IT1402029B1 - Procedimento per la preparazione di erlotinib - Google Patents

Procedimento per la preparazione di erlotinib

Info

Publication number
IT1402029B1
IT1402029B1 ITMI2010A001878A ITMI20101878A IT1402029B1 IT 1402029 B1 IT1402029 B1 IT 1402029B1 IT MI2010A001878 A ITMI2010A001878 A IT MI2010A001878A IT MI20101878 A ITMI20101878 A IT MI20101878A IT 1402029 B1 IT1402029 B1 IT 1402029B1
Authority
IT
Italy
Prior art keywords
erlotinib
procedure
preparation
Prior art date
Application number
ITMI2010A001878A
Other languages
English (en)
Inventor
Andrea Caporale
Andrea Castellin
Lucchi Ottorino De
Original Assignee
Italiana Sint Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43629575&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1402029(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Italiana Sint Spa filed Critical Italiana Sint Spa
Priority to ITMI2010A001878A priority Critical patent/IT1402029B1/it
Priority to IT000464A priority patent/ITMI20110464A1/it
Priority to EP11184698.6A priority patent/EP2433931B2/en
Priority to US13/272,888 priority patent/US8609841B2/en
Publication of ITMI20101878A1 publication Critical patent/ITMI20101878A1/it
Application granted granted Critical
Publication of IT1402029B1 publication Critical patent/IT1402029B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Paper (AREA)
ITMI2010A001878A 2010-10-14 2010-10-14 Procedimento per la preparazione di erlotinib IT1402029B1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI2010A001878A IT1402029B1 (it) 2010-10-14 2010-10-14 Procedimento per la preparazione di erlotinib
IT000464A ITMI20110464A1 (it) 2010-10-14 2011-03-24 Nuovo procedimento per la preparazione di erlotinib
EP11184698.6A EP2433931B2 (en) 2010-10-14 2011-10-11 New method for the preparation of erlotinib
US13/272,888 US8609841B2 (en) 2010-10-14 2011-10-13 Method for the preparation of erlotinib

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A001878A IT1402029B1 (it) 2010-10-14 2010-10-14 Procedimento per la preparazione di erlotinib

Publications (2)

Publication Number Publication Date
ITMI20101878A1 ITMI20101878A1 (it) 2012-04-15
IT1402029B1 true IT1402029B1 (it) 2013-08-28

Family

ID=43629575

Family Applications (2)

Application Number Title Priority Date Filing Date
ITMI2010A001878A IT1402029B1 (it) 2010-10-14 2010-10-14 Procedimento per la preparazione di erlotinib
IT000464A ITMI20110464A1 (it) 2010-10-14 2011-03-24 Nuovo procedimento per la preparazione di erlotinib

Family Applications After (1)

Application Number Title Priority Date Filing Date
IT000464A ITMI20110464A1 (it) 2010-10-14 2011-03-24 Nuovo procedimento per la preparazione di erlotinib

Country Status (3)

Country Link
US (1) US8609841B2 (it)
EP (1) EP2433931B2 (it)
IT (2) IT1402029B1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102675225A (zh) * 2012-05-16 2012-09-19 浙江理工大学 一种盐酸埃罗替尼的合成方法
CN103254142B (zh) * 2013-04-26 2015-10-28 浙江工业大学 4-[4-(2-取代氨基乙酰氨基)苯胺基]喹唑啉类衍生物及制备和应用
CN103254141B (zh) * 2013-04-26 2016-02-24 浙江工业大学 4-[4-(2-二丙氨基乙酰氨基)苯胺基]-6-取代喹唑啉类化合物及制备和应用
CN104193689B (zh) * 2014-07-23 2017-02-08 大连理工大学 一种盐酸厄洛替尼的合成方法
CN107655983B (zh) * 2016-07-25 2021-08-27 重庆华邦胜凯制药有限公司 盐酸厄洛替尼的关键起始原料三乙炔苯胺中潜在基因毒性杂质的分离与测定方法
CN108440309B (zh) * 2018-04-09 2021-01-15 上海倍殊生物科技有限公司 一种间氨基苯乙炔的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219679A (en) 1978-11-06 1980-08-26 Gulf Research & Development Company Selective hydrogenation of nitro groups on nitroaromatic acetylenes using an unsupported cobalt polysulfide catalyst
DE69522717T2 (de) 1995-03-30 2002-02-14 Pfizer Inc., New York Chinazolinderivate
IT1295311B1 (it) 1997-10-10 1999-05-04 Secifarma Spa Processo industriale per la sintesi di ammino acetileni
YU13200A (sh) * 1999-03-31 2002-10-18 Pfizer Products Inc. Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US20060188498A1 (en) 2005-02-18 2006-08-24 Genentech, Inc. Methods of using death receptor agonists and EGFR inhibitors
JP2006282587A (ja) * 2005-03-31 2006-10-19 Fuji Photo Film Co Ltd ３−アミノフェニルアセチレンの製造方法
WO2009009778A1 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders

Also Published As

Publication number Publication date
ITMI20110464A1 (it) 2012-04-15
EP2433931B2 (en) 2016-11-02
ITMI20101878A1 (it) 2012-04-15
EP2433931A1 (en) 2012-03-28
EP2433931B1 (en) 2013-08-21
US8609841B2 (en) 2013-12-17
US20120095228A1 (en) 2012-04-19

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