GB2196634B - Monoclonal antibodies to hiv and related peptides - Google Patents

Monoclonal antibodies to hiv and related peptides

Info

Publication number
GB2196634B
GB2196634B GB8719587A GB8719587A GB2196634B GB 2196634 B GB2196634 B GB 2196634B GB 8719587 A GB8719587 A GB 8719587A GB 8719587 A GB8719587 A GB 8719587A GB 2196634 B GB2196634 B GB 2196634B
Authority
GB
United Kingdom
Prior art keywords
hiv
monoclonal antibodies
related peptides
peptides
monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8719587A
Other languages
English (en)
Other versions
GB8719587D0 (en
GB2196634A (en
Inventor
Mary Kathleen Shriver
Elaine K Thomas
Wesley L Cosand
Larry H Gosting
Edna S Dickinson
Janela
George J Todaro
Robert C Nowinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetic Systems Corp
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Publication of GB8719587D0 publication Critical patent/GB8719587D0/en
Publication of GB2196634A publication Critical patent/GB2196634A/en
Application granted granted Critical
Publication of GB2196634B publication Critical patent/GB2196634B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B25/00—Multi-stage pumps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1054—Lentiviridae, e.g. HIV, FIV, SIV gag-pol, e.g. p17, p24
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mechanical Engineering (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GB8719587A 1986-08-20 1987-08-19 Monoclonal antibodies to hiv and related peptides Expired - Fee Related GB2196634B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89827386A 1986-08-20 1986-08-20
US4502687A 1987-05-01 1987-05-01
US6799687A 1987-06-29 1987-06-29

Publications (3)

Publication Number Publication Date
GB8719587D0 GB8719587D0 (en) 1987-09-23
GB2196634A GB2196634A (en) 1988-05-05
GB2196634B true GB2196634B (en) 1991-05-15

Family

ID=27366600

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8719587A Expired - Fee Related GB2196634B (en) 1986-08-20 1987-08-19 Monoclonal antibodies to hiv and related peptides

Country Status (28)

Country Link
JP (1) JPS6485928A (fr)
KR (1) KR920008744B1 (fr)
AT (1) AT398080B (fr)
AU (1) AU616156B2 (fr)
BE (1) BE1000811A4 (fr)
CH (1) CH675728A5 (fr)
CS (1) CS275838B6 (fr)
DE (1) DE3727703A1 (fr)
DK (1) DK433087A (fr)
ES (1) ES2010727A6 (fr)
FI (1) FI873553A (fr)
FR (1) FR2603107B1 (fr)
GB (1) GB2196634B (fr)
GR (1) GR871298B (fr)
HU (1) HU214439B (fr)
IE (1) IE60671B1 (fr)
IL (1) IL83580A (fr)
IT (1) IT1222518B (fr)
LU (1) LU86972A1 (fr)
NL (1) NL8701950A (fr)
NO (2) NO300462B1 (fr)
NZ (1) NZ221440A (fr)
OA (1) OA08652A (fr)
PL (1) PL155084B1 (fr)
PT (1) PT85567B (fr)
SE (1) SE506025C2 (fr)
YU (1) YU152587A (fr)
ZW (1) ZW15487A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP96A (en) * 1986-06-03 1990-08-12 The Usa Dept Of Commerce Small peptides which inhibit binding to T-4 receptors and act as immunogens.
AU625720B2 (en) * 1987-05-01 1992-07-16 Genetic Systems Corporation Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use
US5834599A (en) * 1987-05-29 1998-11-10 Tanox Biosystems, Inc. Immunoconjugates which neutralize HIV-1 infection
US5981278A (en) * 1987-05-29 1999-11-09 Tanox, Inc. Chimeric monoclonal antibodies which neutralize HIV-1 infection and their applications in therapy and prevention for AIDS
EP0366718B1 (fr) * 1987-05-29 1995-05-10 Tanox Biosystems, Inc. Anticorps monoclonaux neutralisant le hiv-1
US6657050B1 (en) 1987-05-29 2003-12-02 Tanox, Inc. Chimeric viral-neutralizing immunoglobulins
JP2569185B2 (ja) * 1988-01-26 1997-01-08 アメリカ合衆国 抗ｈｉｖ応答を喚起する合成抗原
CA1341285C (fr) * 1988-02-12 2001-08-14 Chang Yi Wang Peptides synthetiques servant a la detection d'anticorps de la proteine de surface gp120 du virus hiv, destines au diagnostic du sida, ainsi que d'etats pre-sidatiques, ou aux fins de vaccins
IL90048A0 (en) * 1988-04-25 1989-12-15 Merck & Co Inc Recombinant gag precursor of hiv,its preparation and its use as aids vaccine
EP0339504A3 (fr) * 1988-04-26 1990-09-12 The Du Pont Merck Pharmaceutical Company Virus d'immunodéficience humaine (HIV) peptide env-codé capable de provoquer les anticorps inhibiteurs du HIV dans les mammifères
US5562905A (en) * 1988-04-26 1996-10-08 E. I. Du Pont De Nemours And Company Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals
FR2632310B1 (fr) * 1988-06-06 1992-04-10 Pasteur Institut Peptides ayant des proprietes protectrices d'un virus pathogene du type hiv dans des cellules sensibles
WO1990003984A1 (fr) * 1988-10-03 1990-04-19 Repligen Corporation Proteines et peptides du vih utiles pour le diagnostic, la prophylaxie ou la therapie du sida
EP0421626A1 (fr) * 1989-09-19 1991-04-10 Merck & Co. Inc. Vaccin contre le SIDA et l'hépatite B
SE9000333D0 (sv) * 1990-01-31 1990-01-31 Britta Wahren Monoklonal antikropp
SE468168B (sv) * 1990-02-20 1992-11-16 Replico Medical Ab Hiv-1, p24 peptider, diagnostiska antigener och foerfarande foer saerskiljande diagnostik av preliminaert hiv-1 positiva serumprov
JPH03271233A (ja) * 1990-03-19 1991-12-03 Inst Pasteur ウイルスエンベロープ糖タンパク質及びその糖タンパク質の中和エピトープに対応するペプチドの間の相乗作用による、ウイルス性感染に対する防御の誘発
CA2047078A1 (fr) * 1990-07-19 1992-01-20 Steven S. Bondy Peptides cycliques neutralisant le vih
CA2047042A1 (fr) * 1990-07-19 1992-01-20 John Hannah Peptides cycliques neutralisant le vih
JPH05310785A (ja) * 1991-09-30 1993-11-22 Nitto Denko Corp Ｈｉｖ関連環状ペプチドおよびこれを固定化した吸着体
DK0960886T3 (da) * 1992-03-27 2004-09-27 Advanced Immuni T Inc Peptid T og beslægtede peptider til behandling af inflammation, herunder multipel sklerose
DK2783697T3 (en) * 2005-12-09 2017-04-10 Vectus Biosystems Ltd VIP Fragments and uses thereof
KR101215215B1 (ko) 2008-09-02 2012-12-24 니혼도꾸슈도교 가부시키가이샤 스파크 플러그

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002383A1 (fr) * 1984-10-18 1986-04-24 Institut Pasteur Antigenes d'enveloppe du virus des lymphadenopathies et leurs applications
EP0185444A2 (fr) * 1984-10-10 1986-06-25 Centocor, Inc. Clonage et expression d'ADN de HTLV-III
WO1986004336A1 (fr) * 1985-01-21 1986-07-31 Institut Pasteur Anticorps monoclonaux contre les proteines de noyau de virus associes aux lymphadenopathies
EP0219106A2 (fr) * 1985-10-17 1987-04-22 F. Hoffmann-La Roche Ag Polypeptides induisant des anticorps contre le virus du SIDA
WO1987002988A1 (fr) * 1985-11-07 1987-05-21 President And Fellows Of Harvard College Proteine de cellules infectees par le virus lymphotrophique des cellules t, et son analyse
EP0231914A2 (fr) * 1986-02-03 1987-08-12 F. Hoffmann-La Roche Ag Peptides d'enveloppe de HTLV-III
GB2188639A (en) * 1986-04-04 1987-10-07 Hoffmann La Roche Expression and purification of an HTLV-111 GAG/ENV gene protein
EP0251612A2 (fr) * 1986-06-23 1988-01-07 Bristol-Myers Squibb Company Anticorps monoclonal humain contre le virus associé à la lymphadénopathie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341423C (fr) * 1984-10-31 2003-03-04 Paul A. Luciw Proteines recombinantes de virus associes au syndrome d'adenopathie et/ou au syndrome d'immuno-deficience acquise
IE64785B1 (en) * 1985-04-08 1995-09-06 Genetic Systems Corp Expression of immunologically reactive viral proteins
ATE109512T1 (de) * 1985-04-08 1994-08-15 Genetic Systems Corp Expression und diagnose mit gag-kodierten peptiden, die mit antikörpern gegen lav immunologisch reaktiv sind.
NZ215867A (en) * 1985-04-19 1989-10-27 Hoffmann La Roche Aids envelope protein, dna vectors and method of production
EP0220273B2 (fr) * 1985-04-29 2007-01-17 Bio-Rad Laboratories, Inc. Antigenes synthetiques permettant la detection d'une infection apparentee au sida
ATE108022T1 (de) * 1985-10-24 1994-07-15 Southwest Found Biomed Res Synthetische peptide und deren verwendung zur diagnose und impfung für aids und arc.
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
EP0525828A3 (en) * 1986-08-01 1993-02-24 Repligen Corporation Recombinant polypeptides and their uses, including assay for aids virus
AU592258B2 (en) * 1986-12-30 1990-01-04 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Synthetic peptides which induce cellular immunity to the aids virus and aids viral proteins

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0185444A2 (fr) * 1984-10-10 1986-06-25 Centocor, Inc. Clonage et expression d'ADN de HTLV-III
WO1986002383A1 (fr) * 1984-10-18 1986-04-24 Institut Pasteur Antigenes d'enveloppe du virus des lymphadenopathies et leurs applications
WO1986004336A1 (fr) * 1985-01-21 1986-07-31 Institut Pasteur Anticorps monoclonaux contre les proteines de noyau de virus associes aux lymphadenopathies
EP0219106A2 (fr) * 1985-10-17 1987-04-22 F. Hoffmann-La Roche Ag Polypeptides induisant des anticorps contre le virus du SIDA
WO1987002988A1 (fr) * 1985-11-07 1987-05-21 President And Fellows Of Harvard College Proteine de cellules infectees par le virus lymphotrophique des cellules t, et son analyse
EP0231914A2 (fr) * 1986-02-03 1987-08-12 F. Hoffmann-La Roche Ag Peptides d'enveloppe de HTLV-III
GB2188639A (en) * 1986-04-04 1987-10-07 Hoffmann La Roche Expression and purification of an HTLV-111 GAG/ENV gene protein
EP0251612A2 (fr) * 1986-06-23 1988-01-07 Bristol-Myers Squibb Company Anticorps monoclonal humain contre le virus associé à la lymphadénopathie

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J.Cellular Biochem.Supp. Vol.0 No.9 part A (1985) p92 *
J.Clin.Microbiology Vol.25 No.5 (1987) pp845-848 *
J.Gen.Virology Vol.68 No.6 (1987) pp1543-1552 *
J.Immunology Vol.136 No.4 (1986) pp1442-1445 *
Proc.Natl.Acad.Sci. (USA) Vol.82 (1985) pp5199-5202 *

Also Published As

Publication number Publication date
HU214439B (hu) 1998-03-30
OA08652A (fr) 1988-11-30
AT398080B (de) 1994-09-26
DK433087D0 (da) 1987-08-19
CH675728A5 (fr) 1990-10-31
CS275838B6 (en) 1992-03-18
FR2603107B1 (fr) 1992-04-24
ES2010727A6 (es) 1989-12-01
GR871298B (en) 1988-01-12
FI873553A (fi) 1988-02-21
GB8719587D0 (en) 1987-09-23
NO934897L (no) 1993-12-29
NO302176B1 (no) 1998-02-02
DK433087A (da) 1988-02-21
ZW15487A1 (en) 1988-09-14
HUT44619A (en) 1988-03-28
FR2603107A1 (fr) 1988-02-26
LU86972A1 (fr) 1988-03-02
IT8721678A0 (it) 1987-08-19
IL83580A0 (en) 1988-01-31
CS8706136A2 (en) 1990-08-14
JPS6485928A (en) 1989-03-30
KR920008744B1 (ko) 1992-10-09
BE1000811A4 (fr) 1989-04-11
PL267401A1 (en) 1988-07-21
YU152587A (sh) 1992-09-07
AU616156B2 (en) 1991-10-24
KR890002547A (ko) 1989-04-10
SE8703225L (sv) 1988-02-21
NZ221440A (en) 1991-11-26
GB2196634A (en) 1988-05-05
IE60671B1 (en) 1994-08-10
ATA208987A (de) 1994-01-15
NO300462B1 (no) 1997-06-02
NO873495L (no) 1988-02-22
IT1222518B (it) 1990-09-05
PT85567B (pt) 1991-02-08
IL83580A (en) 1992-11-15
DE3727703A1 (de) 1988-05-05
NO934897D0 (no) 1993-12-29
PT85567A (en) 1987-09-01
SE506025C2 (sv) 1997-11-03
NL8701950A (nl) 1988-03-16
IE872219L (en) 1988-02-20
NO873495D0 (no) 1987-08-19
FI873553A0 (fi) 1987-08-17
AU7720187A (en) 1988-05-19
PL155084B1 (en) 1991-10-31
SE8703225D0 (sv) 1987-08-19

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19980819