KR830009065A - 아미도-아미노산의 제조방법 - Google Patents

아미도-아미노산의 제조방법 Download PDF

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KR830009065A
KR830009065A KR1019820001157A KR820001157A KR830009065A KR 830009065 A KR830009065 A KR 830009065A KR 1019820001157 A KR1019820001157 A KR 1019820001157A KR 820001157 A KR820001157 A KR 820001157A KR 830009065 A KR830009065 A KR 830009065A
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formula
alkyl
compound
mercapto
substituted
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KR1019820001157A
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KR890001146B1 (ko
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서 죤티이.
바턴 제프리 엔
리간 죤알.
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모리스 이. 실버스타인
유에스 브이 파마슈티칼 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

아미도-아미노산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 아미드 형성조건하에서 일반식(II)의 화합물을 일반식(III)의 산의 아실화 유도체와 반응시키거나, 또는 아미드 형성조건하에서 일반식(II)의 화합물을 일반식(IV)의 화합물과 반응시켜 일반식(V)의 화합물을 얻고 일반식(V)화합물의 카보벤질옥시그룹을 분해시켜 일반식(VI)의 유리아민을 얻은다음 수득된 일반식(VI)의 아민을 일반식(VII)의 α-케토산 또는 에스테르와 반응시켜 이민을 얻고 수득된 이민을 환원시켜 R3및 R4가 수소인 일반식(I)의 화합물을 제조하거나 또는 일반식(VI)의 화합물을 일반식(VIII)의 α-할로산 또는 에스테르와 반응시키고, 경우에 따라 치환 및 전환반응에 의해 여러 치환체를 도입시킴을 특징으로 하여 일반식(I)의 화합물 및 그 염을 제조하는 방법.
    상기식에서
    R1및 R7은 수소, 저급알킬 또는 페닐 저급알킬이고, R2,R3,R4,R5및 R6는 각각 수소, 저급알킬, 저급알케닐, 저급알키닐, 아릴, 융합된 아릴-사이클로알킬, 아르알킬, 사이클로알킬, 헤테로사이클, 또는 하이드록시, 알콕시, 할로, 아미노, 알킬아미노, 멀캅토 및 알킬멀캅토 그룹에 의해 치환된 저급알킬, 치환된 저급알케닐, 치환된 저급 알키닐그룹 및 알킬, 하이드록시, 알콕시, 하이드록시 알킬, 할로, 멀캅토, 알킬멀캅토, 멀캅토알킬, 할로알킬, 아미노, 알킬아미노, 아미노알킬, 니트로, 메틸렌-디옥시, 트리플루오로메틸에 의해 치환된 사이크로알킬, 치환된 아릴 및 치환된 헤테로사이클 그룹이고, 각각의 R8은 저급알킬, 저급알케닐, 저급알키닐, 니트로, 아미노, 알킬아미노, 디알킬아미노, 하이드록시, 알콕시, 멀캅토, 알킬멀캅토, 하이드록시알킬, 멀캅토 알킬, 할로겐, 할로알킬, 아미노알킬, 알킬아미노알킬, 디알킬아미노알킬, 설폰아미도, 메틸렌디옥시 또는 트리플루오로메틸이고, m은 0내지 2의 정수이고, m'는 1내지 3의 정수이고, 단 m이 0일때는 m'는 2 또는 3이고, m이 0이 아닐때는 m'는 1 또는 2이고, n은 0내지 4의 정수이다.
  2. 제1항에 있어서, COOR7치환체가 환중의 질소에 인접한 탄소원자에 연결되어 있는 방법.
  3. 제1항 또는 2항중의 어느하나에 있어서, R7이 수소인 방법.
  4. 제1 내지 2항중의 어느하나에 있어서, R1이 에틸 또는 수소인 방법.
  5. 상기 제1내지 4항중의 어느하나에 있어서, R2가 페닐-저급 알킬인 방법.
  6. 제5항에 있어서, R2가 펜에틸인 방법.
  7. 상기 제1 내지 6항의 어느 하나에 있어서, R6가 메틸인 방법.
  8. 상기 제1항 내지 6항중의 어느하나에 있어서, R6가 이소프로필인 방법.
  9. 상기 제1항 내지 6항중의 어느하나에 있어서, R6가 이소부틸인 방법.
  10. 상기 제1항 내지 5항중의 어느 하나에 있어서, R2는 펜에틸이고, R6는 메틸인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8201157A 1981-03-19 1982-03-18 아미도-아미노산 및 그의 제조 방법 KR890001146B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24540781A 1981-03-19 1981-03-19
US245407 1981-03-19
US245,407 1988-09-16

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KR830009065A true KR830009065A (ko) 1983-12-17
KR890001146B1 KR890001146B1 (ko) 1989-04-25

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JP (1) JPS57165355A (ko)
KR (1) KR890001146B1 (ko)
AU (1) AU558451B2 (ko)
BE (1) BE892552A (ko)
CH (1) CH658455A5 (ko)
DE (1) DE3209708A1 (ko)
DK (1) DK120982A (ko)
ES (3) ES510498A0 (ko)
FI (1) FI820974L (ko)
FR (1) FR2502149A1 (ko)
GB (1) GB2095252B (ko)
IE (1) IE53076B1 (ko)
IL (1) IL65247A (ko)
IN (1) IN156096B (ko)
IT (1) IT1150697B (ko)
NL (1) NL8201066A (ko)
NO (1) NO820903L (ko)
NZ (1) NZ200047A (ko)
PH (1) PH18657A (ko)
SE (1) SE8201654L (ko)
ZA (1) ZA821833B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3622297A1 (de) * 1986-07-03 1988-01-07 Basf Ag Disazothiophenfarbstoffe
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
ES2122941B1 (es) * 1997-05-29 1999-07-01 Esteve Quimica Sa Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
ATE365714T1 (de) * 2002-01-30 2007-07-15 Servier Lab Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
DK1572661T5 (da) 2002-12-16 2007-11-05 Lupin Ltd Krystallinsk form af quinaprilhydrochlorid og fremgangsmåde til fremstilling af samme
US7521566B2 (en) * 2003-02-28 2009-04-21 Les Laboratoires Servier Process for preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
EP0278530A3 (de) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

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ES521030A0 (es) 1984-05-16
KR890001146B1 (ko) 1989-04-25
NO820903L (no) 1982-09-20
FR2502149B1 (ko) 1985-01-18
PH18657A (en) 1985-08-29
ES8501363A1 (es) 1984-12-01
DK120982A (da) 1982-09-20
NL8201066A (nl) 1982-10-18
FI820974L (fi) 1982-09-20
ES8307718A1 (es) 1983-08-01
JPS57165355A (en) 1982-10-12
IE53076B1 (en) 1988-06-08
AU558451B2 (en) 1987-01-29
IL65247A (en) 1987-07-31
ES521031A0 (es) 1984-12-01
GB2095252A (en) 1982-09-29
IT1150697B (it) 1986-12-17
CH658455A5 (de) 1986-11-14
IE820635L (en) 1982-09-19
ZA821833B (en) 1983-01-26
SE8201654L (sv) 1982-09-20
FR2502149A1 (fr) 1982-09-24
DE3209708A1 (de) 1982-10-21
ES8404317A1 (es) 1984-05-16
IN156096B (ko) 1985-05-11
IL65247A0 (en) 1982-05-31
AU8158482A (en) 1982-09-23
GB2095252B (en) 1985-04-17
IT8220259A0 (it) 1982-03-18
BE892552A (fr) 1982-09-20
NZ200047A (en) 1985-07-12
ES510498A0 (es) 1983-08-01

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