KR890001146B1 - 아미도-아미노산 및 그의 제조 방법 - Google Patents

아미도-아미노산 및 그의 제조 방법 Download PDF

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Publication number
KR890001146B1
KR890001146B1 KR8201157A KR820001157A KR890001146B1 KR 890001146 B1 KR890001146 B1 KR 890001146B1 KR 8201157 A KR8201157 A KR 8201157A KR 820001157 A KR820001157 A KR 820001157A KR 890001146 B1 KR890001146 B1 KR 890001146B1
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KR
South Korea
Prior art keywords
compound
alkyl
formula
hydrogen
mercapto
Prior art date
Application number
KR8201157A
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English (en)
Korean (ko)
Other versions
KR830009065A (ko
Inventor
티이.서 죤
엔.바턴 제프리
알.리간 죤
Original Assignee
모리스 이.실버스타인
유 에스 브이 파마슈티칼 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 모리스 이.실버스타인, 유 에스 브이 파마슈티칼 코포레이션 filed Critical 모리스 이.실버스타인
Publication of KR830009065A publication Critical patent/KR830009065A/ko
Application granted granted Critical
Publication of KR890001146B1 publication Critical patent/KR890001146B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
KR8201157A 1981-03-19 1982-03-18 아미도-아미노산 및 그의 제조 방법 KR890001146B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24540781A 1981-03-19 1981-03-19
US245407 1981-03-19
US245,407 1988-09-16

Publications (2)

Publication Number Publication Date
KR830009065A KR830009065A (ko) 1983-12-17
KR890001146B1 true KR890001146B1 (ko) 1989-04-25

Family

ID=22926526

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8201157A KR890001146B1 (ko) 1981-03-19 1982-03-18 아미도-아미노산 및 그의 제조 방법

Country Status (21)

Country Link
JP (1) JPS57165355A (el)
KR (1) KR890001146B1 (el)
AU (1) AU558451B2 (el)
BE (1) BE892552A (el)
CH (1) CH658455A5 (el)
DE (1) DE3209708A1 (el)
DK (1) DK120982A (el)
ES (3) ES510498A0 (el)
FI (1) FI820974L (el)
FR (1) FR2502149A1 (el)
GB (1) GB2095252B (el)
IE (1) IE53076B1 (el)
IL (1) IL65247A (el)
IN (1) IN156096B (el)
IT (1) IT1150697B (el)
NL (1) NL8201066A (el)
NO (1) NO820903L (el)
NZ (1) NZ200047A (el)
PH (1) PH18657A (el)
SE (1) SE8201654L (el)
ZA (1) ZA821833B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3622297A1 (de) * 1986-07-03 1988-01-07 Basf Ag Disazothiophenfarbstoffe
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
ES2122941B1 (es) * 1997-05-29 1999-07-01 Esteve Quimica Sa Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
ATE365714T1 (de) * 2002-01-30 2007-07-15 Servier Lab Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
DK1572661T5 (da) 2002-12-16 2007-11-05 Lupin Ltd Krystallinsk form af quinaprilhydrochlorid og fremgangsmåde til fremstilling af samme
US7521566B2 (en) * 2003-02-28 2009-04-21 Les Laboratoires Servier Process for preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
EP0278530A3 (de) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

Also Published As

Publication number Publication date
ES521030A0 (es) 1984-05-16
NO820903L (no) 1982-09-20
FR2502149B1 (el) 1985-01-18
PH18657A (en) 1985-08-29
ES8501363A1 (es) 1984-12-01
DK120982A (da) 1982-09-20
NL8201066A (nl) 1982-10-18
FI820974L (fi) 1982-09-20
ES8307718A1 (es) 1983-08-01
JPS57165355A (en) 1982-10-12
IE53076B1 (en) 1988-06-08
AU558451B2 (en) 1987-01-29
IL65247A (en) 1987-07-31
ES521031A0 (es) 1984-12-01
GB2095252A (en) 1982-09-29
IT1150697B (it) 1986-12-17
CH658455A5 (de) 1986-11-14
IE820635L (en) 1982-09-19
ZA821833B (en) 1983-01-26
KR830009065A (ko) 1983-12-17
SE8201654L (sv) 1982-09-20
FR2502149A1 (fr) 1982-09-24
DE3209708A1 (de) 1982-10-21
ES8404317A1 (es) 1984-05-16
IN156096B (el) 1985-05-11
IL65247A0 (en) 1982-05-31
AU8158482A (en) 1982-09-23
GB2095252B (en) 1985-04-17
IT8220259A0 (it) 1982-03-18
BE892552A (fr) 1982-09-20
NZ200047A (en) 1985-07-12
ES510498A0 (es) 1983-08-01

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