383A1 (pt)
PL (1) PL2986610T4 (pt)
PT (1) PT2986610T (pt)
RS (1) RS56924B9 (pt)
SG (2) SG11201508328PA (pt)
SI (1) SI2986610T1 (pt)
TW (2) TWI649318B (pt)
UA (1) UA120087C2 (pt)
WO (1) WO2014172644A2 (pt)

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US10040790B2 (en) 2018-08-07
US20140315902A1 (en) 2014-10-23
EP2986610B1 (en) 2017-12-27
CN109912594A (zh) 2019-06-21
LT2986610T (lt) 2018-04-10
JP2020128396A (ja) 2020-08-27
PL2986610T3 (pl) 2018-05-30
WO2014172644A3 (en) 2014-12-18
SG10201708520YA (en) 2017-12-28
DK2986610T5 (en) 2018-12-10
AR096097A1 (es) 2015-12-09
US20210395246A1 (en) 2021-12-23
CA3130452A1 (en) 2014-10-23
EA202090516A2 (ru) 2020-06-30
ME03015B (me) 2018-10-20
CN105263931A (zh) 2016-01-20
AU2014253798A1 (en) 2015-10-29
AU2014253798B2 (en) 2018-08-09
ES2893725T3 (es) 2022-02-09
HUE036571T2 (hu) 2018-07-30
JP6449244B2 (ja) 2019-01-09
EP3318564A2 (en) 2018-05-09
EP2986610B9 (en) 2018-10-17
US10450313B2 (en) 2019-10-22
PH12019502810A1 (en) 2021-01-11
NO3087075T3 (pt) 2018-07-14
IL241982B (en) 2021-02-28
EA202090516A3 (ru) 2020-10-30
CY1120556T1 (el) 2019-07-10
US20170166564A1 (en) 2017-06-15
DK2986610T3 (en) 2018-02-12
EP3318564A3 (en) 2018-08-15
JP2016518372A (ja) 2016-06-23
TW201920173A (zh) 2019-06-01
KR102269032B1 (ko) 2021-06-24
US20190062327A1 (en) 2019-02-28
US20200095244A1 (en) 2020-03-26
SG11201508328PA (en) 2015-11-27
RS56924B9 (sr) 2019-09-30
AU2020250201B2 (en) 2022-07-07
TWI649318B (zh) 2019-02-01
TW201512195A (zh) 2015-04-01
EP2986610A2 (en) 2016-02-24
EA201592005A1 (ru) 2016-02-29
EP3318564B1 (en) 2021-07-28
ECSP15048555A (es) 2017-07-31
CR20150578A (es) 2016-02-29
ES2657451T9 (es) 2018-12-11
AU2014253798C1 (en) 2019-02-07
JP2019069953A (ja) 2019-05-09
MX2015014683A (es) 2016-07-05

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