ES2122941B1 - Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato. - Google Patents

Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

Info

Publication number
ES2122941B1
ES2122941B1 ES09701169A ES9701169A ES2122941B1 ES 2122941 B1 ES2122941 B1 ES 2122941B1 ES 09701169 A ES09701169 A ES 09701169A ES 9701169 A ES9701169 A ES 9701169A ES 2122941 B1 ES2122941 B1 ES 2122941B1
Authority
ES
Spain
Prior art keywords
quinapril
chlorhydrate
solvate
obtaining
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09701169A
Other languages
English (en)
Other versions
ES2122941A1 (es
Inventor
Llagostera Montser Monsalvatje
Sanmarti Marti Bartra
Navarro Jaime Tomas
Llagostera Montse Montsalvatje
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09701169A priority Critical patent/ES2122941B1/es
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to DE1998621483 priority patent/DE69821483T2/de
Priority to EP98920547A priority patent/EP0992495B1/en
Priority to US11/022,424 priority patent/USRE39888E1/en
Priority to US09/424,673 priority patent/US6617457B1/en
Priority to CA002293705A priority patent/CA2293705C/en
Priority to DK98920547T priority patent/DK0992495T3/da
Priority to AU73365/98A priority patent/AU730140B2/en
Priority to AT98920547T priority patent/ATE258920T1/de
Priority to JP50027999A priority patent/JP2002502386A/ja
Priority to PT98920547T priority patent/PT992495E/pt
Priority to KR10-1999-7011151A priority patent/KR100477713B1/ko
Priority to PCT/ES1998/000145 priority patent/WO1998054149A1/es
Priority to ZA984466A priority patent/ZA984466B/xx
Publication of ES2122941A1 publication Critical patent/ES2122941A1/es
Application granted granted Critical
Publication of ES2122941B1 publication Critical patent/ES2122941B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE QUINAPRIL CLORHIDRATO Y SOLVATOS UTILES PARA EL AISLAMIENTO Y PURIFICACION DE QUINAPRIL CLORHIDRATO. EL PROCEDIMIENTO PARA OBTENER QUINAPRIL CLORHIDRATO (I) COMPRENDE LAS ETAPAS DE: A) HIDROGENOLISIS DEL ESTER BENCILICO DEL QUINAPRIL (II) POR TRATAMIENTO EN UN DISOLVENTE ALCOHOLICO, CON ACIDO CLORHIDICO O CON UNA DISOLUCION DE CLORURO DE HIDROGENO EN ISOPROPANOL E HIDROGENACION; B) RETIRADA DEL DISOLVENTE; C) ADICION DE TOLUENO PARA PRECIPITAR EL QUINAPRIL CLORHIDRATO COMO SOLVATO DE TOLUENO; D) TRATAMIENTO DE DICHO SOLVATO CON UN DISOLVENTE DE LA CLASE 3 QUE FORMA UN SOLVATO DE QUINAPRIL CLORHIDRATO DEL QUE SE PUEDE ELIMINAR POR SECADO SIN DEGRADARLO; Y E) SECADO DEL SOLVATO DE LA ETAPA D) PARA RENDIR (I). ESTOS SOLVATOS SON UTILES PARA AISLAR Y PURIFICAR (I), UN AGENTE ANTIHIPERTENSIVO.
ES09701169A 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato. Expired - Fee Related ES2122941B1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES09701169A ES2122941B1 (es) 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
PT98920547T PT992495E (pt) 1997-05-29 1998-05-25 Processo pata obter cloridrato de quinapril e solvatos uteis para isolar e purificar o cloridrato de quinapril
US11/022,424 USRE39888E1 (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
US09/424,673 US6617457B1 (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
CA002293705A CA2293705C (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
DK98920547T DK0992495T3 (da) 1997-05-29 1998-05-25 Fremgangsmåde til opnåelse af quinaprilhydrochlorid og solvater, der er nyttige ved isolation og rensning af quinaprilhydrochlorid
AU73365/98A AU730140B2 (en) 1997-05-29 1998-05-25 Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride
AT98920547T ATE258920T1 (de) 1997-05-29 1998-05-25 Verfahren zur gewinnung von chinaprylhydrochlorid und solvaten, die bei der isolierung und reinigung von chinaprylhydrochlorid nützlich sind
DE1998621483 DE69821483T2 (de) 1997-05-29 1998-05-25 Verfahren zur gewinnung von chinaprylhydrochlorid und solvaten, die bei der isolierung und reinigung von chinaprylhydrochlorid nützlich sind
EP98920547A EP0992495B1 (en) 1997-05-29 1998-05-25 Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride
KR10-1999-7011151A KR100477713B1 (ko) 1997-05-29 1998-05-25 퀸아프릴 하이드로클로라이드와 퀸아프릴하이드로클로라이드 분리 및 정제용 용매화합물 제조방법
PCT/ES1998/000145 WO1998054149A1 (es) 1997-05-29 1998-05-25 Procedimiento para la obtención de quinapril clorhidrato y solvatos utiles para el aislamiento y purificación de quinapril clorhidrato
JP50027999A JP2002502386A (ja) 1997-05-29 1998-05-25 塩酸キナプリルの製法並びに塩酸キナプリルの単離および精製に有用な溶媒和物
ZA984466A ZA984466B (en) 1997-05-29 1998-05-26 Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09701169A ES2122941B1 (es) 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

Publications (2)

Publication Number Publication Date
ES2122941A1 ES2122941A1 (es) 1998-12-16
ES2122941B1 true ES2122941B1 (es) 1999-07-01

Family

ID=8299498

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09701169A Expired - Fee Related ES2122941B1 (es) 1997-05-29 1997-05-29 Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

Country Status (13)

Country Link
US (2) USRE39888E1 (es)
EP (1) EP0992495B1 (es)
JP (1) JP2002502386A (es)
KR (1) KR100477713B1 (es)
AT (1) ATE258920T1 (es)
AU (1) AU730140B2 (es)
CA (1) CA2293705C (es)
DE (1) DE69821483T2 (es)
DK (1) DK0992495T3 (es)
ES (1) ES2122941B1 (es)
PT (1) PT992495E (es)
WO (1) WO1998054149A1 (es)
ZA (1) ZA984466B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
DK1572661T5 (da) * 2002-12-16 2007-11-05 Lupin Ltd Krystallinsk form af quinaprilhydrochlorid og fremgangsmåde til fremstilling af samme
WO2007054966A2 (en) * 2005-09-13 2007-05-18 Aarti Healthcare Limited A process for the preparation of highly pure crystalline quinapril hydrochloride
WO2007069268A2 (en) * 2005-10-14 2007-06-21 Sun Pharmaceutical Industries Limited A process for the preparation of substantially pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives
WO2009053994A1 (en) * 2007-10-26 2009-04-30 Matrix Laboratories Limited Process for preparing pure amorphous quinapril hydrochloride

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (es) * 1981-03-19 1985-05-11 Usv Pharma Corp
JPS58188857A (ja) * 1982-04-26 1983-11-04 Takeda Chem Ind Ltd テトラヒドロイソキノリン誘導体
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
US4761479A (en) * 1987-03-30 1988-08-02 Warner-Lambert Company Crystalline quinapril and a process for producing the same
JPH01275546A (ja) * 1988-04-26 1989-11-06 Nisso Yuka Kogyo Kk 安息香酸ソーダの単離方法
DE4206697A1 (de) * 1992-03-04 1993-09-09 Hoechst Ag Verfahren zur herstellung von modifizierten phenolharzen
JP3211396B2 (ja) * 1992-08-26 2001-09-25 住友化学工業株式会社 アクリル酸及び酢酸の回収方法

Also Published As

Publication number Publication date
ATE258920T1 (de) 2004-02-15
AU7336598A (en) 1998-12-30
ES2122941A1 (es) 1998-12-16
PT992495E (pt) 2004-06-30
AU730140B2 (en) 2001-03-01
JP2002502386A (ja) 2002-01-22
KR20010013167A (ko) 2001-02-26
DE69821483D1 (de) 2004-03-11
KR100477713B1 (ko) 2005-03-18
DK0992495T3 (da) 2004-06-01
EP0992495A1 (en) 2000-04-12
US6617457B1 (en) 2003-09-09
CA2293705C (en) 2008-03-18
DE69821483T2 (de) 2005-01-13
ZA984466B (en) 1998-12-01
EP0992495B1 (en) 2004-02-04
USRE39888E1 (en) 2007-10-16
WO1998054149A1 (es) 1998-12-03
CA2293705A1 (en) 1998-12-03

Similar Documents

Publication Publication Date Title
JO2282B1 (en) Oxazole derivatives
ATE231496T1 (de) Saccharinderivate als proteolytische enzyminhibitoren
BR0009167A (pt) Inibidores de enzima impdh
SV1999000102A (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa. ref. pcs 9475 afae/bb.
DK0414275T3 (da) Fremgangsmåde til fremtilling af cycliske aminosyrederivater samt mellemprodukter
BR0007643A (pt) Processo para obter ésteres de (nitroximetil) fenila de derivados de aspirina, e, (hidroximetil) feniléter de derivados de aspirina
CA2449402A1 (en) Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases
PE20040594A1 (es) Derivados de isoquinolina
FI955855A (fi) Menetelmä ksylitolin tuottamiseksi
BR9003011A (pt) Processo para purificacao de triptofano
ES2122941B1 (es) Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
EP1589018A4 (en) PROCESS FOR PRODUCING A DERIVATIVE OF HEXAHYDROFURANOL, INTERMEDIATE THEREOF AND PROCESS FOR PRODUCING THE SAME
BR9909898A (pt) Processo para purificação de um derivado de cefalosporina
BR0208999A (pt) Processo para a preparação de ácido de cefpodoxima
BR9811348A (pt) Compostos derivados de indol, processo para preparação dos mesmos, e, composições farmacêuticas.
ES2161863T3 (es) Procedimiento de produccion de inhibidores de proteasa de vih.
HUP0303106A2 (hu) Eljárás pravasztatin tisztítására
AR020768A1 (es) Proceso para preparar derivados de beta-alanina y los derivados de beta-alanina obtenidas con dicho proceso
BR9807312A (pt) Derivados de (4-piperidinil)-1h-2-benzopirano úteis como agentes antipsicóticos
DE602004007670D1 (de) Verfahren zur herstellung von 11-(4-ä2-(2-hydroxyethoxy)ethylü-1-piperazinyl)dibenzoäb,füä1,4üthiazepin
HUP0002119A2 (hu) Eljárás nehézfémek eltávolítására
ATE286048T1 (de) Verfahren zur herstellung von carbostyril- derivaten
DK1214315T3 (da) 1,4-Dihydropyridin-5-carboxylsyreesterderivater og fremgangsmåde til fremstilling af samme
PT1019521E (pt) Um metodo para a biotransformacao de compostos de colchicona nos derivados de 3-glicosil correspondentes
DE60010147D1 (de) Verfahren zur Herstellung von organischen Aziden

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19981216

Kind code of ref document: A1

Effective date: 19981216

GC2A Exploitation certificate registered application with search report

Effective date: 20000229

FD2A Announcement of lapse in spain

Effective date: 20180807