FR21C1012I2 - Promedicament derive de carbamoylpyridone polycyclique substituee - Google Patents
Promedicament derive de carbamoylpyridone polycyclique substitueeInfo
- Publication number
- FR21C1012I2 FR21C1012I2 FR21C1012C FR21C1012C FR21C1012I2 FR 21C1012 I2 FR21C1012 I2 FR 21C1012I2 FR 21C1012 C FR21C1012 C FR 21C1012C FR 21C1012 C FR21C1012 C FR 21C1012C FR 21C1012 I2 FR21C1012 I2 FR 21C1012I2
- Authority
- FR
- France
- Prior art keywords
- substituted polycyclic
- polycyclic carbamoylpyridone
- derived prodrug
- prodrug
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- OHEKQGOBJIKKIF-AWEZNQCLSA-N (12as)-n-[(4-fluorophenyl)methyl]-7-hydroxy-6,8-dioxo-3,4,12,12a-tetrahydro-2h-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide Chemical compound C([C@@H]1OCCCN1C(=O)C1=C(C2=O)O)N1C=C2C(=O)NCC1=CC=C(F)C=C1 OHEKQGOBJIKKIF-AWEZNQCLSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010213012 | 2010-09-24 | ||
| PCT/JP2011/071446 WO2012039414A1 (ja) | 2010-09-24 | 2011-09-21 | 置換された多環性カルバモイルピリドン誘導体のプロドラッグ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR21C1012I1 FR21C1012I1 (fr) | 2021-05-07 |
| FR21C1012I2 true FR21C1012I2 (fr) | 2023-02-17 |
Family
ID=45873898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR21C1012C Active FR21C1012I2 (fr) | 2010-09-24 | 2021-03-15 | Promedicament derive de carbamoylpyridone polycyclique substituee |
Country Status (24)
| Country | Link |
|---|---|
| US (6) | US8987441B2 (pl) |
| EP (1) | EP2620436B1 (pl) |
| JP (2) | JP5553393B2 (pl) |
| KR (1) | KR101773226B1 (pl) |
| CN (1) | CN103228653B (pl) |
| AU (1) | AU2011307087B2 (pl) |
| BR (1) | BR112013006722B1 (pl) |
| CA (1) | CA2812363C (pl) |
| DK (1) | DK2620436T3 (pl) |
| ES (1) | ES2683153T3 (pl) |
| FR (1) | FR21C1012I2 (pl) |
| HR (1) | HRP20181250T1 (pl) |
| HU (2) | HUE039859T2 (pl) |
| LT (2) | LT2620436T (pl) |
| MX (1) | MX2013003139A (pl) |
| NO (1) | NO2021011I1 (pl) |
| PL (1) | PL2620436T3 (pl) |
| PT (1) | PT2620436T (pl) |
| RS (1) | RS57490B1 (pl) |
| RU (1) | RU2608519C2 (pl) |
| SI (1) | SI2620436T1 (pl) |
| TR (1) | TR201810736T4 (pl) |
| TW (1) | TWI518085B (pl) |
| WO (1) | WO2012039414A1 (pl) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010147068A1 (ja) * | 2009-06-15 | 2010-12-23 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体 |
| WO2013054862A1 (ja) * | 2011-10-12 | 2013-04-18 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| EA037633B1 (ru) | 2012-12-21 | 2021-04-23 | Джилид Сайэнс, Инк. | Полициклические карбамоилпиридоновые соединения, их фармацевтические композиции и применение |
| US9045486B2 (en) | 2013-01-08 | 2015-06-02 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| CA2916993C (en) | 2013-07-12 | 2019-01-15 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| NO2865735T3 (pl) | 2013-07-12 | 2018-07-21 | ||
| AU2014318832B2 (en) | 2013-09-12 | 2018-11-29 | Janssen Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| AU2014318837B2 (en) | 2013-09-12 | 2019-05-30 | Janssen Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (pl) | 2014-06-20 | 2018-06-23 | ||
| EP3166943A1 (en) * | 2014-07-07 | 2017-05-17 | Savira Pharmaceuticals GmbH | Pyridopyrazine compounds and their use in the treatment, amelioration or prevention of influenza |
| EP3196201B1 (en) * | 2014-08-22 | 2021-04-28 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
| TWI738321B (zh) * | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| CA2975398C (en) | 2015-01-30 | 2023-02-21 | Lieber Institute For Brain Development | Comt inhibiting methods and compositions |
| US10730888B2 (en) * | 2015-02-06 | 2020-08-04 | Mylan Laboratories Limited | Process for the preparation of dolutegravir |
| US10208045B2 (en) | 2015-03-11 | 2019-02-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| BR112017020837A2 (pt) | 2015-04-02 | 2018-07-03 | Gilead Sciences, Inc. | compostos de carbamoilpiridona policíclicos e seu uso farmacêutico |
| SI4219508T1 (sl) * | 2015-04-28 | 2024-09-30 | Shionogi & Co., Ltd | Substituiran policiklični piridonski derivat in njegovo predzdravilo |
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| CN105030819B (zh) * | 2015-07-06 | 2019-04-05 | 中国科学技术大学 | 一种3-羟基-4-吡啶酮类高分子铁螯合剂的用途 |
| TW201726678A (zh) | 2015-10-30 | 2017-08-01 | 赫孚孟拉羅股份公司 | 嘧啶酮衍生物及其於治療、改善或預防病毒性疾病之用途 |
| US10934283B2 (en) | 2015-11-25 | 2021-03-02 | Lieber Institute, Inc. | COMT inhibiting methods and compositions |
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| MX2018016267A (es) * | 2016-06-20 | 2019-05-20 | Shionogi & Co | Metodo para producir derivado de piridona policiclica sustituida y cristal del mismo. |
| RU2727962C1 (ru) | 2016-08-10 | 2020-07-28 | Сионоги Энд Ко., Лтд. | Фармацевтические композиции, содержащие замещенные полициклические пиридоновые производные и их пролекарство |
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| KR102714478B1 (ko) * | 2017-10-06 | 2024-10-10 | 시오노기세야쿠 가부시키가이샤 | 치환된 다환성 피리돈 유도체의 입체 선택적인 제조 방법 |
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| UA126253C2 (uk) | 2018-02-28 | 2022-09-07 | Новартіс Аг | ПОХІДНІ 10-(ДИ(ФЕНІЛ)МЕТИЛ)-4-ГІДРОКСИ-8,9,9а,10-ТЕТРАГІДРО-7H-ПІРОЛО[1',2':4,5]ПІРАЗИНО[1,2-b]ПІРИДАЗИН-3,5-ДІОНУ ЯК ІНГІБІТОРИ РЕПЛІКАЦІЇ ОРТОМІКСОВІРУСУ ДЛЯ ЛІКУВАННЯ ГРИПУ |
| CN108440564B (zh) * | 2018-04-11 | 2019-08-06 | 安帝康（无锡）生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
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