DK172226B1 - Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater - Google Patents

Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater Download PDF

Info

Publication number: DK172226B1
Authority: DK; Denmark
Prior art keywords: alkyl; methyl; azabicyclo; endo; compound
Prior art date: 1987-09-23

Application number

DK526188A

Other languages

Danish (da)

English (en)

Other versions

DK526188A (da

DK526188D0 (da

Inventor

Marco Turconi

Arturo Donetti

Rosamaria Micheletti

Annamaria Uberti

Massimo Nicola

Antonio Giachetti

Ernesto Montagna

Original Assignee

Boehringer Ingelheim Italia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-23

Filing date

1988-09-22

Publication date

1998-01-12

1988-09-22 Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia

1988-09-22 Publication of DK526188D0 publication Critical patent/DK526188D0/da

1989-03-24 Publication of DK526188A publication Critical patent/DK526188A/da

1998-01-12 Application granted granted Critical

1998-01-12 Publication of DK172226B1 publication Critical patent/DK172226B1/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK526188A 1987-09-23 1988-09-22 Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater DK172226B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8721997A IT1231413B (it)	1987-09-23	1987-09-23	Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
IT2199787		1987-09-23

Publications (3)

Publication Number	Publication Date
DK526188D0 DK526188D0 (da)	1988-09-22
DK526188A DK526188A (da)	1989-03-24
DK172226B1 true DK172226B1 (da)	1998-01-12

Family

ID=11189966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK526188A DK172226B1 (da)	1987-09-23	1988-09-22	Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater

Country Status (28)

Country	Link
EP (1)	EP0309423B1 (it)
JP (1)	JPH0631225B2 (it)
KR (1)	KR960003604B1 (it)
AT (1)	ATE107305T1 (it)
BR (1)	BR1100514A (it)
CA (1)	CA1337347C (it)
CZ (1)	CZ279864B6 (it)
DD (1)	DD285354A5 (it)
DE (1)	DE3850203T2 (it)
DK (1)	DK172226B1 (it)
ES (1)	ES2054872T3 (it)
FI (1)	FI89920C (it)
HK (1)	HK142195A (it)
HU (2)	HU200770B (it)
IE (1)	IE63234B1 (it)
IL (1)	IL87795A (it)
IT (1)	IT1231413B (it)
LV (1)	LV11035B (it)
MX (1)	MX9203249A (it)
NO (1)	NO169286C (it)
NZ (1)	NZ226291A (it)
PH (1)	PH29923A (it)
PL (2)	PL151434B1 (it)
SK (1)	SK278812B6 (it)
SU (1)	SU1676451A3 (it)
UA (1)	UA8022A1 (it)
YU (1)	YU46925B (it)
ZA (1)	ZA887083B (it)

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IT1230881B (it) *	1989-06-20	1991-11-08	Angeli Inst Spa	Derivati del r(-) 3-chinuclidinolo
CA2030051C (en) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Indole derivatives
EP0436245A1 (en) *	1989-12-27	1991-07-10	Duphar International Research B.V	Substituted 3,4-annelated benzimidazol-2(1H)-ones
JP3122671B2 (ja) *	1990-05-23	2001-01-09	協和醗酵工業株式会社	複素環式化合物
US5192770A (en) *	1990-12-07	1993-03-09	Syntex (U.S.A.) Inc.	Serotonergic alpha-oxoacetamides
JP3026845B2 (ja) *	1991-02-20	2000-03-27	日清製粉株式会社	ピペリジン誘導体
IT1250629B (it) *	1991-07-04	1995-04-21	Boehringer Ingelheim Italia	Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.
GB9204565D0 (en) *	1992-03-03	1992-04-15	Smithkline Beecham Plc	Pharmaceuticals
JPH05310732A (ja) *	1992-03-12	1993-11-22	Mitsubishi Kasei Corp	シンノリン−３−カルボン酸誘導体
JP2699794B2 (ja) *	1992-03-12	1998-01-19	三菱化学株式会社	チエノ〔３，２−ｂ〕ピリジン誘導体
WO1993024117A2 (en) *	1992-05-23	1993-12-09	Smithkline Beecham Plc	Medicaments for the treatment of anxiety
US5521193A (en) *	1992-06-24	1996-05-28	G. D. Searle & Co.	Benzimidazole compounds
US5280028A (en) *	1992-06-24	1994-01-18	G. D. Searle & Co.	Benzimidazole compounds
US5300512A (en) *	1992-06-24	1994-04-05	G. D. Searle & Co.	Benzimidazole compounds
WO1994000113A2 (en) *	1992-06-27	1994-01-06	Smithkline Beecham Plc	Medicaments containing 5-ht4 receptor antagonists
FR2694292B1 (fr) *	1992-07-29	1994-10-21	Esteve Labor Dr	Dérivés de benzimidazole-2-thione-, leur préparation et leur application en tant que médicament.
US5534521A (en) *	1993-06-23	1996-07-09	G. D. Searle & Co.	Benzimidazole compounds
GB9502582D0 (en) *	1995-02-10	1995-03-29	Smithkline Beecham Plc	Novel process
AU755117B2 (en) *	1999-05-12	2002-12-05	Sydney Gordon Low	A message processing system
TW200533348A (en)	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en)	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en)	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
JP4129445B2 (ja) *	2004-06-15	2008-08-06	ファイザー・インク	ベンズイミダゾロンカルボン酸誘導体
WO2006052640A1 (en)	2004-11-05	2006-05-18	Theravance, Inc.	5-ht4 receptor agonist compounds
US7396933B2 (en)	2004-11-05	2008-07-08	Theravance, Inc.	Quinolinone-carboxamide compounds
RU2404179C2 (ru)	2004-12-22	2010-11-20	Тереванс, Инк.	Индазол-карбоксамидные соединения
US7446114B2 (en)	2005-03-02	2008-11-04	Theravance, Inc.	Quinolinone compounds as 5-HT4 receptor agonists
WO2006133104A2 (en)	2005-06-07	2006-12-14	Theravance, Inc.	Benzoimidazolone-carboxamide compounds as 5-ht4 receptor agonists
MY143574A (en)	2005-11-22	2011-05-31	Theravance Inc	Carbamate compounds as 5-ht4 receptor agonists
NZ583487A (en) *	2007-07-27	2011-09-30	Actelion Pharmaceuticals Ltd	2-aza-bicyclo[3.3.0]octane derivatives
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
PT2432467T (pt)	2009-05-20	2018-04-04	Inst Nat Sante Rech Med	Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais
EP2701699B1 (en)	2011-04-28	2019-10-16	The Broad Institute, Inc.	Inhibitors of histone deacetylase
WO2014018979A1 (en)	2012-07-27	2014-01-30	The Broad Institute, Inc.	Inhibitors of histone deacetylase
WO2014100438A1 (en)	2012-12-20	2014-06-26	The Broad Institute, Inc.	Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
AR101131A1 (es)	2014-07-11	2016-11-23	Comentis Inc	QUINUCLIDINAS PARA LA MODULACIÓN DE ACTIVIDAD DE a7
CA3125731A1 (en)	2018-01-12	2019-07-18	KDAc Therapeutics, Inc.	Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer

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US4250176A (en) *	1976-12-21	1981-02-10	Janssen Pharmaceutica N.V.	Piperazine derivatives
EP0093488A3 (en) *	1982-03-18	1984-05-23	Beecham Group Plc	Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
ES2053451T3 (es) *	1986-01-07	1994-08-01	Beecham Group Plc	Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.

1987
- 1987-09-23 IT IT8721997A patent/IT1231413B/it active
1988
- 1988-09-19 DD DD88319929A patent/DD285354A5/de not_active IP Right Cessation
- 1988-09-19 PL PL1988274751A patent/PL151434B1/pl unknown
- 1988-09-19 DE DE3850203T patent/DE3850203T2/de not_active Expired - Lifetime
- 1988-09-19 IL IL87795A patent/IL87795A/xx active Protection Beyond IP Right Term
- 1988-09-19 EP EP88830375A patent/EP0309423B1/en not_active Expired - Lifetime
- 1988-09-19 ES ES88830375T patent/ES2054872T3/es not_active Expired - Lifetime
- 1988-09-19 PL PL1988279346A patent/PL152951B1/pl unknown
- 1988-09-19 AT AT88830375T patent/ATE107305T1/de not_active IP Right Cessation
- 1988-09-20 CA CA000577840A patent/CA1337347C/en not_active Expired - Lifetime
- 1988-09-20 JP JP63236179A patent/JPH0631225B2/ja not_active Expired - Lifetime
- 1988-09-21 YU YU177888A patent/YU46925B/sh unknown
- 1988-09-21 NZ NZ226291A patent/NZ226291A/xx unknown
- 1988-09-22 CZ CS886307A patent/CZ279864B6/cs not_active IP Right Cessation
- 1988-09-22 ZA ZA887083A patent/ZA887083B/xx unknown
- 1988-09-22 UA UA4356601A patent/UA8022A1/uk unknown
- 1988-09-22 PH PH37579A patent/PH29923A/en unknown
- 1988-09-22 DK DK526188A patent/DK172226B1/da not_active IP Right Cessation
- 1988-09-22 FI FI884350A patent/FI89920C/fi not_active IP Right Cessation
- 1988-09-22 NO NO884202A patent/NO169286C/no not_active IP Right Cessation
- 1988-09-22 SK SK6307-88A patent/SK278812B6/sk unknown
- 1988-09-22 HU HU884970A patent/HU200770B/hu not_active IP Right Cessation
- 1988-09-22 SU SU884356601A patent/SU1676451A3/ru active
- 1988-09-22 IE IE286988A patent/IE63234B1/en not_active IP Right Cessation
- 1988-09-23 KR KR88012299A patent/KR960003604B1/ko not_active IP Right Cessation
1992
- 1992-06-24 MX MX9203249A patent/MX9203249A/es unknown
1995
- 1995-02-17 LV LVP-95-33A patent/LV11035B/en unknown
- 1995-06-30 HU HU95P/P00691P patent/HU211566A9/hu unknown
- 1995-09-07 HK HK142195A patent/HK142195A/xx not_active IP Right Cessation
1997
- 1997-05-13 BR BR1100514-9A patent/BR1100514A/pt active IP Right Grant

Also Published As

Publication number	Publication date
SK630788A3 (en)	1998-03-04
AU610040B2 (en)	1991-05-09
PL151434B1 (en)	1990-09-28
DK526188A (da)	1989-03-24
CZ630788A3 (en)	1995-04-12
CA1337347C (en)	1995-10-17
UA8022A1 (uk)	1995-12-26
ES2054872T3 (es)	1994-08-16
JPH01106882A (ja)	1989-04-24
BR1100514A (pt)	2002-04-02
EP0309423A3 (en)	1989-11-29
ZA887083B (en)	1990-05-30
HUT48250A (en)	1989-05-29
AU2237888A (en)	1989-03-23
KR960003604B1 (en)	1996-03-20
IT1231413B (it)	1991-12-04
IE882869L (en)	1989-03-23
IL87795A (en)	1993-02-21
DK526188D0 (da)	1988-09-22
HU211566A9 (en)	1995-12-28
DE3850203D1 (de)	1994-07-21
HU200770B (en)	1990-08-28
FI89920B (fi)	1993-08-31
SK278812B6 (sk)	1998-03-04
NO169286B (no)	1992-02-24
KR890005105A (ko)	1989-05-11
IT8721997A0 (it)	1987-09-23
EP0309423A2 (en)	1989-03-29
IL87795A0 (en)	1989-03-31
PL152951B1 (en)	1991-02-28
JPH0631225B2 (ja)	1994-04-27
NO884202D0 (no)	1988-09-22
IE63234B1 (en)	1995-04-05
ATE107305T1 (de)	1994-07-15
NZ226291A (en)	1991-05-28
LV11035A (lv)	1996-02-20
PL279346A1 (en)	1990-01-08
SU1676451A3 (ru)	1991-09-07
FI89920C (fi)	1993-12-10
NO169286C (no)	1992-06-03
MX9203249A (es)	1992-07-01
YU177888A (en)	1990-06-30
CZ279864B6 (cs)	1995-07-12
DD285354A5 (de)	1990-12-12
FI884350A (fi)	1989-03-24
HK142195A (en)	1995-09-15
PL274751A1 (en)	1989-09-04
NO884202L (no)	1989-03-28
DE3850203T2 (de)	1994-09-22
LV11035B (en)	1996-08-20
YU46925B (sh)	1994-06-24
PH29923A (en)	1996-09-16
EP0309423B1 (en)	1994-06-15
FI884350A0 (fi)	1988-09-22

Legal Events

Date	Code	Title	Description
1998-01-12	B1	Patent granted (law 1993)
2008-10-13	PUP	Patent expired

Publication	Publication Date	Title
DK172226B1 (da)	1998-01-12	Benzimidazolin-2-oxo-1-carboxylsyrederivater, mellemprodukt herfor, farmaceutiske præparater indeholdende forbindelserne og anvendelse af forbindelserne til fremstilling af farmaceutiske præparater
US5358954A (en)	1994-10-25	Benzimidazoline-2-oxo-1-carboxylic acid derivatives useful as 5-HT receptor antagonists
DE60223715T2 (de)	2008-10-30	Glyt1 transporter inhibitoren und deren anwendung in der behandlung von neurologischen und neuropsychiatischen krankheiten
EP0504679A1 (en)	1992-09-23	New imidazopyridines as serotonergic 5-HT3 antagonists
US7781430B2 (en)	2010-08-24	Benzoxazole carboxamides for treating CINV and IBS-D
JP2643274B2 (ja)	1997-08-20	イミダゾ〔１，２−ａ〕ピリジン誘導体
JPH01132567A (ja)	1989-05-25	新規アミジノ三環誘導体
US5556851A (en)	1996-09-17	Cinnoline-3-carboxylic acid derivatives
US5047410A (en)	1991-09-10	Indolyl derivatives and their use as 5-HT3, receptor antagonists
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