ES481749A1 - Procedimiento de obtencion de compuestos-derivados pirimidi-nicos con cabeza de puente de nitrogeno. - Google Patents

Procedimiento de obtencion de compuestos-derivados pirimidi-nicos con cabeza de puente de nitrogeno.

Info

Publication number
ES481749A1
ES481749A1 ES481749A ES481749A ES481749A1 ES 481749 A1 ES481749 A1 ES 481749A1 ES 481749 A ES481749 A ES 481749A ES 481749 A ES481749 A ES 481749A ES 481749 A1 ES481749 A1 ES 481749A1
Authority
ES
Spain
Prior art keywords
allergic effect
compounds
nitrogen bridgehead
bridgehead compounds
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481749A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES481749A1 publication Critical patent/ES481749A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos derivados pirimidínicos condensados con cabeza de puente de nitrógeno. Estos nuevos compuestos pueden utilizarse en terapia principalmente como agentes antialérgicos y antiasmáticos. Es conocido que los derivados pirido (1, 2-a) pirimidina poseen valiosas propiedades de influencia sobre el sistema nervioso central, entre las que destacan las analgésicas.
ES481749A 1977-12-29 1979-06-01 Procedimiento de obtencion de compuestos-derivados pirimidi-nicos con cabeza de puente de nitrogeno. Expired ES481749A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1794A HU178496B (en) 1977-12-29 1977-12-29 Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity

Publications (1)

Publication Number Publication Date
ES481749A1 true ES481749A1 (es) 1980-07-01

Family

ID=10994683

Family Applications (7)

Application Number Title Priority Date Filing Date
ES476442A Expired ES476442A1 (es) 1977-12-29 1978-12-28 Procedimiento de preparar compuestos con cabeza de puente denitrogeno
ES481747A Expired ES481747A1 (es) 1977-12-29 1979-06-01 Metodo de obtener compuestos derivados pirimidinicos con ca-beza de puente de nitrogeno.
ES481744A Expired ES481744A1 (es) 1977-12-29 1979-06-01 Procedimiento de preparar compuestos derivados pirimidinicoscon cabeza de puente de nitrogeno.
ES481749A Expired ES481749A1 (es) 1977-12-29 1979-06-01 Procedimiento de obtencion de compuestos-derivados pirimidi-nicos con cabeza de puente de nitrogeno.
ES481745A Expired ES481745A1 (es) 1977-12-29 1979-06-01 Procedimiento de fabricar derivados pirimidinicos con cabe- za de puente de nitrogeno.
ES481748A Expired ES481748A1 (es) 1977-12-29 1979-06-01 Metodo de fabricar derivados pirimidinicos con cabeza de puente de nitrogeno.
ES481746A Expired ES481746A1 (es) 1977-12-29 1979-06-01 Metodo de preparar compuestos derivados pirimidinicos con cabeza de puente de nitrogeno.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES476442A Expired ES476442A1 (es) 1977-12-29 1978-12-28 Procedimiento de preparar compuestos con cabeza de puente denitrogeno
ES481747A Expired ES481747A1 (es) 1977-12-29 1979-06-01 Metodo de obtener compuestos derivados pirimidinicos con ca-beza de puente de nitrogeno.
ES481744A Expired ES481744A1 (es) 1977-12-29 1979-06-01 Procedimiento de preparar compuestos derivados pirimidinicoscon cabeza de puente de nitrogeno.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES481745A Expired ES481745A1 (es) 1977-12-29 1979-06-01 Procedimiento de fabricar derivados pirimidinicos con cabe- za de puente de nitrogeno.
ES481748A Expired ES481748A1 (es) 1977-12-29 1979-06-01 Metodo de fabricar derivados pirimidinicos con cabeza de puente de nitrogeno.
ES481746A Expired ES481746A1 (es) 1977-12-29 1979-06-01 Metodo de preparar compuestos derivados pirimidinicos con cabeza de puente de nitrogeno.

Country Status (29)

Country Link
US (2) US4234586A (es)
JP (1) JPS5495598A (es)
AR (3) AR222985A1 (es)
AT (1) AT375936B (es)
AU (1) AU520428B2 (es)
BE (1) BE873194A (es)
CA (1) CA1130284A (es)
CH (1) CH642078A5 (es)
CS (1) CS244654B2 (es)
DD (1) DD139854A5 (es)
DE (1) DE2854115A1 (es)
DK (1) DK157022C (es)
ES (7) ES476442A1 (es)
FI (1) FI66614C (es)
FR (1) FR2413389A1 (es)
GB (1) GB2011898B (es)
GR (1) GR68357B (es)
HU (1) HU178496B (es)
IL (1) IL56078A (es)
IT (1) IT1203210B (es)
LU (1) LU80601A1 (es)
NL (1) NL7812547A (es)
NO (1) NO151287C (es)
PL (5) PL119641B1 (es)
PT (1) PT68935A (es)
SE (1) SE438675B (es)
SU (2) SU999972A3 (es)
YU (3) YU42093B (es)
ZA (1) ZA787385B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity
HU178452B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 9-substituted amino-4-oxo-6,7-dihydro-4h-pyrido/1,2-a/pyrimidine derivatives
HU178453B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-hydrazino-4-oxo-6,7,8,9-tetrahydro-4h-p-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
US4482557A (en) * 1979-05-11 1984-11-13 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having digitalis-like activity
HU176942B (hu) * 1979-05-11 1981-06-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija 2,3- i 3,4-dvuzamehhjonnykh tetragidro-pirrolo!1,2-a!-pirimidinov
HU179443B (en) * 1979-05-11 1982-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted geminal dihalogeno-derivatives of pyrido-square bracket-1,2-a-square closed-pyrimidines,pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines and pyrimido-square bracket-1,2,-a-square bracket closed-asepines
HU183173B (en) * 1980-06-24 1984-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 6-hydrazono-pyrido-aracket-2,1-b-bracket closed-quinazolin-11-ones
AT381093B (de) * 1980-06-24 1986-08-25 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung neuer 6-hydrazono-pyrido(2,1-b)chinazolin-11-on-deriv te, von deren salzen sowie von deren stereomeren
HU183408B (en) 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
US4395549A (en) * 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
US5344933A (en) * 1991-09-11 1994-09-06 Fuji Photo Film Co., Ltd. Pyrrole ring-or condensed pyrrole ring-containing azomethine dye
EP1790649A1 (en) * 2005-11-21 2007-05-30 Sanofi-Aventis Substituted bicyclic pyrimidone derivatives
EP2138492A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138485A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2138495A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138488A1 (en) 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138498A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
EP2138493A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
EP2138494A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786056A (en) * 1954-05-03 1957-03-19 Merck & Co Inc Acylamido-hydroxy pteridines and preparation thereof
US2894031A (en) * 1958-09-16 1959-07-07 Grace W R & Co Process for cyclohexanone hydrazone hydrate
US3140315A (en) * 1959-02-18 1964-07-07 Bayer Ag Alkyl-substituted hydrazines and hydrazones and process for preparation thereof
FR1255365A (fr) * 1959-12-22 1961-03-10 Cfmc Nouveaux colorants basiques, leur procédé de préparation et leurs applications
US3141043A (en) * 1961-03-24 1964-07-14 Purdue Research Foundation Cyclopentadienylimines, process for their production and condensation products thereof
CH441366A (de) * 1961-06-09 1967-08-15 Hoffmann La Roche Verfahren zur Herstellung von substituierten Hydrazinverbindungen
US3417082A (en) * 1965-08-16 1968-12-17 Polaroid Corp Novel chemical compounds and syntheses
DE1795769C3 (de) * 1966-11-02 1978-11-02 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt, Budapest 6,7,8,9-Tetrahydro-2H-pyrido [Ua] pyrimidinderivate, deren Salze mit Säuren und quaternäre Methosalze, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
HU168014B (es) * 1973-03-30 1976-02-28
US4024132A (en) * 1973-09-07 1977-05-17 Ciba-Geigy Corporation Azomethine pigments
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity

Also Published As

Publication number Publication date
DK157022C (da) 1990-04-02
IT7869933A0 (it) 1978-12-22
IT1203210B (it) 1989-02-15
FI66614B (fi) 1984-07-31
ES481745A1 (es) 1980-07-01
JPS5495598A (en) 1979-07-28
IL56078A (en) 1982-11-30
PL119501B1 (en) 1982-01-30
AU4262778A (en) 1979-07-05
NO151287C (no) 1985-03-13
NO151287B (no) 1984-12-03
BE873194A (fr) 1979-04-17
GB2011898A (en) 1979-07-18
ZA787385B (en) 1980-02-27
US4461769A (en) 1984-07-24
IL56078A0 (en) 1979-01-31
ES481746A1 (es) 1980-07-01
FI784013A (fi) 1979-06-30
HU178496B (en) 1982-05-28
AR222985A1 (es) 1981-07-15
DE2854115C2 (es) 1988-07-28
PL119520B1 (en) 1982-01-30
DD139854A5 (de) 1980-01-23
YU41538B (en) 1987-08-31
SE7813226L (sv) 1979-06-30
DK585578A (da) 1979-06-30
FR2413389B1 (es) 1982-03-26
ATA873678A (de) 1984-02-15
AT375936B (de) 1984-09-25
NL7812547A (nl) 1979-07-03
PL122965B1 (en) 1982-09-30
GR68357B (es) 1981-12-23
PL119641B1 (en) 1982-01-30
SU999972A3 (ru) 1983-02-23
AU520428B2 (en) 1982-01-28
YU296478A (en) 1983-10-31
FI66614C (fi) 1984-11-12
ES481748A1 (es) 1980-07-01
PL212212A1 (es) 1980-02-25
YU279682A (en) 1983-10-31
CS244654B2 (en) 1986-08-14
ES481744A1 (es) 1980-06-16
YU42062B (en) 1988-04-30
SU978730A3 (ru) 1982-11-30
US4234586A (en) 1980-11-18
NO784393L (no) 1979-07-02
YU42093B (en) 1988-04-30
DK157022B (da) 1989-10-30
DE2854115A1 (de) 1979-07-12
ES481747A1 (es) 1980-07-01
JPH0146514B2 (es) 1989-10-09
AR227882A1 (es) 1982-12-30
CA1130284A (en) 1982-08-24
PT68935A (en) 1979-01-01
ES476442A1 (es) 1979-11-16
SE438675B (sv) 1985-04-29
LU80601A1 (de) 1979-03-22
GB2011898B (en) 1982-04-28
PL125321B1 (en) 1983-04-30
CH642078A5 (de) 1984-03-30
AR228949A1 (es) 1983-05-13
FR2413389A1 (fr) 1979-07-27
YU279582A (en) 1983-10-31
CS909178A2 (en) 1985-08-15

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506