ES8802155A1 - Procedimiento para preparar derivados de imidazo(1,5-a)piridina - Google Patents

Procedimiento para preparar derivados de imidazo(1,5-a)piridina

Info

Publication number
ES8802155A1
ES8802155A1 ES555539A ES555539A ES8802155A1 ES 8802155 A1 ES8802155 A1 ES 8802155A1 ES 555539 A ES555539 A ES 555539A ES 555539 A ES555539 A ES 555539A ES 8802155 A1 ES8802155 A1 ES 8802155A1
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ES
Spain
Prior art keywords
alkyl
compounds
formula
stereoisomers
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555539A
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English (en)
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ES555539A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8802155A1 publication Critical patent/ES8802155A1/es
Publication of ES555539A0 publication Critical patent/ES555539A0/es
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

LOS DERIVADOS DE IMIDAZO-1,5-A PIRIDINA (I), DONDE NO EXCLUSIVAMENTE N ES 1, 2 O 3, R1 CIANO O NITRO Y R2 ALQUILO C1-4 O FENIL-ALQUILO C1-4; SE OBTIENEN POR REACCION DE UN COMPUESTO (II), DONDE R0 UN GRUPO NH-PROTECTOR O HIDROGENO Y X2 GRUPO SALIENTE, CON UNA BASE, ENTRE C20 Y 200J Y OPCIONALMENTE OBTENER UNA SAL DEL MISMO O RESOLVER LA MEZCLA DE ENATROMEROS. SON INHIBIDORES DE AROMATASAS POR LO QUE SE EMPLEAN PARA EL TRATAMIENTO DE ENFERMEDADES HORMONALES, P.EJ. TUMORES DEPENDIENTES DE ESTROGENOS (CARCINOMA DE MAMA) Y ANORMALIDADES COMO LA GINECOMASTIA.
ES555539A 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina Expired ES8802155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/622,421 US4617307A (en) 1984-06-20 1984-06-20 Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

Publications (2)

Publication Number Publication Date
ES8802155A1 true ES8802155A1 (es) 1988-04-01
ES555539A0 ES555539A0 (es) 1988-04-01

Family

ID=24494112

Family Applications (6)

Application Number Title Priority Date Filing Date
ES544344A Expired ES8702406A1 (es) 1984-06-20 1985-06-19 Procedimiento para preparar derivados de imidazo (1,5-a) pi-ridina
ES555538A Expired ES8802048A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina
ES555541A Expired ES8800681A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina
ES555540A Expired ES8801262A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidiazo (5,5-a) piridina.
ES555542A Expired ES8802049A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina
ES555539A Expired ES8802155A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES544344A Expired ES8702406A1 (es) 1984-06-20 1985-06-19 Procedimiento para preparar derivados de imidazo (1,5-a) pi-ridina
ES555538A Expired ES8802048A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina
ES555541A Expired ES8800681A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina
ES555540A Expired ES8801262A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidiazo (5,5-a) piridina.
ES555542A Expired ES8802049A1 (es) 1984-06-20 1986-05-30 Procedimiento para preparar derivados de imidazo(1,5-a)piridina

Country Status (31)

Country Link
US (1) US4617307A (es)
EP (1) EP0165904B1 (es)
JP (1) JPS6112688A (es)
KR (1) KR900008566B1 (es)
AT (1) ATE62415T1 (es)
AU (1) AU589565B2 (es)
BG (7) BG60262B1 (es)
CA (1) CA1276633C (es)
CS (1) CS268672B2 (es)
CY (1) CY1750A (es)
DD (1) DD237510A5 (es)
DE (1) DE3582452D1 (es)
DK (1) DK170302B1 (es)
DZ (1) DZ799A1 (es)
ES (6) ES8702406A1 (es)
FI (1) FI80694C (es)
GR (1) GR851487B (es)
HK (1) HK23494A (es)
HU (1) HU202529B (es)
IE (1) IE58070B1 (es)
IL (1) IL75546A (es)
MA (1) MA20459A1 (es)
MX (1) MX9203369A (es)
NO (1) NO162467C (es)
NZ (1) NZ212483A (es)
PH (1) PH23390A (es)
PL (6) PL145104B1 (es)
PT (1) PT80661B (es)
RO (1) RO92583A (es)
SU (6) SU1433413A3 (es)
ZA (1) ZA854615B (es)

Families Citing this family (66)

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US5428160A (en) * 1982-12-21 1995-06-27 Ciba-Geigy Corporation Substituted imidazo[5-a]pyridine derviatives and other substituted bicyclic derivatives
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US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
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US4797411A (en) * 1986-07-18 1989-01-10 Farmitalia Carlo Erba S.P.A. Cycloalkyl-substituted 4-pyridyl derivatives and use as aromatase inhibitors
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