UY27606A1 - Inhibidores de la fosfarasa - Google Patents

Inhibidores de la fosfarasa

Info

Publication number
UY27606A1
UY27606A1 UY27606A UY27606A UY27606A1 UY 27606 A1 UY27606 A1 UY 27606A1 UY 27606 A UY27606 A UY 27606A UY 27606 A UY27606 A UY 27606A UY 27606 A1 UY27606 A1 UY 27606A1
Authority
UY
Uruguay
Prior art keywords
phospharase
inhibitors
pyrimido
triazine
useful
Prior art date
Application number
UY27606A
Other languages
English (en)
Inventor
Kevin R Guertin
Lina Q Setti
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY27606A1 publication Critical patent/UY27606A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La invención se refiere a compuestos de fórmula en donde R1 y R2 se definen como en la reivindicaciones 1, y los cuales son de utilidad para la elaboración de medicamentos.
UY27606A 2001-12-27 2002-12-26 Inhibidores de la fosfarasa UY27606A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34393701P 2001-12-27 2001-12-27
US39911002P 2002-07-26 2002-07-26

Publications (1)

Publication Number Publication Date
UY27606A1 true UY27606A1 (es) 2003-06-30

Family

ID=26993696

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27606A UY27606A1 (es) 2001-12-27 2002-12-26 Inhibidores de la fosfarasa

Country Status (19)

Country Link
US (1) US6642381B2 (es)
EP (1) EP1467996B1 (es)
JP (1) JP4188839B2 (es)
KR (1) KR100601769B1 (es)
CN (1) CN100402530C (es)
AT (1) ATE311388T1 (es)
AU (1) AU2002367190B2 (es)
BR (1) BR0215395A (es)
CA (1) CA2471265C (es)
DE (1) DE60207759T2 (es)
ES (1) ES2252554T3 (es)
JO (1) JO2242B1 (es)
MX (1) MXPA04006266A (es)
PA (1) PA8562901A1 (es)
PE (1) PE20030896A1 (es)
PL (1) PL371180A1 (es)
TW (1) TW200306313A (es)
UY (1) UY27606A1 (es)
WO (1) WO2003055883A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696231B2 (en) * 2001-10-30 2010-04-13 Laboratoires Serono Sa Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs)
CA2506565A1 (en) * 2002-11-18 2004-06-03 F. Hoffmann-La Roche Ag Diazinopyrimidines
EP1594847A2 (en) * 2003-02-12 2005-11-16 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
US20040186151A1 (en) * 2003-02-12 2004-09-23 Mjalli Adnan M.M. Substituted azole derivatives as therapeutic agents
ZA200605526B (en) * 2004-02-12 2007-11-28 Transtech Pharma Inc Substituted azole derivatives, compositions and methods of use
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
EA019385B1 (ru) 2006-01-30 2014-03-31 ТРАНСТЕК ФАРМА ЭлЭлСи ЗАМЕЩЕННЫЕ ИМИДАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ РТРазы
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010083645A1 (en) * 2009-01-21 2010-07-29 Shanghai Targetdrug Co., Ltd PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9486433B2 (en) 2012-10-12 2016-11-08 Mochida Pharmaceuticals Co. Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014142364A2 (en) 2013-03-15 2014-09-18 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
US10441560B2 (en) 2013-03-15 2019-10-15 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
GB0022079D0 (en) 2000-09-08 2000-10-25 Inst Of Molecul & Cell Biology Novel protein tyrosine phosphatase inhibitor

Also Published As

Publication number Publication date
ES2252554T3 (es) 2006-05-16
WO2003055883A1 (en) 2003-07-10
EP1467996A1 (en) 2004-10-20
BR0215395A (pt) 2004-12-07
CN100402530C (zh) 2008-07-16
TW200306313A (en) 2003-11-16
JP2005517677A (ja) 2005-06-16
DE60207759T2 (de) 2006-08-03
ATE311388T1 (de) 2005-12-15
PL371180A1 (en) 2005-06-13
PE20030896A1 (es) 2003-11-05
CA2471265C (en) 2010-02-09
US6642381B2 (en) 2003-11-04
US20030153756A1 (en) 2003-08-14
JO2242B1 (en) 2004-10-07
MXPA04006266A (es) 2004-09-27
PA8562901A1 (es) 2003-07-28
AU2002367190B2 (en) 2006-10-05
CN1610683A (zh) 2005-04-27
CA2471265A1 (en) 2003-07-10
KR20040068981A (ko) 2004-08-02
AU2002367190A1 (en) 2003-07-15
DE60207759D1 (de) 2006-01-05
EP1467996B1 (en) 2005-11-30
KR100601769B1 (ko) 2006-07-19
JP4188839B2 (ja) 2008-12-03

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20160621