DE602004027251D1 - Herstellung von 1,3-diphenylprop-2-en-1-onderivaten - Google Patents
Herstellung von 1,3-diphenylprop-2-en-1-onderivatenInfo
- Publication number
- DE602004027251D1 DE602004027251D1 DE602004027251T DE602004027251T DE602004027251D1 DE 602004027251 D1 DE602004027251 D1 DE 602004027251D1 DE 602004027251 T DE602004027251 T DE 602004027251T DE 602004027251 T DE602004027251 T DE 602004027251T DE 602004027251 D1 DE602004027251 D1 DE 602004027251D1
- Authority
- DE
- Germany
- Prior art keywords
- diphenylprop
- preparation
- onderivates
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical group C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0308354A FR2857361B1 (fr) | 2003-07-08 | 2003-07-08 | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
| PCT/FR2004/001797 WO2005005369A1 (fr) | 2003-07-08 | 2004-07-08 | Preparation de derives de 1,3-diphenylprop-2-en-1-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004027251D1 true DE602004027251D1 (de) | 2010-07-01 |
Family
ID=33522868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004027251T Expired - Lifetime DE602004027251D1 (de) | 2003-07-08 | 2004-07-08 | Herstellung von 1,3-diphenylprop-2-en-1-onderivaten |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7385082B2 (de) |
| EP (1) | EP1644312B1 (de) |
| JP (1) | JP2007516189A (de) |
| KR (1) | KR20060030110A (de) |
| CN (1) | CN1819986B (de) |
| AT (1) | ATE468317T1 (de) |
| AU (1) | AU2004255905B2 (de) |
| BR (1) | BRPI0412370A (de) |
| CA (1) | CA2531443C (de) |
| DE (1) | DE602004027251D1 (de) |
| DK (1) | DK1644312T3 (de) |
| EA (1) | EA010410B1 (de) |
| ES (1) | ES2343803T3 (de) |
| FR (1) | FR2857361B1 (de) |
| IL (1) | IL172825A (de) |
| MX (1) | MXPA06000159A (de) |
| NO (1) | NO332411B1 (de) |
| NZ (1) | NZ544792A (de) |
| PL (1) | PL213226B1 (de) |
| SG (1) | SG129448A1 (de) |
| WO (1) | WO2005005369A1 (de) |
| ZA (1) | ZA200601040B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| FR2841900B1 (fr) * | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| ES2441665T3 (es) | 2009-11-26 | 2014-02-05 | Genfit | Utilización de derivados de 1,3-difenilprop-2-en-1-ona para tratar trastornos hepáticos |
| WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
| MX2012013359A (es) * | 2010-05-17 | 2013-02-11 | Genfit | Preparacion mejora de derivados de chalcona. |
| WO2014111584A1 (en) * | 2013-01-18 | 2014-07-24 | Genfit | Methods of treatment of fibrosis and cancers |
| WO2017143038A1 (en) | 2016-02-16 | 2017-08-24 | Concert Pharmaceuticals, Inc. | Deuterated gft-505 |
| CN106674069B (zh) * | 2016-12-06 | 2018-05-11 | 上海博志研新药物技术有限公司 | Gft505及其中间体的制备方法 |
| EP3572399A4 (de) * | 2017-01-22 | 2020-01-22 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Kristallform von gft-505 sowie herstellungsverfahren dafür und verwendung davon |
| CN110300580A (zh) | 2017-02-21 | 2019-10-01 | 基恩菲特公司 | Ppar激动剂与fxr激动剂的组合 |
| EP3661914A1 (de) | 2017-08-04 | 2020-06-10 | Advitech Advisory and Technologies SA | Verfahren zur herstellung von elafibranor und neuen synthesezwischenprodukten |
| EP3710425A1 (de) | 2017-11-16 | 2020-09-23 | Teva Pharmaceuticals International GmbH | Festkörperformen von elafibranor |
| CN109608318A (zh) * | 2019-01-31 | 2019-04-12 | 上海生农生化制品股份有限公司 | 一种戊唑醇中间体α的工业合成方法 |
| CN110156648A (zh) * | 2019-05-30 | 2019-08-23 | 河北科技大学 | 一种Elafibranor中间体的制备方法 |
| CN110143902B (zh) * | 2019-06-12 | 2021-06-04 | 天津科技大学 | 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用 |
| CN110143890B (zh) * | 2019-06-12 | 2020-12-22 | 天津科技大学 | 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用 |
| EP4034236A1 (de) | 2019-09-26 | 2022-08-03 | Abionyx Pharma SA | Verbindungen zur behandlung von lebererkrankungen |
| CN113121394B (zh) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | 一种苯氧乙酸类衍生物的制备方法 |
| TW202207911A (zh) | 2020-05-18 | 2022-03-01 | 法商Ｇｅｎｆｉｔ公司 | 治療原發性硬化性膽管炎之方法 |
| MX2023002159A (es) | 2020-08-26 | 2023-03-01 | Genfit | Composiciones y metodos para el tratamiento de la colangitis biliar primaria. |
| WO2022189856A1 (en) | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| JP2024518521A (ja) | 2021-05-11 | 2024-05-01 | ジェンフィット | 肝不全の治療において使用するためのｐｐａｒアゴニスト |
| EP4337185A1 (de) | 2021-05-11 | 2024-03-20 | Genfit | Elafibranorderivate als agonisten von ppar zur verwendung bei der behandlung von sepsis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2359621C2 (de) * | 1973-11-30 | 1982-11-18 | Hoechst Ag, 6000 Frankfurt | Antiviral wirksame Alkalimetall- oder Ammoniumsalze der Polyacrylsäure |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| JPH023670A (ja) * | 1988-06-22 | 1990-01-09 | Nippon Oil & Fats Co Ltd | アルキルチオカルコン誘導体 |
| JPH05255655A (ja) * | 1992-03-12 | 1993-10-05 | Kanebo Ltd | 紫外線吸収剤 |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| EP0947511A1 (de) * | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Phenoxy-Essigsäurederivate und Phenoxymetyl-Tetrazolderivate mit antitumoraler Wirkung |
| JPH11302243A (ja) * | 1998-04-24 | 1999-11-02 | Mitsubishi Chemical Corp | ジエチレントリアミン５酢酸誘導体 |
-
2003
- 2003-07-08 FR FR0308354A patent/FR2857361B1/fr not_active Expired - Fee Related
-
2004
- 2004-07-08 JP JP2006518300A patent/JP2007516189A/ja active Pending
- 2004-07-08 SG SG200700644A patent/SG129448A1/en unknown
- 2004-07-08 DE DE602004027251T patent/DE602004027251D1/de not_active Expired - Lifetime
- 2004-07-08 KR KR1020067000562A patent/KR20060030110A/ko not_active Application Discontinuation
- 2004-07-08 WO PCT/FR2004/001797 patent/WO2005005369A1/fr active Application Filing
- 2004-07-08 EP EP04767629A patent/EP1644312B1/de not_active Expired - Lifetime
- 2004-07-08 NZ NZ544792A patent/NZ544792A/en not_active IP Right Cessation
- 2004-07-08 ES ES04767629T patent/ES2343803T3/es not_active Expired - Lifetime
- 2004-07-08 CN CN2004800195644A patent/CN1819986B/zh not_active Expired - Lifetime
- 2004-07-08 AU AU2004255905A patent/AU2004255905B2/en not_active Ceased
- 2004-07-08 DK DK04767629.1T patent/DK1644312T3/da active
- 2004-07-08 EA EA200600197A patent/EA010410B1/ru not_active IP Right Cessation
- 2004-07-08 PL PL379543A patent/PL213226B1/pl unknown
- 2004-07-08 AT AT04767629T patent/ATE468317T1/de active
- 2004-07-08 BR BRPI0412370-0A patent/BRPI0412370A/pt not_active Application Discontinuation
- 2004-07-08 CA CA2531443A patent/CA2531443C/fr not_active Expired - Fee Related
- 2004-07-08 US US10/563,057 patent/US7385082B2/en not_active Expired - Lifetime
- 2004-07-08 MX MXPA06000159A patent/MXPA06000159A/es active IP Right Grant
-
2005
- 2005-12-26 IL IL172825A patent/IL172825A/en unknown
-
2006
- 2006-01-06 NO NO20060087A patent/NO332411B1/no not_active IP Right Cessation
- 2006-02-06 ZA ZA200601040A patent/ZA200601040B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20060087L (no) | 2006-02-07 |
| ZA200601040B (en) | 2007-05-30 |
| EP1644312A1 (de) | 2006-04-12 |
| SG129448A1 (en) | 2007-02-26 |
| AU2004255905A1 (en) | 2005-01-20 |
| PL213226B1 (pl) | 2013-01-31 |
| ES2343803T3 (es) | 2010-08-10 |
| CA2531443C (fr) | 2012-05-01 |
| DK1644312T3 (da) | 2010-08-23 |
| NO332411B1 (no) | 2012-09-17 |
| ATE468317T1 (de) | 2010-06-15 |
| IL172825A (en) | 2010-11-30 |
| US20060142611A1 (en) | 2006-06-29 |
| IL172825A0 (en) | 2006-06-11 |
| NZ544792A (en) | 2009-02-28 |
| PL379543A1 (pl) | 2006-10-02 |
| FR2857361A1 (fr) | 2005-01-14 |
| KR20060030110A (ko) | 2006-04-07 |
| AU2004255905B2 (en) | 2010-11-18 |
| FR2857361B1 (fr) | 2005-09-09 |
| CN1819986B (zh) | 2011-02-02 |
| EA010410B1 (ru) | 2008-08-29 |
| WO2005005369A1 (fr) | 2005-01-20 |
| EA200600197A1 (ru) | 2006-06-30 |
| JP2007516189A (ja) | 2007-06-21 |
| US7385082B2 (en) | 2008-06-10 |
| EP1644312B1 (de) | 2010-05-19 |
| MXPA06000159A (es) | 2006-03-21 |
| CN1819986A (zh) | 2006-08-16 |
| CA2531443A1 (fr) | 2005-01-20 |
| BRPI0412370A (pt) | 2006-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |