IL75546A - Pharmaceutical aromatase-inhibiting compositions containing phenyl-substituted imidazo(1,5-a)pyridine and imidazo(1,5-a)azacycloalkane derivatives,certain such derivatives and their preparation - Google Patents

Pharmaceutical aromatase-inhibiting compositions containing phenyl-substituted imidazo(1,5-a)pyridine and imidazo(1,5-a)azacycloalkane derivatives,certain such derivatives and their preparation

Info

Publication number: IL75546A
Authority: IL; Israel
Prior art keywords: derivatives; imidazo; preparation; compositions containing; aromatase
Prior art date: 1984-06-20

Application number

IL75546A

Other languages

English (en)

Other versions

IL75546A0 (en

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-20

Filing date

1985-06-18

Publication date

1990-01-18

1985-06-18 Application filed by Ciba Geigy filed Critical Ciba Geigy

1985-10-31 Publication of IL75546A0 publication Critical patent/IL75546A0/xx

1990-01-18 Publication of IL75546A publication Critical patent/IL75546A/xx

Links

102000014654 Aromatase Human genes 0.000 title abstract 2
108010078554 Aromatase Proteins 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
150000003976 azacycloalkanes Chemical class 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
-1 phenyl-substituted imidazo(1,5-a)pyridine Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IL75546A 1984-06-20 1985-06-18 Pharmaceutical aromatase-inhibiting compositions containing phenyl-substituted imidazo(1,5-a)pyridine and imidazo(1,5-a)azacycloalkane derivatives,certain such derivatives and their preparation IL75546A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/622,421 US4617307A (en)	1984-06-20	1984-06-20	Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

Publications (2)

Publication Number	Publication Date
IL75546A0 IL75546A0 (en)	1985-10-31
IL75546A true IL75546A (en)	1990-01-18

Family

ID=24494112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL75546A IL75546A (en)	1984-06-20	1985-06-18	Pharmaceutical aromatase-inhibiting compositions containing phenyl-substituted imidazo(1,5-a)pyridine and imidazo(1,5-a)azacycloalkane derivatives,certain such derivatives and their preparation

Country Status (31)

Country	Link
US (1)	US4617307A (no)
EP (1)	EP0165904B1 (no)
JP (1)	JPS6112688A (no)
KR (1)	KR900008566B1 (no)
AT (1)	ATE62415T1 (no)
AU (1)	AU589565B2 (no)
BG (7)	BG60262B2 (no)
CA (1)	CA1276633C (no)
CS (1)	CS268672B2 (no)
CY (1)	CY1750A (no)
DD (1)	DD237510A5 (no)
DE (1)	DE3582452D1 (no)
DK (1)	DK170302B1 (no)
DZ (1)	DZ799A1 (no)
ES (6)	ES8702406A1 (no)
FI (1)	FI80694C (no)
GR (1)	GR851487B (no)
HK (1)	HK23494A (no)
HU (1)	HU202529B (no)
IE (1)	IE58070B1 (no)
IL (1)	IL75546A (no)
MA (1)	MA20459A1 (no)
MX (1)	MX9203369A (no)
NO (1)	NO162467C (no)
NZ (1)	NZ212483A (no)
PH (1)	PH23390A (no)
PL (6)	PL145103B1 (no)
PT (1)	PT80661B (no)
RO (1)	RO92583A (no)
SU (6)	SU1433413A3 (no)
ZA (1)	ZA854615B (no)

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US5171858A (en) *	1985-06-05	1992-12-15	Schering A.G.	Preparation of certain 5,6-dihydro-8-phenyl-imidazo[1,5-a]pyridines
US4749713A (en) *	1986-03-07	1988-06-07	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US4978672A (en) *	1986-03-07	1990-12-18	Ciba-Geigy Corporation	Alpha-heterocyclc substituted tolunitriles
US4937250A (en) *	1988-03-07	1990-06-26	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
IL83163A (en) *	1986-07-18	1991-06-10	Erba Carlo Spa	Cycloalkyl-substituted 4-pyridyl derivatives,their preparation and pharmaceutical compositions containing them
GB8820730D0 (en) *	1988-09-02	1988-10-05	Erba Carlo Spa	Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
US5057521A (en) *	1988-10-26	1991-10-15	Ciba-Geigy Corporation	Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
CA2026792A1 (en) *	1989-11-01	1991-05-02	Michael N. Greco	(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
US5066656A (en) *	1989-11-01	1991-11-19	Janssen Pharmaceutica N.V.	Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
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EP0684235A1 (en) *	1994-05-27	1995-11-29	Mochida Pharmaceutical Co., Ltd.	Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity
DE4432106A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung
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US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
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GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
EP1842543A1 (en)	2006-04-05	2007-10-10	Speedel Pharma AG	Pharmaceutical composition coprising an aldosterone synthase inhibitor and a mineralcorticoid receptor antagonist
RU2008150752A (ru) *	2006-05-26	2010-07-10	Новартис АГ (CH)	Ингибиторы альдостеронсинтазы и/или 11-гидроксилазы
AU2007276433B2 (en)	2006-07-20	2011-06-16	Novartis Ag	Amino-piperidine derivatives as CETP inhibitors
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PT2229356E (pt)	2007-12-03	2012-01-20	Novartis Ag	Derivados de 4-benzilamino-pirrolidina 1,2-dissubstituídos como inibidores de cetp úteis para o tratamento de doenças tais como hiperlipidemia ou arteriosclerose
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JP2016527249A (ja)	2013-07-25	2016-09-08	ノバルティスアーゲー	合成アペリンポリペプチドのバイオコンジュゲート
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FR2449689A1 (fr) *	1979-02-20	1980-09-19	Logeais Labor Jacques	Nouveaux derives condenses de pyrrolidine ou de piperidine, leur procede de preparation et leurs applications en therapeutique
US4444775A (en) *	1981-06-22	1984-04-24	Ciba-Geigy Corporation	Substituted imidazo[1,5-A]pyridines
CA1250844A (en) *	1981-06-22	1989-03-07	Neville Ford	Substituted imidazo¬1,5-a\|pyridines, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application
US4361567A (en) *	1981-10-05	1982-11-30	Schering Corporation	Treatment of peptic ulcer disease
US4409226A (en) *	1981-10-05	1983-10-11	Schering Corporation	Imidazo[1,5-a]pyridines
US4588732A (en) *	1982-12-21	1986-05-13	Ciba-Geigy Corporation	Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
US4470986A (en) *	1982-12-21	1984-09-11	Ciba-Geigy Corporation	Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors

1984
- 1984-06-20 US US06/622,421 patent/US4617307A/en not_active Expired - Lifetime
1985
- 1985-06-17 DE DE8585810279T patent/DE3582452D1/de not_active Expired - Lifetime
- 1985-06-17 AT AT85810279T patent/ATE62415T1/de not_active IP Right Cessation
- 1985-06-17 FI FI852399A patent/FI80694C/fi not_active IP Right Cessation
- 1985-06-17 EP EP85810279A patent/EP0165904B1/de not_active Expired - Lifetime
- 1985-06-18 IL IL75546A patent/IL75546A/xx not_active IP Right Cessation
- 1985-06-18 DZ DZ850130A patent/DZ799A1/fr active
- 1985-06-18 GR GR851487A patent/GR851487B/el unknown
- 1985-06-18 CA CA000484263A patent/CA1276633C/en not_active Expired - Lifetime
- 1985-06-18 CS CS854449A patent/CS268672B2/cs not_active IP Right Cessation
- 1985-06-19 BG BG70749A patent/BG60262B2/xx unknown
- 1985-06-19 HU HU852417A patent/HU202529B/hu unknown
- 1985-06-19 NO NO852474A patent/NO162467C/no unknown
- 1985-06-19 MA MA20686A patent/MA20459A1/fr unknown
- 1985-06-19 AU AU43857/85A patent/AU589565B2/en not_active Expired
- 1985-06-19 PT PT80661A patent/PT80661B/pt unknown
- 1985-06-19 RO RO85119210A patent/RO92583A/ro unknown
- 1985-06-19 ES ES544344A patent/ES8702406A1/es not_active Expired
- 1985-06-19 DK DK277685A patent/DK170302B1/da not_active IP Right Cessation
- 1985-06-19 SU SU853917403A patent/SU1433413A3/ru active
- 1985-06-19 KR KR1019850004323A patent/KR900008566B1/ko not_active IP Right Cessation
- 1985-06-19 ZA ZA854615A patent/ZA854615B/xx unknown
- 1985-06-19 IE IE152085A patent/IE58070B1/en not_active IP Right Cessation
- 1985-06-19 PH PH32427A patent/PH23390A/en unknown
- 1985-06-19 NZ NZ212483A patent/NZ212483A/xx unknown
- 1985-06-20 PL PL1985259303A patent/PL145103B1/pl unknown
- 1985-06-20 PL PL1985259306A patent/PL145104B1/pl unknown
- 1985-06-20 PL PL1985259305A patent/PL145814B1/pl unknown
- 1985-06-20 DD DD85277587A patent/DD237510A5/de not_active IP Right Cessation
- 1985-06-20 PL PL1985259307A patent/PL145105B1/pl unknown
- 1985-06-20 PL PL1985254099A patent/PL145087B1/pl unknown
- 1985-06-20 PL PL1985259304A patent/PL145348B1/pl unknown
- 1985-06-20 JP JP60133167A patent/JPS6112688A/ja active Granted
1986
- 1986-05-30 ES ES555539A patent/ES8802155A1/es not_active Expired
- 1986-05-30 ES ES555542A patent/ES8802049A1/es not_active Expired
- 1986-05-30 ES ES555541A patent/ES8800681A1/es not_active Expired
- 1986-05-30 ES ES555540A patent/ES8801262A1/es not_active Expired
- 1986-05-30 ES ES555538A patent/ES8802048A1/es not_active Expired
- 1986-07-02 SU SU864027756A patent/SU1482530A3/ru active
- 1986-07-02 SU SU864027754A patent/SU1436878A3/ru active
- 1986-07-02 SU SU864027758A patent/SU1443802A3/ru active
- 1986-07-02 SU SU864027757A patent/SU1436880A3/ru active
- 1986-07-02 SU SU864027755A patent/SU1436879A3/ru active
1992
- 1992-06-25 MX MX9203369A patent/MX9203369A/es unknown
- 1992-10-22 BG BG097012A patent/BG60352B2/bg not_active Expired - Lifetime
- 1992-10-22 BG BG097010A patent/BG60306B2/bg unknown
- 1992-10-22 BG BG097011A patent/BG60307B2/xx unknown
- 1992-10-22 BG BG097013A patent/BG60353B2/bg unknown
- 1992-10-22 BG BG097009A patent/BG60305B2/bg unknown
1993
- 1993-11-11 BG BG098213A patent/BG60402B2/bg unknown
1994
- 1994-03-17 HK HK234/94A patent/HK23494A/xx not_active IP Right Cessation
- 1994-06-03 CY CY175094A patent/CY1750A/xx unknown

Also Published As

Publication number	Publication date
DK170302B1 (da)	1995-07-31
MA20459A1 (fr)	1985-12-31
US4617307A (en)	1986-10-14
FI80694B (fi)	1990-03-30
ES555538A0 (es)	1988-03-16
PL145103B1 (en)	1988-08-31
SU1482530A3 (ru)	1989-05-23
DE3582452D1 (de)	1991-05-16
DK277685A (da)	1985-12-21
SU1443802A3 (ru)	1988-12-07
CS444985A2 (en)	1989-07-12
KR860000299A (ko)	1986-01-27
PL145105B1 (en)	1988-08-31
PL145814B1 (en)	1988-11-30
BG60402B2 (bg)	1995-02-28
DZ799A1 (fr)	2004-09-13
EP0165904A3 (en)	1987-09-09
NZ212483A (en)	1988-10-28
ES555539A0 (es)	1988-04-01
CA1276633C (en)	1990-11-20
DD237510A5 (de)	1986-07-16
KR900008566B1 (ko)	1990-11-24
ES8800681A1 (es)	1987-11-16
FI852399L (fi)	1985-12-21
IE851520L (en)	1985-12-20
BG60307B2 (en)	1994-07-25
JPS6112688A (ja)	1986-01-21
SU1436880A3 (ru)	1988-11-07
HUT37936A (en)	1986-03-28
SU1433413A3 (ru)	1988-10-23
BG60352B2 (bg)	1994-11-30
PL254099A1 (en)	1986-09-09
ES8802155A1 (es)	1988-04-01
EP0165904B1 (de)	1991-04-10
ES8802049A1 (es)	1988-03-16
EP0165904A2 (de)	1985-12-27
IE58070B1 (en)	1993-06-30
BG60262B1 (bg)	1994-03-31
NO852474L (no)	1985-12-23
MX9203369A (es)	1992-09-01
PL145348B1 (en)	1988-09-30
ATE62415T1 (de)	1991-04-15
JPH047746B2 (no)	1992-02-12
BG60306B2 (bg)	1994-07-25
ES555540A0 (es)	1987-12-16
ES8801262A1 (es)	1987-12-16
GR851487B (no)	1985-11-25
PL145087B1 (en)	1988-08-31
FI852399A0 (fi)	1985-06-17
CS268672B2 (en)	1990-04-11
BG60305B2 (bg)	1994-07-25
DK277685D0 (da)	1985-06-19
ES555541A0 (es)	1987-11-16
ES8702406A1 (es)	1987-01-01
PL145104B1 (en)	1988-08-31
BG60262B2 (en)	1994-03-31
NO162467C (no)	1990-01-10
FI80694C (fi)	1990-07-10
PT80661A (en)	1985-07-01
ES8802048A1 (es)	1988-03-16
ZA854615B (en)	1986-02-26
IL75546A0 (en)	1985-10-31
PH23390A (en)	1989-07-26
HK23494A (en)	1994-03-25
SU1436878A3 (ru)	1988-11-07
RO92583A (ro)	1987-11-30
HU202529B (en)	1991-03-28
SU1436879A3 (ru)	1988-11-07
NO162467B (no)	1989-09-25
CY1750A (en)	1994-06-03
ES555542A0 (es)	1988-03-16
AU4385785A (en)	1986-01-02
BG60353B2 (bg)	1994-11-30
PT80661B (en)	1987-05-04
ES544344A0 (es)	1987-01-01
AU589565B2 (en)	1989-10-19

Legal Events

Date	Code	Title
1998-02-08	HC	Change of name of proprietor(s)
1999-11-30	KB	Patent renewed
2003-07-31	KB	Patent renewed
2005-09-25	EXP	Patent expired

Publication	Publication Date	Title
IL75546A (en)	1990-01-18	Pharmaceutical aromatase-inhibiting compositions containing phenyl-substituted imidazo(1,5-a)pyridine and imidazo(1,5-a)azacycloalkane derivatives,certain such derivatives and their preparation
IL70077A0 (en)	1984-01-31	Beta-carboline derivatives and pharmaceutical compositions containing the same
DK158087D0 (da)	1987-03-27	Hidtil ukendte benzothiazinderivater og sammensaetning indeholdende samme
NZ217650A (en)	1989-09-27	Quinoline derivatives and pharmaceutical compositions
AU4566285A (en)	1986-02-06	Nitrogen containing heterocyclic compounds
DE3161553D1 (en)	1984-01-05	Thiazolo(3,2-a)pyrimidine derivatives, their preparation and pharmaceutical compositions containing them