YU46925B - Postupak za dobijanje novih derivata benzimidazolin-2-okso-1-karboksilne kiseline - Google Patents

Postupak za dobijanje novih derivata benzimidazolin-2-okso-1-karboksilne kiseline

Info

Publication number
YU46925B
YU46925B YU177888A YU177888A YU46925B YU 46925 B YU46925 B YU 46925B YU 177888 A YU177888 A YU 177888A YU 177888 A YU177888 A YU 177888A YU 46925 B YU46925 B YU 46925B
Authority
YU
Yugoslavia
Prior art keywords
alkyl
hydrogen atom
benzimidazoline
oxo
preparation
Prior art date
Application number
YU177888A
Other languages
English (en)
Serbian (sr)
Other versions
YU177888A (en
Inventor
M. Turconi
A. Donetti
R. Micheletti
A. Uberti
M. Nicola
A. Giachetti
E. Montagna
Original Assignee
Boehringer Ingelheim Italia S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Italia S.P.A. filed Critical Boehringer Ingelheim Italia S.P.A.
Priority to SI8811778A priority Critical patent/SI8811778A/sl
Publication of YU177888A publication Critical patent/YU177888A/xx
Publication of YU46925B publication Critical patent/YU46925B/sh
Priority to HRP-1778/88A priority patent/HRP950049B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH DERIVATA BENZIMIDAZOLIN-2-OKSO-1-KARBOKSILNE KISELINE, C alkil, C alkenil ili C alkinil, Y je kiseonik ili N-R, u kome je R vodonik, C alkil ili u datom primeru sa jednim ili više C alkoksi supstituisani benzil, A je grupa izabrana izmedju gde je p 0, 1; R je 0, 1, 2, 3; R je atom vodonika ili C alkil; R je atom vodonika, C alkil, C cikloalkil. C cikloalkil-C alkil, C alkil, supstituisan sa fenilom, ili je R grupa formule -C = N - R, u kojoj je R atom vodonika, C1-6 alkil ili amino grupa, a R7 je atom vodonika ili C1-6 alkil, naznačen time, da reaktivni derivat formule (VIII) u kojoj je R definisan kao gore, a X je grupa koja se odvaja, tretiramo sa jedinjenjem formule (IX) Z - Y - A (IX) u kojoj je Z atom vodonika, litijuma, natrijuma ili kalijuma, a Y i A su definisani kao gore, u aprotičnom rastvaraču u prisustvu akceptora kiseline pri temperaturi od 0 do 200В°C.
YU177888A 1987-09-23 1988-09-21 Postupak za dobijanje novih derivata benzimidazolin-2-okso-1-karboksilne kiseline YU46925B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8811778A SI8811778A (sl) 1987-09-23 1988-09-21 Postopek za pripravo novih derivatov benzimidazolin-2-okso-1-karboksilne kisline
HRP-1778/88A HRP950049B1 (en) 1987-09-23 1995-02-03 Process for the preparation of new benzimidazoline-2oxo-1-carboxylic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8721997A IT1231413B (it) 1987-09-23 1987-09-23 Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht

Publications (2)

Publication Number Publication Date
YU177888A YU177888A (en) 1990-06-30
YU46925B true YU46925B (sh) 1994-06-24

Family

ID=11189966

Family Applications (1)

Application Number Title Priority Date Filing Date
YU177888A YU46925B (sh) 1987-09-23 1988-09-21 Postupak za dobijanje novih derivata benzimidazolin-2-okso-1-karboksilne kiseline

Country Status (28)

Country Link
EP (1) EP0309423B1 (sh)
JP (1) JPH0631225B2 (sh)
KR (1) KR960003604B1 (sh)
AT (1) ATE107305T1 (sh)
BR (1) BR1100514A (sh)
CA (1) CA1337347C (sh)
CZ (1) CZ279864B6 (sh)
DD (1) DD285354A5 (sh)
DE (1) DE3850203T2 (sh)
DK (1) DK172226B1 (sh)
ES (1) ES2054872T3 (sh)
FI (1) FI89920C (sh)
HK (1) HK142195A (sh)
HU (2) HU200770B (sh)
IE (1) IE63234B1 (sh)
IL (1) IL87795A (sh)
IT (1) IT1231413B (sh)
LV (1) LV11035B (sh)
MX (1) MX9203249A (sh)
NO (1) NO169286C (sh)
NZ (1) NZ226291A (sh)
PH (1) PH29923A (sh)
PL (2) PL151434B1 (sh)
SK (1) SK278812B6 (sh)
SU (1) SU1676451A3 (sh)
UA (1) UA8022A1 (sh)
YU (1) YU46925B (sh)
ZA (1) ZA887083B (sh)

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IT1230881B (it) * 1989-06-20 1991-11-08 Angeli Inst Spa Derivati del r(-) 3-chinuclidinolo
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives
EP0436245A1 (en) * 1989-12-27 1991-07-10 Duphar International Research B.V Substituted 3,4-annelated benzimidazol-2(1H)-ones
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
US5192770A (en) * 1990-12-07 1993-03-09 Syntex (U.S.A.) Inc. Serotonergic alpha-oxoacetamides
JP3026845B2 (ja) * 1991-02-20 2000-03-27 日清製粉株式会社 ピペリジン誘導体
IT1250629B (it) * 1991-07-04 1995-04-21 Boehringer Ingelheim Italia Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.
GB9204565D0 (en) * 1992-03-03 1992-04-15 Smithkline Beecham Plc Pharmaceuticals
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
WO1993024117A2 (en) * 1992-05-23 1993-12-09 Smithkline Beecham Plc Medicaments for the treatment of anxiety
US5521193A (en) * 1992-06-24 1996-05-28 G. D. Searle & Co. Benzimidazole compounds
US5280028A (en) * 1992-06-24 1994-01-18 G. D. Searle & Co. Benzimidazole compounds
US5300512A (en) * 1992-06-24 1994-04-05 G. D. Searle & Co. Benzimidazole compounds
WO1994000113A2 (en) * 1992-06-27 1994-01-06 Smithkline Beecham Plc Medicaments containing 5-ht4 receptor antagonists
FR2694292B1 (fr) * 1992-07-29 1994-10-21 Esteve Labor Dr Dérivés de benzimidazole-2-thione-, leur préparation et leur application en tant que médicament.
US5534521A (en) * 1993-06-23 1996-07-09 G. D. Searle & Co. Benzimidazole compounds
GB9502582D0 (en) * 1995-02-10 1995-03-29 Smithkline Beecham Plc Novel process
AU755117B2 (en) * 1999-05-12 2002-12-05 Sydney Gordon Low A message processing system
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
JP4129445B2 (ja) * 2004-06-15 2008-08-06 ファイザー・インク ベンズイミダゾロンカルボン酸誘導体
WO2006052640A1 (en) 2004-11-05 2006-05-18 Theravance, Inc. 5-ht4 receptor agonist compounds
US7396933B2 (en) 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
RU2404179C2 (ru) 2004-12-22 2010-11-20 Тереванс, Инк. Индазол-карбоксамидные соединения
US7446114B2 (en) 2005-03-02 2008-11-04 Theravance, Inc. Quinolinone compounds as 5-HT4 receptor agonists
WO2006133104A2 (en) 2005-06-07 2006-12-14 Theravance, Inc. Benzoimidazolone-carboxamide compounds as 5-ht4 receptor agonists
MY143574A (en) 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
NZ583487A (en) * 2007-07-27 2011-09-30 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.3.0]octane derivatives
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
PT2432467T (pt) 2009-05-20 2018-04-04 Inst Nat Sante Rech Med Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais
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Also Published As

Publication number Publication date
SK630788A3 (en) 1998-03-04
AU610040B2 (en) 1991-05-09
PL151434B1 (en) 1990-09-28
DK526188A (da) 1989-03-24
CZ630788A3 (en) 1995-04-12
CA1337347C (en) 1995-10-17
UA8022A1 (uk) 1995-12-26
ES2054872T3 (es) 1994-08-16
JPH01106882A (ja) 1989-04-24
BR1100514A (pt) 2002-04-02
EP0309423A3 (en) 1989-11-29
ZA887083B (en) 1990-05-30
HUT48250A (en) 1989-05-29
AU2237888A (en) 1989-03-23
KR960003604B1 (en) 1996-03-20
IT1231413B (it) 1991-12-04
IE882869L (en) 1989-03-23
IL87795A (en) 1993-02-21
DK526188D0 (da) 1988-09-22
HU211566A9 (en) 1995-12-28
DE3850203D1 (de) 1994-07-21
DK172226B1 (da) 1998-01-12
HU200770B (en) 1990-08-28
FI89920B (fi) 1993-08-31
SK278812B6 (sk) 1998-03-04
NO169286B (no) 1992-02-24
KR890005105A (ko) 1989-05-11
IT8721997A0 (it) 1987-09-23
EP0309423A2 (en) 1989-03-29
IL87795A0 (en) 1989-03-31
PL152951B1 (en) 1991-02-28
JPH0631225B2 (ja) 1994-04-27
NO884202D0 (no) 1988-09-22
IE63234B1 (en) 1995-04-05
ATE107305T1 (de) 1994-07-15
NZ226291A (en) 1991-05-28
LV11035A (lv) 1996-02-20
PL279346A1 (en) 1990-01-08
SU1676451A3 (ru) 1991-09-07
FI89920C (fi) 1993-12-10
NO169286C (no) 1992-06-03
MX9203249A (es) 1992-07-01
YU177888A (en) 1990-06-30
CZ279864B6 (cs) 1995-07-12
DD285354A5 (de) 1990-12-12
FI884350A (fi) 1989-03-24
HK142195A (en) 1995-09-15
PL274751A1 (en) 1989-09-04
NO884202L (no) 1989-03-28
DE3850203T2 (de) 1994-09-22
LV11035B (en) 1996-08-20
PH29923A (en) 1996-09-16
EP0309423B1 (en) 1994-06-15
FI884350A0 (fi) 1988-09-22

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