KR102452905B1 - the method for skin improvement cosmetic composition containing natural spicule and polydioxanone and the cosmetic composition thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition containing 20 parts by weight of spicule, 10 parts by weight of polydioxanone, 2 parts by weight of polyhydroxy acids (PHAs), and 5 parts by weight of a Carum Petroselinum extract, and a beauty care patch for topical skin care. The present invention has an excellent skin regeneration effect and an excellent effect of delivering oil and moisture into the skin. In addition, the present invention has an effect of accelerating the absorption of active ingredients contained in the cosmetic composition of the present invention into the skin. Therefore, there is a unique effect of increasing the efficacy exerted by the active ingredients of the cosmetic composition. Moreover, the present invention shows an effect of promoting the absorption of the polydioxanone into the skin. As such, there is a unique effect of promoting a skin regeneration ability of the polydioxanone.

Description

The method for skin improvement cosmetic composition containing natural spicule and polydioxanone and the cosmetic composition thereof

The present invention relates to a method for preparing a skin-improving cosmetic composition containing natural spicule and polydioxanone and to the cosmetic composition.

The skin is a membrane that covers the outside of the body. As the body's primary barrier, it performs various physiological functions to protect the body from environmental factors such as various external stimuli, obstacles, and dryness, thereby performing internal organs and other internal organs. It plays an important role in maintaining the homeostasis of the body by protecting and regulating the body. This important skin, like other organs of the human body, also gradually ages as it ages, so the secretion of various hormones that control metabolism decreases, the function of immune cells and the activity of cells decrease, and as a result, the skin There are phenomena such as loss of elasticity, keratinization, generation of wrinkles, and skin atrophy. This skin aging phenomenon not only causes wrinkles on the skin surface but also changes the overall line of the face. In addition, externally, the UV content in the sun's rays increases due to the destruction of the ozone layer, and the excessive physical and chemical stimulation and stress caused by the increase of free radicals and active harmful oxygen as the environmental pollution is further deepened is the normal function of the skin. It can damage the skin by promoting the production of spots, freckles, etc. and skin aging caused by deterioration, melanin deposition.

In order to prevent skin aging and damage caused by these factors and to maintain stronger and more beautiful skin, physiologically active substances obtained from various animals, plants, and microorganisms are added to cosmetics and used to maintain the unique function of the skin and activate skin cells. Efforts to maintain skin health by promoting skin metabolism are continuing, and cosmetics and external preparations for skin are being developed accordingly. In order to supply nutrients to damaged skin, it is recommended to cover the face with a cosmetic tissue or other auxiliary means while applying natural ingredients such as cucumber or tangerine or a pack agent such as massage cream, nutrition pack, cleansing pack, or bleach pack. generally used

However, when these substances are applied to the skin, there is a limitation in the amount used due to safety problems such as irritation, erythema, and redness, or the effect of improving the skin function or wound healing cannot be expected because the effect is insignificant. Therefore, there is an urgent need to develop a new composition for external application for skin that is safer and more effective than the existing composition for external application for skin. Accordingly, there is a demand for the development of a cosmetic composition, a cosmetic sheet, and a patch in which functional substances are effectively absorbed into the skin and thus have excellent skin function improvement effects and less irritation.

Recently, in the cosmetic industry, a number of products using natural products have been developed to reduce skin irritation caused by chemicals. Natural ingredients have fewer side effects on the skin, and as consumers' response to cosmetics using natural ingredients increases, the value of development as a cosmetic raw material is increasing. Accordingly, the demand for cosmetics using natural ingredients with few side effects and high consumer response is gradually increasing. Referring to Korean Patent No. 10-2265128, a cosmetic composition containing spicule, a natural material, is used for skin treatment. Various studies on the development of multi-functional cosmetics that can effectively improve skin health by applying them together with research on materials with excellent biosafety and skin improvement effects are being actively conducted.

Korean Patent Registration No. 10-2265128 (published on June 14, 2021)

The present invention was invented to solve the problems of the prior art, and has the following objects.

According to one embodiment of the present invention, 20 parts by weight of spicule, 10 parts by weight of polydioxanone, 2 parts by weight of poly hydroxy acid (PHA) and 5 parts by weight of Carum Petroselinum Extract An object of the present invention is to provide a cosmetic composition comprising a cosmetic composition and a cosmetic patch for topical skin care.

This will be described in detail as follows. Meanwhile, each description and embodiment disclosed in the present invention may be applied to each other description and embodiment. That is, all combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be considered that the scope of the present invention is limited by the specific descriptions described below.

One embodiment of the present invention for achieving the above object is 20 parts by weight of spicule, 10 parts by weight of polydioxanone, 2 parts by weight of PHA (Poly hydroxy acid) and Carum Petroselinum extract (Carum Petroselinum) Extract) provides a cosmetic composition comprising 5 parts by weight.

In one embodiment of the present invention, 20 parts by weight of spicule, 10 parts by weight of polydioxanone, 2 parts by weight of poly hydroxy acid (PHA) and 5 parts by weight of Carum Petroselinum Extract Including parts, the particle size of the polydioxanone (Polydioxanone) provides a cosmetic composition of 10 μm to 30 μm.

In one embodiment of the present invention, 20 parts by weight of spicule, 10 parts by weight of polydioxanone, 2 parts by weight of poly hydroxy acid (PHA) and 5 parts by weight of Carum Petroselinum Extract Including parts, retinol, retinyl palmitate, retinyl acetate, retinoic acid, coenzyme Q10, elastin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid, ascorbyl glucoside, alpha-bisabolol, tocopherol, tocopherol acetate, arbutin, niacinamide, adenosine, retinol acetate, vitamins A, D, E, and at least one selected from the group consisting of natural extracts, wherein the natural extract is aloe, green tea, ginseng, red ginseng, pearl, wood vinegar , pine needles, ginkgo leaf, propolis, mulberry leaf, silkworm, snail slime, kakadu plum, camu camu, yasai palm, squalane, caviar, broccoli, blueberry, witch hazel, acerola, chlorella, mangosteen, guava, cornflower oil, carrot , caffeine, hamamelis, spirulina, salmon roe, Ecklonia, giant kelp, balm, machi prefecture, green seaweed, agaric, mulberry, raspberry, raspberry, hibiscus, moss, edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, It provides a cosmetic composition, which is extracted from at least one selected from the group consisting of tea tree, gold, eoseongcho, wild juniper and citron.

In one embodiment of the present invention, 20 parts by weight of spicule, 10 parts by weight of polydioxanone, 2 parts by weight of poly hydroxy acid (PHA) and 5 parts by weight of Carum Petroselinum Extract It provides a cosmetic patch for topical skin care, including a cosmetic composition comprising parts, wherein the particle size of the polydioxanone is 30 to 60 μm.

In one embodiment of the present invention, 20 parts by weight of spicule, 10 parts by weight of polydioxanone, 2 parts by weight of poly hydroxy acid (PHA) and 5 parts by weight of Carum Petroselinum Extract A step of attaching a cosmetic patch for topical skin care to the skin, including a cosmetic composition, wherein the particle size of the polydioxanone is 30 to 60 μm, and 3 MHz to 7 MHz in the cosmetic patch for topical skin care. Provided is a method for accelerating skin absorption of the cosmetic composition by applying ultrasonic waves at an output of 1W/cm ² .

The cosmetic composition according to one embodiment of the present invention has excellent skin regeneration effect by itself. In addition, the cosmetic composition of the present invention has an excellent effect of delivering oil and moisture into the skin, and also exhibits an effect of accelerating the absorption of the active ingredient contained in the cosmetic composition into the skin. There is a unique effect that can increase the effect displayed. In addition, since it exhibits an effect of accelerating the absorption of the polydioxanone into the skin, there is a unique effect of promoting the skin regeneration ability of the polydioxanone.

It should be understood that the effects of the present invention are not limited to the above-described effects, and include all effects that can be inferred from the configuration of the invention described in the detailed description or claims of the present invention.

Hereinafter, the present invention will be described in more detail through examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples. The terms used below are only used to describe specific examples. Therefore, for example, a singular expression includes a plural expression unless the context clearly requires it to be singular. In addition, terms such as "comprises" or "comprises" as used in this application are used to clearly indicate that there is a feature step, function, component, or a combination thereof described in the specification, but other features or It should be noted that it is not intended to preliminarily exclude the presence of steps, functions, components, or combinations thereof.

On the other hand, unless otherwise defined, all terms used herein should be regarded as having the same meaning as commonly understood by those of ordinary skill in the art to which the present invention belongs. Accordingly, unless explicitly defined herein, certain terms should not be construed in an unduly idealistic or formal sense. The terminology used herein is for the purpose of describing the embodiments and is not intended to limit the present invention. In this specification, the singular also includes the plural, unless specifically stated otherwise in the phrase. The term “bonding” used below may include both physical and chemical attachment, connection, and the like, and may mean a state that does not separate from each other due to a specific bonding force between materials, but is not limited thereto.

In the present specification, "sponge animal" is also called a sponge (Sponge), a primitive marine creature that does not exist in muscles, nerves, or organs, and there are more than 5,000 species and is a creature found regardless of the depth of the sea. "Bone fragments" are needle-shaped structures that exist in the body of invertebrates and are mainly composed of silicate and calcium carbonate. The fibrous skeleton of sponges has the ability to absorb according to the capillary phenomenon, so it is being applied in various fields such as medicine. As one application example, bone fragments of sponges contain antibiotics for the treatment of osteomyelitis and are used for treatment and prevention of diseases. The sponge animal may be a sponge belonging to the species Spongilla lacustris L. , Spongilla fragilis Leidy and Ephydatia fluviatilis .

In the present specification, "spicule" is a bone fragment of a spongy animal, and as a fine needle-like structure, it penetrates the skin layer to form a micro passage, so that the penetration effect of the applied cosmetic ingredient can be significantly increased. The microneedle can promote the skin regeneration of collagen acting on artificial wound healing and increase the bioactivity by increasing the skin tissue temperature. The spicule is a material harmless to the human body, and when it comes into contact with the skin, it stimulates the skin to form fine pores, and may be dissolved or discharged from the body.

In the present specification, "polydioxanone" is a material with few side effects to the human body because it is friendly with water and hydrolyzed, and is a polymer material in which the ether-ester unit is repeated several times. The polydioxanone (Polydioxanone) can promote the remodeling ability of skin collagen while being hydrolyzed by water in the body. This is, the water-loving polydioxanone (Polydioxanone) surface is a good surface to adhere to macrophages, therefore, collagen production by external factor reaction is easy.

In the present specification, "carum petrosellinum" may mean a biennial herb of the dicotyledonous umbel family, native to the Mediterranean coast and southern France. The Carum Petroselinum is widely used as a spice in basic Western cuisine, and has high nutritional value because it contains a large amount of vitamins and calcium.

As used herein, "active ingredient" refers to a cosmetic or nutritional ingredient that can have an effective effect on the skin.

As used herein, "skin regeneration" refers to a process of repairing skin tissue against damage caused by external and internal causes of the skin. The damage caused by the external cause may include ultraviolet rays, external pollutants, wounds, trauma, and the like, and the damage caused by the internal cause may include stress.

As used herein, "skin microrelief" refers to a three-dimensional microstructure formed by fine lines on the skin surface. It is an indicator of skin condition independently of elasticity, wrinkles, and moisture, and more specifically, skin texture is a reliable indicator of aging that can detect aging before aging begins. In addition, the skin texture reflects the condition inside the skin, not just the rough and smooth skin surface condition. it will be reflected

As used herein, "improving skin texture" refers to a process of recovering the damaged skin texture as described above.

In the present specification, "skin elasticity" is represented by elastic fibers composed of elastin present in the dermal layer, and these elastic fibers have a very low elastic modulus like rubber, so they are easily deformed by a small force, and the When the force is removed, it easily returns to its original shape. In addition, the turning force fibers have a form in which microfibrils are embedded in an amorphous matrix called elastin. It is a protein made up of amino acids. These desmosin and isodesmosin form cross-links in long peptide chains, and this structure makes elastin have rubber-like properties.

As used herein, "enhancement of skin elasticity" means that elastic fibers composed of elastin are present together with collagen fibers called collagen, and that skin elasticity is maintained or increased in a state in which elastin and collagen are sufficiently present.

As used herein, "skin wrinkles" refers to fine lines caused by the deterioration of the skin, and may be caused by a genetic cause, a decrease in collagen and elastin present in the skin dermis, an external environment, and the like.

As used herein, "skin wrinkle improvement" refers to suppressing or inhibiting the generation of wrinkles on the skin, or alleviating the already generated wrinkles.

As used herein, "oil and moisture" refers to oil and/or moisture required by the skin, and by delivering oil and moisture to the skin, the skin tissue can be maintained.

As used herein, the term "dissolvable film" refers to a film that has little residual feeling by being dissolved and permeated into the skin when applied or attached to the skin, and does not require separate washing and washing to remove or remove it. The soluble film may be applied after melting, or may be dissolved after being directly attached to a site requiring management.

As used herein, "hydrogel" refers to a gel using water as a dispersion medium. The hydrosol loses fluidity due to cooling or a hydrophilic polymer having a three-dimensional network structure and microcrystalline structure expands by containing water. Or it can be formed. Hydrogels of electrolyte polymers exhibit high water absorption properties and are practically used in various fields as water absorbent polymers. Some hydrogels undergo a phase transition with temperature, pH, etc., so that the expansion ratio is discontinuously changed.

In the present specification, "temperature-sensitive hydrogel" refers to a hydrogel in which a phase transition occurs from sol to gel or from gel to sol depending on the temperature, and the phenomenon in which the sol is changed to a gel is gelation (gelation). ), and in the present specification, gelation has viscoelasticity and as the temperature increases, the polymer forms a three-dimensional network structure and remains in a state that does not dissolve in a solvent. In particular, it exists in a sol state at room temperature and may be gelled when the temperature is increased by applying it to the skin surface.

As used herein, "localized skin" refers to a part of tissue, such as the eye area, mouth area, nasolabial folds, cheekbones, cheeks, chin, hand, foot, elbow, chest, or the skin of a specific part of an individual.

As used herein, "skin care" refers to an action for skin regeneration, skin texture improvement, skin elasticity enhancement, or skin wrinkle improvement, etc., without limitation, if it is for skin tissue improvement or anti-aging, etc. may be included.

As used herein, "skin irritation" refers to a reversible inflammatory change of the skin caused by exposure to a cosmetic composition.

Hereinafter, examples of the present invention will be described in detail, but it is obvious that the present invention is not limited by the following examples.

The present invention is a cosmetic composition comprising spicule and polydioxanone particles. In contrast, the present invention is a cosmetic composition comprising a skin absorption stimulation accelerator. Specifically, according to one embodiment of the present invention, the cosmetic composition may further include a cosmetic active ingredient.

The cosmetic composition may be formed in the form of a soluble film. The soluble film cosmetic composition may be for skin regeneration, skin texture improvement, or skin absorption promotion of the cosmetic composition.

Specifically, the amount of the spicule may be 0.001 parts by weight to 20 parts by weight when the total cosmetic composition is 100 parts by weight. The spicule has the advantage of exhibiting excellent skin regeneration, wrinkle improvement or skin texture improvement efficacy within the above range, and the formulation of the composition is stabilized.

In addition, the particle size of the spicule may be 40 μm to 200 μm, more specifically, 60 μm to 100 μm, and most specifically, 70 μm to 90 μm.

As such, the spicule penetrates to the basal layer of the skin and activates the therapeutic immune system of the human body to help cell regeneration, and when it penetrates into the pores, it can reach the dermis layer, thereby injecting the polydioxanone into the skin. It helps to convey deeply. In addition, it is possible to promote the absorption of the cosmetic active ingredient into the skin.

Specifically, the polydioxanone (Polydioxanone) particles may be 5 to 10 parts by weight when the total cosmetic composition is 100 parts by weight. The polydioxanone (Polydioxanone) particles can effectively promote absorption of the skin layer by the spicule within the above range, and for a range beyond this, the skin according to the increase of the polydioxanone (Polydioxanone) particles cannot have a significant increase in the effect on Specifically, when the cosmetic composition is 100 parts by weight and the spicule is 20 parts by weight, the polydioxanone particles include 10 parts by weight or more, the polydioxanone particles of A significant increase in the effect on the skin according to the increase in the amount cannot be expected. This is because the delivery and skin penetration promotion of polydioxanone is made by spicule, and the maximum promotion amount of polydioxanone is determined in conjunction with the amount of spicule.

In addition, the particle size of the polydioxanone (Polydioxanone) may be 1 μm to 100 μm. Preferably, the particle size of the polydioxanone (Polydioxanone) may be 10 μm to 30 μm. When the particle size of the polydioxanone is smaller than 10 μm, there is a problem in that the cost of the process is excessively increased in the freeze-drying and pulverizing process. When the particle size of the polydioxanone is greater than 30 μm, it may have difficulty in moving to the stratum corneum, epidermis and dermal layer of the skin, making it difficult to promote the remodeling ability of skin collagen.

Specifically, the skin absorption stimulation accelerator may be alpha hydroxy acid (AHA), beta hydroxy acid (BHA), and poly hydroxy acid (PHA). In addition, the skin absorption stimulation accelerator may be provided in a mixture with Carum Petroselinum extract (Carum Petroselinum Extract). According to an embodiment of the present invention, the skin absorption stimulation promoter is PHA (Poly hydroxy acid) and Carum Petroselinum Extract (Table 1). Through the skin absorption stimulation accelerator, it is possible to promote skin penetration of the polydioxanone without excessive stimulation of the skin.

The poly hydroxy acid (PHA) may be 0.1 parts by weight to 2 parts by weight when the total cosmetic composition is 100 parts by weight. Preferably, the poly hydroxy acid (PHA) may be used in an amount of 1 to 2 parts by weight when the total cosmetic composition is 100 parts by weight. When the PHA (Poly hydroxy acid) is not sufficiently contained in less than 0.1 parts by weight, etc., the skin absorption cannot be stimulated enough to sufficiently promote the skin permeation of the polydioxanone. When the poly hydroxy acid (PHA) is included in excess of 2 parts by weight, excessive skin irritation may damage the skin.

In addition, the Carum Petroselinum extract may be 2 to 2.5 times the weight of the poly hydroxy acid (PHA). When the Carum Petroselinum Extract is not sufficiently contained in an amount less than twice the weight of the PHA (Poly hydroxy acid), it cannot sufficiently compensate for skin irritation, and may damage the skin.

Specifically, the active ingredient may be 0.001 parts by weight to 30 parts by weight when the total cosmetic composition is 100 parts by weight. The amount of the active ingredient may be selected differently depending on the type and formulation of the ingredient.

In addition, the active ingredients include retinol, retinyl palmitate, retinyl acetate, retinoic acid, coenzyme Q10, elastin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid, ascorbyl glucoside, alpha-bisabolol, Tocopherol, tocopherol acetate, arbutin, niacinamide, adenosine, retinol acetate, Batimann A, vitamin D, vitamin E, and may be at least one selected from the group consisting of natural extracts, but is not limited thereto.

In addition, the natural extracts are aloe, green tea, ginseng, red ginseng, pearl, wood vinegar, pine needles, ginkgo leaf, propolis, mulberry leaf, silkworm, snail mucus, kakadu plum, camu camu, yasai yam, squalane, caviar, broccoli, blue Berry, witch hazel, acerola, chlorella, mangosteen, guava, cornflower oil, carrot, caffeine, hamadellis, spirulina, salmon roe, Ecklonia mackerel, giant kelp, balm, machihyun, green onion, agaric, mulberry, raspberry, raspberry, shiitake, Mojaban, edelweiss, chamomile, lavender, repermint, eucalyptus, lemon balm, oregano, tea tree, gold, eoseongcho, sea buckthorn and citron may be extracted from one or more selected from the group consisting of, but is not limited thereto.

In addition, the cosmetic active ingredient may be in the form of a solution, lotion, cream, gel, essence, skin adhesion type cosmetic, lotion, ointment, oil, suspension, emulsion or spray, but is not limited thereto.

Specifically, the soluble film is pullulan, gelatin, agar, carrageenan, alginate, chitosan, chitosan derivative, starch, galatomannan, glucomannan, guar gum, locast bean gum, pluronic, algin, xanthan, gellan, poly One or more polymers selected from the group consisting of vinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), polyethylene oxide (PEO), polyvinyl acrylic acid (PVAc) and polymethacrylic acid (PMAc) may be included as a film forming agent, , but is not limited thereto. More specifically, the film forming agent may include flurane and polyvinylpyrrolidone.

According to one embodiment of the present invention, the soluble film may be a hydrogel. The hydrogel may be a temperature-sensitive hydrogel. The temperature-sensitive hydrogel can be applied directly to the skin surface or attached using the form of a mask sheet or cosmetic patch, and the effect can be sufficiently exhibited by increasing the retention and adhesion time of the active ingredient through gelation according to the temperature. have.

Specifically, the hydrogel may include a branched gelling polymer, an electrolytic gelling polymer, a skin affinity enhancer, a natural biological material, a polyhydric alcohol, a functional additive, and water.

More specifically, the branched gelling polymer may be one or more polymers selected from the group consisting of galactomannan, glucomannan, guar gum, locast bean gum, carob bean gum and pluronic, and the electrolytic gelling polymer is It may be one or more polymers selected from the group consisting of agar, algin, carrageenan, xanthan, and gellan. According to one embodiment of the present invention, a hydrogel composition comprising carob bean gum and carrageenan as a polymer along with spicule and polydioxaone was prepared (Table 1).

According to one embodiment of the present invention, it is possible to provide a cosmetic sheet including a cosmetic composition including the spicule and polydioxanone (Polydioxanone). Specifically, the cosmetic sheet may be for skin regeneration, promotion of oil and moisture absorption, or absorption of active ingredients. The active ingredients that can be included and delivered in the cosmetic composition of the present invention are as described above.

Materials that can be used as a support for the sheet include rayon, urethane, latex, acrylic, and the like, but are not limited thereto, and may be appropriately modified using a material that can be woven or knitted or minimized exposure to the outside. have.

According to another embodiment of the present invention, it is possible to provide a cosmetic patch for topical skin care including a cosmetic composition including the spicule and polydioxanone. Specifically, the cosmetic patch for topical skin care may be appropriately manufactured in a size and shape required for each topical skin applied to manage the topical skin.

The cosmetic sheet or the cosmetic patch may be utilized in various ways in use. The skin is impregnated with a liquid containing active ingredients (moisturizing, anti-allergic, antibacterial, whitening, and wrinkle-improving ingredients), etc. Cosmetic compositions containing dioxanone (Polydioxanone) can be gelled in response to skin temperature and permeated into the skin.

According to another embodiment of the present invention, the steps of a) attaching a topical skin cosmetic patch containing a cosmetic composition to the skin and b) applying ultrasonic waves to the topical skin care cosmetic patch at an output of 1W/cm ² A method for promoting skin absorption of the composition may be provided. Descriptions of specific cosmetic compositions and cosmetic patches for topical skin are as described above. Through this, it can be used for the purpose of promoting skin regeneration and accelerating the delivery of oil and moisture or active ingredients.

The ultrasound may be generated by a separate device. The ultrasound apparatus may identify a skin surface to which the topical skin cosmetic patch is attached. The ultrasound may target a region of interest (ROI). The target area may be located in the subcutaneous tissue below the target topical skin surface. The subcutaneous tissue may include any one or both of an epidermal layer, a cortical layer, a fat layer, a SMAS layer, and a muscle layer. The frequency of the ultrasonic wave may be 1 MHz to 10 MHz. Preferably, the frequency of the ultrasound may be 3 MHz to 7 MHz. The ultrasound may be irradiated from the outer surface of the skin to a depth of 0.001 mm to 10 mm below. Preferably, the ultrasound may be irradiated from the outer surface of the skin to a depth of 3.5 mm to 4.0 mm below. Through this, it is possible to promote the absorption of polydioxanone from the dermal layer to the fascia layer non-invasively.

Hereinafter, Examples and Comparative Examples will be described to help the understanding of the present invention. However, the following description only corresponds to an example regarding the content and effect of the present invention, and the scope and effect of the present invention are not necessarily limited thereto.

Example Preparation 1.

A cosmetic composition including spicule and polydioxanone was prepared by mixing the ingredients shown in Table 1 below. Specifically, the components of phase 1 were put in a preparation tank and mixed and dissolved at Disper 1500~1700rpm, Homo 2000~2500rpm, paddle 30~45rpm and temperature 40~45℃, and then completely mixed at 80℃.

The components of phase 2 are mixed for 15-20 minutes at Disper 1500~1700rpm, Homo 2000~2500rpm, paddle 30~45rpm and temperature 80~85℃, dispersed at 800~1200rpm Disper for 10 minutes, and then the phase 1 was added to the mixture of It was then thoroughly mixed and cooled to 60-65°C.

After that, the components of phase 3 are mixed for 20 minutes at Disper 1500~1700rpm, Homo 2000~2500rpm, paddle 30~45rpm and temperature 60~65℃, and put into the mixture of Phase 1 and Phase 2 at 60~65℃ Mix thoroughly. Thereafter, the paddle was degassed at 15-22 rpm.

At this time, the average size of the mixed polydioxanone (Polydioxanone) particles is 30μm.

award ingredient Example 1 Example 2 Example 3 Award 1 Purified water To 100 To 100 To 100 Disodium EDIT 0.02 0.02 0.02 Phase 2 glycerin 30 30 30 Carob Bean Gum 3 10 10 Hydrolyzed Sponge (Spicule) 20 20 20 Polydioxanone One 4 7 carrageenan 3 3 3 Phase 3 PEG-60 Hydrogenated Castor Oil 0.2 0.2 0.2 Caprylic/Capric Triglycerides 0.1 0.1 0.1 antiseptic 3 3 3 incense 0.1 0.1 0.1 Sum 100wt% 100wt% 100wt% award ingredient Example 4 Example 5 Example 6 Award 1 Purified water To 100 To 100 To 100 Disodium EDIT 0.02 0.02 0.02 Phase 2 glycerin 30 30 30 Carob Bean Gum 10 10 10 Hydrolyzed Sponge (Spicule) 20 20 20 Polydioxanone 10 13 16 carrageenan 3 3 3 Phase 3 PEG-60 Hydrogenated Castor Oil 0.2 0.2 0.2 Caprylic/Capric Triglycerides 0.1 0.1 0.1 antiseptic 3 3 3 incense 0.1 0.1 0.1 Sum 100wt% 100wt% 100wt%

The high-temperature cosmetic composition prepared as described above was molded into a cosmetic sheet or patch in a fluid state at a temperature of 45 to 95° C. and cooled to room temperature to prepare a gel-type hydrogel.

Example Preparation 2.

Example Preparation 1. The preparation method was the same, and with respect to the combination ratio of Example 4, poly hydroxy acid (PHA) and Carum Petroselinum Extract were added to phase 2 as shown in Table 2 below. mixed.

award ingredient Example 7 Example 8 Example 9 Phase 2 Poly hydroxy acid (PHA) 0.1 One 1.5 Carum Petroselinum Extract 0.2 2.5 3.5 award ingredient Example 10 Example 11 Example 12 Phase 2 Poly hydroxy acid (PHA) 2 2.5 3 Carum Petroselinum Extract 5 6 7.5

The high-temperature cosmetic composition prepared as described above was molded into a cosmetic sheet or patch in a fluid state at a temperature of 45 to 95° C. and cooled to room temperature to prepare a gel-type hydrogel.

Example Preparation 3.

In order to confirm the effect according to the size of the polydioxanone (Polydioxanone) particles, Examples were prepared by limiting the size of the polydioxanone (Polydioxanone) particles as shown in Table 2 below. Examples a to g described in Table 2 below were prepared by mixing the same components as in Example 4 (20 parts by weight of spicule, 10 parts by weight of polydioxanone) to prepare a hydrogel composition, the specific mixing method is also the same made it

sample Polydioxanone particle size (μm) Example a 10 Example b 20 Example c 30 Example d 40 Example e 50 Example f 60 Example g 70

The high-temperature cosmetic composition prepared as described above was molded into a cosmetic sheet or patch in a fluid state at a temperature of 45 to 95° C. and cooled to room temperature to prepare a gel-type hydrogel.

Comparative Example Preparation.

A hydrogel composition that does not contain a spicule, a hydrogel composition that does not contain a polydioxanone, or a hydrogel that does not contain a spicule and polydioxanone by mixing the components listed in Table 3 below A composition was prepared, and the specific mixing method was the same as the method described in Example Preparation 1.

At this time, the average size of the mixed polydioxanone (Polydioxanone) particles is 30μm.

award ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Award 1 Purified water To 100 To 100 To 100 Disodium EDIT 0.02 0.02 0.02 Phase 2 glycerin 30 30 30 Carob Bean Gum 3 10 10 Hydrolyzed Sponge (Spicule) 0 20 0 Polydioxanone 0 0 10 carrageenan 3 3 3 Phase 3 PEG-60 Hydrogenated Castor Oil 0.2 0.2 0.2 Caprylic/Capric Triglycerides 0.1 0.1 0.1 antiseptic 3 3 3 incense 0.1 0.1 0.1 Sum 100wt% 100wt% 100wt%

The high-temperature cosmetic composition prepared as described above was molded into a cosmetic sheet or patch in a fluid state at a temperature of 45 to 95° C. and cooled to room temperature to prepare a gel-type hydrogel.

Experimental Example 1. Confirmation of skin regeneration effect of spicule and polydioxanone (Polydioxanone)

The skin regeneration effect through the proliferation of skin cells was confirmed using CCK (Cell counting kit)-8 analysis. Human skin fibroblasts were cultured in DMEN (Dulbecco's Modification of Eagle's Medium) medium supplemented with 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin under conditions of 37° C. and 5% CO 2 . After plating 1,000 human dermal fibroblasts in a 96-well plate, the spicules were treated with a cell culture medium, and the degree of cell proliferation was checked after 3 days. At the time of measurement, CCK-8 solution was added to the cell culture medium (100 μl/well) and reacted in an incubator for 3 hours, then absorbance was measured at 450 nm, and the increase in cell number was investigated based on the results of a standard curve. The results are shown in Table 4 below.

sample Cell count after 3 days control 1750 Spicule 0.1μg/μl treatment 3563 Spicule 10μg/μl treatment 4787 Polydioxanone 0.1 μg/μl treatment 2561 Polydioxanone 10μg/μl treatment 3142 Spicule 10μg/μl and polydioxanone 10μg/μl treatment 5482

As shown in Table 5, when the spicules were treated and cultured for 3 days, a significant increase in the number of cells was shown compared to the control group not treated with the spicules. Therefore, it was confirmed that, when the composition containing the spicule of the present invention is applied to or attached to the skin, an excellent skin regeneration effect can be exhibited by promoting the proliferation of skin cells. In addition, as the concentration of the treated spicules increased, the effect of increasing the number of cells was further increased.

In addition, as shown in Table 5, when polydioxanone was treated and cultured for 3 days, a significant cell number increase effect was shown compared to the control not treated with polydioxanone. Therefore, it was confirmed that, when the composition containing polydioxanone of the present invention is applied to or attached to the skin, an excellent skin regeneration effect can be exhibited by promoting the proliferation of skin cells. In addition, as the concentration of the treated polydioxanone increased, the effect of increasing the number of cells was further increased.

In addition, as shown in Table 5, when spicule and polydioxanone were treated and cultured for 3 days, a significant cell number increase effect was shown compared to the case where each of them was treated separately. Therefore, it was confirmed that, when the composition containing the spicule and polydioxanone of the present invention is applied or attached to the skin, it can exhibit a more excellent skin regeneration effect by further promoting the proliferation of skin cells.

Experimental Example 2. Measurement of skin delivery rate of oil and water

An experiment was performed to confirm the skin absorption promoting effect of the cosmetic compositions prepared in Comparative Examples 1 to 3, Examples 1 to 6, and Examples a to g.

Specifically, the cosmetic compositions of Comparative Examples 1 to 3 and Examples 1 to 6 and Examples a to g were respectively applied, and after 30 minutes, a scalar moisture checker for skin MY-707S ) was used to measure skin moisture.

sample Skin moisture (%) Comparative Example 1 45 Comparative Example 2 62 Comparative Example 3 49 Example 1 63 Example 2 65 Example 3 63 Example 4 64 Example 5 65 Example 6 63 Example a 71 Example b 70 Example c 67 Example d 65 Example e 64 Example f 63 Example g 61

As shown in Table 6, it was confirmed that the skin moisture content of Comparative Examples 2 to 3 containing spicule or polydioxanone was significantly higher than that of Comparative Example 1 not containing spicule.

In addition, as shown in Table 6, it was confirmed that the skin moisture content of Examples 1 to 6 containing spicule and polydioxanone was higher than Comparative Example 2 containing only spicule. .

In addition, as shown in Table 6, compared to Comparative Example 3 containing only polydioxanone, the skin moisture of Examples 1 to 6 containing spicule and polydioxanone (Polydioxanone) was confirmed to be high.

In addition, as shown in Table 6, as can be seen through Examples a to g of the embodiment including the spicule and polydioxanone, the smaller the particle size of the polydioxanone, the smaller the skin It was also confirmed that the moisture content of

Experimental Example 3. Measurement of skin permeability of polydioxanone

To confirm the skin absorption promoting effect of polydioxanone of the cosmetic composition containing the spicule and polydioxanone of Examples 1 to 12 and Examples a to g prepared above An experiment was performed for The cosmetic compositions of Comparative Examples 3, 1 to 12, and Examples a to g including only polyxioxanone were applied, and skin permeability was measured.

Specifically, the dorsal skin of an 8-10 week old hairless mouse was removed, the subcutaneous fat and tissues were removed with physiological saline, and the skin was well stretched and used in the experiment. In the donor compartment of the hairless Pius skin Franz diffusion cell, the stratum corneum was placed between the receptor compartments with the stratum corneum facing, and then, Comparative Examples 3, Examples 1 to 12 and Examples were applied to the surface of the skin above the skin. The cosmetic compositions of Examples a to g were applied. A pH 7.4 phosphate buffer (phosphate buffered saline) was added to the recipient compartment, and stirring was continued at 300 rpm while maintaining the temperature at 37°C. In this case, the area of the skin in contact with the recipient compartment was 2.0 cm ² , and the capacity of the recipient compartment was 5 ml. After administering 1.0 ml of each sample to the skin surface, the sample was collected using a fraction collector. All samples collected were analyzed using enteroflow fractionation.

After plotting the accumulated amount of permeated polydioxanone particles per skin unit area with respect to time, the polydioxanone particle flux at equilibrium was calculated from the slope of the linear region. Lag time (T _L ) was obtained from the time the straight line passed through the x-axis. Polydioxanone (Polydioxanone) particle flow rate and permeation coefficient in the equilibrium state were compared and analyzed using Equation 1 below.

[Equation 1]

는 평형상태에서의 폴리디옥사논(Polydioxanone) 입자 유동량,

는 투과가 일어나는 면적,

는 평형상태에서 피부를 통과하는 폴리디옥사논(Polydioxanone)의 양을 시간에 대하여 도표화하여 얻은 기울기,

는 포화농도, 그리고

는 투과계수를 나타낸다.

is the flow rate of polydioxanone particles at equilibrium,

is the area of permeation,

is the slope obtained by plotting the amount of polydioxanone that passes through the skin against time at equilibrium,

is the saturation concentration, and

is the transmittance coefficient.

The skin permeability measured according to the above analysis method is shown in Table 7 below.

sample Delay time (hr) Polydioxanone flow rate (μg/(cm ² hr)) Transdermal permeability (%) Comparative Example 3 5.3 6.20 2.50 Example 1 3.3 65.33 10.54 Example 2 3.4 78.86 15.22 Example 3 3.1 113.23 29.17 Example 4 2.7 131.28 34.86 Example 5 2.8 131.78 34.92 Example 6 2.5 132.46 35.03 Example 7 2.8 132.10 35.00 Example 8 2.5 138.77 36.77 Example 9 2.2 141.16 37.41 Example 10 2.0 143.96 38.15 Example 11 1.9 147.94 39.20 Example 12 1.5 150.24 39.81 Example a 2.1 158.76 41.11 Example b 2.3 151.32 39.10 Example c 2.7 142.84 37.84 Example d 2.9 115.32 29.91 Example e 3.5 71.51 18.47 Example f 3.7 12.70 2.74 Example g 4.2 2.13 0.54

As shown in the results of Table 7, when the hydrogel compositions of Examples 1 to 12 and Examples a to g were applied, compared to the case of applying Comparative Example 3 that did not contain spicules, It was confirmed that the delivery effect and skin permeation promoting effect of polydioxanone contained therein were increased. From this, in the case of the cosmetic composition including the spicule and polydioxanone of the present invention, the intradermal delivery effect for the included polydioxanone is very excellent, and the skin care effect is very good accordingly. was able to confirm

In addition, looking at Examples 1 to 6 in which the amount of polydioxanone particles were different, as the amount of polydioxanone particles increased, the delivery effect of polydioxanone and skin It was confirmed that the permeation promoting effect was more excellent.

In addition, as shown in the results of Table 7, PHA (Poly hydroxy acid) and Carum Petroselinum Extract than the cosmetic composition (Example 4) containing only spicule and polydioxanone (Carum Petroselinum Extract) It was confirmed that the delivery effect and skin permeation promoting effect of polydioxanone of Examples 7 to 12 further comprising In addition, according to Examples 7 to 12, it was confirmed that as the amount of poly hydroxy acid (PHA) increased, the delivery effect of polydioxanone and the accelerating effect of skin permeation were more excellent.

In addition, looking at Examples a to g in which the size of the polydioxanone particles are different, the larger the size of the polydioxanone particles, the greater the delivery effect of the polydioxanone and the skin It was confirmed that the permeation promoting effect was lowered. It can be seen that the size of the material that can permeate through the skin is limited, however, when the spicule is used in parallel, it may have some permeability (compared to Comparative Example 3 and Example g), but the permeability is limited It was confirmed that there is It can be seen that, unlike Examples a to c, the delivery effect and skin permeation promoting effect of Examples d to Example g of polydioxanone are limited, and polydioxanone (Polydioxanone) particles It was confirmed that it is effective to use a size of 30 μm or less.

Experimental Example 4. Measurement of skin irritation according to the amount of PHA (Poly hydroxy acid)

For the dorsal skin of the hairless mouse of Experimental Example 3., the sample was exposed to the skin for 4 hours, at this time, the sample was applied to the skin, covered with a patch, and fixed with a non-irritating tape. At this time, the patch was removed after 4 hours, and skin irritation (erythema and crust formation/edema formation) was checked.

At this time, the clinical symptoms and skin reaction evaluation table was judged according to the same criteria as in Table 8 below, and grades were given.

Erythema and crusting edema formation reaction Rating reaction Rating no erythema at all 0 no swelling at all 0 Very mild erythema (nearly discernible to the naked eye) One Very mild edema (almost visible to the naked eye) One distinct erythema 2 Mild edema (clearly swollen so that the margins can be distinguished) 2 mildly severe erythema 3 Severe edema (in case of swelling of about 1 mm) 3 Severe erythema and crusting 4 Severe edema (swelling more than 1 mm and extending beyond the exposed area) 4

sample Erythema and crusting (grade) Edema formation (grade) Example 7 0 0 Example 8 0 0 Example 9 0 0 Example 10 0 0 Example 11 One 0 Example 12 One One Example 4 (comparative sample) 0 0

As shown in Table 9, in the case of the cosmetic composition (Example 4) in which poly hydroxy acid (PHA) and Carum Petroselinum Extract were not mixed, there was no skin irritation. In addition, even if PHA (Poly hydroxy acid) and Carum Petroselinum Extract are mixed, the weight of PHA (Poly hydroxy acid) is 2 wt% or less even in the case of cosmetic compositions (Examples 7 to 10) It can be seen that there is no skin irritation.

Through Table 7 and Table 9, the amount of PHA (Poly hydroxy acid) for improving the skin permeability of polydioxanone without irritation to the skin is 2 parts by weight (relative to 100 parts by weight of the total cosmetic composition) value) was confirmed to be included below.

From the above description, those skilled in the art to which the present invention pertains will be able to understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential characteristics thereof. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention, rather than the above detailed description, all changes or modifications derived from the meaning and scope of the claims described below and their equivalents.

Claims (5)

Based on 100 parts by weight of the total cosmetic composition,
0.001 to 30 parts by weight of a cosmetic active ingredient;
0.02 parts by weight of disodium EDTA;
10 parts by weight of carob bean gum;
Spicule 20 parts by weight;
10 parts by weight of polydioxanone particles;
3 parts by weight of carrageenan;
0.1 to 2 parts by weight of poly hydroxy acid (PHA);
0.2 to 5 parts by weight of Carum Petroselinum Extract;
0.2 parts by weight of PEG-60 hydrogenated castor oil; and
0.1 parts by weight of caprylic/capric triglyceride,
The particle size of the polydioxanone is 30 μm,
The cosmetic active ingredients include retinol, retinyl palmitate, retinyl acetate, retinoic acid, coenzyme Q10, elastin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid, ascorbyl glucoside, alpha-bisabolol, tocopherol. , Tocopherol acetate, arbutin, niacinamide, adenosine, retinol acetate, vitamins A, D, E, and a cosmetic composition comprising at least one selected from the group consisting of natural extracts, a cosmetic composition having an effect of promoting absorption into the skin of an active ingredient.
delete The method of claim 1,
The natural extracts are aloe, green tea, ginseng, red ginseng, pearl, wood vinegar, pine needles, ginkgo leaf, propolis, mulberry leaf, silkworm, snail mucus, kakadu plum, camu camu, yasai yaza, squalane, caviar, broccoli, blueberry, Witch hazel, acerola, chlorella, mangosteen, guava, cornflower oil, carrot, caffeine, hamamelis, spirulina, salmon roe, Ecklonia cava, giant kelp, packing, machihyun, green onion, agaric agar, mulberry, raspberry, wild strawberry, hibiscus, mackerel half, Edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, gold, eoseongcho, sea buckthorn, and one or more selected from the group consisting of yuja, a cosmetic composition.
A cosmetic patch for topical skin care comprising the cosmetic composition of claim 1.
a) applying the cosmetic patch for topical skin care of claim 4 to the skin; and
b) A method of accelerating skin absorption of a cosmetic composition by applying an ultrasonic wave of 3 MHz to 7 MHz to the cosmetic patch for topical skin care at an output of 1 W/cm ² .