NO852474L - Substituerte bicykliske fobindelser. - Google Patents

Substituerte bicykliske fobindelser.

Info

Publication number: NO852474L
Authority: NO; Norway
Prior art keywords: alkyl; formula; fabrications; substituted bicyclic; stereoisomers
Prior art date: 1984-06-20

Application number

NO852474A

Other languages

English (en)

Other versions

NO162467B (no

NO162467C (no

Inventor

Leslie J Browne

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-20

Filing date

1985-06-19

Publication date

1985-12-23

1985-06-19 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1985-12-23 Publication of NO852474L publication Critical patent/NO852474L/no

1989-09-25 Publication of NO162467B publication Critical patent/NO162467B/no

1990-01-10 Publication of NO162467C publication Critical patent/NO162467C/no

Links

125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
102000014654 Aromatase Human genes 0.000 abstract 1
108010078554 Aromatase Proteins 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

NO852474A 1984-06-20 1985-06-19 Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazo (1,5)-pyridiner og deres dihydro- og tetrahydroderivater. NO162467C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/622,421 US4617307A (en)	1984-06-20	1984-06-20	Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

Publications (3)

Publication Number	Publication Date
NO852474L true NO852474L (no)	1985-12-23
NO162467B NO162467B (no)	1989-09-25
NO162467C NO162467C (no)	1990-01-10

Family

ID=24494112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO852474A NO162467C (no)	1984-06-20	1985-06-19	Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazo (1,5)-pyridiner og deres dihydro- og tetrahydroderivater.

Country Status (31)

Country	Link
US (1)	US4617307A (no)
EP (1)	EP0165904B1 (no)
JP (1)	JPS6112688A (no)
KR (1)	KR900008566B1 (no)
AT (1)	ATE62415T1 (no)
AU (1)	AU589565B2 (no)
BG (7)	BG60262B1 (no)
CA (1)	CA1276633C (no)
CS (1)	CS268672B2 (no)
CY (1)	CY1750A (no)
DD (1)	DD237510A5 (no)
DE (1)	DE3582452D1 (no)
DK (1)	DK170302B1 (no)
DZ (1)	DZ799A1 (no)
ES (6)	ES8702406A1 (no)
FI (1)	FI80694C (no)
GR (1)	GR851487B (no)
HK (1)	HK23494A (no)
HU (1)	HU202529B (no)
IE (1)	IE58070B1 (no)
IL (1)	IL75546A (no)
MA (1)	MA20459A1 (no)
MX (1)	MX9203369A (no)
NO (1)	NO162467C (no)
NZ (1)	NZ212483A (no)
PH (1)	PH23390A (no)
PL (6)	PL145104B1 (no)
PT (1)	PT80661B (no)
RO (1)	RO92583A (no)
SU (6)	SU1433413A3 (no)
ZA (1)	ZA854615B (no)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4889861A (en) *	1982-12-21	1989-12-26	Ciba-Geigy Corp.	Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
US5428160A (en) *	1982-12-21	1995-06-27	Ciba-Geigy Corporation	Substituted imidazo[5-a]pyridine derviatives and other substituted bicyclic derivatives
US4728645A (en) *	1982-12-21	1988-03-01	Ciba-Geigy Corporation	Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
GB8510541D0 (en) *	1985-04-25	1985-05-30	Wyeth John & Brother Ltd	Heterocyclic compounds
US5171858A (en) *	1985-06-05	1992-12-15	Schering A.G.	Preparation of certain 5,6-dihydro-8-phenyl-imidazo[1,5-a]pyridines
US4978672A (en) *	1986-03-07	1990-12-18	Ciba-Geigy Corporation	Alpha-heterocyclc substituted tolunitriles
US4937250A (en) *	1988-03-07	1990-06-26	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US4749713A (en) *	1986-03-07	1988-06-07	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US4797411A (en) *	1986-07-18	1989-01-10	Farmitalia Carlo Erba S.P.A.	Cycloalkyl-substituted 4-pyridyl derivatives and use as aromatase inhibitors
GB8820730D0 (en) *	1988-09-02	1988-10-05	Erba Carlo Spa	Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
US5057521A (en) *	1988-10-26	1991-10-15	Ciba-Geigy Corporation	Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
CA2026792A1 (en) *	1989-11-01	1991-05-02	Michael N. Greco	(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
US5066656A (en) *	1989-11-01	1991-11-19	Janssen Pharmaceutica N.V.	Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
MTP1076B (en) *	1990-01-12	1991-09-30	Ciba Geigy Ag	Hemihydrate
US5162337A (en) *	1990-10-05	1992-11-10	Merck & Co., Inc.	Animal growth promotion
EP0514015A1 (en) *	1991-04-19	1992-11-19	Merck & Co. Inc.	Control of sex differentiation in fish
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
JPH05176659A (ja) *	1991-04-26	1993-07-20	Merck & Co Inc	家禽における雌性表現型を転換するために抗ミュラー管ホルモンを単独またはアロマターゼ阻害剤と組合せて使用する方法
AU2356195A (en) *	1994-04-14	1995-11-10	Sepracor, Inc.	Treating estrogen-dependent diseases with (-)-fadrozole
CA2150326A1 (en) *	1994-05-27	1995-11-28	Kimihiro Murakami	Azolyl methyl phenyl derivatives having aromatase inhibitory activity
DE4432106A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
ES2276119T3 (es) *	2002-07-30	2007-06-16	Novartis Ag	Combinacion de un inhibidor de aromatasa con un bisfosfonato.
PT1537114E (pt) *	2002-08-07	2006-12-29	Novartis Ag	Compostos orgânicos como agentes para o tratamento de doenças mediadas por aldosterona
ATE398124T1 (de) *	2002-11-18	2008-07-15	Novartis Pharma Gmbh	Imidazoä1,5üa pyridin-derivate und methoden zur behandlung von krankheiten in verbindung mit aldosteron
WO2005007627A1 (ja) *	2003-07-18	2005-01-27	Nihon Nohyaku Co., Ltd.	フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
RU2426532C2 (ru)	2004-03-17	2011-08-20	Новартис Аг	Применение органических соединений
TW200616623A (en) *	2004-05-28	2006-06-01	Speedel Experimenta Ag	Organic compounds
CA2568165A1 (en) *	2004-05-28	2005-12-15	Speedel Experimenta Ag	Heterocyclic compounds and their use as aldosterone synthase inhibitors
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
EP1842543A1 (en)	2006-04-05	2007-10-10	Speedel Pharma AG	Pharmaceutical composition coprising an aldosterone synthase inhibitor and a mineralcorticoid receptor antagonist
KR20090020580A (ko) *	2006-05-26	2009-02-26	노파르티스 아게	알도스테론 신타제 및/또는 11β-히드록실라제 억제제
AR061926A1 (es)	2006-07-20	2008-10-01	Novartis Ag	Compuestos de piperidina, utiles como inhibidores de la proteina de transfe-rencia de esteres de colesterol, composicion farmaceutica y uso
EP2057163A1 (en) *	2006-08-25	2009-05-13	Novartis AG	Fused imidazole derivatives for the treatment of disorders mediated by aldosterone synthase and/or 11-beta-hydroxylase and/or aromatase
WO2008085302A1 (en) *	2006-12-20	2008-07-17	Merck & Co., Inc.	Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
EA022912B1 (ru)	2007-11-05	2016-03-31	Новартис Аг	Производные 4-бензиламино-1-карбоксиацилпиперидина как ингибиторы бпхэ (белка-переносчика холестерилового эфира), применимые для лечения заболеваний, таких как гиперлипидемия или артериосклероз
PT2404901E (pt)	2007-12-03	2013-08-29	Novartis Ag	Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como a hiperlipidemia ou a arteriosclerose
EP2095819A1 (en) *	2008-02-28	2009-09-02	Maastricht University	N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
WO2010136474A2 (en)	2009-05-28	2010-12-02	Novartis Ag	Substituted aminobutyric derivatives as neprilysin inhibitors
ES2523734T3 (es)	2009-05-28	2014-12-01	Novartis Ag	Derivados aminopropiónicos sustituidos como inhibidores de neprilisina
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8673974B2 (en)	2010-11-16	2014-03-18	Novartis Ag	Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en)	2010-11-16	2014-11-04	Novartis Ag	Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
AR086665A1 (es)	2011-06-14	2014-01-15	Lilly Co Eli	Inhibidor de aldosterona sintasa y composiciones farmaceuticas
RU2609200C2 (ru)	2011-07-08	2017-01-30	Новартис Аг	Способ лечения атеросклероза у субъектов с высоким уровнем триглицеридов
CN104039793B (zh) *	2012-01-17	2017-05-10	诺华股份有限公司	二氢吡咯并[1,2‑c]咪唑基醛固酮合成酶或芳香酶抑制剂的形式及盐
UY35144A (es)	2012-11-20	2014-06-30	Novartis Ag	Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
JP6295277B2 (ja)	2013-02-14	2018-03-14	ノバルティスアーゲー	Ｎｅｐ（中性エンドペプチダーゼ）阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体
WO2015013169A2 (en)	2013-07-25	2015-01-29	Novartis Ag	Bioconjugates of synthetic apelin polypeptides
MX2016001020A (es)	2013-07-25	2016-08-03	Novartis Ag	Polipeptidos ciclicos para el tratamiento de insuficiencia cardiaca.
CR20170338A (es)	2015-01-23	2017-09-12	Novartis Ag	Conjugados de ácidos grasos y apelina sintética con mayor vida media
RS61908B1 (sr) *	2015-01-29	2021-06-30	Recordati Ag	Postupak za proizvodnju kondenzovanih imidazolo derivata
GB201511790D0 (en)	2015-07-06	2015-08-19	Iomet Pharma Ltd	Pharmaceutical compound
JP2016074729A (ja) *	2015-12-31	2016-05-12	国立大学法人千葉大学	イミダゾリウム塩及びそれを用いた不斉合成触媒並びにイミダゾリウム塩の製造方法
JOP20190086A1 (ar)	2016-10-21	2019-04-18	Novartis Ag	مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
BR112019007954A2 (pt) *	2016-10-27	2019-07-02	Damian Pharma Ag	inibidor da aldosterona sintase
WO2018078049A1 (en)	2016-10-27	2018-05-03	Damian Pharma Ag	Aldosterone synthase inhibitor
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MX2020011471A (es)	2018-05-03	2020-12-07	Damian Pharma Ag	R-fadrozol para usar en el tratamiento de aldosteronismo.
US20230089867A1 (en)	2018-11-27	2023-03-23	Novartis Ag	Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
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CN113166204A (zh)	2018-11-27	2021-07-23	诺华股份有限公司	作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状肽
WO2023084449A1 (en)	2021-11-12	2023-05-19	Novartis Ag	Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5124517B1 (no) *	1971-03-15	1976-07-24
FR2449689A1 (fr) *	1979-02-20	1980-09-19	Logeais Labor Jacques	Nouveaux derives condenses de pyrrolidine ou de piperidine, leur procede de preparation et leurs applications en therapeutique
US4444775A (en) *	1981-06-22	1984-04-24	Ciba-Geigy Corporation	Substituted imidazo[1,5-A]pyridines
FI75569C (fi) *	1981-06-22	1988-07-11	Ciba Geigy Ag	Analogifoerfarande foer framstaellning av terapeutiskt verkande imidazo/1,5-a/pyridiner.
US4409226A (en) *	1981-10-05	1983-10-11	Schering Corporation	Imidazo[1,5-a]pyridines
US4361567A (en) *	1981-10-05	1982-11-30	Schering Corporation	Treatment of peptic ulcer disease
US4588732A (en) *	1982-12-21	1986-05-13	Ciba-Geigy Corporation	Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
US4470986A (en) *	1982-12-21	1984-09-11	Ciba-Geigy Corporation	Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors

1984
- 1984-06-20 US US06/622,421 patent/US4617307A/en not_active Expired - Lifetime
1985
- 1985-06-17 DE DE8585810279T patent/DE3582452D1/de not_active Expired - Lifetime
- 1985-06-17 FI FI852399A patent/FI80694C/fi not_active IP Right Cessation
- 1985-06-17 EP EP85810279A patent/EP0165904B1/de not_active Expired - Lifetime
- 1985-06-17 AT AT85810279T patent/ATE62415T1/de not_active IP Right Cessation
- 1985-06-18 IL IL75546A patent/IL75546A/xx not_active IP Right Cessation
- 1985-06-18 CA CA000484263A patent/CA1276633C/en not_active Expired - Lifetime
- 1985-06-18 GR GR851487A patent/GR851487B/el unknown
- 1985-06-18 DZ DZ850130A patent/DZ799A1/fr active
- 1985-06-18 CS CS854449A patent/CS268672B2/cs not_active IP Right Cessation
- 1985-06-19 ZA ZA854615A patent/ZA854615B/xx unknown
- 1985-06-19 BG BG070749A patent/BG60262B1/bg unknown
- 1985-06-19 PH PH32427A patent/PH23390A/en unknown
- 1985-06-19 MA MA20686A patent/MA20459A1/fr unknown
- 1985-06-19 ES ES544344A patent/ES8702406A1/es not_active Expired
- 1985-06-19 PT PT80661A patent/PT80661B/pt unknown
- 1985-06-19 NZ NZ212483A patent/NZ212483A/xx unknown
- 1985-06-19 DK DK277685A patent/DK170302B1/da not_active IP Right Cessation
- 1985-06-19 IE IE152085A patent/IE58070B1/en not_active IP Right Cessation
- 1985-06-19 SU SU853917403A patent/SU1433413A3/ru active
- 1985-06-19 KR KR1019850004323A patent/KR900008566B1/ko not_active IP Right Cessation
- 1985-06-19 RO RO85119210A patent/RO92583A/ro unknown
- 1985-06-19 AU AU43857/85A patent/AU589565B2/en not_active Expired
- 1985-06-19 NO NO852474A patent/NO162467C/no unknown
- 1985-06-19 HU HU852417A patent/HU202529B/hu unknown
- 1985-06-20 PL PL1985259306A patent/PL145104B1/pl unknown
- 1985-06-20 PL PL1985259307A patent/PL145105B1/pl unknown
- 1985-06-20 PL PL1985254099A patent/PL145087B1/pl unknown
- 1985-06-20 PL PL1985259304A patent/PL145348B1/pl unknown
- 1985-06-20 PL PL1985259303A patent/PL145103B1/pl unknown
- 1985-06-20 JP JP60133167A patent/JPS6112688A/ja active Granted
- 1985-06-20 PL PL1985259305A patent/PL145814B1/pl unknown
- 1985-06-20 DD DD85277587A patent/DD237510A5/de not_active IP Right Cessation
1986
- 1986-05-30 ES ES555538A patent/ES8802048A1/es not_active Expired
- 1986-05-30 ES ES555541A patent/ES8800681A1/es not_active Expired
- 1986-05-30 ES ES555540A patent/ES8801262A1/es not_active Expired
- 1986-05-30 ES ES555542A patent/ES8802049A1/es not_active Expired
- 1986-05-30 ES ES555539A patent/ES8802155A1/es not_active Expired
- 1986-07-02 SU SU864027754A patent/SU1436878A3/ru active
- 1986-07-02 SU SU864027757A patent/SU1436880A3/ru active
- 1986-07-02 SU SU864027756A patent/SU1482530A3/ru active
- 1986-07-02 SU SU864027758A patent/SU1443802A3/ru active
- 1986-07-02 SU SU864027755A patent/SU1436879A3/ru active
1992
- 1992-06-25 MX MX9203369A patent/MX9203369A/es unknown
- 1992-10-22 BG BG097013A patent/BG60353B2/bg unknown
- 1992-10-22 BG BG097010A patent/BG60306B2/bg unknown
- 1992-10-22 BG BG097011A patent/BG60307B2/xx unknown
- 1992-10-22 BG BG097012A patent/BG60352B2/bg not_active Expired - Lifetime
- 1992-10-22 BG BG097009A patent/BG60305B2/bg unknown
1993
- 1993-11-11 BG BG098213A patent/BG60402B2/bg unknown
1994
- 1994-03-17 HK HK234/94A patent/HK23494A/xx not_active IP Right Cessation
- 1994-06-03 CY CY175094A patent/CY1750A/xx unknown

Also Published As

Publication number	Publication date
DK277685D0 (da)	1985-06-19
EP0165904A3 (en)	1987-09-09
ES555538A0 (es)	1988-03-16
SU1436879A3 (ru)	1988-11-07
FI852399L (fi)	1985-12-21
NZ212483A (en)	1988-10-28
BG60352B2 (bg)	1994-11-30
SU1433413A3 (ru)	1988-10-23
SU1436878A3 (ru)	1988-11-07
CA1276633C (en)	1990-11-20
ES544344A0 (es)	1987-01-01
DK277685A (da)	1985-12-21
BG60307B2 (en)	1994-07-25
PL254099A1 (en)	1986-09-09
PL145105B1 (en)	1988-08-31
PT80661A (en)	1985-07-01
IL75546A0 (en)	1985-10-31
PL145103B1 (en)	1988-08-31
HK23494A (en)	1994-03-25
ES8802048A1 (es)	1988-03-16
ES8801262A1 (es)	1987-12-16
IE851520L (en)	1985-12-20
AU589565B2 (en)	1989-10-19
GR851487B (no)	1985-11-25
ATE62415T1 (de)	1991-04-15
JPS6112688A (ja)	1986-01-21
PL145104B1 (en)	1988-08-31
BG60305B2 (bg)	1994-07-25
ES8802155A1 (es)	1988-04-01
US4617307A (en)	1986-10-14
BG60262B2 (en)	1994-03-31
ES555541A0 (es)	1987-11-16
ES8702406A1 (es)	1987-01-01
BG60306B2 (bg)	1994-07-25
HUT37936A (en)	1986-03-28
DZ799A1 (fr)	2004-09-13
DD237510A5 (de)	1986-07-16
JPH047746B2 (no)	1992-02-12
FI80694C (fi)	1990-07-10
CY1750A (en)	1994-06-03
ZA854615B (en)	1986-02-26
MA20459A1 (fr)	1985-12-31
SU1482530A3 (ru)	1989-05-23
DE3582452D1 (de)	1991-05-16
BG60353B2 (bg)	1994-11-30
CS268672B2 (en)	1990-04-11
AU4385785A (en)	1986-01-02
SU1436880A3 (ru)	1988-11-07
PT80661B (en)	1987-05-04
PL145814B1 (en)	1988-11-30
EP0165904A2 (de)	1985-12-27
NO162467B (no)	1989-09-25
RO92583A (ro)	1987-11-30
EP0165904B1 (de)	1991-04-10
BG60262B1 (bg)	1994-03-31
ES555539A0 (es)	1988-04-01
PL145087B1 (en)	1988-08-31
SU1443802A3 (ru)	1988-12-07
BG60402B2 (bg)	1995-02-28
PL145348B1 (en)	1988-09-30
FI852399A0 (fi)	1985-06-17
KR900008566B1 (ko)	1990-11-24
CS444985A2 (en)	1989-07-12
ES8800681A1 (es)	1987-11-16
PH23390A (en)	1989-07-26
ES555542A0 (es)	1988-03-16
MX9203369A (es)	1992-09-01
HU202529B (en)	1991-03-28
IE58070B1 (en)	1993-06-30
DK170302B1 (da)	1995-07-31
NO162467C (no)	1990-01-10
IL75546A (en)	1990-01-18
FI80694B (fi)	1990-03-30
ES8802049A1 (es)	1988-03-16
ES555540A0 (es)	1987-12-16
KR860000299A (ko)	1986-01-27

Publication	Publication Date	Title
NO852474L (no)	1985-12-23	Substituerte bicykliske fobindelser.
DK0471236T3 (da)	1995-07-24	Imidazopyridinderivater og deres anvendelse
LU88289I2 (fr)	1994-05-04	Methylprednisolonaceponate (Advantan)
DK158087D0 (da)	1987-03-27	Hidtil ukendte benzothiazinderivater og sammensaetning indeholdende samme
NZ217418A (en)	1988-11-29	Tricyclic heterocyclic compounds and pharmaceutical compositions
FI852959L (fi)	1986-02-02	Kvaevehaltiga heterocykliska foereningar.
NZ212658A (en)	1988-02-29	Phenylnaphthyridine derivatives and pharmaceutical compositions
DK316986A (da)	1987-01-06	Kemiske forbindelser, som er phosphodiesterase type iii inhibitorer
SE7909980L (sv)	1980-06-14	I-amino-indolin-derivat, deras framstellning och farmaceutiska kompositioner innehallande desamma
PH22441A (en)	1988-09-12	Quinate salts of the antimaterial compound mefloquine