HC-030031

HC-030031
HC-030031
HC-030031.svg
식별자
  • 2-(1,3-디메틸-2,6-다이옥소푸린-7-일)-N-(4-프로판-2-일페닐)아세트아미드
CAS 번호
PubChem CID
켐스파이더
유니
첸블
CompTox 대시보드 (EPA )
ECHA 정보 카드100.159.785 Edit this at Wikidata
화학 및 물리 데이터
공식C18H21N5O3
몰 질량355.398 g/g−1/g
3D 모델(JSmol)
  • CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)c
  • InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(26)18(26)21(163/5-810-11,9H)
  • 키: HEQDZPHDVAOBLN-UHFFFAOYSA-N

HC-030031은 TRPA1 수용체에 대한 강력한 선택적 길항제로서 진통제 및 항염증 [1][2][3][4]효과가 있는 약물이다.

레퍼런스

  1. ^ Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, et al. (October 2008). "HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity". Molecular Pain. 4: 1744-8069–4-48. doi:10.1186/1744-8069-4-48. PMC 2584039. PMID 18954467.
  2. ^ Pereira LM, Lima-Júnior RC, Bem AX, Teixeira CG, Grassi LS, Medeiros RP, et al. (February 2013). "Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system". European Journal of Pain. 17 (2): 223–33. doi:10.1002/j.1532-2149.2012.00177.x. PMID 22689151. S2CID 9421113.
  3. ^ Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A (January 2014). "TRPA1: a transducer and amplifier of pain and inflammation". Basic & Clinical Pharmacology & Toxicology. 114 (1): 50–5. doi:10.1111/bcpt.12138. PMID 24102997.
  4. ^ Achanta S, Chintagari NR, Brackmann M, Balakrishna S, Jordt SE (September 2018). "TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation". Toxicology Letters. 293: 140–148. doi:10.1016/j.toxlet.2018.03.007. PMC 5975083. PMID 29535050.


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