AR063878A1 - Compuestos de pirrol-piridina y composicion farmaceutica - Google Patents

Compuestos de pirrol-piridina y composicion farmaceutica

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Publication number
AR063878A1
AR063878A1 ARP070105161A ARP070105161A AR063878A1 AR 063878 A1 AR063878 A1 AR 063878A1 AR P070105161 A ARP070105161 A AR P070105161A AR P070105161 A ARP070105161 A AR P070105161A AR 063878 A1 AR063878 A1 AR 063878A1
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AR
Argentina
Prior art keywords
lower alkyl
substituted
fluoro
group
heteroaryl
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ARP070105161A
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English (en)
Inventor
Nespi Marika
Zhu Hongyao
R Artis Dean Ph D
Bremer Ryan
Zhang Chao
Zhang Jiazhong
Wu Guoxian
N Ibrahim Prabha
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Plexxikon Inc
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Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of AR063878A1 publication Critical patent/AR063878A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Se proporcionan los compuestos activos de pirrol-piridina. También se incluyen en este documento las composiciones útiles para el tratamiento de enfermedades o condiciones mediadas por c-kit y/o enfermedades o condiciones mediadas por c-fms, y los métodos para su uso. Enfermedades relacionadas con la proliferación celular. Reivindicación 1: Un compuesto que tenga la estructura química de la fórmula (1), todas las sales, prosustancias, tautómeros e isómeros del mismo, en tanto que D tiene una estructura seleccionada del grupo que consiste en fórmulas (2) en la cual x- indica el punto de unión de D con A2 de la fórmula (2); A2 es -CH2- o -C(O)-; B se selecciona el grupo que consiste en H, -CN, -OR41, -SR41, -NHR41, -NR41R41, -NR39C(O)R41, -NR39S(O)2R41, halógeno, alquilo inferior, cicloalquilo, heterocicloalquilo, aril y heteroaril, en donde el alquilo inferior se sustituye opcionalmente con uno o más sustitutos seleccionados el grupo que consiste en F, alcoxi inferior, alcoxi inferior fluoro-sustituido, alquiltio inferior, alquiltio inferior fluoro-sustituido, mono-alquilamina, dialquilamina, cicloalquil, heterocicloalquil, aril y heteroaril, y en donde cicloalquilo, heterocicloalquilo, aril y heteroaril como B o como sustitutos de alquilo inferior son opcionalmente sustituidos con uno o más sustitutos seleccionados del grupo consistente en -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR42, -SR42, -NHR42, -NR42R42, -NR39C(O)R42, -NR39S(O)2R42, -S(O)2R42, halógeno, alquilo inferior, alquilo inferior fluoro-sustituido y cicloalquilamina; M4 es -NR39CH2, -NR39CH(R40)-, -NR39CH2CH2-, o -NR39C(O)-; M5, M10, y M18 se seleccionan del grupo que consta de un vínculo -NR39-, -S-, -O, -NR39CH2-, -NR39CH2CH2-, - NR39CH(R40)-, -SCH2-, -OCH2-, -C(O)NR39-, -S(O)2NR39-, -CH2NR39-, -CH(R40)NR39-, -NR39C(O)-, y -NR39S(O)2-; M8 se selecciona del grupo que consta de un vínculo -CH2-, -CH2C(O)-, -S(O)2-, -S(O)2CH2-, -S(O)2CH(CH3)-, -S(O)2CH2CH2-, -S(O)2NR39-, - S(O)2NR39CH2-, -S(O)2NR39CH(CH3)-, -S(O)2NR39CH2CH2-, -C(O)-, -C(O)CH2-, -C(O)CH(CH3)-, -C(O)CH2CH2-, -C(O)NR39-, -C(O)NR39CH2, -C(O)NR39CH(CH3)-, y -C(O)NR39CH2CH2-; Q1, Q11, Q41, Q61, y Q141 son aril o heteroaril opcionalmente sustituidos con uno o más sustitutos seleccionados del grupo que consiste en -OR41, -SR41, -S(O)R41, -S(O)2R41, -NHR41, -NR41R41, -NR39C(O)R41, -NR39S(O)2R41, halógeno, alquilo inferior, cicloalquilo, heterocicloalquilo, aril y heteroaril, donde el alquilo inferior es opcionalmente sustituido con uno o más sustitutos seleccionados del grupo consistente en F, alcoxi inferior, alcoxi inferior fluoro-sustituido, alquiltio inferior, alquiltio inferior fluoro-sustituido, monoalquilamina, di-alquilamina, cicloalquil, heterocicloalquilo, aril y heteroaril, y en donde cicloalquilo, heterocicloalquilo, aril y heteroaril, como Q1, Q11, Q41, Q61, o Q141, o como un sustituto de alquilo inferior son opcionalmente sustituidos con uno o más sustitutos seleccionados del grupo que consiste en -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR42, -SR42, -NHR42, -NR42R42, -NR39C(O)R42, -NR39S(O)2R42, -S(O)2R42, halógeno, alquilo inferior, alquilo inferior fluoro-sustituido y cicloalquilamina; Q12 es F, Cl o -CF3; Q13 y Q14 son independientemente H, F, Cl, alquilo inferior o alquilo inferior sustituido; Q22, Q24, Q52, y Q54 se seleccionan independientemente del grupo que consiste en H, halógeno, alquilo inferior, alquilo inferior fluoro-sustituido, -NR44R44, -OR44, y -SR44, en la inteligencia, sin embargo, de que por lo menos uno de Q22 y Q24 y por lo menos uno de Q52 y Q54 sea H, F, Cl, alquilo inferior o alquilo inferior fluoro-sustituido; Q74 y Q152 son de H, F, Cl, alquilo inferior o alquilo inferior fluoro-sustituido, -NR44R44, -OR44, o -SR44; Q72 sea H, alquilo inferior o alquilo inferior fluoro-sustituido; R39 en cada vez que ocurra es independientemente de H o de alquilo inferior; R40 es alquilo inferior o alquilo inferior fluoro-sustituido; R41 en cada vez que ocurra es independientemente seleccionado del grupo que consiste en alquilo inferior, cicloalquilo, heterocicloalquilo, aril y heteroaril, donde el alquilo inferior es opcionalmente sustituido con uno o más sustitutos seleccionados del grupo que consiste en F, alcoxi inferior, alcoxi inferior fluoro-sustituido, alquiltio inferior, alquiltio inferior fluoro-sustituido, mono-alquilamina, di-alquilamina, cicloalquilo, heterocicloalquilo, aril y heteroaril, y donde cicloalquilo, heterocicloalquilo, aril y heteroaril, como R41 o como sustitutos de alquilo inferior son opcionalmente sustituidos con uno o más sustitutos seleccionados del grupo que consiste en -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR42, - SR42, -NHR42, -NR42R42, -NR39C(O)R42, -NR39S(O)2R42, -S(O)2R42, halógeno, alquilo inferior, alquilo inferior fluoro-sustituido y cicloalquilamina; R42 en cada vez que ocurra es independientemente seleccionado del grupo que consiste en alquilo inferior, heterocicloalquilo y heteroaril, donde el alquilo inferior es opcionalmente sustituido con uno o más sustitutos seleccionados del grupo que consiste en F, alcoxi inferior, alcoxi inferior fluoro-sustituido, alquiltio inferior, alquiltio inferior fluoro-sustituido, monoalquilamina, di-alquilamina y cicloalquilamina, y donde heterocicloalquil y heteroaril son opcionalmente sustituidos con uno o más sustitutos seleccionados del grupo que consiste en halógeno, -CN, alquilo inferior, alquilo inferior fluoro-sustituido, alcoxi inferior y alcoxi inferior fluoro-sustituido; y cada R44 es independientemente de H, alquilo inferior o alquilo inferior fluoro-sustituido; en la inteligencia, sin embargo, que el compuesto no es ninguno de las fórmulas (3).
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US9771369B2 (en) 2014-03-04 2017-09-26 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AU2015318233B2 (en) 2014-09-15 2020-03-12 Plexxikon Inc. Heterocyclic compounds and uses thereof

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