ES2006389A6 - Procedimiento de tratamiento termico de trombina. - Google Patents

Procedimiento de tratamiento termico de trombina.

Info

Publication number
ES2006389A6
ES2006389A6 ES8800897A ES8800897A ES2006389A6 ES 2006389 A6 ES2006389 A6 ES 2006389A6 ES 8800897 A ES8800897 A ES 8800897A ES 8800897 A ES8800897 A ES 8800897A ES 2006389 A6 ES2006389 A6 ES 2006389A6
Authority
ES
Spain
Prior art keywords
thrombin
heat treating
contaminating
treating thrombin
stabilizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800897A
Other languages
English (en)
Inventor
Kenji Tanaka
Kenmi Miyano
Hideo Nishimaki
Yoshiro Iga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of ES2006389A6 publication Critical patent/ES2006389A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO DE TRATAMIENTO TERMICO DE TROMBINA, EN EL QUE UNA DISOLUCION ACUOSA QUE CONTIENE TROMBINA SE CALIENTA EN PRESENCIA DE POR LO MENOS UN ESTABILIZANTE ELEGIDO DE ENTRE DISTINTOS AZUCARES PARA DESACTIVAR CON ELLO LOS VIRUS QUE CONTAMINAN EVENTUALMENTE DICHA TROMBINA. LA DESACTIVACION DE LOS VIRUS CONTAMINANTES PUEDE LOGRARSE MANTENIENDO ESTABLE LA TROMBINA. EL EFECTO ESTABILIZANTE PUEDE MEJORARSE ADICIONALMENTE UTILIZANDO UN AMINOACIDO COMO ESTABILIZANTE EN COMBINACION CON EL AZUCAR.SE UTILIZA EN LA PRODUCCION INDUSTRIAL DE PREPARACIONES PROTEINICAS PLASMATICAS.
ES8800897A 1987-03-27 1988-03-24 Procedimiento de tratamiento termico de trombina. Expired ES2006389A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62075562A JPS63243032A (ja) 1987-03-27 1987-03-27 トロンビンの加熱処理方法

Publications (1)

Publication Number Publication Date
ES2006389A6 true ES2006389A6 (es) 1989-04-16

Family

ID=13579744

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800897A Expired ES2006389A6 (es) 1987-03-27 1988-03-24 Procedimiento de tratamiento termico de trombina.

Country Status (4)

Country Link
US (1) US4923815A (es)
JP (1) JPS63243032A (es)
DE (1) DE3809991A1 (es)
ES (1) ES2006389A6 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
NZ232813A (en) * 1989-03-10 1992-08-26 Snow Brand Milk Products Co Ltd Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons
ATE177781T1 (de) * 1990-02-20 1999-04-15 Baxter Int Gereinigtes, virusfreies menschliches thrombin
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
DE4137996A1 (de) * 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
AU6653094A (en) * 1992-12-16 1994-07-04 Immuno Aktiengesellschaft Process for preparing a virus-safe biological composition
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
JP2747979B2 (ja) * 1994-08-19 1998-05-06 雪印乳業株式会社 ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
AT403477B (de) * 1996-04-30 1998-02-25 Immuno Ag Biologisches material frei von viralen und molekularen pathogenen und verfahren zur herstellung
AT407484B (de) * 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
WO2002098445A1 (en) * 2001-05-30 2002-12-12 Chugai Seiyaku Kabushiki Kaisha Protein preparation
AU2003246448A1 (en) * 2002-07-23 2004-02-16 Bio-Products And Bio-Engineering Aktiengesellschaft Pharmaceutically active substance preparations and drugs that are capable of generating thrombin and/or that contain thrombin
US7393674B2 (en) * 2004-06-22 2008-07-01 Zymogenetics, Inc. Thrombin compositions
EP1927658B1 (en) 2004-06-22 2012-10-10 Zymogenetics, Inc. Thrombin compositions
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US9212357B2 (en) 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
TW201702385A (zh) * 2015-03-13 2017-01-16 崇謹 孫 穩定凝血酶之方法及其組合物
CN106568765B (zh) * 2015-10-12 2020-08-04 上海长岛生物技术有限公司 用于抗凝血酶iii活性测定的凝血酶发色底物液、凝血酶水溶液、方法以及试剂盒

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1599930A (en) * 1922-03-25 1926-09-14 Takamine Jokichi Manufacture of bread
US1855592A (en) * 1926-02-03 1932-04-26 Wallerstein Co Inc Invertase preparation and method of making the same
US2495298A (en) * 1945-12-28 1950-01-24 Szent-Gyorgyi Albert Process for the preparation of thrombin
US2567747A (en) * 1948-03-18 1951-09-11 Wallerstein Co Inc Stabilization of enzyme preparations
US3950513A (en) * 1965-12-03 1976-04-13 Novo Terapeutisk Laboratorium A/S Process of stabilizing therapeutically useful plasmin solutions
US3944470A (en) * 1973-06-29 1976-03-16 The Procter & Gamble Company Stabilization and enhancement of enzymatic activity
US4080262A (en) * 1974-07-11 1978-03-21 Boehringer Mannheim Gmbh Stabilizing agent for enzymes
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4585754A (en) * 1984-01-09 1986-04-29 Valcor Scientific, Ltd. Stabilization of proteins and peptides by chemical binding with chondroitin

Also Published As

Publication number Publication date
DE3809991A1 (de) 1988-10-06
US4923815A (en) 1990-05-08
JPS63243032A (ja) 1988-10-07

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