MX2018000929A - Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl. - Google Patents

Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl.

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Publication number
MX2018000929A
MX2018000929A MX2018000929A MX2018000929A MX2018000929A MX 2018000929 A MX2018000929 A MX 2018000929A MX 2018000929 A MX2018000929 A MX 2018000929A MX 2018000929 A MX2018000929 A MX 2018000929A MX 2018000929 A MX2018000929 A MX 2018000929A
Authority
MX
Mexico
Prior art keywords
trifluoro
carbamate derivatives
hydroxybutan
hydroxypropan
magl inhibitors
Prior art date
Application number
MX2018000929A
Other languages
English (en)
Inventor
Victor O'neil Steven
Matthew Gilbert Adam
Ian Montgomery Justin
Scott Johnson Douglas
Aaron Brodney Michael
Mary Beck Elizabeth
Ryan Butler Christopher
Nelsen Rogers Bruce
John Helal Christopher
Robert Verhoest Patrick
Ann Mcallister Laura
Webb Damien
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2018000929A publication Critical patent/MX2018000929A/es

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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

La presente invención proporciona, en parte, compuestos de la fórmula I: (ver fórmula I) y sus sales farmacéuticamente aceptables; procesos para su preparación; intermediarios usados en su preparación; y composiciones que contienen tales compuestos o sales y sus usos para tratar enfermedades y trastornos mediados por MAGL que incluye, por ejemplo, dolor, un trastorno inflamatorio, depresión, ansiedad, enfermedad de Alzheimer, un trastorno metabólico, ACV o cáncer.
MX2018000929A 2015-07-31 2016-07-18 Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl. MX2018000929A (es)

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