IE32504B1 - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
IE32504B1
IE32504B1 IE1425/68A IE142568A IE32504B1 IE 32504 B1 IE32504 B1 IE 32504B1 IE 1425/68 A IE1425/68 A IE 1425/68A IE 142568 A IE142568 A IE 142568A IE 32504 B1 IE32504 B1 IE 32504B1
Authority
IE
Ireland
Prior art keywords
alkyl
hal
benzodiazepine derivatives
phch2
subst
Prior art date
Application number
IE1425/68A
Other versions
IE32504L (en
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of IE32504L publication Critical patent/IE32504L/en
Publication of IE32504B1 publication Critical patent/IE32504B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compds. of general formula (I). R' = H, (1-4C) alkyl, or PhCH2. R2 = (1-4C) alkyl, (1-3C) alkyl subst. by MeO or EtO, allyl, or PhCH2 opt. subst. by hal or (1-2C) alkyl. R3 = H, hal., (1-2C) alkyl, or (1-2C) O-alkyl. R4 = H, hal., OH, NO2, NH2, CN, (1-2C) alkyl, or (1-2C) O alkyl. R5 = H, hal., CF3, (1-2C) alkyl, (1-2C) Alkyl. R6 = H, hal., or (1-2C) alkyl. Psychosedatives and anti-convulsants. Dose 1-100 mg. [DE1810423B2]
IE1425/68A 1967-11-24 1968-11-22 Benzodiazepine derivatives IE32504B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1064767A AT280290B (en) 1967-11-24 1967-11-24 Process for the preparation of new 1-phenyl-4-alkyl-3H-1,4-benzodiazepine-2,5- [1H, 4H] -diones

Publications (2)

Publication Number Publication Date
IE32504L IE32504L (en) 1969-05-24
IE32504B1 true IE32504B1 (en) 1973-08-22

Family

ID=3623762

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1425/68A IE32504B1 (en) 1967-11-24 1968-11-22 Benzodiazepine derivatives

Country Status (13)

Country Link
AT (1) AT280290B (en)
BE (1) BE724364A (en)
BR (1) BR6804236D0 (en)
CH (1) CH523265A (en)
DE (1) DE1810423B2 (en)
DK (1) DK124950B (en)
ES (2) ES360410A1 (en)
FR (2) FR1593335A (en)
GB (1) GB1173540A (en)
IE (1) IE32504B1 (en)
IL (1) IL31146A (en)
NL (1) NL6815755A (en)
SE (1) SE356979B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914216A (en) * 1962-12-18 1975-10-21 Boehringer Sohn Ingelheim 1-Phenyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-diones
DE2117438A1 (en) * 1971-04-08 1972-10-19 CH. Boehringer Sohn, 6507 Ingelheim New substituted 1,3-dihydro-2H-1 ^ -benzodiazepine ^ -ones
BE793460A (en) * 1971-12-29 1973-06-28 Boehringer Sohn Ingelheim NEWS 1-ARYL-3H, 1,4-BENZODIAZEPINE-2,5- (1H
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
IL146222A0 (en) * 1999-04-30 2002-07-25 Univ Michigan Therapeutic applications of pro-apoptotic benzodiazepines
US7691582B2 (en) 2002-09-27 2010-04-06 The Regents Of The University Of Michigan Methods of secretory vimentin detection and modulation
CA2593019A1 (en) 2005-01-03 2006-07-13 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
WO2007053193A2 (en) 2005-06-01 2007-05-10 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
CA2779041A1 (en) 2005-11-01 2007-05-10 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2037741B1 (en) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders
EP2139331B1 (en) 2007-03-09 2013-02-20 The Regents of the University of Michigan Compositions and methods relating to novel compounds and targets thereof
AU2008251557B2 (en) * 2007-05-10 2012-12-06 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN101855203B (en) 2007-09-14 2014-03-19 密执安州立大学董事会 F1F0-ATPase inhibitors and related methods
UA99839C2 (en) 2007-11-06 2012-10-10 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Benzodiazepinone compounds useful in the treatment of skin conditions
WO2010030891A2 (en) 2008-09-11 2010-03-18 The Regents Of The University Of Michigan Aryl guanidine f1f0-atpase inhibitors and related methods
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
JP2013505258A (en) 2009-09-18 2013-02-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Benzodiazepinone compounds and therapeutic methods using the same
EP2501387B1 (en) 2009-11-17 2016-07-27 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
ES2703752T3 (en) 2009-11-17 2019-03-12 Univ Michigan Regents 1,4-Benzodiazepine-2,5-diones and related compounds that exhibit therapeutic properties
EP3043790B1 (en) * 2013-09-11 2021-05-26 The Administrators of the Tulane Educational Fund Novel anthranilic amides and the use thereof

Also Published As

Publication number Publication date
ES378977A1 (en) 1973-01-16
BR6804236D0 (en) 1973-02-08
IL31146A0 (en) 1969-01-29
DE1810423B2 (en) 1973-03-22
AT280290B (en) 1970-04-10
NL6815755A (en) 1969-05-28
BE724364A (en) 1969-05-22
DE1810423C3 (en) 1973-10-11
GB1173540A (en) 1969-12-10
IL31146A (en) 1972-04-27
FR1593335A (en) 1970-05-25
CH523265A (en) 1972-05-31
FR8310M (en) 1970-11-23
SE356979B (en) 1973-06-12
DK124950B (en) 1972-12-11
DE1810423A1 (en) 1969-10-09
IE32504L (en) 1969-05-24
ES360410A1 (en) 1970-11-01

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