IT1393351B1 - Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi - Google Patents

Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Info

Publication number
IT1393351B1
IT1393351B1 ITMI2009A000397A ITMI20090397A IT1393351B1 IT 1393351 B1 IT1393351 B1 IT 1393351B1 IT MI2009A000397 A ITMI2009A000397 A IT MI2009A000397A IT MI20090397 A ITMI20090397 A IT MI20090397A IT 1393351 B1 IT1393351 B1 IT 1393351B1
Authority
IT
Italy
Prior art keywords
naftamide
metossichinolin
methossi
ilossi
aminocyclopropyl
Prior art date
Application number
ITMI2009A000397A
Other languages
English (en)
Inventor
Silvano Spinelli
Valeria Livi
Original Assignee
Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI2009A000397A priority Critical patent/IT1393351B1/it
Application filed by Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa filed Critical Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa
Priority to CN201410380387.8A priority patent/CN104193676B/zh
Priority to PL10712320T priority patent/PL2408739T3/pl
Priority to PT10712320T priority patent/PT2408739E/pt
Priority to EP10712320.0A priority patent/EP2408739B1/en
Priority to CN201080011948.7A priority patent/CN102356063B/zh
Priority to HUE13172499A priority patent/HUE029528T2/en
Priority to JP2012500115A priority patent/JP5817079B2/ja
Priority to EP16171791.3A priority patent/EP3103792A1/en
Priority to CN201610565855.8A priority patent/CN106187882A/zh
Priority to ES13172499.9T priority patent/ES2585221T3/es
Priority to PL13172499T priority patent/PL2641897T3/pl
Priority to ES10712320T priority patent/ES2431618T3/es
Priority to DK13172499.9T priority patent/DK2641897T3/en
Priority to SI201030383T priority patent/SI2408739T1/sl
Priority to SI201031256A priority patent/SI2641897T1/sl
Priority to DK10712320.0T priority patent/DK2408739T3/da
Priority to PCT/EP2010/001519 priority patent/WO2010105761A1/en
Priority to US13/256,722 priority patent/US8642767B2/en
Priority to PT131724999T priority patent/PT2641897T/pt
Priority to EP13172499.9A priority patent/EP2641897B1/en
Publication of ITMI20090397A1 publication Critical patent/ITMI20090397A1/it
Application granted granted Critical
Publication of IT1393351B1 publication Critical patent/IT1393351B1/it
Priority to HK12107948.4A priority patent/HK1167136A1/xx
Priority to HRP20130978AT priority patent/HRP20130978T1/hr
Priority to CY20131100907T priority patent/CY1114503T1/el
Priority to US14/138,302 priority patent/US9012645B2/en
Priority to US14/661,105 priority patent/US9340508B2/en
Priority to JP2015104974A priority patent/JP6061158B2/ja
Priority to HK15105438.2A priority patent/HK1205105A1/xx
Priority to CY20161100749T priority patent/CY1117871T1/el
Priority to HRP20161163TT priority patent/HRP20161163T1/hr
Priority to SM201600356T priority patent/SMT201600356B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/44—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ITMI2009A000397A 2009-03-16 2009-03-16 Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi IT1393351B1 (it)

Priority Applications (31)

Application Number Priority Date Filing Date Title
ITMI2009A000397A IT1393351B1 (it) 2009-03-16 2009-03-16 Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi
US13/256,722 US8642767B2 (en) 2009-03-16 2010-03-11 Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
PT10712320T PT2408739E (pt) 2009-03-16 2010-03-11 Um processo para a preparação de 6-(7-((1-aminociclopropil) metoxi)-6-metoxiquinolin-4-iloxi)-n-metil-1-naftamida e seus intermediários sintéticos
PCT/EP2010/001519 WO2010105761A1 (en) 2009-03-16 2010-03-11 A process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide and synthetic intermediates thereof
CN201080011948.7A CN102356063B (zh) 2009-03-16 2010-03-11 制备6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-n-甲基-1-萘甲酰胺的方法及其合成中间体
HUE13172499A HUE029528T2 (en) 2009-03-16 2010-03-11 Process for the preparation of 6- (7 - ((1-aminocyclopropyl) methoxy) -6-methoxyquinolin-4-yloxy) -N-methyl-1-naphthamide and its synthetic intermediates
JP2012500115A JP5817079B2 (ja) 2009-03-16 2010-03-11 ６−（７−（（１−アミノシクロプロピル）メトキシ）−６−メトキシキノリン−４−イルオキシ）−ｎ−メチル−１−ナフトアミド、またはそれの薬学的に許容される塩を調製するための方法
PL10712320T PL2408739T3 (pl) 2009-03-16 2010-03-11 Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksychinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednich
CN201610565855.8A CN106187882A (zh) 2009-03-16 2010-03-11 制备化合物的方法及其合成中间体
ES13172499.9T ES2585221T3 (es) 2009-03-16 2010-03-11 Un proceso para la preparación de 6-(7-((1-aminociclopropil)metoxi)-6-metoxiquinolin-4-iloxi)-n-metil-1-naftamida y productos intermedios sintéticos de la misma
PL13172499T PL2641897T3 (pl) 2009-03-16 2010-03-11 Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksy-chinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednich
ES10712320T ES2431618T3 (es) 2009-03-16 2010-03-11 Un proceso para la preparación de 6-(7-((1-aminociclopropil)metoxi)-6-metoxiquinolin-4-iloxi)-N-metil-1-naftamida y productos intermedios sintéticos de la misma
DK13172499.9T DK2641897T3 (en) 2009-03-16 2010-03-11 A process for the preparation of 6- (7 - ((1-aminocyclopropyl) methoxy) -6-methoxy-quinolin-4-yloxy) -N-methyl-1-naphthamide and synthetic intermediates thereof
PT131724999T PT2641897T (pt) 2009-03-16 2010-03-11 Um processo para a preparação de 6-(7-((1-aminociclopropil) metoxi)-6-metoxiquinolin-4-iloxi)-n-metil-1-naftamida e seus intermediários de síntese
CN201410380387.8A CN104193676B (zh) 2009-03-16 2010-03-11 制备化合物的方法及其合成中间体
DK10712320.0T DK2408739T3 (da) 2009-03-16 2010-03-11 Fremgangsmåde til fremstilling af 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamid og syntetiske mellemprodukter deraf
EP10712320.0A EP2408739B1 (en) 2009-03-16 2010-03-11 A process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide and synthetic intermediates thereof
EP16171791.3A EP3103792A1 (en) 2009-03-16 2010-03-11 Intermediates for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide
SI201030383T SI2408739T1 (sl) 2009-03-16 2010-03-11 Postopek priprave 6-(7-((1-aminociklopropil)metoksi)-6-metoksikinolin- 4-iloksi)-n-metil-1-naftamida in njegovih sintetiäśnih intermediatov
EP13172499.9A EP2641897B1 (en) 2009-03-16 2010-03-11 A process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
SI201031256A SI2641897T1 (sl) 2009-03-16 2010-03-11 Postopek priprave 6-(7-((1-aminociklopropil)metoksi)-6-metoksikinolin-4-iloksi)-n-metil- 1-naftamida in njegovih sintetičnih intermediatov
HK12107948.4A HK1167136A1 (en) 2009-03-16 2012-08-14 A process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6- methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide and synthetic intermediates thereof 6-(7-((1-))-6--4-)-n--1-
HRP20130978AT HRP20130978T1 (hr) 2009-03-16 2013-10-16 Postupak priprave 6-(7-((1-aminociklopropil)metoksi)-6-metoksikinolin-4-iloksi)-n-metil-1-naftamid i odgovarajućih sintetičkih međuprodukata
CY20131100907T CY1114503T1 (el) 2009-03-16 2013-10-16 Μια μεθοδος για την παρασκευη 6-(7-((1-αμινοκυκλοπροπυλο)μεθοξυ)-6-μεθοξυκινολιν-4-υλοξυ)-ν-μεθυλο-1-ναφθαμιδιου και συνθετικες ενδιαμεσες ενωσεις αυτης
US14/138,302 US9012645B2 (en) 2009-03-16 2013-12-23 Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
US14/661,105 US9340508B2 (en) 2009-03-16 2015-03-18 Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
JP2015104974A JP6061158B2 (ja) 2009-03-16 2015-05-22 ６−（７−（（１−アミノシクロプロピル）メトキシ）−６−メトキシキノリン−４−イルオキシ）−ｎ−メチル−１−ナフトアミド、またはそれの薬学的に許容される塩の合成中間体およびその使用
HK15105438.2A HK1205105A1 (en) 2009-03-16 2015-06-08 A process for the preparation of the compound and synthetic intermediates thereof
CY20161100749T CY1117871T1 (el) 2009-03-16 2016-07-29 Μια μεθοδος για την παρασκευη 6-(7-((1-αμινοκυκλοπροπυλ)μεθοξυ)-6-μεθοξυκινολιν-4-υλοξυ)-ν-μεθυλ-1-ναφθαμιδιου και συνθετικων ενδιαμεσων ενωσεων αυτου
HRP20161163TT HRP20161163T1 (hr) 2009-03-16 2016-09-12 Postupak priprave 6-(7-((1-aminociklopropil)metoksi)-6-metoksikinolin-4-iloksi)-n-metil-1-naftamida i njegovih sintetičkih međuprodukata
SM201600356T SMT201600356B (it) 2009-03-16 2016-10-06 Procedimento per la preparazione della 6-(7-((1- amminociclopropil))metossi)-6- metossichinolin-4-ilossi)-n-metil-1- naftammide e suoi intermedi di sintesi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A000397A IT1393351B1 (it) 2009-03-16 2009-03-16 Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Publications (2)

Publication Number Publication Date
ITMI20090397A1 ITMI20090397A1 (it) 2010-09-17
IT1393351B1 true IT1393351B1 (it) 2012-04-20

Family

ID=41210541

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2009A000397A IT1393351B1 (it) 2009-03-16 2009-03-16 Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Country Status (16)

Country Link
US (3) US8642767B2 (it)
EP (3) EP2408739B1 (it)
JP (2) JP5817079B2 (it)
CN (3) CN102356063B (it)
CY (2) CY1114503T1 (it)
DK (2) DK2641897T3 (it)
ES (2) ES2431618T3 (it)
HK (2) HK1167136A1 (it)
HR (2) HRP20130978T1 (it)
HU (1) HUE029528T2 (it)
IT (1) IT1393351B1 (it)
PL (2) PL2641897T3 (it)
PT (2) PT2641897T (it)
SI (2) SI2641897T1 (it)
SM (1) SMT201600356B (it)
WO (1) WO2010105761A1 (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1393351B1 (it) 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi
EA201591205A1 (ru) * 2013-01-18 2015-12-30 Адвенчен Фармасьютикалс, Ллс Способ получения противоопухолевого агента 6-(7-((1-аминоциклопропил)-метокси)-6-метоксихинолин-4-илокси)-n-метил-1-нафтамида и его кристаллической структуры
CN105311029A (zh) 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
CN105311030B (zh) 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
CA2954999C (en) 2014-07-14 2020-01-07 Advenchen Pharmaceuticals, Nanjing Ltd. Fused quinoline compounds as pi3k, mtor inhibitors
EP3231797B1 (en) 2014-12-09 2020-02-26 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative against non-small cell lung cancer
US9751859B2 (en) 2015-05-04 2017-09-05 Advenchen Pharmaceuticals, LLC Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
AU2016293841B2 (en) 2015-07-11 2020-10-08 Advenchen Pharmaceuticals, LLC Fused quinoline compunds as pi3k/mTor inhibitors
CA3000988A1 (en) 2015-10-05 2017-04-13 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
CN107296811B (zh) 2016-04-15 2022-12-30 正大天晴药业集团股份有限公司 一种用于治疗胃癌的喹啉衍生物
CN109748902B (zh) * 2017-11-02 2020-11-06 杭州科巢生物科技有限公司 一种盐酸安罗替尼的制备方法
AU2019227391B2 (en) 2018-03-02 2024-06-13 Advenchen Laboratories Nanjing Ltd. Crystal of compound as c-Met kinase inhibitor and preparation method therefor and use thereof
EP3762379A1 (en) 2018-03-07 2021-01-13 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
CN110483392A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 合成n-保护的喹啉-7-基氧基甲基环丙基胺衍生物的方法及合成中间体
CN110483393A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 德立替尼的晶型
CN116444489A (zh) * 2018-12-29 2023-07-18 正大天晴药业集团股份有限公司 喹啉衍生物及其制备方法和用途
CN115160221B (zh) * 2022-07-26 2024-10-18 恩祺生物科技(上海)有限公司 德立替尼晶型化合物和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716689B2 (en) * 1996-12-23 2000-03-02 Aventis Pharmaceuticals Inc. 3-aryl-2-(1-substituted-4-piperidinyl)-1(1-DI)oxo-3H-benzo {D}-isothiazole derivatives, their preparation and their use as modulators of neurotransmitter function
MXPA01008182A (es) * 1999-02-10 2003-08-20 Astrazeneca Ab Derivados de quinazolina como inhibidores de angiotensina.
AU2003257666A1 (en) * 2002-08-23 2004-03-11 Kirin Beer Kabushiki Kaisha COMPOUND HAVING TGFss INHIBITORY ACTIVITY AND MEDICINAL COMPOSITION CONTAINING THE SAME
EP1699780A1 (en) * 2003-12-23 2006-09-13 Pfizer, Inc. Novel quinoline derivatives
US8163923B2 (en) * 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
IT1393351B1 (it) 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Also Published As

Publication number Publication date
CN106187882A (zh) 2016-12-07
US9340508B2 (en) 2016-05-17
DK2408739T3 (da) 2013-11-04
CY1114503T1 (el) 2016-10-05
JP5817079B2 (ja) 2015-11-18
SI2408739T1 (sl) 2013-11-29
EP3103792A1 (en) 2016-12-14
US20140114075A1 (en) 2014-04-24
WO2010105761A1 (en) 2010-09-23
HK1205105A1 (en) 2015-12-11
HUE029528T2 (en) 2017-03-28
EP2641897B1 (en) 2016-07-13
EP2408739A1 (en) 2012-01-25
US20120010415A1 (en) 2012-01-12
ITMI20090397A1 (it) 2010-09-17
HK1167136A1 (en) 2012-11-23
CN104193676B (zh) 2016-08-17
CN104193676A8 (zh) 2016-08-17
DK2641897T3 (en) 2016-10-03
PT2408739E (pt) 2013-10-21
PL2408739T3 (pl) 2014-01-31
CY1117871T1 (el) 2017-05-17
CN102356063A (zh) 2012-02-15
HRP20130978T1 (hr) 2013-11-22
JP2015180665A (ja) 2015-10-15
EP2408739B1 (en) 2013-08-14
EP2641897A3 (en) 2013-11-20
US8642767B2 (en) 2014-02-04
HRP20161163T1 (hr) 2016-11-04
JP6061158B2 (ja) 2017-01-18
CN102356063B (zh) 2014-09-24
PL2641897T3 (pl) 2017-01-31
PT2641897T (pt) 2016-08-04
ES2585221T3 (es) 2016-10-04
US9012645B2 (en) 2015-04-21
JP2012520332A (ja) 2012-09-06
SMT201600356B (it) 2016-11-10
EP2641897A2 (en) 2013-09-25
SI2641897T1 (sl) 2016-10-28
CN104193676A (zh) 2014-12-10
US20150191429A1 (en) 2015-07-09
ES2431618T3 (es) 2013-11-27

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