JP2002500667A - 人間の患者に対して経口的にタキサン類を投薬するための方法及び組成物 - Google Patents
人間の患者に対して経口的にタキサン類を投薬するための方法及び組成物Info
- Publication number
- JP2002500667A JP2002500667A JP50066399A JP50066399A JP2002500667A JP 2002500667 A JP2002500667 A JP 2002500667A JP 50066399 A JP50066399 A JP 50066399A JP 50066399 A JP50066399 A JP 50066399A JP 2002500667 A JP2002500667 A JP 2002500667A
- Authority
- JP
- Japan
- Prior art keywords
- taxane
- paclitaxel
- administered
- cyclosporin
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.タキサン応答性のある疾患状態にかかった人間の患者に対するタキサンの 経口投与であって、前記タキサンが、前記の状態を治療するのに有効な量にて投 与されることを特徴とする、タキサン応答性のある疾患状態にかかった人間の患 者に対するタキサンの経口投与。 2.パクリタクセル応答性のある疾患状態にかかった人間の患者に対するパク リタクセルの経口投与であって、前記パクリタクセルが、前記の状態を治療する のに有効な量にて投与されることを特徴とする、パクリタクセル応答性のある疾 患状態にかかった人間の患者に対するパクリタクセルの経口投与。 3.ドセタクセル応答性のある疾患状態にかかった人間の患者に対するドセタ クセルの経口投与であって、前記ドセタクセルが、前記の状態を治療するのに有 効な量にて投与されることを特徴とする、ドセタクセル応答性のある疾患状態に かかった人間の患者に対するドセタクセルの経口投与。 4.パクリタクセル又はドセタクセルの誘導体、類似物又はプロドラッグに対 して応答性のある疾患状態を治療するための、人間の患者への前記誘導体、類似 物又はプロドラッグの経口投与であって、前記誘導体、類似物又はプロドラッグ が、前記の状態を治療するのに効果的な量にて投与されることを特徴とする、人 間の患者への、パクリタクセル又はドセタクセルの誘導体、類似物又はプロドラ ッグの経口投与。 5.前記プロドラッグが、パクリタクセル−2’−MPM又はドセタクセル− 2’−MPMであることを特徴とする請求項4記載の、パクリタクセル又はドセ タクセルのプロドラッグの経口投与。 6.パクリタクセルの前記有効量が、患者の体重に基づいて約2〜30mg/ kgであることを特徴とする請求項2に記載の経口投与。 7.前記有効量が約2〜6mg/kgであることを特徴とする請求項6に記載 の経口投与。 8.パクリタクセルの前記有効量が、患者の身体の表面積に基づいて約20〜 1000mg/m2であることを特徴とする請求項2に記載の経口投与。 9.前記有効量が約50〜200mg/m2であることを特徴とする請求項8 に記載の経口投与。 10.経口的に投与されるタキサンを、タキサン応答性のある疾患状態を治療す るの充分なレベルで人間の患者に対して生物学的利用可能なものとする方法であ って、前記方法が、サイクロスポリンAないしZ、(Me−lle−4)−サイ クロスポリン、ジヒドロサイクロスポリンA、ジヒドロサイクロスポリンC、ア セチルサイクロスポリンAから成るグループより選ばれた経口生体利用率向上剤 の有効量と共に、疾患を治療するのに有効な量のタキサンを前記患者に対して経 口共投与することを含むことを特徴とする、経口的に投与されるタキサンを、人 間の患者に対して生物学的利用可能なものとする方法。 11.前記タキサンがパクリタクセルであることを特徴とする請求項10に記載 の方法。 12.前記タキサンがドセタクセルであることを特徴とする請求項10に記載の 方法。 13.前記タキサンが、パクリタクセル又はドセタクセルの誘導体、類似物又は プロドラッグであることを特徴とする請求項10に記載の方法。 14.前記タキサンが、プロドラッグであるパクリタクセル−2’−MPM又は プロドラッグであるドセタクセル−2’−MPMであることを特徴とする請求項 13に記載の方法。 15.前記の生体利用率向上剤が、サイクロスポリンA、サイクロスポリンC、 サイクロスポリンD、サイクロスポリンF、ジヒドロサイクロスポリンA、ジヒ ドロサイクロスポリンC及びアセチルサイクロスポリンAから成るグループより 選ばれたものであることを特徴とする請求項10に記載の方法。 16.約0.1〜約20mg/kgの前記向上剤が、患者の体重に基づいて投与 されることを特徴とする請求項15に記載の方法。 17.約5mg/kgの前記向上剤が投与されることを特徴とする請求項16に 記載の方法。 18.パクリタクセルの前記有効量が、患者の体重に基づいて約2〜30mg/ kgであることを特徴とする請求項11に記載の方法。 19.前記有効量が約2〜6mg/kgであることを特徴とする請求項18に記 載の方法。 20.パクリタクセルの前記有効量が、患者の身体の表面積に基づいて約20〜 1000mg/m2であることを特徴とする請求項11に記載の方法。 21.前記有効量が約50〜200mg/m2であることを特徴とする請求項2 0に記載の方法。 22.約2〜30mg/kg又は約20〜1000mg/m2のパクリタクセル が、約0.1〜20mg/kgのサイクロスポリンAと共に、前記患者に対して 共投与されることを特徴とする請求項10に記載の方法。 23.前記向上剤が、 a)前記タキサン投与の約0.5〜72時間前、 b)前記タキサン投与の0.5時間以内前、前記タキサン投与と一緒に、 又は前記タキサン投与の0.5時間以内後、又は c)前記タキサン投与の約0.5〜72時間前と、再び、0.5時間以内 前、一緒に、又は0.5時間以内後の両方、 のいずれかで投与されることを特徴とする請求項10に記載の方法。 24.前記タキサンがパクリタクセルであり、しかも前記向上剤がサイクロスポ リンAであることを特徴とする請求項23に記載の方法。 25.前記タキサンと前記向上剤がそれぞれ、個別の経口投薬形態にて投与され ることを特徴とする請求項10に記載の方法。 26.前記タキサンと前記向上剤が、混合型経口投薬形態にて一緒に投与される ことを特徴とする請求項10に記載の方法。 27.タキサン応答性のある疾患状態にかかった人間の患者を治療するための方 法であって、前記方法が、疾患を治療するのに有効な量のタキサンを前記患者に 対して経口共投与することを含むことを特徴とする、タキサン応答性のある疾患 状態にかかった人間の患者の治療方法。 28.前記タキサンがパクリタクセルであることを特徴とする請求項27に記載 の方法。 29.前記タキサンがドセタクセルであることを特徴とする請求項27に記載の 方法。 30.前記タキサンが、パクリタクセル又はドセタクセルの誘導体、類似物又は プロドラッグであることを特徴とする請求項27に記載の方法。 31.前記タキサンが、パクリタクセル−2’−MPM又はドセタクセル−2’ −MPMから成るグループより選ばれたプロドラッグであることを特徴とする請 求項30に記載の方法。 32.パクリタクセルの前記有効量が、患者の体重に基づいて約2〜30mg/ kgであることを特徴とする請求項28に記載の方法。 33.前記有効量が約2〜6mg/kgであることを特徴とする請求項32に記 載の方法。 34.パクリタクセルの前記有効量が、患者の身体の表面積に基づいて約20〜 1000mg/m2であることを特徴とする請求項28に記載の方法。 35.前記有効量が約50〜200mg/m2であることを特徴とする請求項3 4に記載の方法。 36.サイクロスポリンAないしZ、(Me−lle−4)−サイクロスポリン 、ジヒドロサイクロスポリンA、ジヒドロサイクロスポリンC及びアセチルサイ クロスポリンAから成るグループより選ばれた経口生体利用率向上剤の有効量と 共に、前記患者に対して前記タキサンが共投与されることを特徴とする請求項2 7に記載の方法。 37.前記の生体利用率向上剤が、サイクロスポリンA、サイクロスポリンC、 サイクロスポリンD、サイクロスポリンF、ジヒドロサイクロスポリンA、ジヒ ドロサイクロスポリンC及びアセチルサイクロスポリンAから成るグループより 選ばれたものであることを特徴とする請求項36に記載の方法。 38.約0.1〜約20mg/kgの前記向上剤が投与されることを特徴とする 請求項37に記載の方法。 39.約5mg/kgの前記向上剤が投与されることを特徴とする請求項38に 記載の方法。 40.約2〜30mg/kg又は約20〜1000mg/m2のパクリタクセル が、約0.1〜20mg/kgのサイクロスポリンAと共に、前記患者に対して 共投与されることを特徴とする請求項27に記載の方法。 41.前記向上剤が、 a)前記タキサン投与の約0.5〜72時間前、 b)前記タキサン投与の0.5時間以内前、前記タキサン投与と一緒に、 又は前記タキサン投与の0.5時間以内後、又は c)前記タキサン投与の約0.5〜72時間前と、再び、0.5時間以内 前、一緒に、又は0.5時間以内後の両方、 のいずれかで投与されることを特徴とする請求項27に記載の方法。 42.前記タキサンがパクリタクセルであり、しかも前記向上剤がサイクロスポ リンAであることを特徴とする請求項41に記載の方法。 43.前記タキサンと前記向上剤がそれぞれ、個別の経口投薬形態にて投与され ることを特徴とする請求項27に記載の方法。 44.前記タキサンと前記向上剤が、混合型経口投薬形態にて一緒に投与される ことを特徴とする請求項27に記載の方法。 45.前記疾患状態が、癌、腫瘍、悪性腫瘍、組織損傷に二次的な無制御組織ま たは細胞性増殖、多嚢胞性腎臓病及びマラリアから成るグループより選ばれたも のであることを特徴とする請求項10、11、27又は28に記載の方法。 46.前記疾患が、肝細胞性癌、肝臓転移、胃腸管、膵臓、前立腺及び肺の癌、 及びカポージ肉腫から成るグループより選ばれた癌であることを特徴とする請求 項45に記載の方法。 47.タキサン応答性のある疾患状態に対するタキサン療法を受けている人間の 患者における過敏症及びアレルギー性反応を防止又は減少させるための方法であ って、前記方法が、前記患者に対してタキサンを経口投与することを含むことを 特徴とする、タキサン応答性のある疾患状態に対するタキサン療法を受けている 人間の患者における過敏症及びアレルギー性反応を防止又は減少させる方法。 48.前記タキサンがパクリタクセルであることを特徴とする請求項47に記載 の方法。 49.前記タキサンがドセタクセルであることを特徴とする請求項47に記載の 方法。 50.前記タキサンが、パクリタクセル又はドセタクセルの誘導体、類似物又は プロドラッグであることを特徴とする請求項47に記載の方法。 51.前記タキサンが、プロドラッグであるパクリタクセル−2’−MPM又は プロドラッグであるドセタクセル−2’−MPMであることを特徴とする請求項 50に記載の方法。 52.前記タキサンが、過敏症又はタキサンに対するアレルギー性反応を防止す るために、投薬の事前投与を行わずに前記患者に投与されることを特徴とする請 求項47に記載の方法。 53.前記タキサンが、サイクロスポリンAないしZ、(Me−lle−4)− サイクロスポリン、ジヒドロサイクロスポリンA、ジヒドロサイクロスポリンC 及びアセチルサイクロスポリンAから成るグループより選ばれた経口生体利用率 向上剤の有効量と共に、経口的に共投与されることを特徴とする請求項47に記 載の方法。 54.前記の生体利用率向上剤が、サイクロスポリンA、サイクロスポリンC、 サイクロスポリンD、サイクロスポリンF、ジヒドロサイクロスポリンA、ジヒ ドロサイクロスポリンC及びアセチルサイクロスポリンAから成るグループより 選ばれたものであることを特徴とする請求項53に記載の方法。 55.前記の生体利用率向上剤がサイクロスポリンAであることを特徴とする請 求項54に記載の方法。
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PCT/US1998/007776 WO1998053811A1 (en) | 1997-05-27 | 1998-04-22 | Method and compositions for administering taxanes orally to human patients |
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JP (1) | JP2002500667A (ja) |
KR (1) | KR100615783B1 (ja) |
CN (2) | CN1261275A (ja) |
AR (1) | AR012731A1 (ja) |
AT (1) | ATE308365T1 (ja) |
AU (1) | AU7130098A (ja) |
BR (1) | BR9809694A (ja) |
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DE (1) | DE69832173T2 (ja) |
DK (1) | DK0994706T3 (ja) |
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GB9718903D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
AU4955200A (en) | 1999-05-17 | 2000-12-05 | Cancer Research Ventures Limited | A method of improving bioavailability of orally administered drugs, a method of screening for enhancers of such bioavailability and novel pharmaceutical compositions for oral delivery of drugs |
JP2003512443A (ja) * | 1999-10-27 | 2003-04-02 | ベーカー ノートン ファーマシューティカルズ インコーポレイテッド | タキサンをヒト患者に経口投与するための方法及び組成物 |
KR20020013174A (ko) * | 2000-08-11 | 2002-02-20 | 민경윤 | 경구 흡수율이 낮은 약물의 흡수율을 증가시키기 위한경구용 조성물 |
JP2004520398A (ja) * | 2001-01-18 | 2004-07-08 | ファルマシア・アンド・アップジョン・カンパニー | 経口生物学的利用能が改善されたパクリタキセルの化学療法マイクロエマルジョン組成物 |
US7115565B2 (en) | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
EP1623706A3 (en) * | 2001-02-28 | 2006-02-22 | Bristol-Myers Squibb Company | Metronomic dosing of taxanes for inhibiting tumor growth |
UY27185A1 (es) * | 2001-02-28 | 2002-09-30 | Bristol Myers Squibb Co | Dosificación metronómica de taxanos |
US7063977B2 (en) | 2001-08-21 | 2006-06-20 | Bristol-Myers Squibb Company | Enzymatic resolution of t-butyl taxane derivatives |
GB0523659D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
EP4059497A1 (en) * | 2021-03-17 | 2022-09-21 | Dompé farmaceutici S.p.a. | C5ar1 inhibitors for treating hypersensitivity reactions to taxanes |
JP2024512472A (ja) * | 2021-03-17 | 2024-03-19 | ドムペ・ファルマチェウティチ・ソチエタ・ペル・アツィオーニ | タキサンに対する過敏性反応を治療するためのc5ar1阻害薬 |
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AU652996B2 (en) * | 1991-01-11 | 1994-09-15 | Laboratoires Glaxo S.A. | Acridine derivatives |
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US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
CA2221444A1 (en) * | 1996-01-31 | 1997-08-07 | Steven B. Hansel | A method of making pharmaceutically active taxanes orally bioavailable |
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GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
KR100661879B1 (ko) * | 1998-04-01 | 2006-12-27 | 스키에파마 캐나다 인코포레이티드 | 항암 조성물 |
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1998
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1999
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2000
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2012528875A (ja) * | 2009-06-02 | 2012-11-15 | ナイカン ファーマシューティカルズ, エルエルシー | 疾患の処置のためのヒトホルミルペプチド受容体の拮抗作用 |
Also Published As
Publication number | Publication date |
---|---|
CA2290446A1 (en) | 1998-12-03 |
DE69832173T2 (de) | 2006-08-03 |
HK1026637A1 (en) | 2000-12-22 |
WO1998053811A1 (en) | 1998-12-03 |
CZ9904244A3 (cs) | 2001-10-17 |
AR012731A1 (es) | 2000-11-08 |
RU2205005C2 (ru) | 2003-05-27 |
EP0994706B1 (en) | 2005-11-02 |
KR100615783B1 (ko) | 2006-08-25 |
DE69832173D1 (de) | 2005-12-08 |
EP0994706A1 (en) | 2000-04-26 |
CN1550231A (zh) | 2004-12-01 |
KR20010013025A (ko) | 2001-02-26 |
IL132992A (en) | 2006-08-20 |
NO995812D0 (no) | 1999-11-26 |
CN1261275A (zh) | 2000-07-26 |
BR9809694A (pt) | 2000-10-03 |
IL132992A0 (en) | 2001-03-19 |
DK0994706T3 (da) | 2006-03-06 |
UA74767C2 (en) | 2006-02-15 |
ES2247690T3 (es) | 2006-03-01 |
SK157599A3 (en) | 2002-10-08 |
ZA984268B (en) | 1999-06-23 |
PL337064A1 (en) | 2000-07-31 |
AU7130098A (en) | 1998-12-30 |
HUP0003546A3 (en) | 2002-12-28 |
NO995812L (no) | 2000-01-25 |
ATE308365T1 (de) | 2005-11-15 |
CA2290446C (en) | 2008-01-29 |
HUP0003546A2 (hu) | 2002-11-28 |
EP0994706A4 (en) | 2001-05-16 |
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