GB832241A - Improvements in and relating to the preparation of adrenocorticotrophin - Google Patents
Improvements in and relating to the preparation of adrenocorticotrophinInfo
- Publication number
- GB832241A GB832241A GB35920/56A GB3592056A GB832241A GB 832241 A GB832241 A GB 832241A GB 35920/56 A GB35920/56 A GB 35920/56A GB 3592056 A GB3592056 A GB 3592056A GB 832241 A GB832241 A GB 832241A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acth
- blood
- agent
- substance
- extracted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for preparing adrenocorticotrophin (ACTH) from a mammalian blood substance such as whole blood, plasma, serum, defibrinated blood and especially beef plasma or serum comprises treating it with an ACTH-activating agent such as pyridoxine preferably by incubating at a temperature from 15 DEG to 150 DEG C., the preferred range being 90 DEG to 100 DEG C., at a pH of 3.5 to 5.5, preferably 4.7 or 4.8, the pH being obtained by agents such as hydrochloric acid, sodium hydroxide, acetic acid-sodium acetate buffer. An organic reducing agent containing at least one sulphydryl group such as cysteine, beta-mercapto-ethanol, thioglycollic acid may be added to stabilize the ACTH. The ACTH activity may be generated in the blood substance by the treatment with the agent and the ACTH then extracted in the usual ways or a pro-ACTH substance may be extracted which is then treated with the agent. Specification 739,024 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US832241XA | 1955-11-28 | 1955-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB832241A true GB832241A (en) | 1960-04-06 |
Family
ID=22176973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35920/56A Expired GB832241A (en) | 1955-11-28 | 1956-11-23 | Improvements in and relating to the preparation of adrenocorticotrophin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB832241A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112540171A (en) * | 2020-12-04 | 2021-03-23 | 郑州标源生物科技有限公司 | Adrenocorticotropic hormone quality control product and preparation method thereof |
-
1956
- 1956-11-23 GB GB35920/56A patent/GB832241A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112540171A (en) * | 2020-12-04 | 2021-03-23 | 郑州标源生物科技有限公司 | Adrenocorticotropic hormone quality control product and preparation method thereof |
| CN112540171B (en) * | 2020-12-04 | 2023-12-22 | 郑州标源生物科技有限公司 | Corticotropin quality control product and preparation method thereof |
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