BRPI0412370A - processo de preparação de derivados de 1,3-difenilprop-2-en-1-ona substituìdos por um grupamento carboxialquilóxi ou carboxialquiltio - Google Patents

processo de preparação de derivados de 1,3-difenilprop-2-en-1-ona substituìdos por um grupamento carboxialquilóxi ou carboxialquiltio

Info

Publication number
BRPI0412370A
BRPI0412370A BRPI0412370-0A BRPI0412370A BRPI0412370A BR PI0412370 A BRPI0412370 A BR PI0412370A BR PI0412370 A BRPI0412370 A BR PI0412370A BR PI0412370 A BRPI0412370 A BR PI0412370A
Authority
BR
Brazil
Prior art keywords
preparing
diphenylprop
carboxyalkyloxy
group
derivatives substituted
Prior art date
Application number
BRPI0412370-0A
Other languages
English (en)
Inventor
Jean-Francois Delhomel
Karine Caumont-Bertrand
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of BRPI0412370A publication Critical patent/BRPI0412370A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO DE PREPARAçãO DE DERIVADOS DE 1,3-DIFENILPROP-2-EN-1-ONA SUBSTITUìDOS POR UM GRUPAMENTO CARBOXIALQUILóXI OU CARBOXIALQUILTIO". A presente invenção refere-se a um processo de preparação de derivados de 1,3-difenilprop-2-en-1-ona substituídos por um dos dois grupos fenila por um grupamento carboxialquilóxi ou um grupamento carboxialquiltio.
BRPI0412370-0A 2003-07-08 2004-07-08 processo de preparação de derivados de 1,3-difenilprop-2-en-1-ona substituìdos por um grupamento carboxialquilóxi ou carboxialquiltio BRPI0412370A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0308354A FR2857361B1 (fr) 2003-07-08 2003-07-08 PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
PCT/FR2004/001797 WO2005005369A1 (fr) 2003-07-08 2004-07-08 Preparation de derives de 1,3-diphenylprop-2-en-1-one

Publications (1)

Publication Number Publication Date
BRPI0412370A true BRPI0412370A (pt) 2006-09-05

Family

ID=33522868

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412370-0A BRPI0412370A (pt) 2003-07-08 2004-07-08 processo de preparação de derivados de 1,3-difenilprop-2-en-1-ona substituìdos por um grupamento carboxialquilóxi ou carboxialquiltio

Country Status (22)

Country Link
US (1) US7385082B2 (pt)
EP (1) EP1644312B1 (pt)
JP (1) JP2007516189A (pt)
KR (1) KR20060030110A (pt)
CN (1) CN1819986B (pt)
AT (1) ATE468317T1 (pt)
AU (1) AU2004255905B2 (pt)
BR (1) BRPI0412370A (pt)
CA (1) CA2531443C (pt)
DE (1) DE602004027251D1 (pt)
DK (1) DK1644312T3 (pt)
EA (1) EA010410B1 (pt)
ES (1) ES2343803T3 (pt)
FR (1) FR2857361B1 (pt)
IL (1) IL172825A (pt)
MX (1) MXPA06000159A (pt)
NO (1) NO332411B1 (pt)
NZ (1) NZ544792A (pt)
PL (1) PL213226B1 (pt)
SG (1) SG129448A1 (pt)
WO (1) WO2005005369A1 (pt)
ZA (1) ZA200601040B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2841900B1 (fr) * 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
ES2441665T3 (es) 2009-11-26 2014-02-05 Genfit Utilización de derivados de 1,3-difenilprop-2-en-1-ona para tratar trastornos hepáticos
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
MX2012013359A (es) * 2010-05-17 2013-02-11 Genfit Preparacion mejora de derivados de chalcona.
WO2014111584A1 (en) * 2013-01-18 2014-07-24 Genfit Methods of treatment of fibrosis and cancers
WO2017143038A1 (en) 2016-02-16 2017-08-24 Concert Pharmaceuticals, Inc. Deuterated gft-505
CN106674069B (zh) * 2016-12-06 2018-05-11 上海博志研新药物技术有限公司 Gft505及其中间体的制备方法
EP3572399A4 (en) * 2017-01-22 2020-01-22 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF GFT-505 AND METHOD OF PREPARING AND USING THE SAME
CN110300580A (zh) 2017-02-21 2019-10-01 基恩菲特公司 Ppar激动剂与fxr激动剂的组合
EP3661914A1 (en) 2017-08-04 2020-06-10 Advitech Advisory and Technologies SA Process for the preparation of elafibranor and novel synthesis intermediates
EP3710425A1 (en) 2017-11-16 2020-09-23 Teva Pharmaceuticals International GmbH Solid state forms of elafibranor
CN109608318A (zh) * 2019-01-31 2019-04-12 上海生农生化制品股份有限公司 一种戊唑醇中间体α的工业合成方法
CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
CN110143902B (zh) * 2019-06-12 2021-06-04 天津科技大学 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用
CN110143890B (zh) * 2019-06-12 2020-12-22 天津科技大学 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用
EP4034236A1 (en) 2019-09-26 2022-08-03 Abionyx Pharma SA Compounds useful for treating liver diseases
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
TW202207911A (zh) 2020-05-18 2022-03-01 法商Ｇｅｎｆｉｔ公司 治療原發性硬化性膽管炎之方法
MX2023002159A (es) 2020-08-26 2023-03-01 Genfit Composiciones y metodos para el tratamiento de la colangitis biliar primaria.
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
CN113230240B (zh) * 2021-03-22 2022-12-27 广州医科大学 1,3-二苯基丙-2-烯-1-酮衍生物及其应用
JP2024518521A (ja) 2021-05-11 2024-05-01 ジェンフィット 肝不全の治療において使用するためのｐｐａｒアゴニスト
EP4337185A1 (en) 2021-05-11 2024-03-20 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2359621C2 (de) * 1973-11-30 1982-11-18 Hoechst Ag, 6000 Frankfurt Antiviral wirksame Alkalimetall- oder Ammoniumsalze der Polyacrylsäure
GB8426424D0 (en) * 1984-10-19 1984-11-28 Biorex Laboratories Ltd Chalcone derivatives
JPH023670A (ja) * 1988-06-22 1990-01-09 Nippon Oil & Fats Co Ltd アルキルチオカルコン誘導体
JPH05255655A (ja) * 1992-03-12 1993-10-05 Kanebo Ltd 紫外線吸収剤
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
EP0947511A1 (en) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity
JPH11302243A (ja) * 1998-04-24 1999-11-02 Mitsubishi Chemical Corp ジエチレントリアミン５酢酸誘導体

Also Published As

Publication number Publication date
NO20060087L (no) 2006-02-07
ZA200601040B (en) 2007-05-30
EP1644312A1 (fr) 2006-04-12
SG129448A1 (en) 2007-02-26
AU2004255905A1 (en) 2005-01-20
PL213226B1 (pl) 2013-01-31
ES2343803T3 (es) 2010-08-10
CA2531443C (fr) 2012-05-01
DK1644312T3 (da) 2010-08-23
NO332411B1 (no) 2012-09-17
ATE468317T1 (de) 2010-06-15
IL172825A (en) 2010-11-30
US20060142611A1 (en) 2006-06-29
IL172825A0 (en) 2006-06-11
NZ544792A (en) 2009-02-28
PL379543A1 (pl) 2006-10-02
DE602004027251D1 (de) 2010-07-01
FR2857361A1 (fr) 2005-01-14
KR20060030110A (ko) 2006-04-07
AU2004255905B2 (en) 2010-11-18
FR2857361B1 (fr) 2005-09-09
CN1819986B (zh) 2011-02-02
EA010410B1 (ru) 2008-08-29
WO2005005369A1 (fr) 2005-01-20
EA200600197A1 (ru) 2006-06-30
JP2007516189A (ja) 2007-06-21
US7385082B2 (en) 2008-06-10
EP1644312B1 (fr) 2010-05-19
MXPA06000159A (es) 2006-03-21
CN1819986A (zh) 2006-08-16
CA2531443A1 (fr) 2005-01-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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