ES378977A1 - Benzodiazepine Derivatives - Google Patents
Benzodiazepine DerivativesInfo
- Publication number
- ES378977A1 ES378977A1 ES378977A ES378977A ES378977A1 ES 378977 A1 ES378977 A1 ES 378977A1 ES 378977 A ES378977 A ES 378977A ES 378977 A ES378977 A ES 378977A ES 378977 A1 ES378977 A1 ES 378977A1
- Authority
- ES
- Spain
- Prior art keywords
- halogen
- methyl
- ethyl
- ethoxy
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Novel compounds of the general Formula I (R 1 =H, C 1-4 alkyl or benzyl R 2 = C 1-4 alkyl, methoxy-(C 1-3 alkyl), ethoxy-(C 1-3 alkyl), allyl or benzyl optionally substituted by a halogen atom or a methyl or ethyl group R 3 =H, halogen, methyl, ethyl, methoxy or ethoxy R 4 =H, halogen, OH, NO 2 , amino, CF 3 , CN, methyl, ethyl, methoxy or ethoxy R 5 =H, halogen, CF 3 , methyl, ethyl, methoxy or ethoxy R 6 = H, halogen, methyl or ethyl) are prepared by (a) cyclizing a reactive derivative of an acid of the Formula II (b) reacting an acid of the above formula with a carboxylic acid or anhydride, or (c) heating a compound of the Formula III (X= halogen) with an alkali metal alcoholate. The preparation of starting materials of Forml[mu] II and III and of 2-phenylamino-4- chloro-N-ethylbenzamide is described. The compounds of Formula I are psychosedatives and anticonvulsants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier or excipient.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1064767A AT280290B (en) | 1967-11-24 | 1967-11-24 | Process for the preparation of new 1-phenyl-4-alkyl-3H-1,4-benzodiazepine-2,5- [1H, 4H] -diones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES378977A1 true ES378977A1 (en) | 1973-01-16 |
Family
ID=3623762
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES360410A Expired ES360410A1 (en) | 1967-11-24 | 1968-11-19 | Benzodiazepine Derivatives |
| ES378977A Expired ES378977A1 (en) | 1967-11-24 | 1970-04-23 | Benzodiazepine Derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES360410A Expired ES360410A1 (en) | 1967-11-24 | 1968-11-19 | Benzodiazepine Derivatives |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT280290B (en) |
| BE (1) | BE724364A (en) |
| BR (1) | BR6804236D0 (en) |
| CH (1) | CH523265A (en) |
| DE (1) | DE1810423B2 (en) |
| DK (1) | DK124950B (en) |
| ES (2) | ES360410A1 (en) |
| FR (2) | FR1593335A (en) |
| GB (1) | GB1173540A (en) |
| IE (1) | IE32504B1 (en) |
| IL (1) | IL31146A (en) |
| NL (1) | NL6815755A (en) |
| SE (1) | SE356979B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3914216A (en) * | 1962-12-18 | 1975-10-21 | Boehringer Sohn Ingelheim | 1-Phenyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-diones |
| DE2117438A1 (en) * | 1971-04-08 | 1972-10-19 | CH. Boehringer Sohn, 6507 Ingelheim | New substituted 1,3-dihydro-2H-1 ^ -benzodiazepine ^ -ones |
| BE793460A (en) * | 1971-12-29 | 1973-06-28 | Boehringer Sohn Ingelheim | NEWS 1-ARYL-3H, 1,4-BENZODIAZEPINE-2,5- (1H |
| US20060025388A1 (en) | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
| US7572788B2 (en) | 1999-04-30 | 2009-08-11 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US7276348B2 (en) | 1999-04-30 | 2007-10-02 | Regents Of The University Of Michigan | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
| IL146222A0 (en) * | 1999-04-30 | 2002-07-25 | Univ Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| US7691582B2 (en) | 2002-09-27 | 2010-04-06 | The Regents Of The University Of Michigan | Methods of secretory vimentin detection and modulation |
| CA2593019A1 (en) | 2005-01-03 | 2006-07-13 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| WO2007053193A2 (en) | 2005-06-01 | 2007-05-10 | The Regents Of The University Of Michigan | Unsolvated benzodiazepine compositions and methods |
| CA2779041A1 (en) | 2005-11-01 | 2007-05-10 | The Regents Of The University Of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US7759338B2 (en) | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
| EP2037741B1 (en) | 2006-06-09 | 2013-11-27 | The Regents Of The University Of Michigan | Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders |
| EP2139331B1 (en) | 2007-03-09 | 2013-02-20 | The Regents of the University of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| AU2008251557B2 (en) * | 2007-05-10 | 2012-12-06 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| CN101855203B (en) | 2007-09-14 | 2014-03-19 | 密执安州立大学董事会 | F1F0-ATPase inhibitors and related methods |
| UA99839C2 (en) | 2007-11-06 | 2012-10-10 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | Benzodiazepinone compounds useful in the treatment of skin conditions |
| WO2010030891A2 (en) | 2008-09-11 | 2010-03-18 | The Regents Of The University Of Michigan | Aryl guanidine f1f0-atpase inhibitors and related methods |
| WO2010121164A2 (en) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| JP2013505258A (en) | 2009-09-18 | 2013-02-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Benzodiazepinone compounds and therapeutic methods using the same |
| EP2501387B1 (en) | 2009-11-17 | 2016-07-27 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| ES2703752T3 (en) | 2009-11-17 | 2019-03-12 | Univ Michigan Regents | 1,4-Benzodiazepine-2,5-diones and related compounds that exhibit therapeutic properties |
| EP3043790B1 (en) * | 2013-09-11 | 2021-05-26 | The Administrators of the Tulane Educational Fund | Novel anthranilic amides and the use thereof |
-
1967
- 1967-11-24 AT AT1064767A patent/AT280290B/en not_active IP Right Cessation
-
1968
- 1968-11-05 NL NL6815755A patent/NL6815755A/xx unknown
- 1968-11-06 SE SE15032/68A patent/SE356979B/xx unknown
- 1968-11-19 ES ES360410A patent/ES360410A1/en not_active Expired
- 1968-11-20 DK DK566968AA patent/DK124950B/en unknown
- 1968-11-22 BE BE724364A patent/BE724364A/fr unknown
- 1968-11-22 DE DE19681810423 patent/DE1810423B2/en active Granted
- 1968-11-22 FR FR1593335D patent/FR1593335A/fr not_active Expired
- 1968-11-22 CH CH1742668A patent/CH523265A/en not_active IP Right Cessation
- 1968-11-22 BR BR204236/68A patent/BR6804236D0/en unknown
- 1968-11-22 IE IE1425/68A patent/IE32504B1/en unknown
- 1968-11-24 IL IL31146A patent/IL31146A/en unknown
- 1968-11-25 GB GB55844/68A patent/GB1173540A/en not_active Expired
-
1969
- 1969-02-21 FR FR183259A patent/FR8310M/fr not_active Expired
-
1970
- 1970-04-23 ES ES378977A patent/ES378977A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BR6804236D0 (en) | 1973-02-08 |
| IL31146A0 (en) | 1969-01-29 |
| DE1810423B2 (en) | 1973-03-22 |
| AT280290B (en) | 1970-04-10 |
| NL6815755A (en) | 1969-05-28 |
| BE724364A (en) | 1969-05-22 |
| DE1810423C3 (en) | 1973-10-11 |
| GB1173540A (en) | 1969-12-10 |
| IL31146A (en) | 1972-04-27 |
| FR1593335A (en) | 1970-05-25 |
| CH523265A (en) | 1972-05-31 |
| FR8310M (en) | 1970-11-23 |
| SE356979B (en) | 1973-06-12 |
| DK124950B (en) | 1972-12-11 |
| IE32504B1 (en) | 1973-08-22 |
| DE1810423A1 (en) | 1969-10-09 |
| IE32504L (en) | 1969-05-24 |
| ES360410A1 (en) | 1970-11-01 |
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