CN110354295A - A kind of optical-thermal conversion material and preparation method thereof - Google Patents

A kind of optical-thermal conversion material and preparation method thereof Download PDF

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Publication number
CN110354295A
CN110354295A CN201910415080.XA CN201910415080A CN110354295A CN 110354295 A CN110354295 A CN 110354295A CN 201910415080 A CN201910415080 A CN 201910415080A CN 110354295 A CN110354295 A CN 110354295A
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metal ion
tannic acid
native protein
natural
natural polysaccharide
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CN110354295B (en
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于云龙
张仕勇
李鹏飞
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Sichuan University
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Sichuan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract

The present invention is provided based on tannic acid/metal ion complex NIR light hot-cast socket material and preparation method thereof, mainly by the preferable TA of biocompatibility, metal ion (Fe3+、Ru3+、V3+) be added in medical material, utilize TA, metal ion (Fe3+、Ru3+、V3+) formed complex compound NIR light hot-cast socket effect, so that material is generated higher fuel factor under the stimulation of NIR, to achieve the purpose that antibacterial.The material, which is used as photo-thermal antibacterial anti hemorrhagic dressing for skin, has excellent imbibition ability, and TA/ metal ion significantly improves the cell/tissue compatibility of material, has broad application prospects in medical field.

Description

A kind of optical-thermal conversion material and preparation method thereof
Technical field
The invention belongs to technical field of biological materials, and in particular to a kind of photothermal conversion and anti-biotic material.
Technical background
The dressing for skin (film, freezing gel and hydrogel etc.) of natural polymer subbase is because having excellent bio-compatible Property and biodegradability and be widely used in wound healing.However, most natural polymer dressing does not have antibacterial Activity, it is difficult to avoid the microorganism infection during wound healing.Currently, addition antibacterial agent (antibiotic, metal ion and quaternary ammonium Salt) it is the conventional means for improving wound dressing antibacterial activity.However, being widely used for antibiotic may cause bacterial drug resistance Generation, and there are long-term cytotoxicities, and wound healing rate will can be greatly reduced for the use of metal ion and quaternary ammonium salt.
In recent years, near-infrared (NIR) photo-thermal therapy of bacterium infection was because can effectively evade using existing for conventional antibiotic Problems, such as narrow antimicrobial spectrum, drug resistance and poisonous side effect of medicine are big, and the extensive concern by researcher.It is close red Outer photo-thermal antimicrobial technology because do not have special targeting, therefore while killing bacterium will not inducible resistance bacterium generation. Currently, a large amount of near-infrared photosensitizer is such as: noble metal nano particles, carbon nanomaterial, metal and nonmetallic oxide and Some polymer photosensitizers etc. are gradually applied to near-infrared photo-thermal antibacterial and antitumor treatment.However, these Near-infrared photosensitizer still has some problems, and for example, higher cost, the near infrared light thermal efficiency is low, cell compatibility is poor etc..
Summary of the invention
Present invention aims in view of the deficiencies of the prior art, provide based on tannic acid/metal ion complex NIR Optical-thermal conversion material and preparation method thereof obtains one kind and has both good cell compatibility, near infrared light thermal efficiency height, cost Cheap, the photo-thermal antibacterial that has no toxic side effect and oncotherapy medical material.
Major technique design of the invention is a kind of polyphenolic substance of the tannic acid (TA) as natural botanical source, With anti-oxidant, capture free radical, antibacterial characteristic.By the preferable TA of biocompatibility, metal ion (Fe3+、 Ru3+、V3+) It is added in medical material, utilizes TA, metal ion (Fe3+、Ru3+、V3+) formed complex compound NIR light hot-cast socket effect, Material is set to generate higher fuel factor under the stimulation of NIR, to achieve the purpose that antibacterial.Simultaneously as material has mostly sky Structure, imbibition and haemostatic effect are excellent.In addition, NIR illumination is conducive to the regeneration of tissue, wound healing will be played actively Facilitation, protection wound exempt from bacterium infection and promote tissue repair in terms of have broad application prospects.Tannin Acid/metal ion complex raw material sources are extensive, and preparation process is simple and low in cost, are a kind of ideal NIR light hot-cast sockets Material can be widely used in medical field, can greatly reduce treatment cost, have practical clinical value.
The present invention provides a kind of material, specifically based on tannic acid/metal ion complex NIR light hot-cast socket material, Including tannic acid/metal ion complex, the metal ion is Fe3+、Ru3+、V3+At least one of.
It further, further include the material with good cell, tissue affinity and compatibility, it is further, described Material is natural material, it is preferable that the natural material is combined selected from one or both of natural polysaccharide, native protein.
The present invention provides a kind of medical material, specifically based on the hot antibacterial of tannic acid/metal ion complex NIR light Material, including tannic acid/metal ion complex, natural polysaccharide and native protein.
Further, the natural polysaccharide and native protein constitute porous support, and TA and adsorption of metal ions are in porous branch In frame surface and pore structure.
Further, in the tannic acid/metal ion complex, metal ion Fe3+、Ru3+、V3+In at least one Kind.The complex that metal ion and TA are formed, has preferable photothermal conversion ability, higher heat is generated under the stimulation of NIR Effect effectively kills the bacterium of wound location, promotes the healing of tissue.
Further, by quality proportioning, natural polysaccharide: native protein: TA: metal ion=(50~80): (20~ 50): (0.1~10): (0.05~5).Preferably, the quality proportioning of natural polysaccharide and native protein is 2:1, under this proportion The mechanical property of timbering material is more preferable compared to other ratios.
Further, the natural polysaccharide be chitin, it is chitosan, cellulose, konjaku glucan, sodium alginate, transparent At least one of matter acid, starch, spirulina polysaccharide.
Further, the native protein is fibroin albumen, fibroin fiber, fibronectin, albumin, gelatin, collagen egg It is at least one of white.Native protein has preferable biocompatibility, and can promote the proliferation of cell.
Medical material provided by the invention can be used for the photo-thermal therapy of bacterium infection, in photo-thermal antineoplaston.Especially It can be used as antibacterial dressing for skin, wound dressing and hemostatic material.It, which is used as wound dressing and hemostatic material, has excellent imbibition Ability can absorb the blood of wound exudation and carry out quick-acting haemostatic powder to wound；In addition, the dressing can stimulate extraneous near-infrared It is converted into local high fever, local high thermal energy effectively inhibits or kills bacterium and then avoids the bacterium sense during wound healing Dye；Meanwhile TA/ metal ion can significantly improve the cell/tissue compatibility of dressing, and then can promote skin tissue regeneration and Accelerating wound healing.
The preparation method of the hot anti-biotic material of above-mentioned NIR light provided by the invention, it includes following content:
(1) tannic acid/metal ion match or tannic acid and metal ion；
(2) native protein；
(3) natural polysaccharide；
(4) it mixes in a solvent；Further, the solvent is selected from water；
(5) it is freeze-dried.
In the above method, can simultaneously it combine (1)~(4) item content, it can also be by two Xiang Xianyu in (1)~(3) (4) combine, obtained material combines implementation with the residual term in (1)~(3), (4) again after combination, for example, first by (2), (3), (4) it combines, obtained material is combined with (1), (4) again, and gained mixture is freeze-dried up to the material；In another example first will (1), (2), (4) combination, obtained material are combined with (3), (4) again, and gained mixture is freeze-dried up to the material；Example again As first combined (1), (3), (4), obtained material is combined with (2), (4) again, and gained mixture is freeze-dried up to the material Material.
It can be carried out using dropwise addition mode when mixing, such as metal ion solution is added drop-wise to the solution for being dispersed with tannic acid In.
Further, it is 10 that natural polysaccharide and native protein, which are dissolved in water and are made into natural polysaccharide and native protein total concentration, Natural polysaccharide/native protein mixed liquor of~100mg/mL.
Further, the additive amount of tannic acid is the 0.1~10mg/mL of concentration for making tannic acid in mixed solution.
Further, the dripping quantity of metal ion solution is after making to be added dropwise in obtained mixed solution, metal ion it is dense Degree is 0.05~5mg/mL.
The present invention provides a kind of composition, including natural polysaccharide, native protein, TA, metal ion, in terms of quality proportioning, Natural polysaccharide: native protein: TA: metal ion=(50~80): (20~50): (0.1~10): (0.05~5)；Further Ground, the metal ion are Fe3+、Ru3+、V3+At least one of.
In the composition: TA and metal ion can form stable complex, and the effectiveness with photothermal conversion, and thin Cell phase capacitive is preferable, the medical material that can obtain having photo-thermal antibacterial action is combined with natural polysaccharide, native protein, to answer For in photo-thermal antibacterial therapy and photo-thermal antineoplaston.
Compared with prior art, beneficial effects of the present invention:
1. the present invention provides a kind of new photo-thermal antibacterial medical material, wound dressing and hemostatic material, raw material is whole From natural animal and plant, there is good biocompatibility and biodegradability, while TA/ metal ion complex is not Only preparation method is simple, photothermal conversion efficiency is high and has excellent cell/compatibility.
2. the near infrared light thermal conversion efficiency of photo-thermal anti-bacterial material prepared by the present invention, TA/ metal ion is high, and day It so has no toxic side effect, there is excellent cell/compatibility, can effectively avoid Long-term cell toxicity existing for conventional antimicrobial dressing And the problems such as drug resistance.Also, compared to traditional light thermit powder, TA/ metal ion has excellent tissue affinity, can add Fast cell Proliferation promotes regeneration and accelerating wound healing.
3. anti-biotic material prepared by the present invention, which is used as hemostatic material, has excellent imbibition ability, can be carried out at the surface of a wound Quickly sucks blood and stop blooding.
Detailed description of the invention
Fig. 1 is the shape appearance figure of antibacterial skin wound dressing prepared by embodiment 1.
Fig. 2 is the in-vitro antibacterial performance of antibacterial skin wound dressing prepared by embodiment 1.
Fig. 3 is the anthemorrhagic performance of antibacterial skin wound dressing prepared by embodiment 1.
Fig. 4 is the internal skin repair result of antibacterial skin wound dressing prepared by embodiment 1.
Specific embodiment
Above content of the invention is described in further detail by the following examples.It should be appreciated that this place is retouched The specific example stated is only used to explain the present invention, is not intended to limit the present invention.The spirit and principles in the present invention are not being departed from Within any modification for making, and the equivalent replacement or improvement made according to ordinary skill knowledge and customary means, It should all include within the scope of the present invention.
Embodiment 1
A, chitosan and fibroin albumen are dissolved in the water and are configured to chitosan/fibroin albumen (CS/SF) of 30mg/mL Mixed liquor (chitosan/fibroin albumen mass ratio be 2 ﹕ 1).
B, evenly spreading to TA in the chitosan/fibroin albumen mixed liquor being made in A step makes its concentration Then Fe is added dropwise in 0.3mg/mL into mixed liquor again3+Solution and 0.15 mg/mL of concentration for making iron ion in mixed liquor.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.Dressing to preparation Morphology characterization is carried out, as a result as shown in Figure 1, it is seen that gained dressing has relatively rich pore structure.CSTFe (1.5) refers to by shell Glycan, silk-fibroin, tannic acid, iron ion composition supporting structure, wherein TA, Fe3+Content be respectively 150 μ g/mL, 75 μ g/ mL.CSTFe (3), CSTFe (5), CSTFe (10), which represent TA content, successively to be increased, and is 300 μ g/mL, 500 μ g/mL, 1000 μ g/ mL.It can be seen that as TA content increases, the size in hole is shunk, but still remains preferable porous pattern, so that material has There are good Repeated Compression and moisture pick-up properties.
Antibacterial test is carried out to the dressing of preparation
Test method: after doing sterilization treatment to the antibacterial dressing for skin preparation of preparation in advance, then by the antibacterial after sterilizing Dressing for skin is laid in orifice plate bottom, and Escherichia coli or staphylococcus aureus (106 CFU) is added.Antiseptic dressing is replaced For pure chitosan/silk-fibroin (being not introduced into tannic acid and metal ion), pure chitosan/silk-fibroin group is set by the same way, One group of blank control group is separately set again.Above three groups are arranged in parallel two groups respectively, one group of carry out near infrared light photograph, one group not into Row illumination.By three groups in 12 hours of 37 DEG C of baking oven cultures.It takes the bacterium solution after being incubated for carry out solid plate experiment, then trains After supporting 12 hours, takes pictures and count bacterium colony.
Test result: gained dressing as shown in Figure 2 has preferable photo-thermal antibacterial effect.Compared to the control group and pure shell is poly- Sugar/silk-fibroin group, antiseptic dressing group has preferable photo-thermal effect, either to gram-positive bacteria (Staphylococcus aureus Bacterium) or the antibiotic rate of negative bacterium (Escherichia coli) can achieve nearly 100%.
Hemostasis test is carried out to the dressing of preparation
Test method: carrying out docking model foundation for SD rat, the tail of mouse is cut off one third, for setting four Group, uses gauze respectively, chitosan/silk-fibroin and prepared by the present invention contains TA/Fe3+Dressing carry out hemostasis processing, do not do Any processing is as a control group.One piece of clean filter paper is placed in dressing bottom, counts blood loss, and take pictures.
Test result: as shown in figure 3, antiseptic dressing group prepared by the present invention has preferable haemostatic effect, it can be 30 The effect of hemostasis can be played within second.
Skin histology reparative experiment is carried out to the auxiliary material of preparation
Experimental method: establishing the round defect model of 8 mm dias at the back of mouse, then will disinfection treatment Dressing prepared by the present invention afterwards is laid in wound surface, while control group without any processing is arranged.Respectively the 0,7th, It takes pictures to the defect of mouse within 15 days, compares the effect of skin repair.
Experimental result: as shown in figure 4, dressing prepared by the present invention can effectively promote skin histology reparation, have compared with Good rush tissue repairing ability, wound can be allowed in 15 heals completely, and tissue is repaired.
Embodiment 2
A, hyaluronic acid and collagen are dissolved in the water be configured to 30mg/mL hyaluronic acid/collagen it is mixed Close liquid (hyaluronic acid/collagen mass ratio is 1 ﹕ 1).
B, evenly spreading to TA in the hyaluronic acid/collagen mixed liquor being made in A step makes its concentration Then V is added dropwise in 0.2mg/mL into mixed liquor again3+Solution and 0.1 mg/mL of concentration for making vanadium ion in mixed liquor.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.
Embodiment 3
A, sodium alginate and albumin are dissolved in the water and are configured to sodium alginate/albumin mixed liquor of 40mg/mL (sodium alginate/albumin mass ratio is 3 ﹕ 1).
B, evenly spreading to TA in the sodium alginate/albumin mixed liquor being made in A step makes its concentration 1mg/ Then Fe is added dropwise in mL into mixed liquor again3+And make the concentration 0.5mg/mL of iron ion in mixed liquor.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.
Embodiment 4
A, chitosan and fibroin albumen are dissolved in the water and are configured to chitosan/fibroin albumen mixed liquor of 30mg/mL (chitosan/fibroin albumen mass ratio is 2 ﹕ 1).
B, evenly spreading to TA in the chitosan/fibroin albumen mixed liquor being made in A step makes its concentration Then Fe is added dropwise in 0.3mg/mL into mixed liquor again3+And make the concentration 0.15mg/mL of iron ion in mixed liquor.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.
Embodiment 5
A, by chitosan and Gelatin Yu Shuizhong be configured to 40mg/mL chitosan/gelatin mixed liquor (chitosan/ The mass ratio of gelatin is 3 ﹕ 1).
B, evenly spreading to TA in the chitosan/gelatin mixed liquor being made in A step makes 1 mg/mL of its concentration, Then Fe is added dropwise into mixed liquor again3+And make the concentration 0.5mg/mL of iron ion in mixed liquor.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.
Embodiment 6
A, chitosan and fibroin albumen are dissolved in the water and are configured to chitosan/fibroin albumen mixed liquor of 30mg/mL (chitosan/fibroin albumen mass ratio is 2 ﹕ 1).
B, evenly spreading to TA in the chitosan/fibroin albumen mixed liquor being made in A step makes its concentration Then Ru is added dropwise in 0.3mg/mL into mixed liquor again3+And make Ru in mixed liquor3+Concentration be 0.15mg/mL.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.
Embodiment 7
A, cellulose and fibroin fiber are dissolved in the water and are configured to cellulose/fibroin fiber mixed liquor of 40mg/mL (mass ratio of cellulose and fibroin fiber is 1:1).
B, evenly spreading to TA in the chitosan/fibroin albumen mixed liquor being made in A step makes its concentration Then Ru is added dropwise in 0.6mg/mL into mixed liquor again3+And make 0.3 mg/mL of concentration of metal ion in mixed liquor.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.
Embodiment 8
A, konjaku glucan and fibronectin are dissolved in the water and are configured to konjaku glucan/fibronectin of 30mg/mL Mixed liquor (mass ratio of konjaku glucan and fibronectin be 2:1).
B, evenly spreading to TA in the chitosan/fibroin albumen mixed liquor being made in A step makes its concentration 3mg/ Then V is added dropwise in mL into mixed liquor again3+And make the concentration 2mg/mL of metal ion in mixed liquor.
C, being placed in the mixed solution of B step preparation in mold, and being transferred into low temperature environment makes it congeal into ice Shape is finally dried using Freeze Drying Technique, and being formed has the skin dressing of near-infrared photo-thermal antibiotic leather.

Claims (10)

1. a kind of material, which is characterized in that be selected from Fe including metal ion described in tannic acid/metal ion complex3+、Ru3+、V3 +At least one of.
2. material according to claim 1, which is characterized in that further include that there is good cell, tissue affinity and compatibility Material, further, the material be natural material；Further, the natural material is selected from natural polysaccharide, natural egg One or both of white combination.
3. a kind of medical material, which is characterized in that including tannic acid/metal ion complex, natural polysaccharide and native protein.
4. material according to claim 3, which is characterized in that the natural polysaccharide and native protein constitute porous support, single Peaceful acid and adsorption of metal ions are in porous scaffold surface and pore structure.
5. according to the material of claim 3 or 4, which is characterized in that in the tannic acid/metal ion complex, the gold Category ion is Fe3+、Ru3+、V3+At least one of.
6. according to the material of claim 3 or 4, which is characterized in that in terms of quality proportioning, natural polysaccharide: native protein: tannin Acid: metal ion=(50~80): (20~50): (0.1~10): (0.05~5)；Further, natural polysaccharide and natural egg White quality proportioning is 2:1.
7. according to the material of claim 3 or 4, which is characterized in that the natural polysaccharide be chitin, chitosan, cellulose, At least one of konjaku glucan, sodium alginate, hyaluronic acid, starch, spirulina polysaccharide；The native protein is fibroin egg At least one of white, fibroin fiber, fibronectin, albumin, gelatin, collagen.
8. the preparation method of material described in claim 1, which is characterized in that it includes following content:
(1) tannic acid/metal ion match or tannic acid and metal ion；
(2) native protein；
(3) natural polysaccharide；
(4) it mixes in a solvent；Further, the solvent is selected from water；
(5) it is freeze-dried.
9. method according to claim 8, which is characterized in that by natural polysaccharide and native protein be dissolved in water be made into mixing it is molten Tannic acid is distributed in acquired solution by liquid, then acquired solution is mixed with metal ion solution, finally by gained mixture into Row freeze-drying.
10. a kind of composition, which is characterized in that including natural polysaccharide, native protein, tannic acid, metal ion, with quality proportioning Meter, natural polysaccharide: native protein: tannic acid: metal ion=(50~80): (20~50): (0.1~10): (0.05~5)； Further, the metal ion is Fe3+、Ru3+、V3+At least one of.
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