JP2001288061A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for preventing teeth from being colored and stained by cigarette tar and incrustations of tea, and whitening the teeth. SOLUTION: This composition for the oral cavity, such as a toothpaste, a liquid dentifrice, an agent for mouth rinsing and an oral refreshment is characterized in that the composition contains 0.01-50 wt.% silk powder preferably having 0.1-500 μm average particle diameter, and a condensed phosphoric salt. The composition also can contain 0.01-99 wt.% other granules (silica or cellulose) including the silk powder granulated therein, and can have a water-soluble polymer, a sugar, a sugar alcohol, or the like, added thereto.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition having an excellent effect of preventing staining of teeth.

[0002]

2. Description of the Related Art Conventionally, various approaches have been studied to whiten teeth colored with cigarette tar or tea astringent. For example, development of abrasives with high cleaning properties, whitening with peroxides, dissolving of coloring matter with solvents such as polyethylene glycol, removal of iron ions and the like with chelating agents, smoothing of tooth surfaces by remineralization, etc. . However, other than the method using peroxide, the effect is insufficient, and the method using peroxide has also been pointed out as a problem that organic substances on the enamel surface escape and the acid resistance is reduced. Only a physician can do this.
From the above, in order to keep the teeth white effectively and easily under mild conditions, it is necessary not only to remove the adhered stains, but also to suppress the coloring, and the development of the composition is required. I have been waiting.

[0003]

SUMMARY OF THE INVENTION The object of the present invention is to provide a composition for the oral cavity which meets the above-mentioned demands and which is excellent in the effect of preventing coloring and staining of teeth.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, by combining silk powder and condensed phosphate, or It has been found that the use of a granulated product of can prevent the coloring stains on the teeth, and the present invention has been accomplished.

[0005] The applicant of the present invention has previously proposed an oral composition which provides a high plaque reattachment inhibitory effect by using a combination of silk powder and dextranase (Japanese Patent Laid-Open No.
Japanese Patent Application Laid-Open No. 00-63251) discloses that the use of this silk powder in combination with a condensed phosphate or the use of a granulated material of silk powder can prevent coloring stains on teeth. This is new knowledge.

Hereinafter, the present invention will be described in more detail.
The oral composition of the present invention is used for the purpose of preventing coloring stains on teeth due to cigarette tar, tea astringent, etc., and a combination of silk powder and condensed phosphate, or granulation of silk powder. It is a mixture of materials.

Here, the silk powder is silkworm boa
mbyx mori Bombycidae Fibroin powder obtained from silk fiber obtained from cocoons of cocoons, but also obtained from cocoons of mountain cocoon moths, and not limited to the place of origin. Can be. As a silk powder, Brooks' Fibro-
Silk powder, silk powder from China manufactured by Gunze Sangyo KK, silk powder manufactured by Kanebo KK, and the like can be used.

The average particle size of the silk powder is not particularly limited, but is preferably 0.01 to 500 μm, particularly preferably 0.1 to 100 μm.
The above-mentioned silk powders can be used alone or in combination of two or more kinds.
It is 1 to 50% (mass percentage, hereinafter the same), more preferably 0.1 to 30%.

On the other hand, as the silk powder granules, in addition to those obtained by granulating only silk powder, other granules,
For example, 0.01 to 99%, more preferably 0.1 to 97% silk powder in silica or cellulose granules,
More preferably, those containing 1 to 95% can be used. The method of producing the silk powder granules is not particularly limited, but a method of attaching silk powder around a core substance, a method of adhering silk powders with a binder,
It can be produced by a general method such as a method of adding silk powder in the granulation and crystallization process of the granules used together.

When binders are used for granulation of the above-mentioned silk powder, the binders are not particularly limited, and for example, water-soluble polymers, sugars, sugar alcohols, thickened silicas and the like are used.

The water-soluble polymer used as the binder includes hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose,
Examples include sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, carrageenan, xanthan gum, polyacrylic acid and its salts, sodium alginate, propylene glycol alginate, gelatin and the like, and these can be used alone or in combination of two or more.

Examples of the sugar or sugar alcohol used as a binder include xylitol, sorbitol, erythritol, maltitol, arabbit, mannitol, galactit, palatinit, lactose and the like.
They can be used alone or in combination of two or more.

As the thickening silica, there is, for example, Sydent 22S (trade name, manufactured by Degussa). Other suitable silicas include, for example, Zeodent 165 (Zeofin), Sorbosil TC15 (Crossfield),
Thixosyl 43 (Rhone Poulin), Cylox 15X (WR Grace) and the like.

The fine particles constituting the granules include cellulose, silica, alumina, calcium carbonate,
Calcium dihydrogen phosphate, calcium pyrophosphate, hydroxyapatite, perlite, zeolite, pumice,
Volcanic ash, hectorite, saponite, aragonite, dolomite, talcite, hydroxytalcite, spangorite, ginsite, gincosilicate, metaphosphate, aluminum hydroxide, titanium dioxide, polyethylene beads, or a mixture of two or more of them. No. Particularly preferred are cellulose and silica. As the granulated material, a cellulose granulated material containing silk powder and a silica granulated material are preferable.

As the cellulose granules, for example, α-
Cellulose, crystalline cellulose, pulp powder, insoluble powdered cellulose, pulp and granules such as those obtained by insolubilizing and pulverizing cellulose by chemical treatment, and the like are included.

Examples of the granulated silica include precipitated silica, silica gel, titanium silicate, zirconium-bound silicate, germanium-bound silicate, and other Al, M
Examples thereof include those obtained by granulating g, Cu, Zn, or the like combined with silicic anhydride.

The average particle diameter of the above-mentioned granulated silk powder is not particularly limited, but is preferably 1 to 2,000 μm, more preferably 10 to 1,200 μm. If it is larger than that, there is a possibility that a foreign-body sensation may occur in the oral cavity. The shape of the granulated material is not particularly limited, and may be any of a granular shape, a spherical shape, a pellet shape, and the like. It is preferable that the blending amount of the silk powder granules is such that the amount of the silk powder becomes the above-mentioned usage amount.

The above-mentioned granulated silk powder does not necessarily need to be disintegrated at the time of use, but has a disintegration strength of 0.1 per piece.
The amount is preferably 1 g to 30 kg, particularly preferably 0.1 g to 30 kg.
1 g to 10 kg. If it is less than 0.1 g, it will naturally disintegrate in the product, and if it is more than 30 kg, it will feel uncomfortable when used.

The condensed phosphate used in the present invention is represented by the following general formula (1): M _{n + 2} P _n O _{3n + 1} (1) (where M represents Na or K, and n ≧ 2). ) And a cyclic represented by the following general formula (2) (MPO ₃ ) _m (2) (where M represents Na or K and m ≧ 3) , And one or more of these can be used in combination.

The chain length of the above-mentioned linear polyphosphate is not particularly limited as long as it is 2 or more.
Particularly preferred is 2 to 20, for example, sodium or potassium pyrophosphate having a polymerization degree of n = 2, sodium or potassium tripolyphosphate having n = 3,
Examples thereof include sodium tetrapolyphosphate and potassium tetrapolyphosphate with n = 4, and sodium metaphosphate and potassium metaphosphate having a high degree of polymerization.

The chain length of the cyclic polyphosphate is not particularly limited as long as it is 3 or more, but is preferably 3 to 30, particularly preferably 3 to 20, and is, for example, sodium trimetaphosphate having a polymerization degree m = 3. Potassium trimetaphosphate, m
= 4, and sodium hexametaphosphate and potassium hexametaphosphate with m = 6.

The amount of the condensed phosphate used in the present invention is not particularly limited.
It is 1 to 20%, particularly preferably 0.1 to 10%. The above-mentioned condensed phosphate is used as an essential component when silk powder is compounded, and silk powder alone does not provide a sufficient effect of preventing coloring and staining of teeth. In addition, when using the silk powder granules, even if the condensed phosphate is not blended, a good effect of preventing coloring stains is obtained.However, by using the silk powder granules and the condensed phosphate together, Provides an excellent coloring stain prevention effect.

The oral composition of the present invention includes various products applied to the oral cavity. Such products include:
Toothpaste, liquid toothpaste, mouthwash, mouth freshener, chewing gum and the like.

The oral composition of the present invention is prepared by blending the above-mentioned silk powder, the silk powder granulated product, and the condensed phosphate with a conventional oral composition such as a dentifrice or mouthwash in a conventional manner. Can be prepared.

The oral composition of the present invention may contain various abrasives, thickeners, binders, surfactants, sweeteners, flavors, coloring agents, preservatives, active ingredients, and the like, if necessary. it can.

Examples of the abrasive include silica abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate, dibasic calcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina , Magnesium carbonate, tribasic magnesium phosphate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, aluminum silicate, zirconium silicate, and a synthetic resin-based abrasive.

Examples of the thickener include glycerin, sorbitol, xylitol, propylene glycol, polyethylene glycol and the like.

Examples of the binder include carrageenan, sodium alginate, propylene glycol alginate, xanthan gum, polyacrylic acid, sodium polyacrylate, carboxyvinyl polymer, tragacanth gum, guar gum, locust bean gum, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropyl Examples include cellulose, methylcellulose, gellan gum, gelatin, curdlan, gum arabic, agar, pectin, polyvinyl alcohol, polyvinylpyrrolidone, pullulan and the like.

Examples of the surfactant include an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like. Specific examples include sodium lauryl sulfate, sodium N-lauroyl sarcosine, α-olefin sulfone. Acid sodium, N-acylglutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyltaurate, sucrose fatty acid ester, alkylolamide, polyoxyethylene hydrogenated castor oil, polyglycerin Fatty acid esters,
Pluronic, polyoxyethylene sorbitan monostearate and the like.

As a sweetener, sodium saccharin,
Stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone,
And perillartin. Examples of the flavor include terpenes such as l-menthol, carvone, anethole, limonene and the like, and derivatives thereof. As a coloring agent,
Blue No. 1, Yellow No. 4, titanium dioxide and the like.

The active ingredient includes cationic fungicides such as chlorohexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride and decalinium chloride, phenolic compounds such as triclosan, hinokitiol and biosol, dextranase and mutanase. Enzymes such as lysozyme, amylase, protease, lytic enzyme and superoxide dismutase; vitamins such as vitamin E and vitamin C; alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; Sodium, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetic Phosphate, bisabolol, glycerophosphate, chlorophyll, sodium chloride, polyvinyl pyrrolidone, polyethylene glycol, water-soluble inorganic phosphoric acid compounds and the like, can be blended these known active ingredients one or more.

[0032]

According to the present invention, there is provided an oral composition having an excellent effect of preventing coloring stains on teeth.

[0033]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Production Examples, Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% represents mass percentage. In the following examples, the collapse strength of the granulated silk powder was measured by the following method. Disintegration Strength Measurement Method The silk powder granules were immersed in water for 60 seconds, taken out of the water after 60 seconds, and measured for maximum stress when pressed under conditions of a plunger diameter of 10 mm and a compression speed of 10 mm / min. [Production Example] Method for producing granulated silk powder Silica and silk powder were sufficiently mixed, water was added thereto, and the obtained mixture was granulated with a pan granulator. Then, it is dried in an oven at 120 ° C. for 4 hours,
Sieving was performed.

[Examples 1 to 3, Comparative Example 1] Test dentifrices containing the components shown in Table 1 were produced, and the effect of preventing tooth staining and staining was evaluated by the following method. As the silk powder, Gunze Sangyo Co., Ltd. used Chinese silk powder for food. <Test for the effect of preventing tooth stains> First, hydroxyapatite pellets (hereinafter referred to as HAP)
) Is used as a reference value to measure the color difference (L0).
The measured HAP is treated with saliva at 37 ° C. for 30 minutes, followed by treatment with a three-fold diluted solution of test dentifrice at 37 ° C. for 3 minutes. After 3 minutes, the HAP is rinsed with deionized water, followed by H
Remove the water drops on the AP.

Next, HAP was added to a 0.5% aqueous albumin solution → 3% Japanese tea + 1% coffee + 1% black tea extracted aqueous solution →
The immersion operation of the 0.6% iron ammonium citrate aqueous solution was repeated for one hour each. After repeating this operation for 50 cycles, the HAP was taken out of the coloring solution, dried at room temperature for one day, and the surface of the HAP was lightly brushed in running water to remove weakly adhered coloring matter, and then air-dried again. The color difference of the colored HAP produced as described above was measured (L1). The coloring suppression effect was determined by ΔL (L0−L1). Table 1 shows the results.

[0036]

[Table 1] * Silk powder: silica = 1: 9 (mass ratio), average particle size 400 μm, disintegration strength in a wet state of 1.0 kg Judgment criteria ◎: Coloring suppression effect △ L0 or more and less than 35 ：: Coloring suppression effect △ L35 or more 45 Less than Δ: Coloring suppression effect ΔL45 or more and less than 55 ×: Coloring suppression effect ΔL55 or more

From the results shown in Table 1, it was confirmed that the use of a combination system of silk powder and condensed phosphate, or the addition of a granulated material of silk powder can suppress the coloring stain of the teeth.

Example 4 Toothpaste Silk Powder Granules 10.0% (silk powder: crystalline cellulose: xylitol = 1: 7: 2 (mass ratio), average particle diameter 600 μm, disintegration in wet state Strength 70 g) calcium dihydrogen phosphate 45.0 propylene glycol 3.0 carboxymethyl cellulose 1.0 carrageenan 0.2 butyl paraben 0.2 70% sorbitol 22.0 sodium benzoate 0.2 sodium monofluorophosphate 0.7 Thickening silica 3 Titanium dioxide 1 Sodium lauryl sulfate 1.0 Fragrance 1.4 Purified water Balance meter 100.0%

Example 5 Toothpaste Silk powder granulated product 5.0% (silk powder: hydroxypropylcellulose = 99: 1 (mass ratio), average particle size 200 μm, disintegration strength 0.39 kg in a wet state) ) Potassium pyrophosphate 1.0 Xanthan gum 0.4 Sodium alginate 0.6 Cetylpyridinium chloride 0.2 Aluminum hydroxide 40.0 70% Sorbitol 30.0 Propylene glycol 3.0 Sodium lauryl sulfate 0.8 Diethanolamide myristate 1 2.0 Saccharin sodium 0.2 Methyl paraben 0.1 Fragrance 1.0 Purified water Balance meter 100.0%

Example 6 Liquid Toothpaste Sodium Pyrophosphate 3.0% Sodium Tripolyphosphate 4.0 Silk Powder 1.0 Xanthan Gum 0.2 Sodium Polyacrylate 0.2 Butylparaben 0.1 70% Sorbitol 43.0 Silica gel 15.0 Propylene glycol 2.0 Glycerin 28.0 Sodium benzoate 0.2 Tranexamic acid 0.05 Sodium fluoride 0.21 Sodium lauryl sulfate 1.5 Fragrance 1.0 Purified water Balance meter 100.0%

Example 7 Mouthwash Sodium Hexametaphosphate 10.0% Silk Powder 0.1 Ethanol 5.0 Glycerin 10.0 Saccharin Sodium 0.1 Polyoxyethylene Hardened Castor Oil 0.1 Sodium Benzoate 0.3 Perfume 0.5 Purified water Balance meter 100.0%

Example 8 Oral Freshener Sodium Tetrapolyphosphate 0.5% Silk Powder 0.5 Ethanol 30.0 Glycerin 15.0 Saccharin Sodium 0.3 Sucrose Fatty Acid Ester 3.0 Fragrance 1.0 Purified Water Balance 100.0% in total

[Example 9] Chewing gum silk powder granules 2.0% (silk powder: calcium carbonate: sodium alginate = 30:30:40 (mass ratio), average particle diameter 1,000 µm, wet state) Disintegration strength 0.9 kg) Gum base 41.0 Citric acid 2.0 Maltitol 40.0 Glycerin 1.0 Reduced maltose 10.0 Flavor 1.5 Purified water Balance meter 100.0%

Example 10 A rayon / polypropylene tooth sticking sheet having the following gel composition as an adhesive layer (applying the sheet as it is to a tooth). Gel Composition Potassium Tripolyphosphate 5.0% Silk Powder 30.0 Sodium Lauryl Sulfate 2.0 Ethanol 8.0 Sorbit 30.0 Hydroxyethyl Cellulose 4.5 Sodium Alginate 2.5 Saccharin Sodium 0.02 Fragrance 1.0 5N Hydrochloric Acid (PH adjuster) Appropriate amount of purified water Balance meter 100.0%

Example 11 A combination of the following toothpaste composition and a silicone rubber mouse tray (the toothpaste composition was filled, chewed and applied at the time of use). Toothpaste composition Sodium tripolyphosphate 5.0% Sodium pyrophosphate 5.0 Silk powder 15.0 N-Lauroylmethyltaurine sodium 1.0 Sorvitol 15.0 Xylitol 10.0 Silicic anhydride 20.0 Xanthan gum 2.0 Carrageenan 0.5 Saccharin sodium 0.1 Fragrance 1.0 Purified water Balance meter 100.0%

Continued on the front page F term (reference) 4C083 AB172 AB222 AB242 AB281 AB282 AB292 AB332 AC102 AC122 AC132 AC232 AC302 AC312 AC432 AC482 AC622 AC642 AC782 AC792 AC852 AC862 AD212 AD222 AD272 AD282 AD302 AD352 AD451 AD452 CC41 DD22 DD23 DD41 EE35 4C084 AA51 DC MA02 MA52 NA14 ZA671 4C086 AA01 AA02 HA19 MA02 MA04 MA52 NA14 ZA67

Claims (3)

[Claims] An oral composition comprising silk powder and a condensed phosphate. 2. An oral composition comprising a silk powder granule. 3. The oral composition according to claim 2, wherein the disintegration strength of the silk powder granules in a sufficiently wet state is 0.1 g to 30 kg per piece.